62nd ASH Annual Meeting and Exposition: 803. Emerging Diagnostic Tools and Techniques: Poster II

Oral and Poster Abstracts
Poster

Adult, AML, apoptosis, Biological, Leukemia, multiple myeloma, sickle cell disease, bioengineering, Diseases, sickle cell trait, smoldering myeloma, biopsy, cell regulation, GVHD, Therapies, Genetic Disorders, Pediatric, B-Cell Lymphoma, Biological Processes, DNA damage, enzyme inhibitors, Hemoglobinopathies, immune cells, Immune Disorders, Technology and Procedures, Cell Lineage, Plasma Cell Disorders, Lymphoid Malignancies, Study Population, Clinically relevant, genetic profiling, Myeloid Malignancies, imaging, flow cytometry, immune mechanism, mass cytometry, molecular testing, NGS, RNA sequencing, WGS

2459

Diagnostic Utility of Targeted Next Generation Sequencing in Patients with Vascular Anomalies

Whitney Eng, MD, MPH¹, Sophie Dilek, BA¹^*, Abigail Ward¹^*, Harry PW Kozakewich, MD²^*, Alyaa Al-Ibraheemi, MD²^*, Katherine Janeway, MD, MMSc¹^*, Denise M Adams, MD³ and Alanna Church, MD²^*

¹Department of Pediatric Hematology/Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA
²Department of Pathology, Boston Children's Hospital, Boston, MA
³Department of Pediatric Hematology/Oncology, Children's Hospital of Philadelphia, Philadelphia, PA

2460

Immunocluster: A Computational Tool to Explore the Immune Profile and Cellular Heterogeneity of Hematological Diseases Using Liquid and Imaging Mass, and Flow Cytometry Data

Jessica A. Timms¹^*, James W Opzoomer²^*, Kevin Blighe, PhD²^*, Benedetta Apollonio, PhD³, Thanos Mourikis⁴^*, Nicolas Chapuis, PharmD, PhD⁵^*, Richard Bekoe⁶^*, Alan G. Ramsay, BSc, MSc, PhD⁷, Donal P. McLornan, MRCP, PhD, FRCPath^8,9^*, Claire Harrison, DM, FRCPath^1,10, Paul R. Barber¹¹^*, Peter Parker¹^*, Michaela Fontenay, MD, PhD¹², James N. Arnold¹³^* and Shahram Kordasti, MD, PhD^8,14

¹Systems Cancer Immunology Lab, Comprehensive Cancer Centre, King's College London, London, United Kingdom
²Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King's College, London, United Kingdom
³Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom
⁴King's College London, London, GBR
⁵Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8104,, Institut Cochin, INSERM U1016, University Paris Descartes, Paris, France
⁶UCL Cancer Institute, Paul O'Gorman Building, University College London, London, United Kingdom
⁷King's College London, London, United Kingdom
⁸Department of Haematological Medicine, King's College Hospital NHS Foundation Trust, London, United Kingdom
⁹Systems Cancer Immunology, Comprehensive Cancer Centre, Kings's College Hospital, London, United Kingdom
¹⁰Department of Clinical Haematology, Guys and St Thomas NHS Trust, London, United Kingdom
¹¹School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom
¹²Institut National de la Santé et de la Recherche Médicale U1016, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8104,, Université Paris Descartes, AP-HP, Hôpital Cochin, Paris, France
¹³School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, Kings College London, London, United Kingdom
¹⁴Systems Cancer Immunology, Comprehensive Cancer Centre, King's College London, London, United Kingdom

2461

Deep Learning for Distinguishing Morphological Features of Acute Promyelocytic Leukemia

John-William Sidhom, MSc¹^*, Ingharan J Siddarthan¹^*, Bo-Shiun Lai, PhD¹^*, Adam Luo¹^*, Bryan Hambley, MD¹, Jennifer Bynum, MD¹^*, Amy S. Duffield, MD, PhD²^*, Michael B. Streiff, MD³, Alison R. Moliterno, MD⁴, Philip H. Imus, MD¹, Christian B. Gocke, MD, PhD¹, Lukasz P. Gondek, MD, PhD¹, Amy E. DeZern, MD⁵, Alexander S Baras, MD, PhD¹^*, Thomas S. Kickler, MD⁶, Mark Levis, MD, PhD¹ and Eugene Shenderov, MD, DPhil¹^*

¹Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD
²Johns Hopkins University, Baltimore, MD
³Division of Hematology, Department of Medicine & Pathology, Johns Hopkins University School of Medicine, Baltimore, MD
⁴Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
⁵Sidney Kimmel Comprehensive Cancer Center, 1650, Baltimore, MD
⁶Department of Pathology, Johns Hopkins University, Baltimore, MD

2462

The Role of PET-MRI in Multiple Myeloma Patients

Laurent Garderet, MD, PhD¹, Driss Kharroubi-Lakouas, MD²^*, Damien roos Weil³^*, Nathalie Jacque⁴^*, Maya Ouzegdouh Ouarab⁵^*, Suella Martino⁶^*, Veronique Morel⁷^*, Adrien Grenier, MD, PhD⁵^*, Choquet Sylvain⁸^*, Veronique Leblond, MD, PhD⁹, Aurelie Kas, MD PhD²^* and Olivier Lucidarme, MD PhD¹⁰^*

