Khine Z Win, MD^1,2, Nathan Wilson, PharmD^3*, David D Stenehjem, PharmD^4*, Natalee Tanner, PharmD^5*, George M. Rodgers, MD, PhD⁶ and Jeffrey Gilreath, PharmD^7*

¹Department of Hematology/Oncology, University of New Mexico, Albuquerque, NM
²Department of Internal Medicine, University of Utah, Salt Lake city, UT
³University of Utah/ Huntsman Cancer Hospital, Salt Lake city, UT
⁴Department of Pharmacotherapy, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
⁵Department of Pharmacy, Banner MD Anderson cancer center, Gilbert, AZ
⁶Division of Hematology, University of Utah Hospital, Salt Lake City, UT
⁷Division of Hematology, University of Utah, Salt Lake City, UT

Martha L Louzada, BSc, MD, MSc^1,2, Fatimah Al-Ani, MD, MRCP^3*, Michael J. Kovacs, MD¹, Lenicio Siqueira, BSc^4* and Alejandro Lazo-Langner, MD, MSc^2,5

¹Department of Medicine, Division of Hematology, University of Western Ontario, London, ON, Canada
²Department of Epidemiology and Biostatistics, University of Western Ontario, London, ON, Canada
³Department of Medicine, Division of Hematology, University of Western Ontario -London Health Sciences Centre, London, ON, Canada
⁴Department of Medicine, Division of Hematology, University of Western ontario, London, ON, Canada
⁵Department of Medicine, Division of Hematology, Western University - London Health Sciences Centre, London, ON, Canada

Fatimah Al-Ani, MD, MRCP^1*, Martha L Louzada, BSc, MD, MSc^2,3, Jose Maria Bastida Bermejo, PhD^4* and Maria Victoria Mateos, MD, PhD^4*

¹Department of Medicine, Division of Hematology, University of Western Ontario -London Health Sciences Centre, London, ON, Canada
²Department of Medicine, Division of Hematology, University of Western Ontario, London, ON, Canada
³Department of Epidemiology and Biostatistics, University of Western Ontario, London, ON, Canada
⁴Dpt of Hematology, Hospital Universitario de Salamanca, Salamanca, Spain

Kenji Yokoyama, MD, PhD¹, Naoki Ishizuka, PhD^2*, Naomi Uemura, MD, PhD^3*, Yuji Mizokami, MD, PhD^4*, Hideyuki Hiraishi, MD, PhD^5*, Tamio Teramoto, MD, PhD^6*, Kazuyuki Shimada, MD, PhD^7* and Yasuo Ikeda, MD, PhD⁸

¹Department of Hematology/Oncology, Tokai University Hachioji Hospital, Hachioji, Japan
²Clinical Trial Department, Cancer Institute Hospital, Tokyo, Japan
³Department of Gastroenterology and Hepatology, National Center for Global Health and Medicine, Kohnodai Hospital, Ichikawa, Japan
⁴Gastrointestinal Endoscopy Division, University of Tsukuba Hospital, Tsukuba, Japan
⁵Department of Gastroenterology, Dokkyo Medical University, Shimotsuga, Japan
⁶Teikyo Academic Research Center, Teikyo University, Tokyo, Japan
⁷Department of Cardiology, Shin-Oyama City Hospital, Oyama, Japan
⁸Graduate School of Advanced Science and Engineering,Waseda University, Tokyo, Japan

Lai Heng Lee, MBBS, MMed¹, Chuen Wen Tan, MBBS^2*, Wan Hui Wong^1*, Foon yin Fung^2*, Hwee Ling Koh^3*, Yan Zhao^4*, Mei Ching Kun^2*, Xiao Mei Li^2*, Heng Joo Ng, MRCP, MBBS, MMed^1*, Seng Kok Ang^2* and Yeh Ching Linn, MBBS, MRCP^5*

¹Haematology, Singapore General Hospital, Singapore, Singapore
²Singapore General Hospital, Singapore, Singapore
³National University of Singapore, Sinagpore, Singapore
⁴Nanyang Technological University, singapore, Singapore
⁵Haematology, Sinagpore General Hospital, Singapore, Singapore

Andrei Fagarasanu, MD, PhD¹, Ghazi S Alotaibi, MD^1*, Ramona Hrimiuc, MD^1*, Agnes Y. Y. Lee, MD, MSc^2,3 and Cynthia Wu, MD¹

¹Department of Medicine, University of Alberta, Edmonton, AB, Canada
²Department of Medicine, University of British Columbia, Vancouver, BC, Canada
³British Columbia Cancer Agency, Vancouver, BC, Canada

Srinath Sundararajan, MD¹, Mugilan Poongkunran, MBBS^2*, Chithra Poongkunran, MD^3*, Arun Kannan, MD^4* and Saravananan Balamuthusamy, MD, FASN^5*

¹Hematology-Oncology, University of Arizona, Tucson, AZ
²Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
³Internal Medicine, University of Arizona, Tucson, AZ
⁴Cardiology, University of Arizona, Tucson, AZ
⁵Tarrant Nephrology Associates, Fort Worth, TX

Aurelien Delluc, MD, PhD^1*, Florence Hemon, MD^1*, Fabrice Fouchard, MD^2*, Cecile Tromeur, MD^1*, Francis Couturaud, MD, PhD^3*, Karine Lacut, MD, PhD^1*, Dominique Mottier, PhD, MD^1* and Gregoire Le Gal, MD, PhD⁴

¹Brest university hospital, Brest, France
²Brest university, Brest, France
³Brest university hospital, CHU de Brest, France
⁴The Ottawa Hospital Research Institute, Ottawa, ON, Canada

