Simona Soverini, PhD¹, Caterina De Benedittis, PhD^1*, Claudia Venturi, PhD^2*, Cristina Papayannidis, MD, PhD³, Manuela Mancini, PhD^1*, Katerina Machova Polakova^4*, Domenico Russo, MD, PhD⁵, Paola Bresciani, MD^6*, Alessandra Iurlo, MD, PhD^7*, Elisabetta Abruzzese, MD⁸, Federica Sorà, MD, PhD^9*, Michele Baccarani¹⁰, Michele Cavo, MD^2*, Torsten Haferlach¹¹ and Giovanni Martinelli, MD, PhD³

¹"Seràgnoli" Institute of Hematology, Bologna University School of Medicine, Bologna, Italy
²Institute of Hematology, S.Orsola-Malpighi University Hospital, Bologna, Italy
³Bologna University School of Medicine, Bologna, Italy
⁴Institute of Hematology and Blood Transfusion, University of Prague, Prague, Czech Republic
⁵Chair of Hematology, Unit of Blood Diseases and Stem Cell Transplantation, University of Brescia, Brescia, Italy
⁶University of Modena, Bone Marrow Transplant Unit, Department of Oncology and Hematology, Modena, Italy
⁷Division of Hematology, IRCCS Maggiore Policlinico Hospital Foundation, Milano, Italy
⁸Hematology, S. Eugenio Hospital, Roma, Italy
⁹Università Cattolica del Sacro Cuore, Rome, Italy
¹⁰Institute of Hematology, University of Bologna, Bologna, Italy
¹¹MLL Munich Leukemia Laboratory, Munich, Germany

Hassan B Alkhateeb, MD¹, Tasha Lin, MD², Moussab Damlaj, MD¹, Aref Al-Kali, MD¹, Naseema Gangat, MBBS¹, William J Hogan, MBChB¹, Michelle Elliott, MD^1*, Grzegorz S. Nowakowski, MD¹, Carrie Thompson, MD¹, Thomas E. Witzig, MD¹, Stephen M Ansell, M.D., Ph.D.¹, Mark R Litzow, MD¹ and Mrinal M Patnaik, MBBS¹

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Department of Internal Medicine, Mayo Clinic, Rochester, MN

Eunice S. Wang, MD¹, Gary J Schiller, MD², Leonard T. Heffner, MD³, Wendy Stock, MD⁴, Arati V. Rao, MD⁵, Gail J. Roboz, MD⁶, Peter Westervelt, MD, PhD⁷, Matthew J. Wieduwilt, MD, PhD⁸, Jay Yang, MD⁹, Lucy Prasad^10*, Karen Segarini^10* and Stuart L. Goldberg, MD¹¹

¹Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY
²University of California, Los Angeles, CA
³Department of Hematology and Medical Oncology, Emory University - Winship Cancer Institute, Atlanta, GA
⁴University of Chicago Medical Center, Chicago, IL
⁵Duke Cancer Institute, Duke University, Durham, NC
⁶Division of Hematology and Oncology, Department of Medicine, Weill Cornell Medical College, New York, NY
⁷Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO
⁸University of California, San Diego, La Jolla, CA
⁹Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI
¹⁰spectrum pharmaceuticals, irvine
¹¹Division of Leukemia, John Theurer Cancer Center of Hackensack University Medical Center, Hackensack, NJ

Xavier Thomas, MD, PhD¹, Yves Bertrand, MD, PhD^2*, Andre Baruchel, MD, PhD³, Nicolas Blin, MD^4*, Emmanuelle Tavernier, MD^5*, Stephane Ducassou, MD^6*, Norbert Vey⁷, Virginie Gandemer, MD, PhD⁸, Victoria Cacheux, MD^9*, Francoise Mazingue, MD¹⁰, Emmanuel Raffoux^11*, Genevieve Plat, MD^12*, Jose Fernandes, MD^13*, Maryline Poiree, MD^14*, Luc Fornecker, MD^15*, Jean-Louis Stephan, MD^16*, Mathilde Hunault, MD, PhD^17*, Anne Auvrignon, MD^18*, Thibault Leguay, MD^19*, Stephane Lepretre, MD^20*, Alina Ferster, MD, PhD²¹, Isabelle Pellier, MD^22*, Emmanuel Plouvier, MD^23*, Claudine Schmitt^24*, Cecile Bonin, Pharm D^25*, Yann Godfrin, PhD²⁵ and Iman El Hariry, MD, PhD^25*