¹Service Hematologie, Sorbonne Université, Hopital Pitié Salpêtière APHP, Paris, France
²Nuclear medicine department, Sorbonne Université Hôpital Pitié Salpêtrière APHP, Paris, France
³Hematology department, Sorbonne Université Hôpital Pitié Salpêtrière APHP, Paris, FRA
⁴Service d'Hematologie Clinique, Hôpital Pitié Salpêtrière, APHP, Paris, France
⁵Hematology department, Hôpital Pitié Salpêtrière APHP, Paris, France
⁶hematology department, Hôpital Pitié Salpêtrière, APHP, Paris, FRA
⁷APHP, La Pitié Salpétrière, Hematology, Paris Cedex 13, FRA
⁸Département d’Hématologie, Hôpital de la Pitié Salpêtriere, APHP, Courbevoie, France
⁹Service d'hématologie, Hopital Pitie-Salpetriere, Sorbonne Université, Paris, FRA
¹⁰Radiology department, Sorbonne Université Hôpital Pitié Salpêtrière APHP, Paris, France

2463

Comparative Analysis of Flow Cytometry and Real-Time Quantitative Polymerase Chain Reaction for the Detection of Minimal Residual Disease in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia before Hematopoietic Stem Cell Transplantation

Xinyu Wang, MD^*, Yingjun Chang^*, Yanrong Liu^*, Yazhen Qin^*, Lanping Xu^*, Yu Wang^*, Xiaohui Zhang^*, Xiaojun Huang, MD and Xiaosu Zhao, PhD^*

Peking University People’s Hospital & Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China

2464

CD22 Gating for Flow Cytometric Analysis in Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia after CD19 CAR-T Therapy

Xinjian Yu¹^*, Pan Li¹^*, Heyuan Feng¹^*, Jian Kang¹^*, Xichang Zheng¹^*, Yunmei Zhang¹^*, Wenhong Yang¹^*, Tong Wu, MD² and Shuangyou Liu¹^*

¹Beijing Boren Hospital, Beijing, China
²Bone Marrow Transplantation, Beijing Boren Hospital, Beijing, China

2465

One Tube 24 Color Full Spectral Flow Cytometry and Multi-Dimensional Software to Study the Maturation Pattern and Antigen Expression of the Myeloid

Man Chen¹^*, Hui Wang, MD²^*, Minjing Fu³^*, Aixian Wang¹^*, Meiwei Gong¹^*, Junyi Zhen¹^*, Xueying Wu⁴^*, Kun Zhao³^* and Peihua Lu, MD⁵

¹Pathology & Laboratory Medicine Division, Hebei Yanda Ludaopei hospital, Langfang, China
²Pathology & Laboratory Medicine Division, Hebei Yanda Lu Daopei Hospital, Beijing, Beijing, China
³Beijing Ludaopei Hospital, Beijing, China
⁴Pathology & Laboratory Medicine Division, Hebei Yanda Ludaopei Hospital, Langfang, China
⁵Hebei Yanda Lu Daopei Hospital, Langfang, China

2466

Metagenomics Next-Generation Sequencing for Identifying Pathogens in Central Nervous System Complications after Allogeneic Hematopoietic Stem Cell Transplantation

Wenjun Liu¹^*, Zhiping Fan, MD²^*, Fen Huang²^*, Na Xu²^*, Hui Liu²^*, Li Xuan, MD²^*, Zhixiang Wang²^*, Jun Xu³^*, Pengcheng Shi⁴^*, Jing Sun, MD², Qifa Liu, MD² and Ren Lin, MD²^*

¹Department of hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
²Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
³Department of hematology,Nanfang Hospital, Southern Medical University, Guangzhou, China
⁴Nanfang Hospital, Southern Medical University, Guangzhou, China

2467

Characterization of the Immunoglobulin Heavy- and Light-Chain Repertoires in a Single Reaction

Geoffrey Lowman¹^*, Michelle Toro, MS¹^*, Jayde Chang¹^*, Loni Pickle¹^*, Chenchen Yang, PhD²^* and Timothy Looney, PhD³

¹Thermo Fisher Scientific, Carlsbad, CA
²ThermoFisher Scientific, South San Francisco, CA
³Thermo Fisher Scientific, AUSTIN, TX

2468

High Dimensional Interrogation of Stress Response Patterns and Cell Death Modes in AML

Muharrem Muftuoglu, MD¹, Po Yee Mak¹^*, Vivian Ruvolo, MS¹^*, Yuki Nishida, MD, PhD², Peter P. Ruvolo, PhD¹, Bing Z Carter, PhD³ and Michael Andreeff, MD, PhD¹

¹Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Section of Molecular Hematology and Therapy, Department of Leukemia, MD Anderson Cancer Center, Houston, TX
³Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX

2469

A Deep Learning Framework for Sickle Cell Disease Microfluidic Biomarker Assays

Niksa Praljak^1,2^*, Brandon Shipley¹^*, Ayesha Gonzales¹^*, Utku Goreke, MSc¹^*, Shamreen Iram¹^*, Gundeep Singh¹^*, Ailis Hill¹^*, Umut A. Gurkan, PhD¹ and Michael Hinczewski, PhD¹^*

¹Case Western Reserve University, Cleveland, OH
²Cleveland State University, Cleveland, OH

2470

The Diverse Landscape of Fusion Transcripts in 25 Different Hematological Entities

Claudia Haferlach, MD, Wencke Walter, PhD^*, Manja Meggendorfer, PhD, Constance Baer, PhD, Anna Stengel, PhD, Stephan Hutter, PhD^*, Niroshan Nadarajah^*, Wolfgang Kern, MD and Torsten Haferlach, MD

MLL Munich Leukemia Laboratory, Munich, Germany

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