62nd ASH Annual Meeting and Exposition: 618. Acute Lymphoblastic Leukemia: Biology, Cytogenetics, and Molecular Markers in Diagnosis and Prognosis I

Oral and Poster Abstracts
Oral

ALL, Leukemia, cell division, Diseases, Non-Biological, Therapies, chemotherapy, Biological Processes, DNA damage, white blood cells, Technology and Procedures, Lymphoid Malignancies, Clinically relevant, imaging, metabolomics, microenvironment, molecular interactions, pathways, senescence, signal transduction

Moderators:

Olaf Heidenreich, PhD, Newcastle University and Judith M. Boer, PhD, Princess Máxima Center for Pediatric Oncology, Erasmus MC - Sophia Children's Hospital

Disclosures:

Heidenreich: Syndax: Research Funding.

1:30 PM

694

Tumor Associated Macrophages Express High-Levels of FLT3 Ligand, Which Induces Activation of FLT3 Signaling That Promotes Survival of Neoplastic Cells in B-Cell Acute Lymphoblastic Leukemia

Yao Guo, PhD¹^*, Junbin Huang, MD, PhD²^*, Dengyang Zhang, PhD³^*, Liqin Zhang¹^*, Yuming Zhao¹^*, Liuting Yu⁴^*, Zhiguang Chang, PhD⁴^*, Han Zhong Pei⁴^*, Chun Chen, MD, PhD²^*, Hongman Xue, MD, PhD¹^*, Xiaojun Xu, MD, PhD¹, Zhizhuang Joe Zhao, PhD⁵ and Yun Chen, PhD¹^*

¹The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China
²The Seventh Affiliated Hospital, Sun Yat-sen University, shenzhen, China
³The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen City, Guangdong Provience, China
⁴The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China
⁵Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK

1:45 PM

695

Combined Inhibition of CXCR4 Signaling and System x_c^- Transporter Activity Induces Synthetic Lethality in T-ALL Cells By Suppressing Gsh and Inducing Ferroptosis

Jun Xia, PhD¹^*, Stephanie Sun²^*, Matthew RM Jotte³^*, Geoffrey L Uy, MD⁴, Ella Sorani, PhD⁵^*, Abi Vainstein⁶^*, Liron Shemesh Davish⁷^*, Katherine E Caldwell⁸^*, William G Hawkins⁹^* and Daniel C. Link, MD¹⁰

¹Division of Oncology, Department of Medicine, Washington University School of Medicine, O Fallon, MO
²Washing University, St.Louis
³University of Chicago, Chicago
⁴Washington University School of Medicine, Saint Louis, MO
⁵BioLineRx Ltd., Modi'in, Israel
⁶BioLineRx LTD, Jerusalem, Israel
⁷BiolineRx. Ltd, Modi'in, Israel
⁸Washington University School of Medicine, st.louis, MO
⁹Washnington University School of Medicine, st.louis, MO
¹⁰Washington University School of Medicine, St Louis, MO

2:00 PM

696

Obesity-Induced Chemoresistance in B-Cell Acute Lymphoblastic Leukemia Cells Is Mediated By Reduced Chemotherapy Uptake and Interleukin-9 Signaling

Jamie A.G. Hamilton, BS¹, Miyoung Lee, PhD²^*, Ganesh R Talekar, PhD²^* and Curtis J. Henry, PhD³

¹Aflac Cancer and Blood Disorders Center/Pediatrics, Emory University, Atlanta, GA
²Emory University, Atlanta, GA
³Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA

2:15 PM

697

Preclinical Investigation of the p53-MDM2 Antagonist Idasanutlin (RG7388) Demonstrates Significant Activity in High Risk Adult Acute Lymphoblastic Leukemia

Hayden L Bell¹^*, Mankaran Singh, MSc²^*, Helen J Blair, PhD²^*, Frederik W. van Delft, MD, PhD²^*, Anthony V. Moorman, PhD², John Lunec, PhD MRCR(Hon) FRCPath³^* and Julie Irving, PhD²

¹Wolfson Childhood Cancer Research Centre, Newcastle University, Newcastle-upon-Tyne, ENG, United Kingdom
²Wolfson Childhood Cancer Research Centre, Newcastle University, Newcastle upon Tyne, ENG, United Kingdom
³Paul O'Gorman Building, Newcastle University, Newcastle upon Tyne, ENG, United Kingdom

2:30 PM

698

The SIX1 homeobox Gene Is a Novel Therapeutic Target in CALM-AF10 Leukemogenesis

Waitman K. Aumann, MD, MS¹, Catherine P. Lavau, DVM, PhD²^*, Amanda Harrington, MD³^*, Donald Tope⁴^*, Amanda E. Conway, PhD⁵^*, Hengbo Zhou, PhD⁶^*, Heide Ford, PhD⁷^* and Daniel S. Wechsler, MD, PhD¹

¹Aflac Cancer & Blood Disorders Center of Children's Healthcare of Atlanta and Department of Pediatrics, Emory University, Atlanta, GA
²Department of Neurosurgery, Duke University Medical Center, Durham, NC
³Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA
⁴Department of Pediatrics, Emory University, Atlanta, GA
⁵NIH/NIEHS, Research Triangle, NC
⁶Massachusetts General Hospital, Boston, MA
⁷Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO

2:45 PM

699

DYRK1A Is Required to Alleviate Replication Stress in KMT2A-Rearranged Acute Lymphoblastic Leukemia

Christian Hurtz, PhD¹, Gerald Wertheim, M.D., Ph.D.^2,3, Rahul S. Bhansali, MD PHD⁴, Sung June Lee, BA⁵^*, Anil Kumar, PhD⁶^*, Anne Lehman⁷^*, Joseph Patrick Loftus, BS⁸^*, Grace Jeschke, PhD⁹^*, John D. Crispino, PhD¹⁰, Thierry Besson, PhD¹¹^*, Junwei Shi, PhD¹²^*, Srividya Swaminathan, PhD^6,13, Sarah K Tasian, MD^8,14 and Martin P. Carroll, MD¹⁵

¹Medicine, University Of Pennsylvania, Philadelphia, PA
²Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA
³Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
⁴Division of Hematology and Oncology, Northwestern University, Chicago, IL
⁵Systems Biology, City of Hope, Monrovia, CA
⁶Department of Systems Biology, Beckman Research Institute of City of Hope, City of Hope, Duarte, CA
⁷University of Pennsylvania, Philadelphia, PA
⁸Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
⁹Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
¹⁰Experimental Hematology, St. Jude Children's Research Hospital, Memphis
¹¹Normandie University, UNIROUEN, INSA Rouen, CNRS, COBRA UMR 6014, 76000, Rouen, France
¹²Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
¹³Department of Hematological Malignancies and Translational Science, Beckman Research Institute of City of Hope, City of Hope, Duarte, CA
¹⁴Department of Pediatrics and Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
¹⁵Medicine, University of Pennsylvania, Philadelphia, PA

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^*signifies non-member of ASH

618.O1.6 618. Acute Lymphoblastic Leukemia: Biology, Cytogenetics, and Molecular Markers in Diagnosis and Prognosis I