Hanying Wang^1,2*, Xin He, MD^1*, Feiteng Huang, MS^1,3*, Haojie Dong, PhD^1*, Wei Chen, PhD^4*, Zheng Li, MS^1*, Jie Sun, PhD^1*, Yinghui Zhu, PhD^1*, Lei Zhang, MD^1,3, Yuhui Wu, MD^1,2*, Lifeng Feng, PhD^5*, Jing Zhang, PhD⁶, Samer Khaled, MD⁷, Guido Marcucci, MD¹, David Sykes, MD, PhD⁸, Hongchuan Jin, MD, PhD^5*, Xian Wang, MD, PhD^2* and Ling Li, PhD¹

¹Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope, Monrovia, CA
²Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
³Department of Hematology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
⁴Integrative Genomics Core, Beckman Research Institute, City of Hope, Monrovia, CA
⁵Laboratory of Cancer Biology, Provincial Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
⁶McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI
⁷Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA
⁸Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA

Warren Fiskus, BSc, PhD¹, Christopher Peter Mill, PhD, BA^2*, Christine Birdwell^3*, Bernardo H Lara^4*, Prithviraj Bose, MD^5,6, Lucia Masarova, MD^7*, Tapan M. Kadia, MD⁸, Joseph D. Khoury, MD⁹, Taghi Manshouri, PhD^7*, Srdan Verstovsek, MD, PhD⁷ and Kapil N. Bhalla, MD¹

¹Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
²MD Anderson Cancer Center, Houston, TX
³The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Leukemia, MD Anderson Cancer Center, Houston, TX
⁵Department of Leukemia, MD Anderson Cancer Center, Houston, TX
⁶Department of Leukemia, UT Texas MD Anderson Cancer Center, Houston, TX
⁷Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁸Department of Leukemia, M.D. Anderson Cancer Center, Houston, TX
⁹Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX

Yuki Nishida, MD, PhD¹, Rafael Heinz Montoya, BS^2*, Kiyomi Morita, MD, PhD³, Tomoyuki Tanaka, MD, PhD^4*, Feng Wang, PhD^4*, Koichi Takahashi, MD, PhD⁴, Jo Ishizawa, MD, PhD², Prasanna Kumar, PhD^5*, Parul Patel, PhD^5*, Cedric E. Dos Santos, PhD⁵, Courtney D. DiNardo, MD, MSc⁶ and Michael Andreeff, MD, PhD²

¹Section of Molecular Hematology and Therapy, Department of Leukemia, MD Anderson Cancer Center, Houston, TX
²Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Genomic Medicine, University of Texas/MD Anderson Cancer Center, Houston, TX
⁴Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Daiichi Sankyo Inc., Basking Ridge, NJ
⁶Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX

Yang Song, MD^1*, Yannan Jia^1*, Guangji Zhang^2*, Shuning Wei^1*, Yan Li, MD^2*, Yimin Hu^2*, Qishan Hao^1*, Zhe Wang^1*, Qiuyun Fang^2*, Zheng Tian, BS^1*, Shangzhu Li^1*, Min Wang, MD^1*, Jianxiang Wang, MD^1,2 and Yingchang Mi^1,2

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
²National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China

Mary Figueroa, BS^1,2,3, Maninder Khosla, BS^4*, Yue Lu, PhD^5*, Marcos Estecio, PhD^6*, Seyed Javad Moghaddam, MD^7,8*, Elias Jabbour, MD⁹, Marina Konopleva, MD, PhD¹⁰, Courtney D. DiNardo, MD, MSc¹¹ and Joya Chandra, PhD^1,2,7,12

¹Department of Pediatrics-Research, University of Texas M.D. Anderson Cancer Center, Houston, TX
²Center for Cancer Epigenetics, University of Texas MD Anderson Cancer Center, Houston, TX
³UTHealth Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Pediatrics-Research, UT MD Anderson Cancer Center, Houston, TX
⁵Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston
⁶Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX
⁸Department of Pulmonary Medicine, University of Texas MD Anderson Cancer Center, Houston, TX
⁹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
¹⁰Department of Leukemia, University of Texas, MD Anderson Cancer Center, Houston, TX
¹¹Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX
¹²Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX

Hongxing Liu, MD^1,2,3, Jiaqi Chen, MD^1,2*, Fang Wang, MD¹, Jiancheng Fang^1*, Wen Teng, BS^1*, Xue Chen, MD^4*, Yang Zhang, MD¹, Xiaoli Ma, MD^1*, Panxiang Cao, MS^1*, Daijing Nie^5*, Yu Li^6* and Xiaosu Zhou^1*

¹Division of Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Langfang, China
²Beijing Lu Daopei Institute of Hematology, Beijing, China
³Division of Laboratory Medicine, Beijing Lu Daopei Hospital, Beijing, China
⁴Division of Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Beijing, China
⁵Division of Laboratory Medicine, Hebei Yanda Lu Daopei Hospita, Langfang, China
⁶Divison of Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Langfang, China

Dengyang Zhang, PhD^1*, Yao Guo, PhD^2*, Yuming Zhao, MD^3*, Liuting Yu^3*, Zhiguang Chang, PhD^3*, Han Zhong Pei^3*, Junbin Huang, MD, PhD^4*, Chun Chen, MD, PhD^4,5*, Hongman Xue, MD, PhD^2*, Yihang Pan, MD^3*, Ningning Li, PhD^1*, Chengming Zhu, PhD^6*, Zhizhuang Joe Zhao, PhD⁷, Jian Yu, PhD^8* and Yun Chen, PhD^2*

¹The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen City, Guangdong Provience, China
²The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China
³The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China
⁴The Seventh Affiliated Hospital, Sun Yat-sen University, shenzhen, China
⁵Sun Yat-sen Memorial Hospital, Guangzhou, China
⁶The seventh affiliated hospital, Sun Yat-sen University, shenzhen, China
⁷Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
⁸Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University, Beijing, China

Quentin Fovez^1*, Raeeka Khamari^1*, Anne Trinh, PhD^1*, William Laine^1*, Bruno Quesnel, MD, PhD^2,3, Philippe Marchetti, MD, PhD^1,4* and Jérôme Kluza, PhD^1*

¹UMR9020-U1277 - CANTHER, INSERM CNRS, LILLE, France
²UMR9020-U1277 - CANTHER, INSERM CRNS, LILLE, France
³Service des Maladies du Sang, Hôpital Huriez, Centre Hospitalier Universitaire de Lille, LILLE, France
⁴Centre de Biologie-Pathologie, CHU Lille, Lille, France

Daniel J. Coleman, PhD^*, Brittany M. Smith^*, Cody Coblentz^*, Rowan L. Callahan^*, Jake VanCampen^*, Garth L. Kong^*, Brian J. Druker, MD, Julia E. Maxson, PhD and Theodore P. Braun, MD, PhD

Knight Cancer Institute, Oregon Health & Science University, Portland, OR