Jiangyan Yu, MSc^1*, Simon V. van Reijmersdal^1*, Alexander Hoischen, PhD^1*, Edwin Sonneveld, PhD^2*, Peter M. Hoogerbrugge, MD, PhD^2,3, Esmé Waanders, PhD¹ and Roland P. Kuiper, PhD¹

¹Department of Human Genetics, Radboud university medical center, Nijmegen, Netherlands
²Dutch Childhood Oncology Group, The Hague, Netherlands
³Princess Máxima Center for Pediatric Oncology, De Bilt, Netherlands

Gabriele Escherich, MD^1*, Udo zur Stadt, PhD^2*, Malik Alawi^3* and Martin A. Horstmann, MD^4*

¹University Medical Center Hamburg Eppendorf, German Cooperative Study Group for Childhood Acute Lymphoblastic Leukemia (COALL), Eppendorf, Germany
²Center for Diagnostics, University Medical Center Hamburg Eppendorf, Hamburg, Germany
³Bioinformatics Core, University Medical Center Hamburg Eppendorf, Hamburg, Germany
⁴Pediatric Hem., Hamburg Univ. Med. Ctr., Hamburg, Germany

Annette Fasan, PhD^*, Wolfgang Kern, MD, Niroshan Nadarajah, M.Sc.^*, Simone Weber^*, Sonja Schindela^*, Nicole Schlenther^*, Susanne Schnittger, PhD, Torsten Haferlach and Claudia Haferlach, MD

MLL Munich Leukemia Laboratory, Munich, Germany

Yuko Sekiya, MD^1*, Yusuke Okuno, MD, Ph.D.^1*, Hideki Muramatsu, MD, PhD¹, Atsushi Narita, M.D.^1*, Kyogo Suzuki, MD^1*, Xinan Wang, PhD^1*, Nozomu Kawashima, MD^1*, Yinyan Xu, PhD^1*, Hirotoshi Sakaguchi, MD, PhD^2*, Nao Yoshida, MD, PhD^2*, Asahito Hama, MD, PhD^1*, Yoshiyuki Takahashi, MD, PhD¹, Koji Kato, MD, PhD² and Seiji Kojima, MD, PhD^1*

¹Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
²Department of Hematology and Oncology, Children's Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan

Shalini C. Reshmi, PhD^1*, Eileen Stonerock, BS^2*, Michael J. Borowitz, MD, PhD³, William J Geese, PhD^4*, Diane Healey, MS^5*, Julie M. Gastier-Foster, PhD¹, Stephen P. Hunger, MD⁶, Andrea Biondi, Prof, MD⁷ and Giovanni Cazzaniga⁸

¹The Ohio State University, Nationwide Children's Hospital, Columbus, OH
²Nationwide Children’s Hospital, Columbus, OH
³Hematologic Pathology, Johns Hopkins University, Baltimore, MD
⁴Bristol-Myers Squibb, Princeton, NJ
⁵Research and Development/Global Clinical Research Oncology, Bristol-Myers Squibb, Wallingford, CT
⁶Children's Hospital Philadelphia, Philadelphia, PA
⁷Centro Ricerca Tettamanti, Clinica Pediatrica, Universitŕ Milano Bicocca, Osp. San Gerardo/Fondazione MBBM, Monza (MB), Italy
⁸Centro Ricerca Tettamanti, Department of Pediatrics, University of Milano-Bicocca, Fondazione MBBM/San Gerardo Hospital, Monza, Italy

Marian H. Harris, MD, PhD^1*, Traci M. Blonquist, MS^2*, Uma H. Athale, M.D., M.Sc.³, Luis A. Clavell, MD⁴, Peter D. Cole, MD⁵, Kara M. Kelly, MD⁶, Caroline Laverdiere, MD⁷, Jean-Marie Leclerc, MD⁷, Bruno Michon, MD, FRCPC^8*, Marshall A. Schorin, MD⁹, Jennifer J.G. Welch, MD¹⁰, Donna S. Neuberg, Sc.D.², Stephen E. Sallan, MD^11,12 and Lewis B. Silverman, MD^11,13

