Thomas Cluzeau, MD, PhD^1,2*, Orianne Wagner-Ballon^3*, Thomas Boyer^4*, Estelle Guerin^5*, Emmanuel Benayoun^3*, Daniel Lusina^6*, Isabelle Garcia^7*, Claude Gardin^8*, Pierre Fenaux, MD, PhD⁹, Cecile Pautas^10*, Bruno Quesnel, MD, PhD¹¹, Dominique Bordessoule¹², Christine Terré^13*, Xavier Thomas, MD, PhD¹⁴, Sylvie Castaigne¹⁵, Aline Renneville^16*, Claude Preudhomme⁴ and Herve Dombret, MD¹⁷

¹INSERM U1065, Centre Mediterraneen de Medecine Moleculaire, Nice, France
²Hematology, Saint Louis Hospital, Paris, France
³Hematology Laboratory, Henri Mondor Hospital, Creteil, France
⁴Hematology Laboratory, CHRU Lille, Lille, France
⁵Hematology Laboratory, Dupuytren Hospital, Limoges, France
⁶Hematology Laboratory, CHU Avicenne, Paris, France
⁷Hematology Laboratory, CH Versailles, Versailles, France
⁸Hematology, Hopital Avicenne, Bobigny, France
⁹Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France
¹⁰Hematology Department, Henri Mondor Hospital, Creteil, France
¹¹Service des Maladies du Sang, CHU Lille, Lille, France
¹²Hematologie Clinique, CHU de Limoges, Limoges, France
¹³Hematology Laboratory, CH, Versailles, France
¹⁴CHU, Lyon, France
¹⁵Dept. Hematologie, Hopital Mignot, Le Chesnay, France
¹⁶Hematology Laboratory, CHRU, Lille, France
¹⁷Hopital Saint Louis, Paris, France

Megan Othus, PhD^1*, Brent L. Wood, MD, PhD², Elihu H. Estey, MD^3,4*, Stephen Petersdorf, MD⁵, Frederick R. Appelbaum, MD^1,6, Harry P. Erba, MD, PhD⁷ and Roland B. Walter, MD, PhD, MS^3,8,9

¹Fred Hutchinson Cancer Research Center, Seattle, WA
²Department of Laboratory Medicine/Division of Hematopathology, University of Washington, Seattle, WA
³Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
⁴Division of Hematology, University of Washington, Seattle, WA
⁵Seattle Cancer Care Alliance, Seattle, WA
⁶University of Washington, Seattle, WA
⁷Internal Medicine, Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL
⁸Division of Hematology/Department of Medicine, University of Washington, Seattle, WA
⁹Department of Epidemiology, University of Washington, Seattle, WA

George S. Laszlo, PhD^1*, Todd A. Alonzo, PhD^2,3, Chelsea J. Gudgeon, BS^1*, Kimberly H. Harrington, BS^1*, Alex Kentsis, MD, PhD⁴, Robert B. Gerbing, MA^3*, Yi-Cheng Wang, MS^3*, Rhonda E. Ries, MA^1*, Susana C. Raimondi, PhD^3,5, Betsy A. Hirsch, PhD^3,6*, Alan S. Gamis, MD, MPH^3,7, Soheil Meshinchi, MD, PhD^1,3 and Roland B. Walter, MD, PhD, MS^1,8,9

¹Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
²Keck School of Medicine, University of Southern California, Los Angeles, CA
³Children's Oncology Group, Monrovia, CA
⁴Memorial Sloan Kettering Cancer Center, New York, NY
⁵Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
⁶University of Minnesota, Minneapolis, MN
⁷Division of Hematology/Oncology/Bone Marrow Transplantation, Children's Mercy Hospitals and Clinics, Kansas City, MO
⁸Division of Hematology/Department of Medicine, University of Washington, Seattle, WA
⁹Department of Epidemiology, University of Washington, Seattle, WA

Daisuke Araki, MD^1*, Brent L Wood, MD, PhD², Megan Othus, PhD^3*, Jerald P. Radich, MD^4,5, Anna B. Halpern, MD⁶, Yi Zhou, MD, PhD^7*, Marco Mielcarek, MD^4,8, Elihu H. Estey, MD^4,9*, Frederick R. Appelbaum, MD^3,10 and Roland B. Walter, MD, PhD, MS^4,11,12

¹Department of Medicine, University of Washington, Seattle, WA
²Department of Laboratory Medicine, University of Washington, Seattle, WA
³Fred Hutchinson Cancer Research Center, Seattle, WA
⁴Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
⁵Department of Medicine/Division of Medical Oncology, University of Washington, Seattle, WA
⁶Hematology/Oncology Fellowship Program, University of Washington/Fred Hutchinson Cancer Research Center, Seattle, WA
⁷Department of Laboratory Medicine/Division of Hematopathology, University of Washington, Seattle, WA
⁸Department of Medicine/ Division of Medical Oncology, University of Washington, Seattle, WA
⁹Division of Hematology, University of Washington, Seattle, WA
¹⁰University of Washington, Seattle, WA
¹¹Department of Medicine/Division of Hematology, University of Washington, Seattle, WA
¹²Department of Epidemiology, University of Washington, Seattle, WA

