62nd ASH Annual Meeting and Exposition: 711. Cell Collection and Processing

Oral and Poster Abstracts
Oral

antibodies, apheresis, Biological, HSCs, Diseases, Therapies, blood banking, Fanconi Anemia, Biological Processes, iron deficiency, gene therapy, immune cells, PNH, Technology and Procedures, Cell Lineage, Infectious Diseases, Xenograft models, Study Population, Clinically relevant, hematopoiesis, transplantation, stem cells, pathways

Moderators:

Antonio Di Stasi, MD, University of Alabama at Birmingham and Nan Zhang, Children's National Medical Center

Disclosures:

No relevant conflicts of interest to declare.

12:00 PM

183

Unexpected Novel Findings That Caspase-1-KO Mice Are Poor Mobilizers and Engraft Poorly with Wild Type Bone Marrow Cells – Indicating a Presence of an Autocrine Feedback Loop Involving Interleukin 1b and Interleukin 18 Signaling That Potentiates Nlrp3 Inflammasome Activity, Both in HSPCs and in the BM Microenvironment for Optimal Stem Cell Trafficking

Arjun Thapa¹^*, Janina Ratajczak, MD, PhD, DSci², Magdalena Kucia, PhD, DSci^3,4 and Mariusz Z Ratajczak, MD, PhD, DSc^2,3

¹Stem Cell Program at JGB Cancer Center, University of Louisville, Louisville, KY
²Stem Cell Institute at JGB CC, University of Louisville, Louisville, KY
³Department of Regenerative Medicine, Warsaw Medical University, Warsaw, Poland
⁴Stem Cell Institute, University Of Louisville Brown Cancer Center, Louisville, KY

12:15 PM

184

Mgta-145, in Combination with Plerixafor in a Phase 1 Clinical Trial, Mobilizes Large Numbers of Human Hematopoietic Stem Cells and a Graft with Immunosuppressive Effects for Allogeneic Transplant

Kevin A. Goncalves, PhD¹^*, Sharon L. Hyzy, MS¹^*, Katelyn J. Hammond, BS¹^*, Patrick C. Falahee, PhD¹^*, Haley Howell, BS, BA¹^*, Jan Pinkas, PhD¹, Veit Schmelmer, PhD¹^*, Jonathan G. Hoggatt, PhD², David T. Scadden, MD^3,4, Steven M Devine, MD⁵, John F. DiPersio, MD⁶, Will J. Savage, MD, PhD^1,7 and John C. Davis Jr., MD, MPH, MS¹^*

¹Magenta Therapeutics, Cambridge, MA
²Cancer Center and Center for Transplantation Sciences, Massachusetts General Hospital, Charlestown, MA
³Massachusetts General Hospital/Harvard Stem Cell Institute, Boston, MA
⁴Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA
⁵National Marrow Donor Program (NMDP)/Be The Match, Minneapolis, MN
⁶Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO
⁷Magenta Therapeutics, Newton Highlands, MA

12:30 PM

185

Rapid Engraftment, Immune Cell Reconstitution and Sustained Donor Chimerism in Patients Receiving G-CSF Mobilized Peripheral Blood Stem Cells (PB-SC) from Related or Unrelated Donors Undergoing CD34 Enrichment with Mononuclear Cell (T cell) Addback in Children, Adolescents, and Adults with Malignant and Nonmalignant Diseases

Jordan Milner¹^*, Cydney Nichols¹^*, Janet Ayello, MS, MT(ASCP)¹^*, Karen P. Seiter, MD², Delong Liu, MD, PhD³, Erin Morris, RN, BSN¹^*, Sandra Fabricatore, RN, PNP, MSN¹^*, Yaya Chu, PhD¹^*, Rosemarie Shaw⁴^*, Carmella van de Ven, MA¹^*, Allyson M. Flower, MD¹^* and Mitchell S Cairo, MD¹

¹Pediatrics, New York Medical College, Valhalla, NY
²Medicine, New York Medical College, Larchmont, NY
³Medicine, New York Medical College, Valhalla, NY
⁴Pediatrics, New York Medical College, Armonk, NY