¹Department of Pathology, Boston Children's Hospital, Boston, MA
²Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA
³Division of Hematology/Oncology, McMaster Children's Hospital, Hamilton Health Sciences, Hamilton, ON, Canada
⁴San Jorge Children's Hospital, San Juan, PR
⁵Pediatrics, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY
⁶Pediatric Hematology/Oncology/Stem Cell Transplantation, Columbia University Medical Center, New York, NY
⁷Hematology-Oncology Division, Charles Bruneau Cancer Center, Sainte-Justine University Hospital, University of Montreal, Montreal, QC, Canada
⁸Centre Hospitalier Universitaire de Quebec, Sainte-Foy, QC, Canada
⁹Inova Fairfax Hospital for Children, Falls Church, VA
¹⁰Pediatric Hematology Oncology, Hasbro Children's Hospital/Brown University, Providence, RI
¹¹Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA
¹²Division of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA
¹³Division of Pediatric Hematology, Boston Children's Hospital, Boston, MA

Mary Sartor, PhD^1*, Draga Barbaric, MBBS^2,3,4*, Tamara Law, BSc (Hons)^5*, DR Anuruddhika Dissanayake, PhD^6*, Nicola C Venn^5*, Mawar Karsa, BSc (Hons), MSc^6*, Sue W J Wong, BSc, MSc(med)^1*, Murray D Norris, PhD^6,7*, Tamas Revesz, MD, PhD^8,9*, Petra Ritchie, MBBS^8*, Peter J Shaw¹⁰, Kenneth F Bradstock, MBBS PhD FRACP FRCPA¹¹, Luciano Dalla Pozza, MBBS, FRACP^12,13*, Toby N Trahair, PhD, MBBS^3,6,14,15* and Rosemary Sutton, PhD^4,13,16*

¹Flow Cytometry Unit, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Sydney, Australia
²Kids Cancer Centre, Sydney Children’s Hospital, Randwick, Australia
³Australian and New Zealand Children’s Haematology/Oncology Group, Melbourne, Australia
⁴School of Women’s and Children’s Health,, University of New South Wales, Sydney, Australia
⁵Molecular Diagnostics, Children's Cancer Institute Australia, Sydney, Australia
⁶Molecular Diagnostics, Children's Cancer Institute, Sydney, Australia
⁷Centre for Childhood Cancer Research, University of New South Wales, Sydney, Australia
⁸SA Pathology, Women and Children’s Hospital, Adelaide, Australia
⁹Faculty of Health Science, University of Adelaide, Adelaide, Australia
¹⁰Bone Marrow Transplant Services, Sydney Children’s Hospital Network, Westmead, Sydney, Australia
¹¹Haematology, Westmead Hospital, Westmead, Australia
¹²Sydney Children's Hospital Network, Sydney, Australia
¹³Australian and New Zealand Children's Haematology/Oncology Group, Melbourne, Australia
¹⁴Kids Cancer Centre, Sydney Children’s Hospital Network, Randwick, Australia
¹⁵School of Women’s and Children’s Health,, University of NSW, Sydney, Australia
¹⁶Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, Australia

Nikhil Patkar, MD^1*, Papagudi Ganesan Subramanian, MD^1*, Prashant Tembhare, MD,^1*, Pratibha Amare Kadam, PhD^2*, Asma Bibi, MD,^1*, Karishma Chopra, MSc^1*, Satish Mirgal, MSc^1*, Sagar Rambhiya, MSc^1*, Swapnali Joshi, MSc^1*, Shruti Chaudhary, PhD^1*, Russel Mascrenhas, MSc^1*, Sona Dusseja, MSc^1*, Gaurav Narula, MD,^3*, Brijesh Arora, DM^3*, Shripad Banavali, MD^3* and Sumeet Gujral, MD⁴