Katerina Kuzelova, PhD^1*, Barbora Brodská, PhD^1*, Jana Marková^1*, Grzegorz Helbig, MD, PhD^2*, Slawomira Kyrcz-Krzemien, MD, PhD² and Petr Cetkovsky, MD, MBA, PhD^1*

¹Institute of Hematology and Blood Transfusion, Prague, Czech Republic
²Department of Hematology and Bone Marrow Transplantation, Medical University of Silesia, Katowice, Poland

Madlen Jentzsch, MD^*, Luba Schuhmann^*, Marius Bill, MD PhD^*, Sabine Leiblein, PhD^*, Ulrike Bergmann^*, Martina Pless^*, Karoline Schubert^*, Laura Katharina Schmalbrock, MD^*, Juliane Grimm^*, Maria Knyrim^*, Wolfram Poenisch, MD^*, Georg-Nikolaus Franke, MD^*, Vladan Vucinic, MD^*, Michael Cross, PhD^*, Gerhard Behre, MD^*, Dietger Niederwieser, MD and Sebastian Schwind, MD

Hematology and Oncology, University of Leipzig, Leipzig, Germany

Peak-Ling Lee^1*, Benedict Yan, MBBS, FRCPath^1*, Chin-Hin Ng, MD, MRCP, FRCPATH^2*, Kenneth Hon-Kim Ban, MD, PhD^3*, Wee-Joo Chng, MBBS, MRCP, FRCPath, PhD^3,4,5 and Evelyn Siew-Chuan Koay, FRCPath, PhD^1,3*

¹National University Hospital, National University Health System, Singapore, Singapore
²Department of Haematology-Oncology, National University Cancer Institute of Singapore, Singapore, Singapore
³Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
⁴National University Cancer Institute, National University Health System, Singapore, Singapore
⁵Cancer Science Institute, National University of Singapore, Singapore, Singapore

Norio Shiba, MD, PhD^1*, Kenichi Yoshida, MD, Ph.D.^2*, Yuichi Shiraishi, MD, Ph.D.^3*, Yusuke Hara, MD^1*, Genki Yamato, MD^1*, Taeko Kaburaki^4*, Masashi Sanada, MD, Ph.D.^5*, Kentaro Oki, MD, PhD^6*, Daisuke Tomizawa, MD, PhD⁷, Manabu Sotomatsu^8*, Hirokazu Arakawa^9*, Keizo Horibe, MD, PhD¹⁰, Myoung-Ja PARK^11*, Takashi Taga, MD, PhD^12*, Souichi Adachi, MD, PhD¹³, Akio Tawa, MD, PhD^14*, Satoru Miyano, MD, Ph.D.^3*, Seishi Ogawa, MD, Ph.D.² and Yasuhide Hayashi, MD, PhD¹⁵

¹Department of Pediatrics, Gunma University Graduate School of Medicine, Maebashi, Japan
²Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
³Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
⁴Gunma Unversity Graduste School of Medicine, Maebashi, Japan
⁵Department of Advanced Diagnosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
⁶Gunma Children's Medical Center, Shibukawa, Japan
⁷Division of Leukemia and Lymphoma, Children’s Cancer Center, National Center for Child Health and Development, Tokyo, Japan
⁸Hematology/Oncology, Gunma Children's Medical Center, shibukawa, Japan
⁹Pediatrics, Gunma Unversity Graduste School of Medicine, Maebashi, Japan
¹⁰Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
¹¹Hematology/Oncology, Gunma Children's Medical Center, Shibukawa, Japan
¹²Department of Pediatrics, Shiga University of Medical Science, Otsu, Japan
¹³Department of Human Health Sciences, Kyoto University, Kyoto, Japan
¹⁴Department of Pediatrics, National Hospital Organization, Osaka National Hospital, Osaka, Japan
¹⁵Department of Hematology/Oncology, Gunma Children's Medical Center, Shibukawa, Japan

Fabiana Ostronoff, MD¹, Todd A. Alonzo, PhD², Megan Othus, PhD^3*, Matthew A. Kutny, MD⁴, Robert B. Gerbing, MA^5*, Jerald P. Radich, MD¹, Harry P. Erba, MD, PhD⁶, Frederick R. Appelbaum, MD⁷, E. Anders Kolb, MD⁸, Alan S. Gamis, MD, MPH⁹, Derek L. Stirewalt, MD¹⁰ and Soheil Meshinchi, MD, PhD¹

¹Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
²Keck School of Medicine, University of Southern California, Los Angeles, CA
³SWOG Statistical Center, Seattle, WA
⁴University of Alabama at Birmingham, Birmingham
⁵Children's Oncology Group, Monrovia, CA
⁶Internal Medicine, Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL
⁷Fred Hutchinson Cancer Research Center, Seattle, WA
⁸Nemours Center for Cancer and Blood Disorders, Alfred I. duPont Hospital for Children, Wilmington, DE
⁹Division of Hematology/Oncology/Bone Marrow Transplantation, Children's Mercy Hospitals and Clinics, Kansas City, MO
¹⁰Fred Hutchinson Cancer Research Ctr., Seattle, WA