12:45 PM

186

Impact of Cryopreservation of Donor Grafts on Outcomes of Allogeneic Hematopoietic Cell Transplant (HCT)

Jack W. Hsu, MD¹, Nosha Farhadfar, MD², Hemant S. Murthy, MD³, Brent Logan, PhD⁴^*, Stephanie Bo-Subait, MPH⁵^*, Noelle V. Frey, MD, MS⁶, Steven C. Goldstein, MD⁷, Mary M. Horowitz, MD, MS⁸, Hillard M Lazarus, MD⁹, Joshua Schwanke¹⁰^*, Nirali N. Shah, MD¹¹, Stephen R. Spellman, MS¹²^*, Galen E. Switzer, PhD¹³^*, Steven M Devine, MD¹⁴, Bronwen E. Shaw, PhD, MRCP, FRCPath¹⁵ and John R. Wingard, MD¹⁶^*

¹Department of Medicine/Division of Hematology Oncology, University of Florida, Gainesville, FL
²Shands HealthCare & University of Florida, Gainesville, FL
³Division of Hematology-Oncology and Blood and Marrow Transplantation Program, Mayo Clinic, Jacksonville, FL
⁴Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI
⁵CIBMTR (Center for International Blood and Marrow Transplant Research), National Marrow Donor Program/Be The Match, Minneapolis, MN
⁶Abramson Cancer Center, Hospital of the University of Pennsylvania, Philadelphia, PA
⁷Florida Hospital Cancer Institute, Orlando, FL
⁸Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI
⁹Adult Hematologic Malignancies & Stem Cell Transplant Section, University Hospitals Cleveland Medical Center, Shaker Heights, OH
¹⁰NMDP, Minneapolis, MN
¹¹Pediatric Oncology Branch, National Cancer Institute/Nih, Bethesda, MD
¹²CIBMTR (Center for International Blood and Marrow Transplant Research), Medical College of Wisconsin, Milwaukee, WI
¹³University of Pittsburgh, Pittsburgh, PA
¹⁴National Marrow Donor Program (NMDP)/Be The Match, Minneapolis, MN
¹⁵CIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI
¹⁶Division of Hematology & Oncology, Department of Medicine, Shands HealthCare & University of Florida, Gainesville, FL

1:00 PM

187

Manipulation of Tropomysin 1 in iPSCs to Enhance in Vitro Blood Cell Production

Christopher Thom, MD, PhD¹, Chintan Jobaliya²^*, Benjamin F Voight, PhD³^*, Stella P Chou, MD⁴ and Deborah L French, PhD²

¹Department of Pediatrics, Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA
²Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA
³Department of Genetics, University of Pennsylvania, Philadelphia, PA
⁴Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA

1:15 PM

188

Impact of Daratumumab on Stem Cell Collection, Graft Composition and Engraftment Among Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplant

Shivaprasad Manjappa, MD, MBBS¹, Robert Fox²^*, Jane Reese²^*, Amin Firoozamand, MD³^*, Hannah Schmikla, RN⁴^*, Savannah Nall, RN⁵^*, Merle Kolk²^*, Paolo F Caimi, MD², James J. Driscoll, MD, PhD^6,7, Marcos de Lima, MD² and Ehsan Malek, MD⁸

¹Case Western Reserve University, BEACHWOOD, OH
²Adult Hematologic Malignancies & Stem Cell Transplant Section, University Hospitals Seidman Cancer Center, Cleveland, OH
³University Hospital Cleveland Medical Center/ Seidman Cancer Center, Cleveland, OH
⁴University Hospitals Cleveland Medical Center, Cleveland, OH
⁵University Hospital Cleveland Medical Center, Cleveland, OH
⁶Case Western Reserve University, Cleveland, OH
⁷Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH
⁸Adult Hematologic Malignancies & Stem Cell Transplant Section, University Hospitals Seidman Cancer Center, Shaker Hts, OH

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^*signifies non-member of ASH

711.O1.6 711. Cell Collection and Processing