¹Hematopathology Laboratory, Tata Memorial Centre, Mumbai, India
²Cytogenetics Department,, Tata Memorial Centre, Mumbai, India
³Department of Medical & Pediatric Oncology, Tata Memorial Centre, Mumbai, India
⁴Department of Pathology, Tata Memorial Centre, Mumbai, India

Kara L. Davis, DO¹, Jolanda Sarno^2*, Andrea Biondi, Prof, MD³, Astraea Jager, BS^4*, Giuseppe Gaipa, PhD⁵, Zinaida Good^6* and Garry P. Nolan, Prof, PhD^4*

¹Pediatrics, Stanford University, Palo Alto, CA
²Centro Ricerca Tettamanti, Department of Pediatrics, University of Milano-Bicocca, Fondazione MBBM/San Gerardo Hospital, Monza, Italy
³Centro Ricerca Tettamanti, Clinica Pediatrica, Universitŕ Milano Bicocca, Osp. San Gerardo/Fondazione MBBM, Monza (MB), Italy
⁴Department of Microbiology and Immunology, Baxter Laboratory for Stem Cell Biology, Stanford University School of Medicine, Palo Alto, CA
⁵Department of Pediatrics, Tettamanti Research Center, University of Milano-Bicocca, Fondazione MBBM/San Gerardo Hospital, Monza, Italy
⁶Stanford University, Stanford, CA

Benjamin Kobitzsch^1*, Nicola Gökbuget, MD², Stefan Schwartz, MD^1*, Richard Reinhardt, PhD^3*, Monika Brueggemann^4*, Andreas Viardot, MD^5*, Ralph Wäsch, MD, PhD^6*, Michael Starck, MD^7*, Eckhard Thiel, MD¹, Dieter Hoelzer, MD² and Thomas Burmeister, MD^1*

¹Hematology, Oncology and Tumor Immunology, Charité, Berlin, Germany
²Dept. of Medicine II, Hematology/Oncology, Goethe University, Frankfurt / Main, Germany
³Max Planck Genome Center Cologne, Cologne, Germany
⁴Department of Hematology, University Hospital Schleswig-Holstein, Kiel, Germany
⁵Med. Dept. III (Hematology, Oncology), Ulm University, Ulm, Germany
⁶Department of Hematology, Oncology and Stem Cell Transplantation, University of Freiburg Medical Center, Freiburg, Germany
⁷Dept. of Hematology, Klinikum München-Schwabing, Munich, Germany

Kathryn G. Roberts¹, Debbie Payne-Turner, BS^1*, Kelly McCastlain^1*, Zhaohui Gu, PhD^1*, Ilaria Iacobucci, PhD^1*, Richard C. Harvey², I-Ming Chen², Marcus Valentine^3*, Deqing Pei^4*, Yongjin Li, PhD^5*, Jinghui Zhang, PhD^5*, Cheng Cheng, Ph.D^4*, Alessandro Rambaldi, MD⁶, Orietta Spinelli, PhD^7*, Jerald P. Radich⁸, Mark D. Minden, MD, PhD⁹, Anthony V Moorman, PhD¹⁰, Bella Patel, MBBS^11*, Adele K. Fielding, MB BS, PhD¹², Jacob M. Rowe, MD¹³, Selina Luger, MD¹⁴, Jessica Kohlschmidt, PhD, BS, MS¹⁵, Krzysztof Mrózek, MD, PhD¹⁵, Guido Marcucci, MD¹⁶, Clara D. Bloomfield, MD¹⁵, Wendy Stock, MD¹⁷, Hagop M. Kantarjian, MD¹⁸, Marina Konopleva, MD, PhD¹⁸, Elisabeth Paietta, PhD¹⁹, Cheryl L Willman² and Charles G. Mullighan¹

¹Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
²University of New Mexico Cancer Center, Albuquerque, NM
³Cytogenetics Shared Resource, St. Jude Children's Research Hospital, Memphis, TN
⁴Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
⁵Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, TN
⁶Department of Hematology, Hospital Papa Giovanni XXIII, Bergamo, Italy
⁷Hematology and Bone Marrow Transplant Unit, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy
⁸Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
⁹Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
¹⁰Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom
¹¹Queen Mary University of London, London, United Kingdom
¹²Department of Hematology, UCL Cancer Institute, London, United Kingdom
¹³Hematology, Shaare Zedek Medical Center, Jerusalem, Israel
¹⁴Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
¹⁵Comprehensive Cancer Center, The Ohio State University, Columbus, OH
¹⁶City of Hope, Duarte, CA
¹⁷University of Chicago Medical Center, Chicago, IL
¹⁸Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
¹⁹Cancer Center, Montefiore Medical Center North Division, Bronx, NY

Katherine Dormon, MSci^1*, Elda S Latif, PhD^2*, Matthew Bashton, PhD^1*, Deepali Pal, PhD^1*, Matthew Selby, MSci^1*, Helen Blair, PhD^1*, Vikki Rand, PhD^1*, Andrew G Hall, PhD¹, Josef Vormoor, MD, FRCPCH¹ and Olaf Heidenreich, PhD^1*

¹Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom
²National University of Maylasia, Bangi, Malaysia

Prashant Deshpande, MD^*, Punit Jain, DM^*, Ansu Abu Alex Sr., MSc^*, Anu Korula, MD, DM^*, Kavitha M Lakshmi, MSc^*, Nisham P N, DM^*, Fouzia NA, DM^*, Aby Abraham, MD, DM^*, Alok Srivastava, MD, Poonkuzhali Balasubramanian, M.Sc., Ph.D, Biju George, DM and Vikram Mathews, DM

Department of Haematology, Christian Medical College, Vellore, India

Alyssa I. Clay, BS^1*, Theresa Hahn, PhD², Leah Preus, MS^1*, Kenan Onel, MD, PhD³, Qianqian Zhu, PhD^4*, Christopher Haiman, ScD^5*, Daniel O. Stram, PhD^5*, Loreall C. Pooler, MS^5*, Xin Sheng, MS^5*, Daniel Weisdorf, MD⁶, Li Yan, PhD^4*, Qian Liu, MA^7*, Qiang Hu, MD, PhD^4*, Song Liu, PhD^4*, Sebastiano Battaglia, PhD^8*, Xiaochun Zhu, MS^9*, AnneMarie W. Block, PhD¹⁰, Sheila Sait, PhD^10*, Christine B. Ambrosone, PhD^1*, David Tritchler, ScD^7,11*, Stephen R. Spellman, MBS^12*, Marcelo C. Pasquini, MD¹³, Philip L. McCarthy, MD² and Lara E. Sucheston-Campbell, PhD^1*

¹Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY
²Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY
³The University of Chicago, Comer Children's Hospital, Chicago, IL
⁴Biostatistics & Bioinformatics, Roswell Park Cancer Institute, Buffalo, NY
⁵Preventive Medicine, University of Southern California, Los Angeles, CA
⁶Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN
⁷Biostatistics, State University of New York at Buffalo, Buffalo, NY
⁸Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY
⁹Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI
¹⁰Clinical Cytogenetics Laboratory, Roswell Park Cancer Institute, Buffalo, NY
¹¹Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
¹²CIBMTR® (Center for International Blood and Marrow Transplant Research), National Marrow Donor Program/Be The Match®, Minneapolis, MN
¹³Medicine, Medical College of Wisconsin, Milwaukee, WI

Valeria Cazzaniga, PhD^1,2*, Paola De Lorenzo^3*, Federica Mottadelli^2*, Grazia Fazio, PhD^2*, Tiziana Villa^2*, Vincenzo Rossi^2*, Martina Pigazzi, PhD^4*, Marcela B. Mansur, PhD^1*, Marco Zecca, MD^5*, Elena Barisone, MD^6*, Franco Locatelli, MD⁷, Giuseppe Basso, Prof, MD⁴, Maria Grazia Valsecchi, PhD³, Mel Greaves, FRS¹, Andrea Biondi, Prof, MD⁸, Anthony M Ford¹ and Giovanni Cazzaniga²

