62nd ASH Annual Meeting and Exposition: 803. Emerging Diagnostic Tools and Techniques: Poster I

Oral and Poster Abstracts
Poster

ALL, AML, antibodies, Biological, Leukemia, multiple myeloma, Diseases, Lymphoma (any), Bone Marrow Failure, Therapies, MDS, Non-Hodgkin Lymphoma, Biological Processes, DNA damage, DNA repair, Technology and Procedures, cytogenetics, Plasma Cell Disorders, Lymphoid Malignancies, Clinically relevant, genetic profiling, genomics, Myeloid Malignancies, imaging, Quality Improvement , flow cytometry, molecular testing, NGS, RNA sequencing, pathogenesis, WGS

1552

Clinical Utility of Plasma Cell-Free DNA for Detection and Quantification of Clonal Hematopoiesis

Fernanda Gutierrez-Rodrigues, PhD¹^*, Isabel Beerman, PhD²^*, Emma M. Groarke, MD¹, Bhavisha A Patel, MD¹, Nina Spitofsky¹^*, Diego Quinones Raffo, MSc¹^*, Sachiko Kajigaya, PhD¹^*, Luigi Ferrucci, MD, PhD³^* and Neal S. Young, MD¹

¹Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
²National Institute on Aging, NIH, Baltimore, MD
³National Institute of Aging, Baltimore, MD

1553

Comparison of Deep Whole Exome Versus Targeted Gene Sequencing for Assessment of Persistent Molecular Disease in Acute Myeloid Leukemia Samples

Michael Slade, MD, MS¹, Michelle O'Laughlin²^*, Robert S Fulton²^*, Eric J. Duncavage, MD³, Timothy J Ley, MD¹, Meagan A. Jacoby, MD¹ and David H Spencer, MD¹

¹Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO
²McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO
³Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO

1554

Minimal Residual Disease (MRD) at 10^-6 Measured By Next Generation Flow (NGF) during Daratumumab Consolidation Therapy: Analysis at 18 Months Follow up of DART4MM Study (Daratumumab Treatment For Multiple Myeloma Eradication)

Alessandro Gozzetti¹^*, Donatella Raspadori¹^*, Paola Pacelli¹^*, Elisabetta Antonioli, MD²^*, Elena Bestoso¹^*, Sara Ciofini¹^*, Francesca Bacchiarri, MD¹^*, Gabriele Buda, MD, PhD³, Dania Tocci¹^*, Cristiana Cafarelli¹^*, Anna Marina Liberati⁴^*, Piero Galieni⁵^*, Giulia Lucco Navei¹^*, Ubaldo Occhini⁶^*, Anna Sicuranza, PhD¹^*, Michela Staderini²^*, Rosaria Crupi¹^*, Mario Petrini, MD, PhD⁷, Alberto Bosi, MD⁸^* and Monica Bocchia⁹^*

¹Hematology, University of Siena, Azienda Ospedaliera Universitaria Senese, Siena, Italy
²Azienda Ospedaliera Universitaria Careggi, Firenze, Italy
³Hematology Division, U.O. Hematology, Pisa, Pisa, Italy
⁴S.C. Oncoematologia, Università degli Studi di Perugia, A.O. Santa Maria, Terni, Italy
⁵UOC Ematologia e Terapia Cellulare, Ospedale "C. e G. Mazzoni", Ascoli Piceno, Italy
⁶Hematology, Usl8, Arezzo, ITA
⁷Hematology Division, U.O.Hematology, Pisa, Pisa, Italy
⁸SODc Ematologia, AOU Careggi, Firenze, Italy
⁹Hematology, University of Siena, Siena, Italy

1555

A Novel Approach to Blood Smear Analysis Based on Specimen Topology: Implications for Human and Artificial Intelligence Decision Making

Ben Zion Katz, PhD^1,2^*, Irit Avivi, MD^1,2^*, Dan Benisty, MD³^*, Shahar Karni, M. Sc.⁴^*, Hadar Shimoni⁴^*, Omri Grooper⁴^* and Olga Pozdnyakova, MD, PhD⁵^*

¹Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
²Department of Hematology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
³Hematology, Tel Aviv Medical Center, Tel Aviv, Israel
⁴Scopio Labs, Tel Aviv, Israel
⁵Department of Pathology, Brigham and Women's Hospital, Boston, MA

1556

Detection of Del(17p) in Hematological Malignancies By Imaging Flow Cytometry

Wendy N. Erber, MD^1,2, Henry Hui, PhD³^*, Jason Stanley, BSc (Hons)³^*, Thomas Mincherton, BSc³^*, Kathryn Clarke, PhD⁴^*, Bradley Augustson, MBBS FRACP FRCPA^5,6^*, Teng Fong Ng, BSc, MBBS, MRCP⁷, Chan Yoon Cheah, MBBS^8,9, Andrew David McQuillan, MBBS, FRACP, FRCPA¹⁰^* and Kathy Fuller, PhD³^*

¹University of Western Australia, Crawley W.A., Australia
²PathWest Laboratory Medicine, Nedlands, Australia
³School of Biomedical Sciences, The University of Western Australia, Crawley, WA, Australia
⁴Queen's University, Belfast, United Kingdom
⁵Department of Haematology, Pathwest QEII Medical Centre, Nedlands, Australia
⁶Department of Haematology, Sir Charles Gairdner Hospital, Nedlands, Australia
⁷Royal Perth Hospital, Perth, Australia
⁸University of Western Australia, Crawley, WA, Australia
⁹Department of Haematology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia
¹⁰Hollywood Hospital, Nedlands, Australia