Mauricette Michallet, MD, PhD¹, Mohamad Sobh, PharmD^1*, Hélène Labussière-wallet, MD^1*, Marie Balsat, MD^1*, Caroline Lejeune, MD^1*, Isabelle Mollet, Tech.^2*, Philippe Moskovtchenko, Tech.^2*, Xavier Thomas¹, Fiorenza Barraco, MD^1*, Valérie Mialou, Tech.^2*, Valérie Dubois, MD^2* and Franck E. Nicolini, MD, PhD¹

¹Hematology department 1G, Centre Hospitalier Lyon Sud, Pierre Bénite, France
²Histocompatibility laboratory, EFS Rhône Alpes, Lyon, France

Claudia Haferlach, MD¹, Niroshan Nadarajah, M.Sc.^1*, Annette Fasan, PhD^1*, Karolína Perglerová^2*, Wolfgang Kern, MD¹, Susanne Schnittger, PhD¹ and Torsten Haferlach¹

¹MLL Munich Leukemia Laboratory, Munich, Germany
²MLL2 s.r.o., Praha, Czech Republic

Farhad Ravandi, MD¹, Jorgensen L Jeffrey, MD, PhD^2*, Elias J Jabbour, MD¹, Gautam Borthakur, MD¹, Tapan Kadia, MD¹, Stefan Faderl, MD^3*, Sherry Pierce, BSN, BA^1*, Mark Brandt, BS^4*, Sa A. Wang, MD^5*, Sergej Konoplev, MD, PhD⁶, Naval Daver, MD¹, Naveen Pemmaraju, MD¹, Guillermo Garcia-Manero, MD⁷, Michael Andreeff, MD, PhD⁸, Marina Konopleva, MD, PhD⁹, Jorge E. Cortes, MD⁴ and Hagop M. Kantarjian, MD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Hematopathology, University of Texas - MD Anderson Cancer Center, Houston, TX
³John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ
⁴Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, Houston, TX
⁸Section of Molecular Hematology and Therapy, Leukemia Department, UT MD Anderson Cancer Center, Houston, TX
⁹Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

Bernhard Reis, Ph.D.^1*, Lori Jukofsky^2*, Gong Chen, Ph.D.^2*, Giovanni Martinelli³, Hua Zhong, Ph.D.^2*, Venus So, Ph.D.^2*, Michael J. Dickinson, MBBS, FRACP, FRCPA⁴, Mark W. Drummond, PhD, MD^5*, Sarit E. Assouline, MD MSc⁶, Maneja Hashemyan^2*, Michel Theron, Ph.D.^1*, Steven Blotner, Ph.D.^2*, Je-Hwan Lee, MD, PhD⁷, Margaret Kasner, M.D.⁸, Sung-Soo Yoon⁹, Ruediger Rueger, M.D.^10*, Karen Seiter, MD¹¹, Steven Middleton, PhD^2*, Kevin R. Kelly, M.D., Ph.D.¹², Norbert Vey¹³, Karen W.L. Yee, MD¹⁴, Gwen Nichols, MD¹⁵, Lin-Chi Chen, MD, PhD² and William E. Pierceall, PhD²

¹Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland
²Roche Pharma Research & Early Development, Roche Innovation Center New York, New York, NY
³"Seràgnoli" Institute of Hematology, University of Bologna, Bologna, Italy
⁴Department of Haematology, Peter MacCallum Cancer Centre, Melbourne, Australia
⁵Beatson West of Scotland Cancer Centre, NHS Greater Glasgow and Clyde, Glasgow, United Kingdom
⁶Jewish General Hospital, Montreal, QC, Canada
⁷Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
⁸Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA
⁹Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea
¹⁰Roche Pharma Research & Early Development, Roche Innovation Center Penzberg, Penzberg, Germany
¹¹New York Medical College, Valhalla, NY
¹²University of Southern California Keck School of Medicine, Los Angeles, CA
¹³Hematology, Institut Paoli-Calmettes, Marseille, France
¹⁴Princess Margaret Cancer Center, Toronto, ON, Canada
¹⁵Roche Pharma Research & Early Development, Roche Innovation Center, New York, NY

Marie Balsat, MD^1*, Aline Renneville^2*, Xavier Thomas¹, Alice Marceau^2*, Stéphane De Botton^3*, Olivier Nibourel^2*, Emmanuel Raffoux^4*, Céline Rodriguez^2*, Jean-Michel Cayuela^4*, Sandrine Hayette^5*, Christine Terré^6*, Karine Celli-Lebras^7*, Hervé Dombret⁴, Claude Preudhomme² and Nicolas Boissel⁴

¹Hematology, Centre Hospitalier Lyon-Sud, Pierre Bénite, France
²Hematology Laboratory, CHRU, Lille, France
³Hematology, Gustave Roussy, Villejuif, France
⁴Hematology, Hôpital Saint-Louis, Paris, France
⁵Hematology Laboratory, Centre Hospitalier Lyon-Sud, Pierre Bénite, France
⁶Hematology Laboratory, Centre Hospitalier, Versailles, France
⁷ALFA Coordination, Hôpital Saint-Louis, Paris, France