¹Centre for Evolution and Cancer, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom
²Centro Ricerca Tettamanti, Department of Pediatrics, University of Milano-Bicocca, Fondazione MBBM/San Gerardo Hospital, Monza, Italy
³EsPhALL Trial Data Center, University of Milano-Bicocca, Monza, Italy
⁴Woman and Child Health Department, University of Padova, Padova, Italy
⁵Pediatric Hematology/Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
⁶Pediatric Hemato-Oncology, Ospedale Infantile Regina Margherita, Turin, Italy
⁷Department of Pediatric Hematology and Oncology, IRCCS Ospedale Pediatrico Bambino Gesů, Rome, Italy
⁸Centro Ricerca Tettamanti, Clinica Pediatrica, Universitŕ Milano Bicocca, Osp. San Gerardo/Fondazione MBBM, Monza (MB), Italy

Anna Ferrari, PhD^1*, Andrea Ghelli Luserna Di Rora^2*, Italo Do Valle^3,4*, Marianna Garonzi^5*, Valentina Robustelli^2*, Jesus Maria Hernandez-Rivas, PhD^6*, Alessandra Santoro^7*, Sarka Pospisilova, Prof.^8*, Torsten Haferlach⁹, Antonella Padella^1*, Giorgia Simonetti, PhD^1*, Cristina Papayannidis, MD, PhD¹⁰, Maria Chiara Abbenante, MD^1*, Marco Sazzini^11*, Alberto Ferrarini, PhD^5*, Julien Schira^12*, Massimo Delledonne, PhD^13*, Gastone Castellani^3*, Daniel Remondini, PhD^3* and Giovanni Martinelli, MD, PhD¹⁰

¹University of Bologna, Bologna, Italy
²DIMES, Department of Hematology and Medical Sciences “L. and A. Serŕgnoli”, Bologna, Italy, Bologna, Italy
³Department of Physics and Astronomy, University of Bologna, Bologna, Italy
⁴CAPES Foundation, Ministry of Education of Brazil, Brasília, Brazil
⁵Department of Biotechnology, University of Verona, Verona, Italy
⁶Hematology, Salamanca Universitary Hospital, Salamanca, Spain
⁷Divisione di Ematologia con UTMO, A.O. Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy
⁸Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
⁹MLL Munich Leukemia Laboratory, Munich, Germany
¹⁰Bologna University School of Medicine, Bologna, Italy
¹¹Department of Biological, Geological and Environmental Sciences, University of Bologna, Bologna, Italy
¹²FASTERIS, Geneve, Switzerland
¹³Personal Genomics, Verona, Italy

Dino Mašić, MRes^*, Amir Enshaei, PhD^*, Lisa Jones, BSc^*, Christine Harrison, PhD FRCPath FMedSci and Lisa Jane Russell, PhD^*

Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom

Lorenz Bastian^1,2*, Martin Neumann, MD^1,2*, Nicola Gökbuget, MD³, Cornelia Schlee^1*, Jutta Ortiz Tanchez^1*, Sebastian Vosberg, MSc^4,5,6*, Alva Rani James^1,2,7*, Michael P Schroeder^1*, Stefan Schwartz, MD^8*, Dieter Hoelzer⁹, Alexander Graf, PhD^6*, Stefan Krebs, PhD^6*, Helmut Blum, PhD^6*, Jochen Hecht^10,11*, Monika Brüggemann^12*, Philipp A. Greif^7,13,14* and Claudia D. Baldus, MD, PhD^2,15*