¹Hematology Department, Hopital Edouard Herriot, Lyon, France
²Pediatric hematology, CHU Lyon, Lyon, France
³Pediatric Hematology, Hopital Saint Louis, Paris, France
⁴Department of Hematology, Nantes University Hospital, Nantes, France
⁵hematology, Institut de cancerologie de la Loire, Saint Priez en jarez, 42271, France
⁶Pediatric Hematology, CHU de Bordeaux,Hopital des Enfants-Hôpital Pellegrin, Bordeaux, France
⁷Hematology, Institut Paoli-Calmettes, Marseille, France
⁸Pediatric Hematology, Centre Hospitalier Universitaire de Rennes, Rennes, France
⁹Hematology Clermont Ferrand,, CHU Clermont Ferrand, Clermont Ferrand, France
¹⁰hematology, CHRU Lille, Lille, France
¹¹Hematology Department, Saint Louis Hospital, Paris, France
¹²pediatric hematology, CHU Toulouse, Toulouse, France
¹³Centre Hospitalier Valenciennes Hematology, Valenciennes, France
¹⁴CHU Lenval Pediatric Hematology, Nice, France
¹⁵Oncology and Hematology, Hopital de Hautepierre, Strasbourg, France
¹⁶Hopital Nord - CHU Saint Etienne, Saint Priez en jarez, 42271, France
¹⁷Hematology Department, CHU, Angers, France
¹⁸Pediatric Hematology, AP-HP,GH-HUEP Trousseau Hospital, PARIS, France
¹⁹Department of Hematology, CHU, Bordeaux, Bordeaux,, France
²⁰Hematology, CLCC H Becquerel, Rouen, France
²¹Dept. of Hémato-oncologie pédiatrique, Children's University Hospital Reine Fabiola, Brussels, Belgium
²²CHU Angers, Angers Cedex, France
²³pediatric hematology, CHRU Besançon, Besançon, France
²⁴Pediatric Hematology, CHU de nancy, Nancy, France
²⁵ERYTECH Pharma, Lyon, France

Rob S Sellar, MBChB, FRCPath^1,2*, Clare Rowntree, PhD^3*, Ajay J. Vora⁴, Caroline L Furness, MD^5*, Nicholas Goulden, MD, PhD⁶, Chris Mitchell, FRCPCH^7*, Anthony V. Moorman, PhD⁸ and Rachael Hough, MD, BMBS, FRCP, FRCPath^1*

¹Cancer Institute, University College London, London, United Kingdom
²Department of Haematology, University College London Hospitals, London, United Kingdom
³University Hospital of Wales, Cardiff, United Kingdom
⁴Dept. of Pediatric Hematology, The Children's Hospital, Sheffield, United Kingdom
⁵Haemato-Oncology, Royal Marsden NHS Foundation Trust, London, United Kingdom
⁶Department of Haematology, Great Ormond Street Hospital For Children, London, United Kingdom
⁷John Radcliffe Hospital, Oxford, United Kingdom
⁸Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom

Myriam Ruth Guitter, MD^1*, Jorge Gabriel Rossi, PhD^2*, Elisa Sajaroff, PhD^3*, Carolina Carrara, PhD^3*, Pizzi Silvia, MD^4*, Raquel Staciuk, MD^5*, Eduardo Lagomarsino, PhD^1*, Natalia Millan, MD^1*, Patricia Rubio, PhD^1*, Cristina Noemi Alonso, PhD^1*, Pedro Zubizarreta, MD^1* and Maria Sara Felice, MD, PhD^1*

¹Hematology and Oncology, Hospital Nacional de Pediatria Prof. Dr. J. P. Garrahan, Buenos Aires, Argentina
²Immunology and Rheumatology, Hospital Nacional de Pediatría Prof. Dr. J. P. Garrahan, Buenos Aires, Argentina
³Immunology and Rheumatology, Hospital Nacional de Pediatria Prof. Dr. J. P. Garrahan, Buenos Aires, Argentina
⁴Stem Cell Transplantation Unit, Hospital Nacional de Pediatria Prof. Dr. J. P. Garrahan, Buenos Aires, Argentina
⁵Stem Cell Transplantation Unit, Hospital Nacional de Pediatria Prof. Dr. J. P. Garrahan, Buenos Aires, Argentina