Papagudi Ganesan Subramanian, MD^1*, Nikhil Patkar, MD^1*, Prashant Tembhare, MD,^1*, Yajamanam Badrinath^2*, Sitaram G Ghogale, BSc^2*, Sumeet Gujral, MD³ and Navin Khattry, MD DM^4*

¹Hematopathology Laboratory, Tata Memorial Centre, Mumbai, India
²Hematopathology Laboratory, Tata Memorial Hospital, Mumbai, India
³Department of Pathology, Tata Memorial Centre, Mumbai, India
⁴Tata Memorial Center, ACTREC, Mumbai, India

Yusuke Hara, MD^1,2*, Genki Yamato, MD^1,2*, Norio Shiba, MD, PhD^1,2*, Kentaro Ohki, MD, PhD^2,3*, Myoung-Ja Park, MD, PhD^2*, Daisuke Tomizawa, MD, PhD⁴, Tomohiko Taki, MD, PhD⁵, Takashi Taga, MD, PhD^6*, Hirokazu Arakawa, MD, PhD^1*, Akio Tawa, MD, PhD^7*, Keizo Horibe, MD, PhD⁸, Souichi Adachi, MD, PhD⁹ and Yasuhide Hayashi, MD, PhD^2,10

¹Department of Pediatrics, Gunma University Graduate School of Medicine, Maebashi, Japan
²Department of Hematology/Oncology, Gunma Children's Medical Center, Shibukawa, Japan
³Departmentof Pediatric Hematology and Oncology Research, National Center for Child Health and Development, Tokyo, Japan
⁴Division of Leukemia and Lymphoma, Children’s Cancer Center, National Center for Child Health and Development, Tokyo, Japan
⁵Department of Molecular Diagnostics and Therapeutics, Kyoto Prefectural University of Medicine, Kyoto, Japan
⁶Department of Pediatrics, Shiga University of Medical Science, Otsu, Japan
⁷Department of Pediatrics, National Hospital Organization, Osaka National Hospital, Osaka, Japan
⁸Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
⁹Department of Human Health Sciences, Kyoto University, Kyoto, Japan
¹⁰Japanese Red Cross Gunma Blood Center, Maebashi, Japan

Dirkje W. Hanekamp^1*, Barbara Denys^2*, Gertjan J.L. Kaspers, MD, PhD³, Jeroen G. te Marvelde^4*, Gerrit Jan Schuurhuis, PhD¹, Valerie De Haas, MD, PhD⁵, Barbara De Moerloose, MD, PhD^6*, Eveline S. de Bont⁷, Anja de Jong^5*, Jan Philippé, MD, PhD^2*, Jacqueline Cloos, PhD^1,3* and Vincent H.J. van der Velden, PhD^4*

¹Department of Hematology, VU University Medical Center, Amsterdam, Netherlands
²Department of Clinical Biology, Microbiology and Immunology, Ghent University, Ghent, Belgium
³Department of Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, Netherlands
⁴Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
⁵Dutch Childhood Oncology Group, The Hague, Netherlands
⁶Department of Pediatrics, Ghent University, Ghent, Belgium
⁷Department of Pediatric Oncology/Hematology, Beatrix Children’s Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands

Frauke Theis^1*, Peter Paschka, MD¹, Daniela Weber^1*, Verena I. Gaidzik, MD^1*, Lars Bullinger, MD¹, Maria-Veronica Teleanu, MD^1*, Gudrun Göhring, MD^2*, Helmut R. Salih, MD³, Andrea Kündgen^4*, Hans-Juergen Salwender, MD^5*, Joerg Westermann, MD^6*, Walter Fiedler, MD⁷, Katharina Götze⁸, Heinz-August Horst, MD, PhD⁹, Gerald G Wulf, MD¹⁰, Michael Luebbert, MD^11*, Dominik Wolf, MD^12*, Thomas Kindler, MD^13*, Mark Ringhoffer, MD^14*, Doris Kraemer, MD^15*, Jürgen Krauter, MD^16*, Felicitas Thol, MD¹⁷, Michael Heuser, M.D.¹⁷, Arnold Ganser, M.D.¹⁷, Hartmut Döhner, MD¹, Richard F. Schlenk, MD¹ and Konstanze Döhner, MD¹

¹Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
²Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
³Department of Hematology and Oncology, Eberhard Karls University, Tuebingen, Germany
⁴Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany
⁵Asklepios Hospital Hamburg Altona, Hamburg, Germany
⁶Department of Hematology, Oncology and Tumor Immunology, Charité-University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany
⁷Hubertus Wald University Cancer Center Department of Oncology and Hematology, University Medical Center Eppendorf, Hamburg, Germany
⁸Department of Internal Medicine III, University Hospital of Munich, Munich, Germany
⁹Department of Internal Medicine II, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
¹⁰Department of Hematology and Oncology, University Hospital of Göttingen, Göttingen, Germany
¹¹Department of Medicine, Devision of Hematology and Oncology, University Hospital of Freiburg, Freiburg, Germany
¹²Department of Internal Medicine III, Oncology, Hematology and Rheumatology, University Hospital Bonn, Bonn, Germany
¹³University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
¹⁴Department of Internal Medicine III, Municipal Hospital of Karlsruhe, Karlsruhe, Germany
¹⁵Department of Oncology and Hematology, Klinikum Oldenburg, Oldenburg, Germany
¹⁶Department of Internal Medicine III, Municipal Hospital of Braunschweig, Braunschweig, Germany
¹⁷Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany

Mridul Agrawal, MD^1*, Andrea Corbacioglu, PhD^1*, Nikolaus Jahn, MD^1*, Lars Bullinger, MD¹, Maria-Veronica Teleanu, MD^1*, Verena I. Gaidzik, MD^1*, Daniela Weber^1*, Gudrun Göhring, MD^2*, Michael Luebbert, MD^3*, Walter Fiedler, MD⁴, Peter Brossart, MD⁵, Thomas Kindler, MD^6*, Markus Radsak, MD^6*, Mark Ringhoffer, MD^7*, Katharina S. Götze, MD⁸, Richard Greil, MD⁹, Felicitas Thol, MD¹⁰, Michael Heuser, MD¹⁰, Arnold Ganser, M.D.¹⁰, Richard F. Schlenk, MD¹¹, Hartmut Döhner, MD^1*, Peter Paschka, MD¹ and Konstanze Döhner, MD¹

¹Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
²Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
³Department of Hematology, Oncology and Stem Cell Transplantation, University of Freiburg Medical Center, Freiburg, Germany
⁴Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
⁵Internal Medicine III, Oncology, Hematology and Rheumatology, University Clinic Bonn, Bonn, Germany
⁶University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
⁷Department of Internal Medicine III, Municipal Hospital of Karlsruhe, Karlsruhe, Germany
⁸III. Department of Medicine, Hematology and Medical Oncology, Technical University of Munich, Munich, Germany
⁹3rd Medical Department with Hematology and Medical Oncology, Hemostaseology, Rheumatology and Infectious Diseases, Laboratory for Immunological and Molecular Cancer Research, Oncologic Center, Paracelsus Medical University Hospital Salzburg, and Center for Clinical Cancer and Immunology Trials at Salzburg Cancer Research Institute, Salzburg, Austria
¹⁰Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
¹¹University Hospital of Ulm, Ulm, Germany

Jason E. Farrar, M.D.¹, Todd A. Alonzo, PhD^2,3, Rhonda E. Ries, MA^4*, Robert B. Gerbing, MA^3*, Jaime M. Guidry Auvil, PhD^5*, Tanja M. Davidsen, PhD^5*, Patee Gesuwan^5*, Leandro C. Hermida^5*, Marco A Marra, PhD⁶, Andrew J. Mungall, PhD⁶, Karen Mungall, PhD^6*, Yussanne Ma, PhD^6*, William Long, PhD^6*, Stuart Zong^6*, E. Anders Kolb, MD⁷, Malcolm A. Smith, MD, PhD⁸, Daniela S. Gerhard, PhD^5*, Alan S. Gamis, MD, MPH⁹ and Soheil Meshinchi, MD, PhD⁴

¹Department of Pediatics/Hematology Oncology Section, University of Arkansas for Medical Sciences, Little Rock, AR
²Keck School of Medicine, University of Southern California, Los Angeles, CA
³Children's Oncology Group, Monrovia, CA
⁴Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
⁵Office of Cancer Genomics, National Cancer Institute, Bethesda, MD
⁶Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, Canada
⁷Nemours Center for Cancer and Blood Disorders, Alfred I. duPont Hospital for Children, Wilmington, DE
⁸Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD
⁹Division of Hematology/Oncology/Bone Marrow Transplantation, Children's Mercy Hospitals and Clinics, Kansas City, MO

Louise Roulin^1*, Ashfaq Ali^1*, Aline Masse^2*, Marie-Magdelaine Coudé^2*, Dominique Bluteau^1*, Thorsten Braun, MD, PhD^2,3*, Jeannig Berrou^2*, Olivier Bluteau^1*, Marc Delord^4*, Maria Eugenia Riveiro^5*, Patrice EDOUARD Herait, MD^6*, Jean Soulier, MD, PhD⁷, André Baruchel, MD^2,8, Claude Gardin, MD^2,9*, Hervé Dombret^2,10 and Raphaël Itzykson, MD, PhD^1,11

¹UMR7212/U944, Institut National de la Santé et de la Recherche Médicale, Saint-Louis Institute, University Paris 7, Paris, France
²Laboratoire de Transfert des Leucémies, Institut Universitaire d'Hématologie, University Paris VII, Paris, France
³Clinical Hematology, CHU Avicenne, Bobigny, France
⁴Bioinformatics, Institut Universitaire d'Hématologie, University Paris VII, Paris, France
⁵OTD, Clichy, France
⁶ONCOETHIX, SOISY SOUS MONTMORENCY, France
⁷Institute of hematology, University Paris-Diderot, Paris, France
⁸Department of Hematology, Hopital Robert Debré, Paris, France
⁹Hematology Department, Avicenne Hospital, APHP, University Paris 13, Bobigny, France
¹⁰Leukemia Unit, Hematology department, Hôpital Saint-Louis, Paris, France
¹¹Hematology Department, Saint-Louis Hospital, University Paris 7, Paris, France

Marcus Celik Hansen, MSc in Biomedical Engineering^1*, Sadudee Chotirat, MD^2*, Chirayu Udomsakdi Auewarakul, MD, PhD, Professor^3* and Peter Hokland, MD D.Med.Sci, Professor¹

