Elisa Ten Hacken, PhD^1,2, Tomasz Sewastianik, PhD^3,4*, Robert A. Redd, MS^5*, Geoffrey Fell, PhD^6*, Mohamed Uduman, PhD^5*, Michaela Gruber, MD, PhD^7,8,9,10*, Shanye Yin, PhD^7*, Kendell Clement, PhD^1,10,11*, Erin Michelle Parry, MD, PhD^7,12, Shuqiang Li, PhD^10,13*, Maria Hernandez-Sanchez, PhD^14*, Leah Billington, BA^7*, Elizabeth Witten^7*, Kaitlyn J Baranowski^7*, Lili Wang, MD, PhD¹⁵, Luca Pinello, PhD^1,10,11*, Kenneth J. Livak, PhD^13*, Donna S. Neuberg, ScD¹⁶, Ruben D. Carrasco, MD, PhD^1,4,17* and Catherine J. Wu, MD^1,7,10,18

¹Harvard Medical School, Boston, MA
²Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA
³Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland
⁴Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA
⁵Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
⁶Dana-Farber Cancer Institute, Boston, MA
⁷Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁸Department of Medicine I, Division of Hematology and Hemostaseology, and Comprehensive Cancer Center, Medical University of Vienna, A - 1090 Vienna, AUT
⁹CeMM, Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
¹⁰Broad Institute of MIT and Harvard, Cambridge, MA
¹¹Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA
¹²Department of Medical Oncology, Brigham & Women's Hospital/Massachusetts General Hospital, Boston, MA
¹³Translational Immunogenomics Lab, Dana-Farber Cancer Institute, Boston, MA
¹⁴Universidad de Salamanca, IBSAL, Centro de Investigación del Cáncer, IBMCC-CSIC, Salamanca, Spain
¹⁵Department of Systems Biology, Beckman Research Institute, City of Hope, Monrovia, CA
¹⁶Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA
¹⁷Dept. of Pathology, Brigham and Women's Hospital, Boston, MA
¹⁸Department of Internal Medicine, Brigham and Women’s Hospital, Boston, MA

Binyamin A. Knisbacher, PhD^1*, Ziao Lin, BS^1,2*, Cynthia K. Hahn, MD, PhD^1,3*, Ferran Nadeu^4,5*, Martí Duran-Ferrer^4,5*, Kristen E. Stevenson, MS^6*, Eugen Tausch, MD^7*, Alex Barbera-Mourelle^1,8*, Andrew Dunford^1*, Shankara Anand^1*, Julio Delgado, MD^4,5,9, Julian M. Hess^1*, Amaro Taylor-Weiner, PhD^1*, Helene Kretzmer, PhD^10*, Pablo Bousquets Muñoz^11*, Conner J. Shaughnessy^12*, Stacey M. Fernandes, BS^3,13*, Mariela Sivina^14*, Laura Z. Rassenti, PhD¹⁵, Alexander Meissner, PhD^1,10,16*, Adrian Wiestner, MD, PhD¹⁷, Jan A. Burger, MD, PhD¹⁸, Thomas J. Kipps, MD, PhD¹⁵, Jennifer R Brown, MD, PhD^2,12, Michael Hallek^19,20,21, François Aguet, PhD^1*, Donna S. Neuberg, ScD⁶, Xose S Puente, PhD^11*, Chip Stewart, PhD^1*, José I. Martín-Subero, PhD^4,5,22,23*, Stephan Stilgenbauer, MD^24,25, Catherine J. Wu, MD^1,2,3,26, Elías Campo, MD, PhD^4,5,23,27 and Gad Getz, PhD^1,2,8,28*

¹Broad Institute of MIT and Harvard, Cambridge, MA
²Harvard Medical School, Boston, MA
³Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁴Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
⁵Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain
⁶Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
⁷Department of Internal Medicine III, Ulm University, Ulm, Germany
⁸Center for Cancer Research, Massachusetts General Hospital, Boston, MA
⁹Servicio de Hematología, Hospital Clínic, IDIBAPS, Barcelona, Spain
¹⁰Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany
¹¹Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain
¹²Dana-Farber Cancer Institute, Boston, MA
¹³Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA
¹⁴Department of Leukemia, UT M.D. Anderson Cancer Center, Houston, TX
¹⁵Moores Cancer Center, University of California, San Diego, La Jolla, CA
¹⁶Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA
¹⁷Laboratory of Lymphoid Malignancies, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
¹⁸Department of Leukemia, The University of Texas, MD Anderson Cancer Center, Houston, TX
¹⁹Center for Molecular Medicine, Cologne, Germany
²⁰Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf and German CLL Study Group, University of Cologne, Cologne, Germany
²¹Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany
²²Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
²³Departament de Fonaments Clinics, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
²⁴Department of Internal Medicine I, Saarland University Medical School, Homburg, Germany
²⁵Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany
²⁶Department of Internal Medicine, Brigham and Women’s Hospital, Boston, MA
²⁷Hematopathology Section, Laboratory of Pathology, Hospital Clinic of Barcelona, Barcelona, Spain
²⁸Department of Pathology, Massachusetts General Hospital, Boston, MA

Miguel Quijada Álamo, MSc^1,2*, Maria Hernandez-Sanchez, PhD^1,2,3*, Ana E. Rodriguez, PhD^1,2*, Claudia Pérez Carretero, MSc, BSc^1,2*, Marta Martín Izquierdo, MSc^1,2*, Verónica Alonso Pérez, PhD^1,2*, Ignacio García-Tuñón, PhD^2,4*, Jose Maria Bastida, MD, PhD^2*, Maria Jesus Vidal, MD^5*, Josefina Galende DEL Canto, MD^6*, Carlos Aguilar, MD^7*, José Antonio Queizán, MD^8*, Isabel González-Gascón Y Marín, MD, PhD^9*, Jose-Angel Hernandez, MD, PhD^9*, Rocio Benito, PhD^1,2*, José Luis Ordóñez, PhD^1,2* and Jesus Maria Hernández-Rivas, MD, PhD^1,10

