-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

641.P1.30 641. CLL: Biology and Pathophysiology, excluding Therapy: Poster I

Program: Oral and Poster Abstracts
Type: Poster
Hematology Disease Topics & Pathways:
Biological, Leukemia, cell division, CLL, Diseases, Combinations, Therapies, cellular interactions, Non-Hodgkin Lymphoma, Biological Processes, DLBCL, cell expansion, immune cells, Technology and Procedures, Young Adult, Cell Lineage, Plasma Cell Disorders, Lymphoid Malignancies, Study Population, Clinically relevant, genomics, imaging, flow cytometry, molecular testing, NGS, microenvironment, RNA sequencing, pathogenesis
Saturday, December 5, 2020: 7:00 AM-3:30 PM

Andrea GS Pepper, PhD1*, Antonella Zucchetto, PhD2*, Kevin Norris, PhD3*, Erika Tissino, PhD4*, Jerry Polesel5*, Zarni Soe6*, David Allsup7*, Anna Hockaday8*, Pei Loo Ow9*, Peter Hillmen, MBChB, PhD10*, Andrew Rawstron, PhD11*, Daniel Catovsky, MD, FRCP12, Riccardo Bomben, PhD2*, Duncan M Baird, PhD13*, Christopher Fegan14*, Valter Gattei, MD15 and Chris Pepper, BSc, PhD16

1University of Sussex, Brighton and Sussex Medical School, Falmer, GBR
2Clinical and Experimental Onco-Hematology Unit, IRCCS Centro Di Riferimento Oncologico, Aviano, Italy
3Division of Cancer & Genetics, Cardiff University, Cardiff, United Kingdom
4Clinical and Experimental Onco-Hematology Unit, IRCCS Centro Di Riferimento Oncologico, Aviano, Pn, Italy
5Unit of Cancer Epidemiolog, IRCCS Centro Di Riferimento Oncologico, Aviano, Italy
6Haematology, Leeds Teaching Hospital Trust, Leeds, United Kingdom
7Centre for Atherothrombosis and Metabolic Disease, Hull York Medical School, Hull, ENG, United Kingdom
8Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, Leeds, United Kingdom
9University of Leeds, Leeds, GBR
10Department of Haematology, St James University Hospital, Leeds, United Kingdom
11HMDS, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
12The Institute of Cancer Research, London, United Kingdom
13Division of Cancer and Genetics, Cardiff University, Cardiff, United Kingdom
14School of Medicine, Division of Cancer and Genetics, Cardiff University, Cardiff, United Kingdom
15Clinical and Experimental Onco-Hematology Unit, Centro Di Riferimento Oncologico, Aviano, Italy
16Brighton and Sussex Medical School, University of Sussex, Brighton, United Kingdom

Erin Michelle Parry, MD, PhD1, Romain Guieze, MD2,3*, Ignaty Leshchiner, PhD4*, Daniel Rosebrock4*, Bria Persaud5*, Camilla K Lemvigh, MSc6*, Eugen Tausch, MD7*, Matthew S. Davids, MD8, Johannes Bloehdorn, MD9*, Christof Schneider, MD10*, Liudmila Elagina4*, Aina Zurita Martinez4*, Amaro Taylor-Weiner, PhD5*, Nitin Jain, MD11, William G. Wierda, MD, PhD12, Laura Z. Rassenti, PhD13, Thomas J. Kipps, MD, PhD13, Julien Broséus, Dr14*, Florence Cymbalista, MD, PhD15*, Neil E. Kay, MD16, Kenneth J. Livak, PhD17*, Shuqiang Li, PhD17*, Teddy Huang, BS17*, Noelia Purroy, MD, PhD1*, Annabelle J Anandappa, MD1,18, Stacey M. Fernandes, BS19*, Filippo Utro, PhD20*, Kahn Rhrissorrakrai, PhD20*, Chaya Levovitz, MD, PhD20*, Brian P Danysh, PhD5*, Kara Slowik5*, Sameer A. Parikh, MD16, Jennifer R Brown, MD, PhD19,21,22, Laxmi Parida, PhD20*, Donna S. Neuberg, ScD23, Stephan Stilgenbauer, MD24, Gad Getz, PhD4,25,26* and Catherine J. Wu, MD1,4,25