Lidewij T Warris, MD^1,2*, Marry M van den Heuvel-Eibrink, MD, PhD^1,3, Femke K Aarsen, MSc PhD^1*, Saskia MF Pluijm^4*, Marc B Bierings, MD PhD⁵, Cor van den Bos, MD PhD^6*, Christian M. Zwaan, MD, PhD¹, Wim JE Tissing, MD, PhD^7*, Margreet A Veening, MD^8*, Rob Pieters, MD, PhD^3,9 and Erica LT van den Akker, MD PhD^2*

¹Department of Pediatric Oncology, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands
²Department of Pediatric Endocrinology, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands
³Princess Máxima Centre for Pediatric Oncology, Utrecht, Netherlands
⁴Department of Paediatric Oncology/Hematology, Erasmus MC-Sophia’s Children’s Hospital, Rotterdam, Netherlands
⁵Department of Hematology and Immunology, Wilhelmina Children's Hospital, Utrecht, Netherlands
⁶Department of Pediatric Oncology, Academic Medical Center, Amsterdam, Netherlands
⁷Department of Paediatric Oncology, University Medical Center Groningen, Groningen, Netherlands
⁸Department of Pediatric Oncology, VU medical center, Amsterdam, Netherlands
⁹Department of Pediatric Oncology/Hematology, Erasmus MC - Sophia Children's Hospital, Rotterdam, Netherlands

Koji Sasaki, MD¹, Susan O'Brien, MD², Farhad Ravandi, MD², Deborah A Thomas, MD², Haim G Moore^2*, Jorge E. Cortes, MD², Naveen Pemmaraju, MD², Musa Yilmaz, MD^3*, Tapan Kadia, MD⁴, Rebecca Garris^2*, Guillermo Garcia-Manero, MD², Twilla Victoria Jeanis, RN^2*, Jad Chahoud, MD⁵, Gautam Borthakur, MD², William Wierda, MD, PhD⁴, Alessandra Ferrajoli, MD², Hagop M. Kantarjian, MD² and Elias Jabbour²

¹Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Hematology & Oncology, Baylor College of Medicine, Houston, TX
⁴Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
⁵University of Texas Hosuton Health Science Center, Houston, TX

Elena N. Parovichnikova, MD, PhD^1*, Vera V. Troitskaya, MD, PhD^1*, Andrey Sokolov^2*, Galina Kliasova^2*, Larisa A. Kuzmina, MD, PhD^3*, Sergey Kravchenko, MD, PhD^1*, Elena Gribanova^2*, Segey Bondarenko^4*, Olga Baranova^5*, Tatyana Kaporskaya^6*, Tatyana Ryltzova^7*, Nina Minaeva^8*, Tatiana Zinina^9*, Olga Samoilova^10*, Alfiya Nizamutdinova^11*, Alexandra Klimovich^12*, Elena Karyakina^13*, Alexandra Eluferieva^14*, Lyubov Gavrilova, MD,^15*, Tatyana Konstantinova^16*, Natalya Vopilina^17*, Kamil Kaplanov^18*, Valery A. Lapin^19*, Alexander Pristupa^20*, Tatyana Tikunova^21*, Zalina Akhmerzaeva^2*, Tatiana N. Obukhova, PhD^1*, Mikhail Rusinov^2*, Sergei M Kulikov, PhD^1* and Valeri G. Savchenko, MD, PhD, Prof.¹

¹National Research Center for Hematology, Moscow, Russia
²National Research Center For Hematology, Moscow, Russia
³Department of BMT, National Research Center for Hematology, Moscow, Russia
⁴Raisa Gorbacheva Memorial Institute, Saint-Petersburg, Russia
⁵Nathional Research Center For Oncology, Moscow, Russia
⁶Irkutsk's Regional Hospital, Irkutsk, Russia
⁷Tula's Regional Hospital, Tula, Russia
⁸Kirov's Blood Transfusion Research Center, Kirov, Russia
⁹Surgut's Clinical Hospital, Surgut, Russia
¹⁰GBUZ NO NOKB Im N.a.Semashko, Nizhniy Novgorod, Russia
¹¹Alexander Multisectoral Hospital, St. Petersburg, Russia
¹²Clinical Hospital №31, Saint-Petersburg, Russia
¹³Regional Clinical Hospital, Saint-Petersburg, Russia
¹⁴Regional Clinical Hospital, Samara, Russia
¹⁵Saransk Clinical Hospital, Saransk, Russia
¹⁶Ekaterinburg Clinical Hospital, Ekaterinburg, Russia
¹⁷Tambov's Regional Hospital, Tambov, Russia
¹⁸Clinical Oncology Hospital, Volgograd, Russia
¹⁹Yaroslavl Regional Hospital, Yaroslavl, Russia
²⁰Ryazan Clinical Hospital, Ryazan, Russia
²¹Regional Clinical Hospital, Belgorod, Russia