¹Department of Hematology, Aarhus University Hospital, Aarhus, Denmark
²Leukemia Research Laboratory, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
³Chulabhorn Cancer Centre and Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand

Krzysztof Giannopoulos, MD, PhD^1,2*, Malgorzata Zajac, PhD^1,3*, Olga Jankowska-Lecka, PhD^4*, Joanna Zaleska^1*, Joanna Purkot^1*, Tomasz Gromek, MD^4*, Maria Soroka-Wojtaszko, MD, PhD^4*, Aneta Szudy-Szczyrek, MD^4*, Marek Hus, MD, PhD^4* and Lars Bullinger, MD⁵

¹Department of Experimental Hematooncology, Medical University of Lublin, Lublin, Poland
²Department of Hematology, St. John’s Cancer Center, Lublin, Poland
³Postgraduate School of Molecular Medicine of Warsaw, Warsaw, Poland
⁴Department of Hematooncology and Bone Marrow Transplantation Unit, Medical University of Lublin, Lublin, Poland
⁵University of Ulm, Ulm, Germany

Marlise R. Luskin, MD¹, Phyllis Gimotty, PhD^2*, Catherine Smith^3*, Alison Loren, MD, MS⁴, Maria Figueroa, MD^5*, Jenna Harrison^3*, Zhuoxin Sun, PhD^6*, Martin S Tallman, MD⁷, Elisabeth Paietta, PhD⁸, Mark R Litzow, MD⁹, Ross L. Levine, MD¹⁰, Hugo F. Fernandez, M.D.¹¹, Selina Luger, MD¹², Martin Carroll, MD¹², Stephen Master, MD, PhD^13* and Gerald Wertheim, MD, PhD^14*

¹Brigham and Women's Hospital, Boston, MA
²Department of Biostatistics & Epidemiology, University of Pennsylvania, Philadelphia, PA
³Department of Pathology, Children's Hospital of Philadelphia, Philadelphia, PA
⁴Abramson Cancer Center of the University of Pennsylvania, Philadelphia, PA
⁵University of Michigan Medical School, Ann Arbor, MI
⁶Dana-Farber Cancer Institute, Boston, MA
⁷Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁸Cancer Center, The North Division of Montefiore Medical Center, Bronx, NY
⁹Division of Hematology, Mayo Clinic, Rochester, MN
¹⁰Memorial Sloan Kettering Cancer Center, New York, NY
¹¹Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center, Tampa, FL
¹²Division of Hematology & Oncology, University of Pennsylvania, Philadelphia, PA
¹³Department of Pathology & Laboratory Medicine, Weill Cornell Medical College, New York, NY
¹⁴Department of Pathology & Laboratory Medicine, University of Pennsylvania, Philadelphia, PA

Jessica Leonard, MD¹, Jennifer Dunlap, MD², Tanaya L Neff^1*, Andrea Warrick^1*, Fei Yang^3*, Richard D. Press, MD, PhD⁴, Brian J. Druker, MD⁵ and Elie Traer, M.D., Ph.D.⁶

¹Oregon Health and Science University, Portland, OR
²Department of Pathology, Oregon Health & Science University, Portland, OR
³Oregon Health & Science University, Portland, OR
⁴Prof. & Dir. of Molecular Pathology, Oregon Health & Science Univ., Portland, OR
⁵Howard Hughes Medical Institute, Oregon Health & Science University, Knight Cancer Institute, Portland, OR
⁶Division of Hematology and Medical Oncology, Oregon Health & Science University, Knight Cancer Institute, Portland, OR

Thomas Köhnke, MD^1,2*, Sandra Rechkemmer^1*, Veit Leonhard Bücklein, MD^1,2*, Kristina Pfannes, PhD^1*, Michael Fiegl, MD^1*, Karsten Spiekermann, MD¹, Wolfgang Hiddemann, MD³ and Marion Subklewe, MD^1,2

¹Department of Internal Medicine III, Klinikum der Universität München, Munich, Germany
²Clinical Cooperation Group Immunotherapy at the Helmholtz Zentrum München, Munich, Germany
³Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany

Srikanth Gottipati, PhD^1*, Shashank Rohatagi, PhD^1*, Woonbok Chung, PhD^2*, Pietro Taverna, PhD^3*, Hagop M. Kantarjian, MD⁴, Gail J. Roboz, MD⁵, Patricia L. Kropf, MD⁶, Mohammad Azab, MD³ and Jean-Pierre Issa, MD²

¹Otsuka Pharmaceutical Development & Commercialization, Inc., Princeton, NJ
²Fels Institute, Temple University, Philadelphia, PA
³Astex Pharmaceuticals, Inc., Pleasanton, CA
⁴Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Division of Hematology and Oncology, Department of Medicine, Weill Cornell Medical College, New York, NY
⁶Fox Chase Cancer Center, Philadelphia, PA

Daeyoon Kim^1*, Youngil Koh, MD^1,2*, Jeonghwan Youk^2*, Kwang-Sung Ahn, PhD^3*, Hwi-Joong Yoon, M.D., Ph.D.⁴, Hyun Jung Lee, MD^5*, Hyo Jung Kim, MD, PhD^6*, Junglim Lee, MD⁷ and Sung-Soo Yoon, MD PhD^1,2

