62nd ASH Annual Meeting and Exposition: 502. Hematopoiesis: Regulation of Gene Transcription, Cytokines, Signal Transduction, Apoptosis, and Cell Cycle Regulation: Poster II

Oral and Poster Abstracts
Poster

AML, HSCs, Animal models, Diseases, platelets, MDS, red blood cells, Biological Processes, white blood cells, Technology and Procedures, Cell Lineage, Xenograft models, gene editing, Study Population, genomics, Myeloid Malignancies, hematopoiesis, flow cytometry, NGS, RNA sequencing, pathways

1837

Transcriptional Heterogeneity Governs Cell Fate Diversification during Pre-Leukemia to Leukemia Progression

Shikha Gupta, MS¹^*, Ana Filipa Domingues^2,3,4^*, Oliwia Cyran⁵^*, George Giotopoulos, PhD^2,3,6^*, Sudhakaran Prabakaran, PhD^5,7^*, Brian J. P. Huntly, PhD, MRCP, MB, FRCPath^2,3,6, Oliver M. Dovey, PhD⁴^*, George S. Vassiliou, MD, PhD, FRCPath, MRCP^2,8,9^* and Cristina Pina, MD, DPhil¹⁰

¹Department of Genetics, University of Cambridge, Cambridge, ENG, United Kingdom
²Department of Haematology, University of Cambridge, Cambridge, United Kingdom
³Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom
⁴Wellcome Trust Sanger Institute, Cambridge, United Kingdom
⁵Department of Genetics, University of Cambridge, Cambridge, United Kingdom
⁶Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, United Kingdom
⁷Biology, Indian Institute of Science Education and Research, Pune, India
⁸Department of Haematology, University of Cambridge, Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom
⁹Wellcome Trust Sanger Institute, Cambridge, ENG, United Kingdom
¹⁰College of Health, Medicine and Life Sciences - Division of Biosciences, Brunel University London, London, United Kingdom

1838

Zrsr2 Deficient Zebrafish Display Hematopoietic Defects and U12-Type Intron Retention in mRNA Processing Genes

Rachel N. Weinstein¹^*, Elizabeth Broadbridge^1,2^*, Kevin Bishop¹^*, Blake Carrington¹^*, Kai Yu, PhD¹^*, Abdel G. Elkahloun, PhD¹^*, WeiWei Wu¹^*, Wuhong Pei, PhD¹^*, Shawn M. Burgess, PhD¹^*, Paul P. Liu, MD, PhD¹, Erica Bresciani, PhD¹^* and Raman Sood, PhD¹^*

¹NHGRI, NIH, Bethesda, MD
²Johns Hopkins University, Baltimore, MD

1839

Functional Investigation of the Argonaute Proteins in Human Hematopoietic Stem and Progenitor Cells

Gordon G. L. Wong, BS^1,2^*, Gabriela Krivdova, BSc^1,2, Olga I. Gan, PhD³^*, Jessica L. McLeod³^*, John E. Dick, PhD, FRS^3,4 and Eric R. Lechman, PhD¹

¹Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
²Molecular Genetics, University of Toronto, Toronto, ON, Canada
³Princess Margaret Cancer Centre, University Health Network (UHN), Toronto, ON, Canada
⁴Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada

1840

GFI1 Is a Downstream Target of EVI1 in Normal Hematopoiesis

Akira Chiba, MD, PhD, Yosuke Masamoto, MD, PhD, Hideaki Mizuno, MD, PhD^* and Mineo Kurokawa, MD, PhD

Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

1841

Irs1^S57X Heterozygous Mutant Mice Display Normal Hematopoiesis and Phenotypic Features, While Homozygous Knockout Exhibit High Fetal or Postnatal Lethality

Bruna Alves Fenerich, BSc^1,2^*, Jaqueline Cristina Fernandes, BSc, MSc^1,2^*, Cleide Lúcia Araújo Silva, MSc²^*, Juan L Coelho-Silva, BSc, MSc^1,2^*, Antonio Bruno Alves Silva, BSc, MSc^1,2^*, Natasha Peixoto Fonseca, B.Sc., M.Sc.^1,2^*, João Agostinho Machado-Neto, PhD³^* and Fabiola Traina, MD, PhD^1,2

¹Hematology Division of Medical Images, Hematology, and Clinical Oncology Department, University of Sao Paulo at Ribeirao Preto Medical School, Ribeirao Preto, Brazil
²Center for Cell-based Therapy and Regional Hemotherapy Center, University of Sao Paulo at Ribeirao Preto Medical School, Ribeirao Preto, Brazil
³Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

See more of: Oral and Poster Abstracts

<< Previous Session | Next Session >>

^*signifies non-member of ASH