Ryan D. Cassaday, MD^1,2,3, Philip A. Stevenson^4*, Brent L. Wood, MD, PhD^3,5, Pamela S. Becker, MD, PhD^1,2,3, Paul C. Hendrie, MD, PhD^2,3*, Brenda M. Sandmaier, MD^1,3,6, Jerald P. Radich^1,3,6 and Andrei R. Shustov, MD^1,2,3

¹Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
²Division of Hematology, University of Washington, Seattle, WA
³Seattle Cancer Care Alliance, Seattle, WA
⁴Clinical Statistics Division, Fred Hutchinson Cancer Research Center, Seattle, WA
⁵Department of Laboratory Medicine/Division of Hematopathology, University of Washington, Seattle, WA
⁶Division of Medical Oncology, University of Washington, Seattle, WA

Jessica C. Hochberg, MD^1*, Javier Oesterheld, MD^2*, Olga Miitano, PharmD^1*, Lauren Harrison, RN, MSN^1* and Mitchell S. Cairo, MD^1,3,4,5,6

¹Pediatrics, New York Medical College, Valhalla, NY
²Pediatric Blood and Marrow Transplantation, Levine Children's Hospital, Charlotte, NC
³Pathology, New York Medical College, Valhalla, NY
⁴Cell Biology & Anatomy, New York Medical College, Valhalla, NY
⁵Microbiology & Immunology, New York Medical College, Valhalla, NY
⁶Medicine, New York Medical College, Valhalla, NY

Ryota Imanaka, MD^1*, Taiichi Kyo, MD¹, Kayo Toishigawa, MD^2*, Tetsuro Ochi, MD^1*, Takeshi Okatani, MD^1*, Kouhei Kyo, MD^1*, Mitsuhiro Itagaki, MD^1*, Hisao Nagoshi, MD^3*, Yuta Katayama, MD, PhD^1*, Koji Iwato, MD^4* and Hideki Asaoku, MD^5*

¹Internal Medicine, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Hiroshima, Japan
²Internal Medicine, Hiroshima Red Cross Hospital, Hiroshima, Japan
³Division of Hematology and Oncology, Kyoto Prefectural University of Medicine, Kyoto, Japan
⁴Department of Transfusion, Hiroshima Red Cross Hospital, Hiroshima, Japan
⁵Department of Laboratory, Hiroshima Red Cross Hospital, Hiroshima, Japan

Gertjan J.L. Kaspers, MD, PhD¹, Denise Niewerth, PhD^1*, Bram Wilhelm, PharmD^2*, Satianand Ramnarain, MSc^3*, Hans Berkhof, PhD^4*, Valerie De Haas, MD, PhD⁵, Ron A.A. Mathôt, PharmD, PhD^6*, Andishe Attarbaschi, MD^7*, Andre Baruchel, MD⁸, Eveline S. de Bont⁹, Franca Fagioli, MD^10*, Claudia Rossig, MD¹¹, Thomas Klingebiel, MD¹², Barbara De Moerloose, MD, PhD^13*, Brigitte Nelken, MD^14*, Giuseppe Palumbo, MD^15*, Dirk Reinhardt, MD¹⁶, Pierre Simon Rohrlich, MD^17*, Pauline Simon, MD^18*, Arend Stackelberg, MD^19* and C. Michel Zwaan, MD, PhD²⁰