¹Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
²Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea
³Functional Genome Institute, PDXen Biosystems Inc., Seoul, South Korea
⁴Kyung Hee University College of Medicine, Seoul, South Korea
⁵Department of Internal Medicine, Dongguk University Ilsan Hospital, Ilsan, South Korea
⁶Department of Internal Medicine, Hallym University College of Medicine, Anyang, South Korea
⁷Daegu Fatima Hospital Public Cord Blood Bank, Daegu, South Korea

Taehyung Simon Kim, PhD^1,2*, Zhaolei Zhang, PhD^1,3,4*, Marc Tyndel^1,5*, Jae-Sook Ahn, MD, PhD^6*, Yeo-Kyeoung Kim, M.D., Ph.D.⁶, Seung Hyun Choi, PhD^7*, Hyeoung-Joon Kim, MD, PhD^6,7, Moses Lee^8*, Murim Choi^8*, Jeffrey H. Lipton, MD, PhD⁹ and Dennis Dong Hwan Kim, MD, PhD¹⁰

¹Department of Computer Science, University of Toronto, Toronto, Canada
²The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada
³The Donnelly Centre, University of Toronto, Toronto, Canada
⁴Department of Molecular Genetics, University of Toronto, Toronto, Canada
⁵The Edward S. Rogers Sr. Department of Electrical and Computer Engineering, University of Toronto, Toronto, Canada
⁶Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, South Korea
⁷Genomic Research Center for Hematopoietic Diseases, Chonnam National University Hwasun Hospital, Hwasun, South Korea
⁸Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea
⁹Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, ON, Canada
¹⁰Department of Medical Oncology & Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada

Andrew M. Brunner, MD^1,2, Donna S Neuberg, ScD³, Seth A. Wander, MD, PhD¹, Hossein Sadrzadeh, MD⁴, Karen K. Ballen, MD¹, Philip C. Amrein, MD¹, Gabriela S. Hobbs, MD¹, Yi-Bin Chen, MD¹, Ashley M. Perry, BS^1*, Christelle Joseph^1*, Meghan E. Burke^1*, Aura Y Ramos^1*, Regina Silver^1*, Ilene Galinsky, ANP⁵, Sophia Adamia, PhD², Darrell Borger, PhD^1*, Anthony J Iafrate, MD, PhD^1*, Richard M. Stone, MD⁵ and Amir T. Fathi, MD¹

¹Massachusetts General Hospital, Boston, MA
²Dana-Farber Cancer Institute, Boston, MA
³Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA
⁴Capital Health system, Trenton, NJ
⁵Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA

Jasmijn de Rooij, MD^1*, Riccardo Masetti, MD^2*, Marry M. van den Heuvel-Eibrink, MD, PhD^1,3*, Jean-Michel Cayuela^4*, Jan Trka⁵, Dirk Reinhardt, MD⁶, Edwin Sonneveld, PhD^7*, Todd A. Alonzo, PhD⁸, Maarten Fornerod^1*, Martin Zimmermann^9*, Martina Pigazzi, PhD^10*, Rob Pieters, MD, PhD³, Soheil Meshinchi, MD, PhD¹¹, C. Michel Zwaan¹ and Franco Locatelli¹²

¹Pediatric Oncology/Hematology, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands
²Pediatric Oncology and Hematology, University of Bologna, Bologna, Italy
³Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
⁴Hematology, Hôpital Saint-Louis, Paris, France
⁵Department of Paediatric Haematology and Oncology, 2nd School of Medicine, Charles University, Prague, Czech Republic
⁶AML-BFM Study Group, Pediatric Hematology/Oncology, University Children’s Hospital Essen, Essen, Germany
⁷Dutch Childhood Oncology Group, The Hague, Netherlands
⁸Children's Oncology Group, Monrovia, CA
⁹AML-BFM Study Group, Pediatric Hematology and Oncology, Medical School Hannover, Hannover, Germany
¹⁰Woman and Child Health Department, University of Padova, Padova, Italy
¹¹Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
¹²IRCCS Ospedale Pediatrico Bambino Gesù, University of Padua, Rome, Italy

Ashvind A Prabahran, MBBS^1*, Mark Tacey, BSc^2,3*, Shaun Fleming, MBBS (Hons), FRACP, FRCPA^4*, Danielle Strong^5*, Andrew Wei, MBBS, PhD⁶, Courtney Tate, MBBS^7*, Paula Marlton, MBBS⁷, Joel Wight, MBBS^8*, Andrew Grigg, MBBS, MD, FRACP, FRACPA^9*, Annabel Tuckfield, MBBS, FRACP, FRCPA, PhD^10*, Jeff Szer, MB, BS, FRACP¹¹, David S. Ritchie, MD, PhD¹¹ and Lynette C.Y. Chee, MBBS, FRACP, FRCPA, PhD¹²