1557

Opportunities of Genome Imaging for Genetic Diagnosis in Acute Lymphoblastic Leukemia

Jolien De Bie, MD, PhD^1,2^*, Barbara Dewaele¹^*, Olga Gielen³^*, Katrina Rack, PhD¹^*, Johan A. Maertens, MD, PhD⁴^*, Heidi Segers, MD, PhD⁵^*, Joris Vermeesch, PhD¹^*, Kim De Keersmaecker, PhD⁶, Jan Cools, PhD⁷ and Lucienne Michaux, MD, PhD⁸^*

¹Center for Human Genetics, Department of Human Genetics, University Hospitals Leuven, Leuven, Belgium
²Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium
³Laboratory for Molecular Biology of Leukemia, Department of Human Genetics, Center for Cancer Biology, VIB-KU Leuven, Leuven, Belgium
⁴Department of Hematology, University Hopitals Leuven, Leuven, Belgium
⁵Department of Pediatric Hemato-Oncology, University Hospitals Leuven, Leuven, Belgium
⁶Laboratory for Disease Mechanisms in Cancer, KU Leuven, Leuven, Belgium
⁷Laboratory for Molecular Biology of Leukemia, Department of Human Genetics, VIB Center for the Biology of Disease, Leuven, Belgium
⁸Center for Human Genetics, Department of Human Genetics, University Hospitals Leuven, Leuven, BEL

1558

Employment of Machine Learning Models Yields Highly Accurate Hematological Disease Prediction from Raw Flow Cytometry Matrix Data without the Need for Visualization or Human Intervention

Martha-Lena Müller, PhD¹^*, Niroshan Nadarajah¹^*, Kapil Jhalani¹^*, Inseok Heo, PhD²^*, William Wetton²^*, Claudia Haferlach, MD¹, Torsten Haferlach, MD¹ and Wolfgang Kern, MD¹

¹MLL Munich Leukemia Laboratory, Munich, Germany
²Amazon Web Services, Envision Engineering, Herndon

1559

The Quick Antigen Identification By Tissue Flow Cytometry for CAR-T Therapy in Relapsed/Refractory B-Cell Malignancies without Bone Marrow Involvement or Serous Cavity Effusions

Xinjian Yu¹^*, Pan Li¹^*, Heyuan Feng¹^*, Jian Kang¹^*, Xichang Zheng¹^*, Yunmei Zhang¹^*, Wenhong Yang¹^*, Tong Wu, MD² and Shuangyou Liu¹^*

¹Beijing Boren Hospital, Beijing, China
²Bone Marrow Transplantation, Beijing Boren Hospital, Beijing, China

1560

A Highly Sensitive and Specific Gene Fusion Algorithm Based on Multiple Fusion Callers and an Ensemble Machine Learning Approach

Brad B Thomas¹^*, Yanglong Mou, PhD¹^*, Lauryn Keeler²^*, Christophe Magnan, PhD³^*, Vincent Funari, PhD⁴^*, Lawrence Weiss, MD⁴^*, Shari Brown, MD⁵^* and Sally Agersborg, MD, PhD⁴^*

¹NeoGenomics Laboratories, Inc., Houston, TX
²NeoGenomics, Carlsbad, CA
³NeoGenomics Laboratories, Inc., Carlsbad, CA
⁴NeoGenomics Laboratories, Inc., Aliso Viejo, CA
⁵Neogenomics, Inc., Aliso Viejo, CA

1561

Development of a Machine Learning Algorithm for Rapid, Point-of-Care Prediction of Serum Monoclonal Proteins in Multiple Myeloma

Ehsan Malek, MD¹, Jeries Kort, MD², Gi-Ming Wang, PhD³^*, Paolo F Caimi, MD⁴, Kirsten M Boughan, DO⁴, Stanton L. Gerson, MD⁵, Brenda W. Cooper, MD⁴, Molly M Gallogly, MD, PhD⁴, Benjamin K. Tomlinson, MD⁴, Marcos de Lima, MD⁴, Curtis Tatsuoka, PhD³^* and James Driscoll⁶^*

¹Adult Hematologic Malignancies & Stem Cell Transplant Section, Seidman Cancer Center, University Hospitals Cleveland Medical Center, Cleveland, OH
²University Hospitals Cleveland Medical Center, Cleveland, OH
³Department of Population and Quantitative Health Sciences, Case Western Reserve University, School of Medicine, Cleveland, OH
⁴Adult Hematologic Malignancies & Stem Cell Transplant Section, University Hospitals Seidman Cancer Center, Cleveland, OH
⁵Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH
⁶Case Western Reserve University, Cleveland, OH

1562

Development of a Hydrashift 2/4 Isatuximab Assay to Mitigate Interference with Monoclonal Protein Detection on Immunofixation Electrophoresis in Vitro Diagnostic Tests in Multiple Myeloma

Greg Finn, PhD¹^*, Sandrine Macé²^*, Ruiyin Chu³^*, Helgi van de Velde, MD, PhD³, Samia Menad⁴^*, Marie-Thérèse Melki, PhD⁵^* and Georges Nouadje⁴^*

¹Sanofi R&D, Cambridge, MA
²Sanofi Research and Development, Vitry-Sur-Seine, France
³Sanofi, Cambridge, MA
⁴Sebia, Lisses, France
⁵Sebia, Evry, FRA

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^*signifies non-member of ASH

803.P1.33 803. Emerging Diagnostic Tools and Techniques: Poster I