Alexander T Cohen, MBBS MSc MD^1*, Christopher Wallenhorst, MSc^2*, Anja Katholing, MSc^2*, Melissa Hamilton, MPH^3*, Sreevalsa Unniachan, MBBS MPH^3* and Carlos Martinez, MD MSc^2*

¹Haematological Medicine, Guy's and St Thomas' NHS Trust, King's College London, London, United Kingdom
²Institute for Epidemiology, Statistics and Informatics GmbH, Frankfurt, Germany
³Worldwide Health Economics and Outcomes Research, BMS, Princeton, NJ

Deepa Jayakody Arachchillage^1,2*, Ian J Mackie^1*, Maria Efthymiou^1*, Andrew Chitolie^1*, Beverley J Hunt^3,4*, David Isenberg^5,6*, Munther Khamashta^7,8*, Samuel Machin^1* and Hannah Cohen^1,9*

¹Haemostasis Research Unit, University College London, London, United Kingdom
²Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom
³Haematology, Guy's and St Thomas NHS Foundation Trust, London, United Kingdom
⁴Haematology, King's College London, London, United Kingdom
⁵Centre for Rheumatology, University College London, London, United Kingdom
⁶University College London Hospitals NHS Foundation Trust, London, United Kingdom
⁷Rheumatology, Guy's and St Thomas Hospitals NHS Foundation Trust, London, United Kingdom
⁸Rheumatology, King's College London, London, United Kingdom
⁹Haematology, University College Hospitals NHS Foundation Trust, London, United Kingdom

Genmin Lu, PhD^*, Joyce Lin, BS^*, John T. Curnutte, MD, PhD and Pamela B. Conley, PhD

Portola Pharmaceuticals, Inc., South San Francisco, CA

Jennifer L Fan, MSIV^1*, Laura E Roberts, MD^2*, Mona D Shah, MD, MS³ and YoungNa J Lee-Kim, MD³

¹Pediatrics, Baylor College of Medicine, Houston, TX
²Pediatrics, Baylor College of Medicine / Texas Children's Hospital, Houston, TX
³Texas Children's Cancer and Hematology Centers, Baylor College of Medicine / Texas Children's Hospital, Houston, TX

John K Abdou, MPharm^1,2*, Jignesh P Patel, PhD^1,2*, Bipin Vadher, MD^2*, Alison Brown, BPharm^2*, Lara N Roberts, MD^2*, Raj K Patel, MD^2*, Roopen Arya, PhD^2* and Vivian Auyeung, PhD^1*

¹Institute of Pharmaceutical Sciences, King's College London, London, United Kingdom
²King's Thrombosis Centre, Department of Haematological Medicine, King's College Hospital NHS Foundation Trust, London, United Kingdom

Kirill Lobastov, PhD^1,2*, Iliya Schastlivtsev, PhD^1,2*, Victor Barinov, PhD, MD^1,2* and Valeriy Boyarintsev^1*

¹Clinical Hospital no.1 of the President's Administration of Russian Federation, Moscow, Russia
²Pirogovs Russian National Research Medical University, Moscow, Russia

Laura E Roberts, MD^1*, Jennifer L Fan, MSIV^2*, YoungNa J Lee-Kim, MD^2,3 and Mona D Shah, MD, MS^2,3

¹Pediatrics, Baylor College of Medicine / Texas Children's Hospital, Houston, TX
²Pediatrics, Baylor College of Medicine, Houston, TX
³Texas Children's Cancer and Hematology Centers, Baylor College of Medicine / Texas Children's Hospital, Houston, TX

Jon Mabley, PhD^1*, Greg Scutt, PhD^2*, Kathryn Jane Lang, MRCP, MBBS^3*, Jignesh P Patel, PhD^4,5* and Roopen Arya, PhD^5*

¹School of Pharmacy and Biomolecular Sciences, Brighton, United Kingdom
²Brighton and Sussex Centre for Medicines Optimisation, School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, United Kingdom
³King's College Hospital NHS Foundation Trust, London, United Kingdom
⁴Institute of Pharmaceutical Sciences, King's College London, London, United Kingdom
⁵King's Thrombosis Centre, Department of Haematological Medicine, King's College Hospital NHS Foundation Trust, London, United Kingdom

Shammim Haji, MPharm^1*, Jignesh P Patel, PhD^2,3*, Vivian Auyeung, PhD^2*, Lara N Roberts, MD^3*, Julia Czuprynska, MBBS^3*, Raj K Patel, MD^3* and Roopen Arya, PhD^3*

¹King's Thrombosis Centre, Department of Haematological Medicine, King's College Hospital, London, United Kingdom
²Institute of Pharmaceutical Sciences, King's College London, London, United Kingdom
³King's Thrombosis Centre, Department of Haematological Medicine, King's College Hospital NHS Foundation Trust, London, United Kingdom

Brett L. Houston, MD^1*, Dhruva J. Dwivedi, PhD.^2,3*, Peter Grin^3*, Michelle Kwong^3*, Enrico Rullo^3*, Momina A. Khan, MSc^3*, Senay Asma, PhD.^3*, Guillaume Pare, MD, MSc^2,3*, Patricia C. Liaw, PhD.^2,3, Ryan Zarychanski, MD, MSc⁴ and Alison E. Fox-Robichaud, MD, MSc^2,3*

¹Department of Medicine, University of Toronto, Toronto, ON, Canada
²Department of Medicine, McMaster University, Hamilton, ON, Canada
³Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada
⁴Department of Medicine, Sections of Hematology / Medical Oncology and Critical Care, University of Manitoba, Winnipeg, MB, Canada