Caroline Diorio, MD¹, Kevin O McNerney, MD, MSTR^2*, Michele P. Lambert, MD, MSTR³, Michele Paessler, D.O.^4*, Julie Chase, MD, PhD^5*, Kandace Gollomp, MD⁶, Benjamin L Laskin, MD^7*, Laura A Vella, MD, PhD^8*, Sarah E Henrickson, MD PhD^5*, Emily Liebling, MD^5*, Chakkapong Burudpakdee, BS^9*, Jessica Lee, BS^10*, Fran Balamuth, MD PhD^11*, Allison M Blatz, MD^5*, Kathleen Chiotos, MD, MSCE^12*, Julie C Fitzgerald, MD^13*, Therese Giglia, MD, MSCE^14*, Audrey R Odom John, MD PhD^5*, Whitney Petrosa, CPNP^9*, Kathleen Sullivan, MD, PhD^15*, Char M Witmer, MD¹⁶, Hamid Bassiri, MD/PhD^5*, Edward M Behrens, MD^5* and David T. Teachey, MD¹⁷

¹Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
²Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
³Hematology, Children's Hospital of Philadelphia, Philadelphia, PA
⁴Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
⁵Children's Hospital of Philadelphia, Philadelphia, PA
⁶Department of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA
⁷Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, PA
⁸Infectious Disease, Children's Hospital of Philadelphia, Philadelphia, PA
⁹Immune Dysregulation Frontier Program, Children's Hospital of Philadelphia, Philadelphia, PA
¹⁰Immune Dysregulation Frontier Program, Children's Hospital Philadelphia, Philadelphia, PA
¹¹Division of Emergency Medicine, Children's Hospital of Philadelphia, Philadelphia, PA
¹²Division of Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA
¹³Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA
¹⁴Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA
¹⁵Division of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, PA
¹⁶Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA
¹⁷Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and The Perelman School of Medicine at The University of Pennsylvania, Rutledge, PA

Paula M Jacobi^1* and Sarah E Sartain, MD²

¹Baylor College of Medicine/Texas Children's Hospital, Houston, TX
²Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine/Texas Children's Hospital, Houston, TX

Gowtham K Annarapu, PhD¹, Deirdre Nolfi-Donegan, MD², Anuradha Bharara Singh, PhD^1*, Michael Reynolds^3* and Sruti Shiva, PhD^1,4,5*

¹Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA
²Pediatric Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA
³University of Pittsburgh, Pittsburgh, PA
⁴Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA
⁵Center for Metabolism and Mitochondrial Medicine (C3M), University of Pittsburgh, Pittsburgh, PA

Ana Belen Moreno-Castaño, MD, PhD Student^1*, Sara Fernandez, MD^2*, Marta Palomo, PhD^3*, Patricia Molina, Technician^4*, Julia Martinez-Sanchez, PhD Student^5*, Sergi Torramade-Moix, PhD Student^1*, Helena Ventosa, MD^6*, Ferran Segui, MD^6*, Gines Escolar, MD, PhD^7*, Enric Carreras, MD, PhD^5*, Jose Maria Nicolas, MD, PhD^8*, Edward Richardson, MD^9*, David Garcia-Bernal, PhD^10*, Carmelo Carlo-Stella, MD¹¹, Jose Maria Moraleda, MD, PhD^12*, Paul G. Richardson, MD¹³, Maribel Diaz-Ricart^1* and Pedro Castro, MD, PhD^14*

¹Hematopathology, Pathology Department, CDB, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona Endothelium Team, Barcelona, Spain., Barcelona, Spain
²Department of Critical Care Medicine, Hospital Clínic of Barcelona, Barcelona, Spain
³Josep Carreras Leukaemia Research Institute, Hospital Clínic of Barcelona, University of Barcelona, Barcelona Endothelium Team (BET), Barcelona, Spain, Barcelona, Spain, Spain
⁴Hematopathology, Pathology Department, CDB, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain., Barcelona, Spain
⁵Josep Carreras Leukaemia Research Institute, Hospital Clínic of Barcelona, University of Barcelona, Barcelona Endothelium Team (BET), Barcelona, Spain, Barcelona, Spain
⁶Department of Critical Care Medicine, Hospital Clínic of Barcelona, Barcelona, Spain, Barcelona, Spain
⁷Hematopathology, Pathology Department, CDB, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona Endothelium Team, Barcelona, Spain., Barcelona, Barcelona, Spain
⁸Department of Critical Care Medicine, Hospital Clínic of Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain, Barcelona, Spain
⁹Frank H. Netter M.D. School of Medicine at Quinnipiac University, North Haven, Connecticut, USA; Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA, New Haven, CT
¹⁰Hematopoietic Transplant and Cellular Therapy Unit, Instituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, Virgen de la Arrixaca University Hospital, University of Murcia, Murcia, Spain., Murcia, Spain
¹¹Humanitas Cancer Center, Rozzano, Milano, Italy
¹²Hematopoietic Transplant and Cellular Therapy Unit, Instituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, Virgen de la Arrixaca University Hospital, University of Murcia, Murcia, Spain, Murcia, Spain
¹³Dana-Farber Cancer Institute, Boston, MA
¹⁴Department of Critical Care Medicine, Hospital Clínic of Barcelona, IDIBAPS, University of Barcelona, Barcelona Endothelium Team (BET), Barcelona, Spain, Barcelona, Spain

Tomasz Brzoska, PhD¹, Tomasz W. Kaminski, PharmD¹, Ravi Vats, MSc^1,2, Egemen Tutuncuoglu, MSc^1*, Mark T. Gladwin, MD^1,3 and Prithu Sundd, PhD^1,2,3

¹Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA
²Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA
³Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA