Program: Oral and Poster Abstracts
Session: 332. Antithrombotic Therapy: Poster II
The Switching study comprises a series of studies investigating illness perceptions and medicines beliefs in those prescribed chronic anticoagulation therapy. We report early results from the first sub-study: This sub-study compares patient beliefs in those with TTR<50% to those with TTR>75% prescribed VKA, to determine if illness perceptions and/ or medication beliefs are associated with anticoagulation control and adherence with VKA.
Patients were identified and recruited from the DAWN® databases of the two anticoagulation clinics within King’s College Hospital (UK). Eligible patients were administered a questionnaire pack comprised of validated instruments; the revised illness perceptions questionnaire (IPQ-R), the beliefs about medicines questionnaire (BMQ) and the anti-clot treatment scale (ACTS), to assess patients beliefs about their illness, their medicines and their anticoagulation related quality of life. Patients with a TTR>75% were mailed the questionnaire packs. Those with TTR<50% were invited to a pharmacist-led clinic to discuss their anticoagulation and were administered the questionnaire at the point of switching to a DOAC. Completed questionnaires were computed and individual sub-scales analysed using non-parametric tests.
To date, 71 patients with TTR>75% and 77 patients with TTR<50% have been recruited. Median age in the TTR>75% group was 73, with 65% diagnosed with AF and 63% were male. Median age in the TTR<50% group was 68, with 73% diagnosed with AF and 66% were male. Patients with TTR>75%, compared to those with TTR<50%, had lower levels of concerns about VKA (p<0.001) and higher perceptions of the necessity of taking it (p=0.005). The <50% TTR group found VKAs more burdensome (p<0.001) but no difference was found between groups regarding benefits of therapy. The TTR<50% group were more likely to perceive their condition as being acute in duration (p=0.012), cyclical in nature (p=0.003) with more severe consequences (p=0.007) and experienced greater emotional distress relating to their condition (p=0.004). Post-hoc analysis according to indication revealed differences in beliefs between the two groups was driven by the AF cohort. Furthermore, AF patients with TTR<50% were more likely to believe medicines were overused (p=0.027) and harmful (p=0.029) whilst being less likely to believe VKAs are beneficial (p=0.048) with less coherent beliefs regarding their illness (p=0.042) compared to the TTR>75% group.
Our early results demonstrate that AF patients with good INR control have a distinct pattern of beliefs compared to those with poor control. This provides scope for anticoagulation services to target specific beliefs in those with poor anticoagulation control to improve adherence in those requiring long-term anticoagulation in AF. This is of particular importance if this sub-set of patients is likely to be prescribed DOACs where patients are not routinely engaged by services.
Disclosures: Patel: Bayer plc: Research Funding . Arya: Bayer plc: Research Funding . Auyeung: Bayer PLC: Research Funding .
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