¹Department of Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, Netherlands
²Laboratory of Pharmacology and Pharmacy, VU University Medical Center, Amsterdam, Netherlands
³Pediatric Oncology, Erasmus MC, Rotterdam, Netherlands
⁴Department of Epidemiology & Biostatistics, VU University Medical Center, Amsterdam, Netherlands
⁵Dutch Childhood Oncology Group, The Hague, Netherlands
⁶Clinical Pharmacology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
⁷Children's Cancer Research Institute and St. Anna Kinderspital, Vienna, Austria
⁸Dept. of Pediatric Hematology, Hopital Saint Louis, Paris, France
⁹Department of Pediatric Oncology/Hematology, Beatrix Children’s Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
¹⁰Università degli Studi di Torino, Turin, Italy
¹¹Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany
¹²Department of Pediatrics, University Hospital Frankfurt, Frankfurt am Main, Germany
¹³Department of Pediatrics, Ghent University, Ghent, Belgium
¹⁴Pediatric Hematology, Hospital Jeanne de Flandre, Lille, France
¹⁵Ospedale Pediatrico Bambino Gesù, Rome, Italy
¹⁶AML-BFM Study Group, Pediatric Hematology/Oncology, University Children’s Hospital Essen, Essen, Germany
¹⁷Hematology-Pediatry, CHU L'Archet, Nice, France
¹⁸Pediatric Oncology, University Hospital of Besancon, Besancon, France
¹⁹Department of Pediatric Oncology/Hematology, Charité Universitätsmedizin, Berlin, Germany
²⁰Pediatric Hematology/Oncology, DCOG, Den Haag, Erasmus MC - Sophia Children's Hospital, Den Haag, Rotterdam, Netherlands

Karen R. Rabin, MD, PhD¹, Johann Hitzler, MD, FRCP (C), FAAP², Vilmarie Rodriguez, MD³, Reuven Schore, MD⁴, Anne Angiolillo, MD^4*, Michael J. Burke, MD^5,6, Wanda Salzer, MD⁷, Kelly Maloney, MD⁸, Xiaomin Lu, Ph.D.^9*, Meenakshi Devidas, PhD¹⁰, Mignon L. Loh, MD¹¹, Elizabeth Raetz, MD¹² and Stephen P Hunger, MD¹³

¹Pediatrics, Hematology/Oncology, Baylor College of Medicine, Houston, TX
²Division of Haematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada
³Division of Pediatric Hematology and Oncology, Mayo Clinic, Rochester, MN
⁴Children's National Medical Center, Washington, DC
⁵Division of Hematology/Oncology/Bone Marrow Transplantation, Medical College of Wisconsin, Milwaukee, WI
⁶Children's Hospital of Wisconsin, Milwaukee, WI
⁷U.S. Army Medical Research and Materiel Command, Fort Detrick, MD
⁸The Childrens' Hospital Colorado, Aurora, CO
⁹Department of Biostatistics, University of Florida, Gainesville, FL
¹⁰Department of Biostatistics, Colleges of Medicine, Public Health & Health Profession, University of Florida, Gainesville, FL
¹¹Department of Pediatrics, Benioff Children’s Hospital, University of California at San Francisco, San Francisco, CA
¹²Department of Pediatrics, Huntsman Cancer Institute and Primary Children's Hospital, University of Utah, Salt Lake City, UT
¹³Department of Pediatrics, Children’s Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

Guillermo Montalban-Bravo, MD^1*, Hagop M. Kantarjian, MD², Punit L Jain, MD^1*, Guillermo Garcia-Manero, MD³, Farhad Ravandi, MD², Jorge E. Cortes, MD³, Naval Daver, MD⁴, Koichi Takahashi, MD², Nitin Jain, MD², Srdan Verstovsek, MD², Tapan Kadia, MD², Sherry Pierce, BSN, BA^2* and Elias Jabbour²

¹Department of Leukemia, M D Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, Houston, TX

Guillermo Montalban-Bravo, MD^1*, Hagop M. Kantarjian, MD², Jorge E. Cortes, MD², Farhad Ravandi, MD², Guillermo Garcia-Manero, MD², Jain Punit, MD^3*, Naveen Pemmaraju, MD², Gautam Borthakur, MD², Tapan Kadia, MD², Marina Konopleva, MD, PhD⁴, Sherry Pierce, BSN, BA^2*, Susan O'Brien, MD⁵ and Elias Jabbour²

¹Department of Leukemia, M D Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, MD Anderson Cancer Center, Houston, TX
⁴Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵University of California - Irvine, Orange, CA