1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
2Université Clermont Auvergne, Clermont-Ferrand, France
3Service d'Hématologie Clinique et Thérapie Cellulaire, CHU, Université Clermont Auvergne EA7453 Chelter CIC-1405, Clermont-Ferrand, France
4Broad Institute of MIT and Harvard, Cambridge, MA
5Broad Institute of Harvard and MIT, Cambridge, MA
6Department of Department of Health Technology, Technical University of Denmark, Lyngby, Denmark
7Department III of Internal Medicine, Ulm University, Ulm, Germany
8Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA
9Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany
10Department of Internal Medicine III, Ulm University, Ulm, Germany
11Associate Professor of Medicine Department of Leukemia The University of Texas MD Anderson Cancer Center, Houston, TX
12Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
13Moores Cancer Center, University of California, San Diego, La Jolla, CA
14Laboratory Department, CHRU Nancy, Vandoeuvre-lès-Nancy, France
15Laboratoire d'Hématologie, APHP Hôpital Avicenne, Bobigny, France
16Division of Hematology, Mayo Clinic, Rochester, MN
17Translational Immunogenomics Lab, Dana-Farber Cancer Institute, Boston, MA
18Department of Medicine, Massachusetts General Hospital, Boston, MA
19Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
20IBM T.J. Watson Research Center, Yorktown Heights, NY
21CLL Center, Dana-Farber Cancer Institute, Boston, MA
22Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
23Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
24University of Ulm, Ulm, Germany
25Harvard Medical School, Boston, MA
26Cancer Center and Department of Pathology, Massachusetts General Hospital, Boston, MA

Zhiquan Wang, PhD1, Justin C. Boysen1*, Huihuang Yan, PhD2*, Charla R. Secreto1*, Sameer A. Parikh, MD1, Saad S. Kenderian, MD1, Wei Ding, MD, PhD1, Esteban Braggio, PhD3, Susan L. Slager, PhD2* and Neil E. Kay, MD1

1Division of Hematology, Mayo Clinic, Rochester, MN
2Department of Health Sciences Research, Mayo Clinic, Rochester, MN
3Division of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ

Daniel Goldstein, MD1*, Kyle A. Beckwith, MD PhD2, Cecelia Miller, PhD3*, Ying Huang, MS, MA2*, Lynne V. Abruzzo, MD, PhD3, Seema A Bhat, MD2, David A. Bond, MD, BS4, John C. Byrd, MD2, Michael R. Grever, MD2, Nyla A Heerema, PhD3, Kerry A. Rogers, MD2*, Amy S. Ruppert, PhD2, Jennifer A. Woyach, MD2 and Adam S. Kittai, MD2

1Department of Internal Medicine, The Ohio State University, Columbus, OH
2Division of Hematology, The Ohio State University, Columbus, OH
3Department of Pathology, The Ohio State University, Columbus, OH
4Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH

Charline Moulin1*, Francis Guillemin, MD, PhD1*, Thomas Remen2*, Florian Bouclet3*, Hélène Augé4*, Anne Quinquenel, MD, PhD5*, Caroline Dartigeas, MD6*, Romain Morizot4*, Sandra Lomazzi7*, Hélène Busby, MD8*, Sebastien Hergalant9*, Eugen Tausch, MD10*, Cécile Tomowiak, MD11*, Veronique Leblond, MD, PhD12*, Catherine Thieblemont, MD, PhD13, Florence Cymbalista, MD, PhD14*, Kamel Laribi, MD15*, Marie C Bene, PharmSci, PhD16*, Stephan Stilgenbauer, MD17, Romain Guieze, MD18*, Pierre Feugier, MD, PhD19* and Julien Broséus, Dr20*

1CIC-EC 1433, Nancy University Hospital, VANDOEUVRE, France
2Unit of Methodology and Statistics, Nancy University Hospital, VANDOEUVRE, France
3CHU Estaing, Unit of adult cell therapy and clinical hematology, University Hospital of Clermont-Ferrand, Clermont-Ferrand, Auvergne, France
4Haematology Department, Nancy University Hospital, Vandoeuvre-lès-Nancy, France
5Haematology Department, Robert Debré University Hospital, Reims, France
6CHU Tours, Tours, France
7Biocollection repository, Nancy University Hospital, Vandoeuvre-lès-Nancy, France
8Pathology Department, Nancy University Hospital, Vandoeuvre-lès-Nancy, France
9U1256, Inserm, Vandoeuvre-lès-Nancy, France
10Department of Internal Medicine III, Ulm University, Ulm, Germany
11Department of Oncology-Haematology and Cell Therapy, University Hospital of Poitiers, Poitiers, France
12Département d’ Hématologie Hôpital Pitié-Salpêtrière APHP, UPMC Université Paris, Paris, France
13Hôpital Saint-Louis, Paris, France
14Laboratoire d'Hématologie, APHP Hôpital Avicenne, Bobigny, France
15Centre Hospitalier Du Mans, Le Mans, France
16CRCINA, INSERM, CNRS, Université d'Angers, Université de Nantes, Nantes, France
17Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany
18CHU Estaing, Unit of adult cell therapy and clinical hematology, University Hospital of Clermont-Ferrand, Brookline, MA
19Hematology Department, Nancy University Hospital, Vandoeuvre-lès-Nancy, France
20Laboratory Department, CHRU Nancy, Vandoeuvre-lès-Nancy, France