¹Department of Hematology and Oncology, Charité University Hospital, Berlin, Germany
²German Cancer Consortium (DKTK), Berlin, Germany
³Dept. of Medicine II, Hematology/Oncology, Goethe University, Frankfurt / Main, Germany
⁴German Cancer Consortium (DKTK), Heidelberg, Germany
⁵Department of Internal Medicine III, Ludwig-Maximilians-University, Munich, Germany
⁶Laboratory for Functional Genome Analysis, Gene-Center, Ludwig-Maximilians-University, Munich, Germany
⁷German Cancer Research Center (DKFZ), Heidelberg, Germany
⁸Hematology, Oncology and Tumor Immunology, Charité, Berlin, Germany
⁹Department of Medicine II, Hematology/Oncology, Goethe University Hospital, Frankfurt / Main, Germany
¹⁰Centre for Genomic Regulation, Barcelona, Spain
¹¹Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité-Universitätsmedizin, Berlin, Germany
¹²Department of Hematology and Oncology, University Hospital Kiel, Kiel, Germany
¹³Department of Internal Medicine 3, Ludwig-Maximilians-University, Munich, Germany
¹⁴German Cancer Consortium (DKTK), Munich, Germany
¹⁵Charité University Hospital, Berlin, Germany

Brenton G. Mar, MD, PhD¹, Josephine Kahn, MD, MSc^2*, Rebecca L Zon, BA², Peter V Grauman, BS^2*, Kevin Boettger, BS^2*, Scott Haihua Chu, PhD^3*, Scott A. Armstrong, MD, PhD⁴ and Benjamin L. Ebert, MD⁵

¹Dana-Farber Cancer Institute, Boston, MA
²Brigham and Women's Hospital, Boston, MA
³Memorial Sloan Kettering Cancer Cancer, New York, NY
⁴Memorial Sloan-Kettering Cancer Center, New York, NY
⁵Division of Hematology, Brigham and Women's Hospital, Boston, MA

Hui Li, phd^1*, Benshang Li^1*, Fan Yang^2*, Caiwen Duan^2*, Yun Bai^3*, Jun J Yang, PhD⁴, Jing Chen, MD, PhD^5*, Arend von Stackelberg, MD⁶, Hongzhuan Chen, PhD^7*, JingYan Tang, MD⁸, Adolfo A. Ferrando, MD, PhD⁹, Jinghui Zhang, PhD^10*, Shengyue Wang^11*, Renate Kirschner-Schwabe, PhD^12* and Bin-Bing S. Zhou, PhD^1*

¹Department of Hematology & Oncology, Shanghai Children’s Medical Center, shanghai, China
²Key Laboratory of Pediatric Hematology & Oncology Ministry of Health，Department of Hematology & Oncology, Shanghai Children’s Medical Center, shanghai, China
³Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China., shanghai, China
⁴Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN
⁵Division of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai, P.R. China, Shanghai, China
⁶Pediatric oncology, Charite Universitaetsmedizin Berlin, Berlin, Germany
⁷Department of Pharmacology, School of Basic Medicine and Collaborative Innovation Center for Translational Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China., shanghai, China
⁸Key Laboratory of Pediatric Hematology & Oncology Ministry of Health,Department.of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai, P.R. China, Shanghai, China
⁹Institute for Cancer Genetics, Columbia University, New York, NY
¹⁰Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, TN
¹¹Pediatric Translational Medicine Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China
¹²Universitätsmedizin Charité, Berlin, Germany

Masafumi Seki, MD^1*, Kenichi Yoshida, MD, Ph.D.^2*, Yuichi Shiraishi, MD, Ph.D.^3*, Kenichi Chiba, BA^3*, Hiroko Tanaka, BA^3*, Motohiro Kato, MD, PhD⁴, Shunsuke Kimura, MD^5*, Ryoji Hanada, MD^6*, Katsuyoshi Koh, MD^7*, Satoru Miyano, MD, Ph.D.^3*, Toshihiko Imamura, MD, PhD⁸, Keizo Horibe, MD, PhD⁹, Nobutaka Kiyokawa, MD, PhD^10*, Atsushi Manabe, MD, PhD⁵, Akira Ohara, MD, PhD¹¹, Yasuhide Hayashi, MD, PhD^12,13, Akira Oka, MD, PhD^1*, Seishi Ogawa, MD, Ph.D.² and Junko Takita, MD, PhD^14*

