62nd ASH Annual Meeting and Exposition: 636. Myelodysplastic Syndromes

Oral and Poster Abstracts
Oral

AML, Anemias, Diseases, Animal models, aplastic anemia, Bone Marrow Failure, cellular interactions, MDS, Biological Processes, MPN, PNH, Technology and Procedures, epigenetics, erythropoiesis, Study Population, Myeloid Malignancies, genomics, integrative -omics, molecular testing, iron metabolism, microenvironment, RNA sequencing, pathogenesis, pathways, signal transduction

Moderators:

Eric Padron, MD, Moffitt Cancer Center and Jennifer S. Carew, PhD, University of Arizona Cancer Center

Disclosures:

No relevant conflicts of interest to declare.

12:00 PM

406

SF3B1-Mutant Myelodysplastic Syndrome with Ringed Sideroblasts (MDS-RS) at the Single-Cell Level

Rashmi Kanagal-Shamanna, MD¹, Vera Adema, PhD²^*, Feiyang Ma, Bs³^*, Andrea Santoni, PhD⁴^*, Hui Yang, MD, PhD⁵, Irene Ganan-Gomez, PhD⁵, Natthakan Thongon, PhD⁴^*, Guillermo Montalban-Bravo, MD⁴^*, Matteo Pellegrini, PhD³^*, Carlos E. Bueso-Ramos, MD, PhD⁶, Guillermo Garcia-Manero, MD⁴ and Simona Colla, PhD⁷^*

¹Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
²The University of Texas MD Anderson Cancer Center, Houston, TX
³Molecular Biology Institute, Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA
⁴Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX
⁷Department of Leukemia, The University of Texas MD Anderson Cancer Center, HOUSTON, TX

12:15 PM

407

Mutant TRP53-R172H Has Gain-of-Function or Dominant-Negative Effects in Response to Different Hematopoietic Stressors in Mice

Tanzir Ahmed, PhD¹, Tuoen Liu, MD, PhD²^*, Michael O. Alberti, MD, PhD^3,4, Brian Wadugu, PhD⁵, Matthew Ndonwi, PhD¹^*, Sarah Grieb¹^* and Matthew J. Walter, MD⁶

¹Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO
²Department of Biomedical Sciences, West Virginia School of Osteopathic Medicine, Lewisburg, WV
³Department of Pathology & Immunology, Washington University In St Louis, Saint Louis, MO
⁴Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO
⁵Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO
⁶Department of Medicine, Division of Oncology, Washington University In St. Louis, Saint Louis, MO

12:30 PM

408

The Genomic Landscape of Myeloid Neoplasms Evolved from AA/PNH

Carmelo Gurnari, MD^1,2^*, Simona Pagliuca, MD^2,3, Bhumika J. Patel, MD⁴, Hassan Awada, MD², Cassandra M Kerr, MS²^*, Wenyi Shen, MD⁵^*, Sunisa Kongkiatkamon, MD²^*, Laila Terkawi²^*, Misam Zawit, MBBS²^*, Jibran Durrani, MD²^*, Valeria Visconte, PhD², Seth J. Corey, MD⁶, Maria Teresa Voso, MD¹, Hetty E. Carraway, MD, MBA^2,7 and Jaroslaw P. Maciejewski, MD, PhD⁸

¹Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
²Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
³Université de Paris, Paris, France
⁴Leukemia Program, Department of Hematology and Medical Oncology, Cleveland Clinic, Cleveland, OH
⁵Department of Translational Hematology and Oncology Research,Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
⁶Departments of Pediatrics, Cancer Biology, THOR, Cleveland Clinic, Cleveland, OH
⁷Department of Hematology and Medical Oncology, Leukemia Program, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
⁸Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH

12:45 PM

409

Signaling Gene Mutations Are Characterized By Diverse Patterns of Expansion and Contraction during Progression from MDS to Secondary AML

Andrew J Menssen, BA¹, Ajay Khanna¹^*, Christopher A Miller, PhD¹^*, Gue Su Chang, PhD²^*, Jin J Shao¹^*, Sridhar Nonavinkere Srivatsan, MS¹^*, Joshua Robinson¹^*, Michelle O'Laughlin³^*, Catrina Fronick, BS⁴^*, Robert Fulton, MS⁴^*, Kimberly J Brendel¹^*, Sharon E Heath⁵^*, Peter Westervelt, MD PhD⁶^*, John F. DiPersio, MD⁷, Daniel C. Link, MD⁸, Meagan A. Jacoby⁵^*, Eric Duncavage, M.D.⁹^*, Timothy J Ley, MD¹⁰ and Matthew J. Walter, MD¹¹

¹Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO
²Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, MO
³McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO
⁴McDonnell Genome Institute, Washington University School of Medicine, Saint Louis, MO
⁵Washington University School of Medicine, St. Louis, MO
⁶Washington University, Saint Louis
⁷Washington University School of Medicine, Saint Louis, MO
⁸Washington University School of Medicine, St Louis, MO
⁹Department of Pathology and Immunology, Washington University In St Louis, St Louis, MO
¹⁰Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO
¹¹Department of Medicine, Division of Oncology, Washington University In St. Louis, Saint Louis, MO

1:00 PM

410

High-Resolution Binding Atlas of U2AF1 Mutants Uncovers New Complexity in Splicing Alterations and Kinetics in Myeloid Malignancies

Giulia Biancon, PhD¹, Poorval Joshi, PhD¹^*, Torben Hunck¹^*, Josh Zimmer, MS²^*, Yimeng Gao, PhD¹^*, Martin Machyna, PhD²^*, Valentina Botti, PhD²^*, Ashley Qin¹^*, Gabriella Viero, PhD³^*, Nils Neuenkirchen, PhD⁴^*, Ashley Taylor¹^*, Rana Gbyli, MS¹^*, Amisha Patel, MS¹^*, Anastasia Ardasheva, BS¹^*, Xiaoying Fu, MD¹^*, Haifan Lin, PhD⁴^*, Matthew D Simon, PhD²^*, Karla M Neugebauer, PhD²^*, Toma Tebaldi, PhD¹^* and Stephanie Halene, MD ¹

¹Section of Hematology, Department of Internal Medicine and Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, CT
²Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT
³Institute of Biophysics, CNR, Trento, Italy
⁴Department of Cell Biology and Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT

1:15 PM

411

Coordinated Mis-Splicing of Multiple Mitochondrial Iron Metabolism Genes Causes Ring Sideroblast Formation in SF3B1-Mutant MDS

Courtnee Clough^1,2, Joseph Pangallo, PhD³^*, Martina Sarchi, MD^2,4^*, Stephanie Busch, B.S.²^*, Janis L. Abkowitz, MD^2,5,6, Robert K. Bradley, PhD^7,8,9^* and Sergei Doulatov, PhD^10,11

¹Molecular and Cellular Biology Program, University of Washington, Seattle, WA
²Division of Hematology, University of Washington, Seattle, WA
³Fred Hutchinson Cancer Research Center, Seattle, WA
⁴Department of Molecular Medicine, University of Pavia, Pavia, ITA
⁵Seattle Cancer Care Alliance, Seattle, WA
⁶Department of Medicine, University of Washington, Seattle, WA
⁷Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA
⁸Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA
⁹Genome Sciences, University of Washington, Seattle, WA
¹⁰University of Washington, Seattle, WA
¹¹Division of Hematology, University of Washington School of Medicine, Seattle, WA

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^*signifies non-member of ASH

636.O2.6 636. Myelodysplastic Syndromes — Basic and Translational Studies