62nd ASH Annual Meeting and Exposition: 622. Lymphoma Biology—Non-Genetic Studies: Microenvironment and Immune Response in Hodgkin Lymphoma

Oral and Poster Abstracts
Oral

Adult, Biological, Diseases, Lymphoma (any), Hodgkin Lymphoma, Therapies, cellular interactions, Non-Hodgkin Lymphoma, Biological Processes, white blood cells, immune cells, T-Cell Lymphoma, Technology and Procedures, Cell Lineage, immunotherapy, Lymphoid Malignancies, Study Population, Clinically relevant, immune mechanism, inflammation, mass cytometry, integrative -omics, microenvironment, RNA sequencing, multi-systemic interactions, serologic tests, pathogenesis, pathways

Moderators:

Anne J. Novak, PhD, Mayo Clinic and Eric D. Hsi, MD, Cleveland Clinic Foundation

Disclosures:

Novak: Celgene/BMS: Research Funding. Hsi: Eli Lilly: Research Funding; Abbvie: Research Funding; CytomX: Consultancy, Honoraria; Miltenyi: Consultancy, Honoraria; Seattle Genetics: Consultancy, Honoraria.

9:00 AM

594

Single-Cell Analysis of the Classical Hodgkin Lymphoma Immune Environment Reveals a Clonally-Expanded CD8⁺ T Cell Population with a Cytotoxic Phenotype

Jovian Yu, MD^1,2, Xiufen Chen, PhD¹^*, James Godfrey, MD¹, Girish Venkataraman, MD, MBBS ³, Sonali M. Smith, MD⁴, Mengjie Chen, PhD^2,5,6,7^* and Justin Kline, MD^1,5

¹Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL
²Committee on Genetics, Genomics and Systems Biology, University of Chicago, Chicago, IL
³Department of Pathology, University of Chicago, Chicago, IL
⁴Department of Oncology, University of Chicago, Chicago, IL
⁵Committee on Cancer Biology, University of Chicago, Chicago, IL
⁶Department of Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL
⁷Department of Human Genetics, University of Chicago, Chicago, IL

9:15 AM

595

Increased Tumor Specific Cytotoxic T Cell Responses and Reversion to a Favorable Cytokine Profile after Treatment in Patients with Newly Diagnosed High Risk Hodgkin Lymphoma Treated on Children’s Oncology Group Trial-AHOD1331

Hema Dave¹, Mimi Mai²^*, Anushree Datar²^*, Gaye Jenkins, BS³^*, Qinglin Pei, PhD⁴^*, Yue Wu, MS⁵^*, Frank G. Keller, M.D.⁶, Sharon M. Castellino, MD, MSc⁷, Terzah M Horton, MD, PhD⁸ and Catherine M. Bollard, MD, MBChB¹

¹Children's National Hospital and The George Washington University, Washington, DC
²Program for Cell Enhancement and Technologies for Immunotherapy (CETI), Children's National Hospital, Washington, DC
³Baylor College of Medicine, Houston
⁴Children's Oncology Group Statistics & Data Center, Gainesville, FL
⁵Department of Biostatistics, Children's Oncology Group Statistics & Data Center, Gainesville, FL
⁶Pediatric Hematology/Oncology, Emory University, Atlanta, GA
⁷Aflac Cancer and Blood Disorders Center, Emory University School of Medicine / Children's Healthcare of Atlanta, Atlanta, GA
⁸Baylor College of Medicine, Houston, TX

9:30 AM

596

High-Dimensional and Single-Cell Transcriptome Analysis of AITL Tumor Microenvironment Reveals Gross Expansion of Novel Dysfunctional CD8+ T Cell Populations, Global Shift in B Cell Phenotypes

Joshua C. Pritchett, MD¹, Zhi-Zhang Yang, PhD¹, Hyojin Kim, PhD¹^*, Jose C Villasboas, MD², Andrew L. Feldman, MD³, James R. Cerhan, MD, PhD⁴ and Stephen M. Ansell, MD, PhD⁵

¹Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN
²Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN
³Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁴Division of Hematology, Mayo Clinic, Rochester, MN
⁵Mayo Clinic, Rochester, MN

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^*signifies non-member of ASH

622.O1.6 622. Lymphoma Biology—Non-Genetic Studies: Microenvironment and Immune Response in Hodgkin Lymphoma