¹University of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center, Salamanca, Spain
²Department of Hematology, University Hospital of Salamanca, Salamanca, Spain
³Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁴IBSAL, IBMCC, CIC, Universidad de Salamanca-CSIC, Salamanca, Spain
⁵Department of Hematology, Hospital Virgen Blanca, Leon, Spain
⁶Department of Hematology, Hospital del Bierzo, Ponferrada, Spain
⁷Department of Hematology, Hospital Santa Bárbara, Soria, Spain
⁸Department of Hematology, Hospital General de Segovia, Segovia, Spain
⁹Department of Hematology, Hospital Universitario Infanta Leonor, Madrid, Spain
¹⁰Department of Hematology, University Hospital of Salamanca, IBSAL, Salamanca, Spain

Bo Zhang, MD, PhD¹, Prajish Iyer, PhD^2*, Meiling Jin, PhD^3*, Elisa Ten Hacken, PhD⁴, Zachary Cartun, BS^4*, Kevyn Hart, BS^3*, Laura Z. Rassenti, PhD⁵, Thomas J. Kipps, MD, PhD⁶, Donna S. Neuberg, ScD⁷, Ruben D. Carrasco, MD, PhD^8*, Catherine J. Wu, MD⁹ and Lili Wang, MD, PhD³

¹Department of Systems Biology, NCI Comprehensive Cancer Center, Beckman Research Institute | City of Hope, 1218 South 5th Avenue, Monrovia, CA, 91016, Monrovia, CA
²Systems Biology Department, City of Hope National Medical Centre, Monrovia, CA
³Department of Systems Biology, Beckman Research Institute, City of Hope, Monrovia, CA
⁴Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA
⁵Moores Cancer Center, University of California, San Diego, La Jolla, CA
⁶UCSD Moores Cancer Center, San Diego, CA
⁷Data Sciences Institute, Dana Farber, Boston
⁸Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA
⁹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA

Supriya Chakraborty, PhD^1*, Claudio Martines, MS^1*, Fabiola Porro, MS^1*, Ilaria Fortunati, BS^1*, Alice Bonato, BA^1*, Marija Dimishkovska, PhD^2*, Brijesh Yadav, PhD^3*, Idanna Innocenti, MD, PhD^4*, Rosa Fazio, BA^1*, Tizianna Vaisitti, PhD⁵, Silvia Deaglio, MD⁵, Alberto Zamò, MD, PhD^6*, Aleksandar Dimovski, MD, PhD^2*, Luca Laurenti, MD^4* and Dimitar G Efremov, MD, PhD⁷

¹Molecular Hematology, International Center for Genetic Engineering and Biotechnology, Trieste, Italy
²RCGEB, Macedonian Academy of Sciences and Arts, Skopje, MKD
³University of Information Science and Technology "St. Paul the Apostle", Ohrid, MI, Macedonia, The former Yugoslav Republic of
⁴Institute of Hematology, Università Cattolica del Sacro Cuore - Policlinico A. Gemelli, Rome, Italy
⁵Department of Medical Sciences, University of Turin, Torino, Italy
⁶Institute of Pathology, University of Würzburg, Würzburg, Germany
⁷Molecular Hematology Unit, International Center for Genetic Engineering and Biotechnology, Trieste, Italy

Claudia Pérez Carretero, MSc, BSc^1,2*, Miguel Quijada Álamo, MSc^1,2*, Maria Hernandez-Sanchez, PhD^1,2*, Ana E. Rodriguez, PhD^1,2*, Ana B Herrero, PhD^3,4*, Jesus M Hernández-Sánchez, PhD^2,5*, Marta Martín Izquierdo, MSc^1*, Teresa González, PhD^2*, Sandra Santos-Mínguez^1,2*, Cristina Miguel-García^6*, Araceli Rubio-Martínez^7*, Alfonso García de Coca, MD, PhD^8*, Julio Dávila^9*, Jose-Angel Hernandez, MD, PhD^10*, Rocio Benito, PhD^1,2*, José Luis Ordóñez, PhD^3,4* and Jesus Maria Hernández-Rivas, MD, PhD¹¹

¹Universidad de Salamanca, IBSAL, Centro de Investigación del Cáncer, IBMCC-CSIC, Salamanca, Spain
²Servicio de Hematología, Hospital Universitario de Salamanca, Salamanca, Spain
³University of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center, Salamanca, Spain
⁴Department of Hematology, University Hospital of Salamanca, Salamanca, Spain
⁵IBSAL, IBMCC, CIC, Universidad de Salamanca-CSIC, Salamanca, Spain
⁶Universidad de Salamanca, IBSAL, Centro de Investigación del Cáncer, IBMCC-CSIC, Servicio de Hematología, Hospital Universitario de Salamanca, Salamanca, Spain
⁷Servicio de Hematología, Hospital Miguel Servet, Zaragoza, Spain
⁸Servicio de Hematología, Hospital Clínico, Valladolid, Spain
⁹Departamento de Hematología, Hospital Nuestra Señora de Sónsoles, Ávila, Spain
¹⁰Hematology Department, Hospital Infanta Leonor, Madrid, Spain
¹¹Hospital Universitario de Salamanca, Salamanca, Spain