¹Department of Pediatrics, The University of Tokyo, Tokyo, Japan
²Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
³Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
⁴Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
⁵Department of Pediatrics, St. Luke's International Hospital, Tokyo, Japan
⁶Department of Hematology/Oncology, Seriatim Children's Medical Hospital, Saitama, Japan
⁷Department of Hematology/Oncology, Saitama Children’s Medical Center, Saitama, Japan
⁸Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
⁹Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
¹⁰Department of Pediatric Hematology and Oncology Research, National Research Institute For Child Health and Development, Tokyo, Japan
¹¹Department of Pediatrics, Toho University School of Medicine, Tokyo, Japan
¹²Department of Hematology/Oncology, Gunma Children's Medical Center, Shibukawa, Japan
¹³Japanese Red Cross Gunma Blood Center, Maebashi, Japan
¹⁴Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Laurens T Van Der Meer, PhD^1*, Jiangyan Yu, MSc^2*, Miriam Butler, MSc^1*, Jolien M R van der Meer, MSc^1*, Roland P Kuiper, PhD² and Frank N van Leeuwen, PhD¹

¹Laboratory of Pediatric Oncology, Radboud university medical center, Nijmegen, Netherlands
²Department of Human Genetics, Radboud university medical center, Nijmegen, Netherlands

Ebinger Sarah, M. Sc.^1*, Özdemir Erbey, M. Sc.^1*, Sebastian Tiedt, PhD^1*, Christoph Ziegenhain, M. Sc.^2*, Catarina Castro Alves, PhD^1*, Wolfgang Enard, Prof. Dr. rer. nat.^2* and Irmela Jeremias, MD^1,3,4*

¹Research Unit Gene Vectors, Helmholtz Center Munich, German Research Center for Environmental Health, Munich, Germany
²Anthropology and Human Genetics, Department Biology II, Faculty of Biology, Ludwig-Maximilians-Universität München, Munich, Germany
³Department of Oncology, Dr. von Haunersches Kinderspital, Ludwig Maximilians University, Munich, Germany
⁴German Cancer Research Center (DKFZ), Heidelberg, Germany

Felix Seyfried^*, Salih Demir, MSc^*, Klaus-Michael Debatin, MD PhD and Lueder Hinrich Meyer, MD^*

Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany

Michela Carlet, PhD^1*, Jenny Vergalli, M.Sc.^1*, Cornelia Finkenzeller, M.Sc.^1*, Michaela Grunert, PhD^1* and Irmela Jeremias, MD^1,2,3*

¹Research Unit Gene Vectors, Helmholtz Center Munich, German Research Center for Environmental Health, Munich, Germany
²German Consortium for Translational Cancer Research (DKTK) and German Cancer Research Center (DKFZ), Munich, Germany
³Department of Oncology, Dr. von Haunersches Kinderspital, Ludwig Maximilians University, Munich, Germany

Olivia L Francis, BS, PhD¹, Terry-Ann MIlford, BS^1*, Ineavely Baez, BS^1*, Jacqueline Coats, BS^1*, Christopher L. Morris, MD, PhD¹, Ross Fisher, MD,^1*, Benjamin Joseph Van Handel, BS, PhD^2*, Ruijun Su, MD, PhD¹, Batul T. Suterwala, MD^1*, Shadi Farzingohar, MD^1*, Sinisa Dovat, M.D., Ph.D.³ and Kimberly Payne, PhD¹

¹Loma Linda University, Loma Linda, CA
²Novogenix Labs, Los Angeles, CA
³Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA

Vera Muench^1,2*, Luca Trentin, PhD^1*, Julia Herzig^1*, Johann Krauss^3*, Hans A Kestler^3,4*, Geertruy te Kronnie^5*, Klaus-Michael Debatin, MD PhD⁶ and Lueder Hinrich Meyer, MD^6*

¹Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany
²International Graduate School of Molecular Medicine, Ulm University, Ulm, Germany
³Ulm University, Ulm, Germany
⁴Fritz Lipmann Institute, Jena, Germany
⁵University of Padua, Padova, Italy
⁶Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany