62nd ASH Annual Meeting and Exposition: 621. Lymphoma—Genetic/Epigenetic Biology: Clinical implications of biological insights in lymphoma

Oral and Poster Abstracts
Oral

Biological, Adult, apoptosis, Follicular Lymphoma, Diseases, Lymphoma (any), cell division, CLL, Therapies, biopsy, Mantle Cell Lymphoma, Non-Hodgkin Lymphoma, DLBCL, B-Cell Lymphoma, Biological Processes, immune cells, Technology and Procedures, Cell Lineage, immunotherapy, Xenograft models, Lymphoid Malignancies, Study Population, Clinically relevant, genetic profiling, genomics, immune mechanism, integrative -omics, vaccines, NGS, microenvironment, RNA sequencing, pathogenesis, pathways

Moderators:

Mark A. Murakami, MD, MA, MMSc, Dana-Farber Cancer Institute and Georg Lenz, University Hospital Muenster

Disclosures:

Lenz: BMS: Consultancy; AstraZeneca: Consultancy, Honoraria, Research Funding; Bayer: Consultancy, Honoraria, Research Funding, Speakers Bureau; Agios: Research Funding; AQUINOX: Research Funding; Novartis: Consultancy; Gilead: Consultancy, Honoraria, Research Funding, Speakers Bureau; Roche: Consultancy, Honoraria, Research Funding, Speakers Bureau; Janssen: Consultancy, Honoraria, Research Funding, Speakers Bureau; Celgene: Consultancy, Honoraria, Speakers Bureau; Verastem: Research Funding; Morphosys: Consultancy, Honoraria, Research Funding; Incyte: Consultancy, Honoraria, Speakers Bureau; Abbvie: Consultancy, Honoraria, Speakers Bureau; Nanostring: Consultancy.

11:30 AM

638

Single Cell Transcriptomic Evolution and Resistance Mechanisms of BTK and BCL-2 Inhibition in Mantle Cell Lymphoma

Vivian Changying Jiang, PhD¹, Shaojun Zhang, PhD²^*, Junwei Lian, PhD¹^*, Yuanxin Wang²^*, Rongjia Zhang¹^*, Yang Liu, PhD¹^*, Joseph McIntosh, BS¹^*, Guangchun Han²^*, Ruiping Wang, PhD²^*, David Santos³^*, Maria Badillo, MSN, RN, OCN, CCRP¹^*, Angela Leeming¹^*, Zhihong Chen¹^*, Kimberly Hartig¹^*, John Bigcal¹^*, Hun Lee, MD¹^*, Raphael Eric Steiner, MD¹, Jorge Enrique Romaguera, MD¹, Preetesh Jain, MBBS, MD, DM, PhD¹, Krystle Nomie, PhD¹^*, Andy Futreal²^*, Linghua Wang, MD, PhD, MS² and Michael Wang, MD^1,4

¹Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston
⁴Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX

11:45 AM

639

The Tumor Associated Antigen PRAME Exhibits Dualistic Functions That Are Targetable in Diffuse Large B-Cell Lymphoma

Katsuyoshi Takata, MD, PhD¹^*, Lauren C. Chong, MSc²^*, Daisuke Ennishi, MD, PhD¹^*, Avinash Thakur, Ph.D.³^*, Shannon Healy, PhD⁴^*, Elena Viganò, PhD⁴, Tao Dao, MD, PhD⁵^*, Julie S Nielsen⁶^*, Susana Ben-Neriah, BSc²^*, Tomohiro Aoki, MD, PhD⁴^*, Ethan Tse⁷^*, Stacy Hung⁸^*, Michael Y. Li, BS⁷^*, Merrill Boyle, BSc⁴^*, Sung Soo Mun⁵^*, Christopher Bourne⁹^*, Bruce W Woolcock⁴^*, Adele Telenius⁴^*, Allen Zhang⁷^*, Ali Bashashati¹⁰^*, Saeed Saberi¹¹^*, Gianluca D' Antonio⁶^*, Brad H Nelson⁶^*, Sohrab P Shah¹²^*, Pamela Hoodless³^*, Ari Melnick, MD¹³, Randy D. Gascoyne, MD⁴^*, Joseph M Connors, MD¹⁴^*, David A. Scheinberg, MD, PhD⁵, Wendy Béguelin, PhD¹⁵, David W. Scott, MBChB, PhD¹⁶ and Christian Steidl, MD⁴

¹British Columbia Cancer Centre for Lymphoid Cancer, Vancouver, BC, Canada
²Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada
³Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
⁴Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada
⁵Memorial Sloan Kettering Cancer Center, New York, NY
⁶Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, BC, Canada
⁷BC Cancer, Centre for Lymphoid Cancer, Vancouver, BC, Canada
⁸Lymphoid Cancer Research, BC Cancer Agency, Vancouver, BC, Canada
⁹Memorial Sloan Kettering Cancer Center, New York
¹⁰Molecular Oncology, British Columbia Cancer, Vancouver, BC, Canada
¹¹Department of Molecular Oncology, British Columbia Cancer, Vancouver, BC, Canada
¹²Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
¹³Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medical College, New York, NY
¹⁴BC Cancer Centre for Lymphoid Cancer, Vancouver, BC, Canada
¹⁵Department of Medicine, Division of Hematology & Medical Oncology, Weill Cornell Medicine, New York, NY
¹⁶British Columbia Cancer, Vancouver, Canada

12:00 PM

640

Targeting Inhibition of N⁶-Methyladenosine Demethylase Fto Displays Potent Anti-Tumor Activities in Chronic Lymphocytic Leukemia

Ya Zhang, MD^1,2^*, Xinting Hu, MM^1,2^*, Yang Han, MM^1,2^*, Xiangxiang Zhou, MD^1,2^*, Huimin Zhang, BS^1,2^*, Xiaoya Yun, BS^1,2^* and Xin Wang, MD, PhD^1,2

¹Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China
²Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China

12:15 PM

641

Single Cell Analysis of Serial Lymphoma Biopsies Reveals Dynamic Immune Modulation and Predictors of Response in Patients Undergoing in Situ Vaccination

Tanaya Shree, MD, PhD, BA¹, Sarah Haebe, MD¹^*, Anuja Sathe, PhD¹^*, Grady Day¹^*, Debra K. Czerwinski, BA¹, HoJoon Lee, PhD¹^*, Susan Grimes, BSc²^*, Steven R. Long, MD³^*, Brock Martin, MD⁴^*, Hanlee Ji, MD²^* and Ronald Levy, MD⁵

¹Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA
²Stanford Genome Technology Center, Stanford University School of Medicine, Stanford, CA
³Department of Pathology, University of California San Francisco, San Francisco, CA
⁴Department of Pathology, Stanford University, Stanford, CA
⁵Stanford Univ. School of Medicine, Stanford, CA

12:30 PM

642

Neoantigens Are Typically Associated with Intact HLA Class I Presentation in Early-Stage Follicular Lymphoma

Hennes Tsang, BSc¹^*, Ann-Marie Patch, PhD²^*, Colm Keane, MD^3,4, Soi C. Law, PhD³^*, Jay Gunawardana, PhD³^*, Piers Blombery, MBBS^5,6^*, Ella R Thompson, PhD, BSc^7,8^*, Muhammed B. Sabdia³^*, Lilia Merida De Long³^*, Clemence J Belle⁹^*, Karthik Nath, MBBS³^*, Joshua W.D. Tobin, MD³^*, Stephen H Kazakoff, PhD²^*, John F. Seymour, MBBS¹⁰, Michael MacManus¹¹^* and Maher K. Gandhi, PhD, FRACP, FRCPath^4,12

¹Mater Research Institute, University of Queensland, Brisbane, QLD, Australia
²QIMR Berghofer Medical Research Institute, Brisbane, Australia
³Translational Research Institute, Blood Cancer Research Laboratory, Mater Research, University of Queensland, Brisbane, Australia
⁴Department of Haematology, Princess Alexandra Hospital, Brisbane, Australia
⁵Department of Pathology, Peter MacCallum Cancer Center, East Melbourne, Australia
⁶University of Melbourne, Melbourne, Australia
⁷The University of Melbourne, Melbourne, Australia
⁸Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, Australia
⁹University of Nice, Nice, France
¹⁰Peter Maccallum Cancer Centre, Melbourne, VIC, Australia
¹¹Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia
¹²Blood Cancer Research Group, Mater Research, University of Queensland, Brisbane, QLD, Australia

12:45 PM

643

DNMT3A Mutations Identify a Prognostic Subgroup in Peripheral T-Cell Lymphoma

Tyler A. Herek, BS, MS¹, Alyssa Bouska, PhD¹^*, Waseem G. Lone, PhD¹^*, Tayla B. Heavican, PhD²^*, Catalina Amador, MD¹^*, Sunandini Sharma, BS¹^*, d'Amore Francesco, MD PhD³^*, Wing C. Chan, MD⁴ and Javeed Iqbal, PhD¹^*

¹Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE
²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
³Department of Hematology, Aarhus University Hospital, Aarhus, Denmark
⁴Department of Pathology, City of Hope National Medical Center, Duarte, CA

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^*signifies non-member of ASH

621.O2.6 621. Lymphoma—Genetic/Epigenetic Biology: Clinical implications of biological insights in lymphoma