Hua-Jay J Cherng, MD1, Nadya Jammal, PharmD2*, Shilpa Paul, PharmD2*, Xuemei Wang, MS3*, Koji Sasaki, MD4, Philip A. Thompson, MB, MS5, Jan A. Burger, MD, PhD6, Alessandra Ferrajoli, MD7, Zeev E. Estrov, MD6, Susan M. O'Brien, MD8, Michael J. Keating, MBBS7, William G. Wierda, MD, PhD9 and Nitin Jain, MD10

1Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX
2Department of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston, TX
3Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX
4Department of Leukemia, MD Anderson Cancer Center, Houston, TX
5The University of Texas MD Anderson Cancer Center, Houston, TX
6Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
7Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
8UCI Cancer Center, Orange, CA
9Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
10Associate Professor of Medicine Department of Leukemia The University of Texas MD Anderson Cancer Center, Houston, TX

Nadine Abdallah, MD1*, Angela Dispenzieri, MD2*, Eli Muchtar, MD3*, Francis K. Buadi, MB, CHB3*, Prashant Kapoor, MD3, Martha Q. Lacy, MD3, Yi L. Hwa, NP2, Amie Fonder, PA-C, MS2*, Miriam A. Hobbs, APRN, CNP, DNP2*, Suzanne R. Hayman, MD2, Nelson Leung, MD3, David Dingli, MD, PhD3, John A. Lust, MD, PhD2, Ronald S. Go, MD4, Yi Lin, MD, PhD2, Wilson I Gonsalves, MD3, Taxiarchis Kourelis, MD3, Rahma M Warsame, MD5, Robert A. Kyle, MD3, S. Vincent Rajkumar, MD3, Morie A Gertz, MD2 and Shaji K. Kumar, MD2

1Department of Internal Medicine, Division of Hematology and Oncology, Mayo Clinic, Rochester, MN
2Division of Hematology, Mayo Clinic, Rochester, MN
3Mayo Clinic Rochester, Division of Hematology, Rochester, MN
4Mayo Clinic Rochester, Division of Hematology, Onalaska, WI
5Mayo Clinic, Rochester, MN

Segun C Jung, PhD1*, Maya Thangavelu, PhD1, Hyunjun Nam, PhD2*, Ryan Bender, PhD, FACMGG2*, Sally Agersborg, MD, PhD1*, Lawrence Weiss, MD1* and Vincent Funari, PhD1*

1NeoGenomics Laboratories, Inc., Aliso Viejo, CA
2NeoGenomics Laboratories, Inc., Carlsbad, CA

Shanye Yin, PhD1*, Gregory Lazarian, PharmD2,3*, Elisa Ten Hacken, PhD4, Tomasz Sewastianik, PhD5*, Satyen Gohil, BSc, MBBS, MRCP, FRCPath6, Shuqiang Li, PhD1,7*, Laura Z. Rassenti, PhD8, Leah Billington, BA1*, Elizabeth Witten1*, Teddy Huang, BS7*, Kenneth J. Livak, PhD1,7*, Donna S. Neuberg, ScD9, Fanny Baran-Marszak, MD, PhD3*, Thomas J. Kipps, MD, PhD10, Florence Cymbalista, MD, PhD3*, Ruben D. Carrasco, MD, PhD11,12* and Catherine J. Wu, MD1,13,14

1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
2Department of Medical Oncology, Dana-Farber Cancer Institute, PARIS, France
3Laboratoire d'Hématologie, APHP Hôpital Avicenne, Bobigny, France
4Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA
5Dept. of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland
6University Ci, Enfield, United Kingdom
7Translational Immunogenomics Lab, Dana-Farber Cancer Institute, Boston, MA
8Moores Cancer Center, University of California, San Diego, La Jolla, CA
9Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA
10UCSD Moores Cancer Center, San Diego, CA
11Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA
12Dept. of Pathology, Brigham and Women's Hospital, Boston, MA
13Broad Institute of MIT and Harvard, Cambridge, MA
14Dana-Farber Cancer Institute, Boston, MA

*signifies non-member of ASH