¹Clinical Haematology, Royal Melbourne Hospital, Parkville, Australia
²Epicentre, Royal Melbourne Hospital, Parkville, Australia
³Epicentre, University of Melbourne, Parkville, Australia
⁴Department of Haematology, Alfred Hospital, Melbourne, Australia
⁵Medical School, Monash University, Caufield, Australia
⁶Haematology, The Alfred Hospital, Melbourne, Australia
⁷Clinical Haematology, Princess Alexandra Hospital, Brisbane, Australia
⁸Clinical Haematology, Austin Hospital, Heidelberg, Australia
⁹Austin Health, Heidelberg, Australia
¹⁰Royal Melbourne Hosp., Parkville, Australia
¹¹Royal Melbourne Hospital, Parkville, Australia
¹²The Royal Melbourne Hospital, Parkville, Australia

Maria Chiara Fontana^1*, Viviana Guadagnuolo, PhD^2*, Cristina Papayannidis, MD, PhD³, Giorgia Simonetti, PhD^2*, Antonella Padella^2*, Anna Ferrari, PhD^2*, Marco Manfrini, PhD^3*, Italo Faria do Valle^4,5*, Barbara Santacroce^6*, Margherita Perricone^7*, Giovanni Marconi, MD^2*, Emanuela Ottaviani^2*, Jelena D. Milosevic Feenstra, PhD^8*, Doris Chen, PhD^8*, Nicole C.C. Them^8*, Simona Soverini⁹, Daniel Remondini, PhD^5*, Gerardo Musuraca^10*, Michele Cavo, MD^11*, Robert Kralovics, PhD⁸ and Giovanni Martinelli¹¹

¹Seragnoli Institute, University of Bologna, Bologna, Italy
²University of Bologna, Bologna, Italy
³Bologna University School of Medicine, Bologna, Italy
⁴Ministry of Education of Brazil, CAPES Foundation, Brazilia, Brazil
⁵Department of Physics and Astronomy, University of Bologna, Bologna, Italy
⁶DIMES - Department of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology, University of Bologna, Bologna, Italy
⁷Institute of Hematology, Bologna, Italy
⁸CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
⁹Institute of Hematology, S.Orsola-Malpighi University Hospital, Bologna, Italy
¹⁰Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori, Meldola (FC),, Meldola, Italy
¹¹"Seràgnoli" Institute of Hematology, University of Bologna, Bologna, Italy

Guardo Daniela, MD^*, Fabio Guolo, MD^*, Paola Minetto, MD^*, Marino Clavio, MD^*, Livia Giannoni, MD^*, Elisa Coviello, MD^*, Giordana Pastori, MD^*, Giulia Rivoli, MD^*, Filippo Ballerini, MD^*, Nicoletta Colombo, PhD^*, Raffaella Grasso, PhD^*, Maurizio Miglino, PhD^*, Roberto Massimo Lemoli, MD and Marco Gobbi, MD^*

Chair of Hematology, Department of Internal Medicine (DiMI), IRCCS AOU San Martino-IST, University of Genoa, Genoa, Italy

Emily Silgard, M.S. Computational Linguistics^1*, Vicky Sandhu, MD, MPH^2*, Elihu H. Estey, MD^3,4 and Daniel Herman, M.D., PhD^4*

¹Fred Hutchinson Cancer Research Center, Seattle, WA
²Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA
³Seattle Cancer Care Alliance, Seattle, WA
⁴University of Washington School of Medicine, Seattle, WA

Alyssa Carey, B.S.^1*, Swati Garg^1*, Megan M Cleary, B.S., B.A.^1*, David K Edwards V, B.A., B.S.², Marc Loriaux, MD, PhD^1*, Shannon L Winski, PhD^3*, LouAnn Cable, B.S.^3*, Jeffrey W. Tyner, PhD² and Anupriya Agarwal, PhD¹

¹Knight Cancer Institute, Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, OR
²Knight Cancer Institute, Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR
³Array BioPharma Inc., Boulder, CO

Brittany Knick Ragon, MD¹, Naval Daver, MD², Guillermo Garcia-Manero, MD², Maro Ohanian, DO^2*, Alessandra Ferrajoli, MD², Naveen Pemmaraju, MD², Hagop M Kantarjian, MD² and Gautam Borthakur, MD²

¹Hematology/Oncology Fellowship, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

Aaron C. Shaver, MD, PhD^1*, Adam C. Seegmiller, MD, PhD^1*, Stephen A. Strickland, MD², Robert D. Daber, Ph.D.^3*, Sanjay R. Mohan, MD^2*, Paul Brent Ferrell Jr., MD⁴, Cindy Vnencak-Jones, Ph.D.^1*, David R. Head, MD¹, Annette S. Kim, MD, PhD¹, Mary M. Zutter, MD¹ and Michael R. Savona, MD⁴

¹Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN
²Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN
³BioReference Laboratories, Elmwood Park, NJ
⁴Department of Medicine, Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN

Huthayfa Mujahed, MS.c^1*, Deneberg Stefan^1* and Soren Lehmann, MD, PhD²

¹Center for Haematology and regenerative medicine, Karolinska institute, Stockholm, Sweden
²Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden

Michael Boyiadzis, MD, MHSc, Chang Sook Hong, PhD^* and Theresa L Whiteside, PhD^*

University of Pittsburgh Cancer Institute, Pittsburgh, PA