62nd ASH Annual Meeting and Exposition: 723. Clinical Allogeneic and Autologous Transplantation: Late Complications and Approaches to Disease Recurrence II

Oral and Poster Abstracts
Oral

Leukemia, Biological, Adult, ALL, AML, multiple myeloma, Diseases, CML, Therapies, CAR-Ts, CMML, Pediatric, MDS, Biological Processes, MPN, cell expansion, immune cells, Technology and Procedures, Young Adult, Plasma Cell Disorders, Lymphoid Malignancies, Study Population, Myeloid Malignancies, Clinically relevant, transplantation, immune mechanism, stem cells

Moderators:

Antonia MS Mueller, MD, University Hospital Zurich and Pavan Bachireddy, MD, Dana-Farber Cancer Institute

Disclosures:

No relevant conflicts of interest to declare.

2:00 PM

491

Impact of Minimal Residual Disease (MRD) By Multiparameter Flow Cytometry (MFC) and Next-Generation Sequencing (NGS) on Outcome: Results of Newly Diagnosed Transplant-Eligible Multiple Myeloma (MM) Patients Enrolled in the Forte Trial

Stefania Oliva¹^*, Elisa Genuardi¹^*, Maria Teresa Petrucci¹, Mattia D'Agostino, MD¹^*, Daniel Auclair², Antonio Spadano¹^*, Allison P. Jacob³^*, Michele Cea¹^*, Luca De Rosa¹^*, Alessandro Gozzetti¹^*, Marina Ruggeri¹^*, Andrea Capra¹^*, Milena Gilestro¹^*, Norbert Pescosta¹^*, Angelo D. Palmas¹, Agostina Siniscalchi¹^*, Ilan R. Kirsch, MD³, Paolo Corradini¹, Pellegrino Musto¹, Mario Boccadoro¹, Elena Zamagni, MD¹^* and Francesca Gay, MD¹

¹GIMEMA, European Myeloma Network, Italy
²Multiple Myeloma Research Foundation, Norwalk, CT
³Adaptive Biotechnologies, Seattle, WA

2:15 PM

492

Phase I Study of Adoptive Immunotherapy with HA-1-Specific CD8⁺ and CD4⁺ Memory T Cells for Children and Adults with Relapsed Acute Leukemia after Allogeneic Hematopoietic Stem Cell Transplantation (HCT): Trial in Progress

Elizabeth F Krakow, MD, MSc^1,2, Corinne Summers, MD^1,2,3, Ann Dahlberg, MD^1,2,3^*, Merav Bar^1,2, Melinda Ann Biernacki^1,2^*, Tanya Cunningham, MSc¹^*, Nicole Vartanian, MSc¹^*, Megan Hickner, RN¹^*, Colette Chaney, RN¹^*, Tsadik Habtetsion, PhD¹^*, Kyle Woodward, PhD¹^*, Robson Dossa, PhD¹^*, Michelle Brault, PhD¹^* and Marie Bleakley, MBBS MMSc PhD^1,2,3

¹Fred Hutchinson Cancer Research Center, Seattle, WA
²University of Washington, Seattle, WA
³Seattle Children's, Seattle, WA

2:30 PM

493

Influence of Inherited and Acquired Hematological and Immunological Gene Variants on the Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Hematological Malignancies

Zhihui Li¹^*, Yongqiang Zhao, MD¹^*, Yanzhi Song, MD¹^*, Caiyan Zhang, PHD²^*, Qinlong Zheng, PHD³^*, Chunrong Tong⁴^* and Tong Wu, MD¹

¹Bone Marrow Transplantation, Beijing Boren Hospital, Beijing, China
²Department of Hematology Pathology, beijing, China
³Laboratory of Molecular Diagnostics, Beijing Boren Hospital, Beijing, China
⁴Hematological Pathology, Beijing Boren Hospital, Beijing, China

2:45 PM

494

Peripheral Blood CD34⁺ Donor Chimerism Is Superior to CD3⁺ Donor Chimerism for Predicting Relapse Following Allogeneic Stem Cell Transplantation for Myeloid Malignancies

Tongted Das, PhD¹^*, Daniel North²^*, Shaun Fleming¹^*, David Kliman²^*, Andrew Spencer², Andrew H. Wei¹, Sushrut S. Patil²^*, Jacueline Widjaja²^*, Maureen O'Brien²^* and David J. Curtis, MBBS, PhD¹

¹Department of Clinical Haematology, Alfred Hospital, Melbourne, Australia
²Department of Clinical Haematology, Alfred Hospital, Melbourne, VIC, Australia

3:00 PM

495

Survival Following Post-HCT Relapse in Adult Acute Lymphoblastic Leukemia Has Improved in the Era of Novel Immunotherapies: A Single Institution Analysis

Juliana Craig, BA¹^*, Maria Iglesias, BS¹^*, Kristen Cunanan, PhD²^*, Sally Arai, MD, MS³, Matthew J. Frank, MD, PhD³, Laura J. Johnston, MD³, Robert Lowsky, MD, FRCP³, Everett H Meyer, MD, PhD³^*, David B. Miklos, MD, PhD³, Robert S. Negrin, MD³, Andrew R. Rezvani, MD³, Judith A Shizuru, MD, PhD³, Surbhi Sidana, MD⁴, W-K Weng, MD, PhD⁵, Parveen Shiraz, MD³ and Lori Muffly, MD, MS⁶

¹Stanford University School of Medicine, Stanford, CA
²Stanford Medicine Quantitative Sciences, Palo Alto, CA
³Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA
⁴Division of Blood and Marrow Transplantation, Stanford University School of Medicine, Stanford, CA
⁵Division of Blood and Marrow Transplantation, Dept. of Medicine, Stanford Univ. School of Med., Stanford, CA
⁶Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University, Stanford, CA

3:15 PM

496

Viral Reactivation in Acute Leukemia Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation in Complete Remission: Stimulation of the Immune System

Sandrine Loron, MD¹^*, Mohamad Sobh, PharmD²^*, Bruno Lina, MD, PhD³^*, Florence Ader, MD³^*, Myriam Renault, CRA¹^*, Marie-Cecile Michallet, PhD⁴^*, Hélène Labussière, MD¹^* and Mauricette Michallet, MD, PhD²

¹Hematology department 1 G, Centre Hospitalier Lyon Sud, Pierre Benite, France
²Hematology, Centre Leon Berard, Lyon, France
³Infectious diseases, Hospices Civils de Lyon, Lyon, France
⁴Cancer Research Center Lyon (CRCL), Lyon, France

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723.O2.6 723. Clinical Allogeneic and Autologous Transplantation: Late Complications and Approaches to Disease Recurrence II