Ayana Kon, MD, PhD^1*, Masahiro Marshall Nakagawa, MD, PhD^1,2, Ryosaku Inagaki, MSc^1,3*, Keisuke Kataoka, MD, PhD⁴, Hideki Makishima, MD, PhD¹, Yotaro Ochi, MD^1*, Manabu Nakayama, PhD^5*, Haruhiko Koseki, MD, PhD^6*, Yasuhito Nannya, MD, PhD¹ and Seishi Ogawa, MD, PhD¹

¹Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
²DSK Project, Medical Innovation Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan
³DSK Project, Medical Innovation Center, Graduate School of Medicine, Kyoto University, Kyoto City, KYO, Japan
⁴Division of Molecular Oncology, National Cancer Center Research Institute, Tokyo, Japan
⁵Department of Technology Development, Kazusa DNA Research Institute, Chiba, Japan
⁶Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

Zeya Cao^1,2*, Vikas Madan, PhD^2*, Weoi Woon Teoh^2*, Pushkar Dakle^2*, Lin Han, PhD^1,2*, Pavithra Shyamsunder^2,3*, Siqin Zhou^2*, Jia Li, PhD^2*, Hazimah Binte Mohd Nordin^2*, Shi Jizhong^2*, Yu Shuizhou^2*, Henry Yang, PhD^2*, Md Zakir Hossain^2*, Wee-Joo Chng, MBBS, PhD, FRCPath, FRCP^1,2,4 and H. Phillip Koeffler, MD^2,5,6

¹Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
²Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
³Cancer & Stem Cell Biology Programme, DUKE-NUS Medical School, Singapore, Singapore
⁴Hematology-Oncology, National University Cancer Institute, NUHS, Singapore, Singapore, Singapore
⁵Cedars-Sinai Medical Center, Division of Hematology/Oncology, UCLA School of Medicine, Los Angeles, CA
⁶National University Cancer Institute, National University Hospital Singapore, Singapore, Singapore

Alexander Schaeffer^1*, Ewelina Czlonka^2*, Irene Tirado-González^3*, Thomas Böse^1*, Jennifer Beauvarlet^4*, Ivan Kur^1*, Aline Bözec^5*, Halvard Bönig^6*, Christian H. Brandts, MD^7*, Uwe Platzbecker, MD⁸, Katharina S. Götze⁴ and Hind Medyouf^3*

¹Georg-Speyer-Haus, Frankfurt, Germany
²Gerog-Speyer-Haus, Frankfurt, Germany
³Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt am Main, Germany
⁴Department of Medicine III, Technical University of Munich, Munich, Germany
⁵Universitätsklinikum Erlangen, Erlangen, Germany
⁶German Red Cross Blood Service BaWüHe, Goethe University, , Institute for Transfusion Medicine and Immunohematology, Frankfurt, Germany
⁷Goethe University Frankfurt, Frankfurt, DEU
⁸Hematology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany

Giulia Maggioni, MD^1*, Erica Travaglino^1*, Ana Alfonso Pierola, MD, PhD^2*, Jennifer Kaivers, MD^3*, Montserrat Arnan, MD^4*, Manja Meggendorfer, PhD⁵, Laura Giordano^6*, Matteo Bersanelli^7*, Cristina Astrid Tentori, MD^1*, Marta Ubezio^1*, Lucio Morabito^1*, Alessia Campagna, MD^1*, Emanuele Angelucci, MD⁸, Massimo Bernardi, MD^9*, Lorenza Maria Borin^10*, Maria Teresa Voso, MD¹¹, Francesco Passamonti^12*, Armando Santoro^13*, Valeria Santini¹⁴, Guillermo F Sanz, MD, PhD¹⁵, Torsten Haferlach, MD¹⁶, Ulrich Germing^17*, Maria Diez-Campelo, PhD, MD^18* and Matteo Giovanni Della Porta, MD^1*

¹Cancer Center, IRCCS Humanitas Research Hospital & Humanitas University, Rozzano (Milan), Italy
²Hematology Department, Clínica Universidad de Navarra, University of Navarra, Pamplona, Spain
³Dept. of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany
⁴Hematology Department, Institut Català d'Oncologia-Hospital Duran i Reynals, L'Hospitalet del Llobregat, Spain
⁵MLL Munich Leukemia Laboratory, Munich, Bavaria, Germany
⁶Biostatistics Unit, IRCCS Humanitas Research Hospital, Milano, Italy
⁷Department of Physics and Astronomy, University of Bologna, Bologna, Italy
⁸Ematologia e Centro Trapianti, IRCCS Ospedale Policlinico San Martino, Genova, Italy
⁹Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy
¹⁰Department of Hematology, San Gerardo Hospital, Monza, Italy
¹¹University of Rome Tor Vergata, Rome, Italy
¹²Division of Hematology, Department of Medicine and Surgery, University of Insubria, Varese, Italy
¹³IRCCS Humanitas Research Hospital & Humanitas University, Rozzano, Italy
¹⁴MDS Unit- Hematology, AOU Careggi-University of Florence, Firenze, Fi, Italy
¹⁵Department of Haematology, Hospital Universitario y Politécnico La Fe, Valencia, Spain
¹⁶MLL Munchner Leukamie Labor Gmbh, Munchen, Germany
¹⁷Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University, Faculty of Medicine, Düsseldorf, Germany
¹⁸Hematology Department, Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, Salamanca, Spain

Zixian Liu^1*, Erlie Jiang^2*, Yi He^2*, Lixia Liu^3*, Chengcheng Wang^4*, Jialin Wei^2*, Donglin Yang^2*, Tao Zhou^5*, Aiming Pang, MD, PhD^6*, Yong Huang^2*, Rongli Zhang, MD^2*, Qiaoling Ma^2*, Mengmeng Zhang^7*, Feng Lou^8*, Shanbo Cao^9*, Qianqian Wang^10*, Weihua Zhai, MD^2*, Sizhou Feng^11*, Zhijian Xiao, MD^11* and Ming-Zhe Han, MD²

¹Institute of Hematology and Blood Diseases Hospital, Tianjin, CHN
²National Clinical Research Center for Blood Diseases, State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
³Acornmed Biotechnology Co., Ltd., Beijing, China
⁴AcornMed Biotechnology Co., Ltd., Beijing, China
⁵AcornMed Biotechnology Co., Beijing, China
⁶National Clinical Research Center for Blood Diseases, State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, Tianjin, China
⁷AcornMed Biotechnology Co., Ltd, Beijing, China
⁸AcornMed Biotechnology Co., Ltd.7 Floor, Building 8, Vpark, No.18 Kechuang 13th Street, Beijing, China, Beijing, China
⁹Acornmed Biotechnology Co.,Ltd., Beijing, China
¹⁰National Clinical Research Center for Blood Disease, Institute of Hematology and Blood Diseases Hospital & Peking Union Medical College and Chinese Academy of Medical Sciences, Tianjin, CHN
¹¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

Hannah Fields^1,2*, Valentina Ferrari, BA^2,3*, Alison Tarke, BS^2,4,5*, Randy Guo-Shi Tsai, BS, BA^1*, Timothy Luger^1,6*, Colin McCarthy, BS^1*, Ruifeng Chen^1*, Xinlian Zhang^1*, Thomas A Lane, MD², Antonella Vitiello, Dr. Pharm.^2*, Rafael Bejar, MD, PhD¹ and Tiffany N Tanaka, MD¹

¹Moores Cancer Center, University of California San Diego, La Jolla, CA
²PersImmune, Inc., San Diego, CA
³Department of Biomedical Sciences, Humanitas University, Milan, Italy
⁴Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, San Diego, CA
⁵Department of Biomedical Research, University of Genova, Genova, Italy
⁶Arcturus Therapeutics, San Diego, CA

Mónica Del Rey^1*, Luis A Corchete, PhD^2*, Teresa González, PhD^1*, Félix López Cadenas, MD^3*, Eva Lumbreras^1*, Marta Martín Izquierdo, MSc^1*, Sandra Santos-Mínguez^1*, Sofía M Toribio^1*, Blanca Xicoy, MD^4*, Joaquín Sánchez-García, MD, PhD^5*, Teresa Bernal, MD, PhD^6*, Guillermo F Sanz, MD, PhD⁷, Benet Nomdedeu, MD^8*, Pierre Fenaux, MD, PhD⁹, Jesús M Hernández Rivas, MD, PhD^1,3 and Maria Diez-Campelo, PhD, MD^3*

¹Unidad de Diagnóstico Molecular y Celular del Cáncer, Centro de Investigación del Cáncer-Universidad de Salamanca (IBMCC, USAL-CSIC); Genética Molecular en Oncohematología, Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain
²Instituto de Investigación Biomédica de Salamanca (IBSAL); Departamento de Hematología, Hospital Clínico Universitario de Salamanca; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Salamanca, Spain
³Hematology Department, Hospital Clínico Universitario de Salamanca, Salamanca, Spain
⁴Hematology Department, Institut Català d'Oncologia-Hospital Germans Trias i Pujol; Josep Carreras Leukemia Research Institute, Universitat Autònoma de Barcelona, Badalona, Spain
⁵Hematology Department, Hospital Reina Sofía, Córdoba, Spain
⁶Hematology Department, Hospital Universitario Central de Asturias, Oviedo, Spain
⁷Hematology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain
⁸Hematology Department, Hospital Clinic i Provincial de Barcelona, Barcelona, Spain
⁹Hôpital Saint-Louis, Paris, France

Moritz Binder, MD, MPH¹, Sandeep Potluri, MA, MBBChir, MRCP^2*, Ryan M. Carr, MD, PhD¹, Terra Lasho, PhD¹, Christy Finke, BS^1*, Abhishek A. Mangaonkar, MBBS¹, Christopher Pin, PhD^3*, Kurt Berger^3*, Tamas Ordog, MD^4*, Bonnie Alver, PhD^5*, Keith Robertson, PhD^5*, David Marks, PhD^6*, Martin Fernandez-Zapico, MD^7*, Alexandre Gaspar Maia, PhD^5* and Mrinal M. Patnaik, MD, MBBS¹

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, ENG, United Kingdom
³London Regional Transgenic and Gene Targeting Facility, Lawson Health Research Institute University of Western Ontario, London, ON, Canada
⁴Center for Individualized Medicine, Mayo Clinic, Rochester, MN
⁵Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁶Division of Oncology Research, Mayo Clinic, Rochester, MN
⁷Mayo Clinic, Rochester, MN

Hiroto Horiguchi, MD, PhD¹, Masayoshi Kobune, MD, PhD², Kento Ono, M.D.^2*, Saori Shimoyama, M.D.^2*, Chisa Fujita, M.D.^2*, Akari Goto, MD.PhD^2*, Hiroshi Ikeda, MD.PhD^2* and Satoshi Iyama, MD, PhD^1*

¹Sapporo Medical University School of Medicine, Sapporo, Japan
²Department of Hematology, Sapporo Medical University School of Medicine, Sapporo, Japan