62nd ASH Annual Meeting and Exposition: 802. Chemical Biology and Experimental Therapeutics: Poster II

Oral and Poster Abstracts
Poster

Adult, AML, Anemias, antibodies, Biological, Animal models, Diseases, Lymphoma (any), Non-Biological, cell regulation, Combinations, Mantle Cell Lymphoma, Therapies, Adverse Events, cellular interactions, Non-Hodgkin Lymphoma, B-Cell Lymphoma, Biological Processes, DLBCL, PNH, T-Cell Lymphoma, Technology and Procedures, Lymphoid Malignancies, Study Population, Clinically relevant, Myeloid Malignancies, pharmacology, flow cytometry, stem cells, metabolomics, multi-systemic interactions, signal transduction

2454

Preclinical Evaluation of a Novel MALT1 Inhibitor CTX-177 for Relapse/Refractory Lymphomas

Daisuke Morishita, PhD¹^*, Akio Mizutani, PhD²^*, Hirokazu Tozaki, PhD²^*, Yasuyoshi Arikawa, PhD²^*, Takuro Kameda, MD³, Ayako Kamiunten, MD⁴^*, Keisuke Kataoka, MD, PhD⁵, Akinori Yoda, PhD⁶^*, Yotaro Ochi, MD⁶^*, Kotaro Shide, MD, PhD⁴, Koji Izutsu, MD, PhD⁷, Yosuke Minami, MD, PhD⁸, Kazuya Shimoda, MD, PhD⁴, Hiroshi Miyake, PhD²^* and Seishi Ogawa, MD, PhD⁶

¹Chordia Therapeutics Inc., FUJISAWA, Japan
²Chordia Therapeutics Inc., Fujisawa, Japan
³Department of Gastroenterology and Hematology, University of Miyazaki, Miyazaki, Japan
⁴Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
⁵Division of Molecular Oncology, National Cancer Center Research Institute, Tokyo, Japan
⁶Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⁷Department of Hematology, National Cancer Center Hospital, Tokyo, Japan
⁸National Cancer Center Hospital East, Kashiwa, Japan

2455

Targeting the Glucagon Receptor Signaling Pathway As a Novel Strategy to Counteract PI3K Inhibitor Induced Hyperglycemia While Sustaining Tumor PI3K Inhibition

Jie Wang, MD, MS¹, Michael Morse, MD¹^*, Frank Calzone²^*, Hai Yan³^*, Zung Thai³^*, Takuya Osada, MD PhD¹^* and Herbert Lyerly, MD¹^*

¹Duke University, Durham, NC
²ImmPACT-bio, Camarillo, CA
³REMD Biotherapeutics, Camarillo, CA

2456

The Combined Treatment with the FLT3-Inhibitor AC220 and the Complex I Inhibitor Iacs-010759 Synergistically Depletes Wt- and FLT3-Mutated Acute Myeloid Leukemia Cells

Xiyuan Lu¹^*, Alessia Lodi, PhD²^*, Lina Han, PhD³, Joseph R Marszalek, PhD⁴^*, Marina Konopleva, MD, PhD⁵ and Stefano Tiziani, PhD²

¹Department of Nutritional Sciences, The University of Texas at Austin, Austin, TX
²Department of Nutritional Sciences & Department of Pediatrics, Dell Medical School, The University of Texas at Austin, Austin, TX
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Institute for Applied Cancer Science & Center for Co-Clinical Trials, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Leukemia, University of Texas, MD Anderson Cancer Center, Houston, TX

2457

Risk Factors for Thrombotic Events in Patients with PNH: A Nested Case-Control Study in the International PNH Registry

Britta Hoechsmann¹^*, Regis Peffault De Latour, MD, PhD²^*, Anita Hill, MD, PhD³^*, Alexander Röth, MD⁴, Timothy Devos, MD⁵, Christopher Patriquin⁶^*, Wen-Chien Chou, MD, PhD⁷, Deepak Jain⁸^*, Ke Zu⁸^* and Jong Wook Lee, M.D., Ph.D.⁹

¹Institute of Transfusion Medicine, University of Ulm, Ulm, Germany
²French Reference Center for Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria, Assistance Publique – Hôpitaux de Paris, Université de Paris, Paris, France
³Department of Haematology, Leeds Teaching Hospitals, Leeds, MA, United Kingdom
⁴Department of Hematology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
⁵Department of Microbiology and Immunology, Laboratory of Molecular Immunology (Rega Institute), KU Leuven, Leuven, Belgium; Division of Hematology, University Hospitals Leuven, Leuven, Belgium
⁶Division of Medical Oncology & Hematology, University of Toronto, Toronto, Canada
⁷Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan
⁸Alexion Pharmaceuticals, Inc., Lexington, MA
⁹Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)

2458

Human Placenta Derived Exosomes Enhance Ischemia Repair in a Mouse Model of Hind-Limb Ischemia

Qian Ye, PhD¹^*, Shuyang He, PhD²^*, Joseph Gleason, MS²^*, Bhavani Stout²^*, Navjot Shah²^*, John Hariri²^*, Chole Holland³^*, Srinivas Somanchi, PhD²^*, Xiaokui Zhang, PhD² and Robert Hariri, MD, PhD²^*

¹Celularity, Inc., Warren, NJ
²Celularity Inc., Warren, NJ
³Celularity.com, Warren, NJ

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^*signifies non-member of ASH