Jaira F. de Vasconcellos^*, Y. Terry Lee^*, Colleen Byrnes, MS^*, Laxminath Tumburu^*, Antoinette Rabel^* and Jeffery L. Miller, MD

Molecular Genomics and Therapeutics Section, Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD

Margaret F. Bennewitz, PhD¹, Ravi Vats, MS^1*, Egemen Tutuncuoglu, MS^1*, Mark T. Gladwin, MD^1,2 and Prithu Sundd, PhD^1,2,3

¹Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA
²Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA
³Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA

Patricia A Shi, MD¹, Erika Choi, BA^1*, Julia Nguyen, BS^2*, Xinhua Guo, BS^3*, Narla Mohandas, DSc¹, Abdu Alayash, PhD^4*, Elizabeth Manci, MD⁵, John D. Belcher, PhD⁶ and Gregory M Vercellotti⁶

¹New York Blood Center, New York, NY
²Vascular Biology Center, Division of Hematology, Oncology & Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN
³Red Cell Physiology Laboratory, New York Blood Center, New York, NY
⁴FDA, CBER, Silver Spring, MD
⁵University of South Alabama Health System, Mobile, AL
⁶Department of Medicine, Vascular Biology Center, Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN

Marcus A Carden, MD^1,2*, Meredith Ellen Fay, BS^2*, Yumiko Sakurai, MSc^1,2*, Robert G Mannino, BS^1,2*, Jordan Ciciliano, BS^3*, Reginald Tran, BS^2* and Wilbur A Lam, MD, PhD^1,2

¹Department of Pediatrics, Aflac Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA
²Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA
³Woodruff School of Mechanical Engineering, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA

Beverly A Schaefer, MD¹, Jonathan M Flanagan, PhD², Thad A. Howard, MS^1*, Kerri A Nottage, MD, MPH³, Connie M. Piccone, MD⁴, Scott T. Miller, MD⁵, Alex George, M.D., Ph.D.², Beatrice E. Gee, M.D.⁶, Barry R Davis, MD PhD^7* and Russell E. Ware, MD, PhD¹

¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²Baylor College of Medicine, Houston, TX
³St. Jude Children's Research Hospital, Memphis, TN
⁴Case Western Reserve University, Cleveland, OH
⁵SUNY Downstate, Brooklyn, NY
⁶Morehouse School of Medicine, Atlanta, GA
⁷University of Texas School of Public Health, Houston, TX

Daniel Gil de Lamadrid^1,2, Yaritza Inostroza-Nieves^2,3*, Joshua Cazares^1,2*, Isamar Alicea^1,2,3*, Analaura Santiago^1,2,4*, Shirley Valentin^1,4*, Jose R Romero^2* and Alicia Rivera¹

¹Department of Laboratory Medicine, Boston Childen's Hospital and Department of Pathology, Harvard Medical School, Boston, MA
²Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA
³Department of Biochemistry and Pharmacology, San Juan Bautista School Of Medicine, Caguas, PR
⁴Department of Microbiology, San Juan Bautista School Of Medicine, Caguas, PR

Pradeep K Dagur, PhD^1*, J. Philip McCoy, PhD², J Nichols^3*, Laurel Mendelsohn, BS^4*, C Seamon^3*, Gregory J Kato, MD^5* and Eduard J van Beers, MD, PhD^6*

¹Flow Cytometry Core Facility, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD
²Flow Cytometry Core Facility, National Heart, Lung, and Blood Institute, Bethesda, MD
³Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD
⁴Sickle Cell Vascular Disease Section, Hematology Branch, National Heart, Lung and Blood Institute, Bethesda, MD
⁵Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA
⁶Van Creveldkliniek, center for benign hematology, University Medical Centre, Utrecht, Netherlands

Paula L Croal, PhD^1*, Malambing G Serafin^1*, Przemyslaw Kosinski, BSc^2,3*, Jackie Leung, MASc^1*, Suzan Williams, MD⁴ and Andrea Kassner, PhD^1,5*

¹Peter Gilgan Centre for Learning and Research, Physiology & Experimental Medicine, The Hospital for Sick Children, Toronto, ON, Canada
²Institute of Medical Science, University of Toronto, Toronto, ON, Canada
³Peter Gilgan Centre for Research and Learning, Physiology & Experimental Medicine, The Hospital for Sick Children, Toronto, ON, Canada
⁴Division of Hematology, The Hospital for Sick Children, Toronto, ON, Canada
⁵Medical Imaging, University of Toronto, Toronto, ON, Canada

Ying Wang, MD, PhD^*, Jianxun Lei, PhD^*, Yann Y Lamarre, PhD^*, Ritu Jha, M.sc^*, Fei Peng, M.sc^*, Sarah Lam^*, Ellis Raduenz^*, Deniz Ercan-Fang^* and Kalpna Gupta, PhD

Vascular Biology Center, Division of Hematology, Oncology & Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN

Richard J Kulmacz, PhD^1*, Wen Liu, PhD^2*, Vladimir Berka, PhD^1*, Mohammad H. Rahbar, PhD^3*, Modupe Idowu, MD¹, Alex George, M.D., Ph.D.⁴ and Harinder S. Juneja, MD¹

¹Department of Internal Medicine-Hematology Division, University of Texas Health Science Center at Houston, Houston, TX
²Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX
³Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, TX
⁴Hematology Center, Texas Children's Hospital, Houston, TX

Chia-Hao Liu, PhD^1*, Olusola Laja, BA, MSc^2*, Laurel Mendelsohn, BS^3*, Kathleen Vaughan, BA^4*, Lena Diaw, PhD^5*, Jefferey Kopp, MD^6* and James G. Taylor, M.D.⁷

¹NHLBI/NIH, Bethesda, MD
²Meharry Medical College, Nashville, TN
³Sickle Cell Vascular Disease Section, Hematology Branch, National Heart, Lung and Blood Institute, Bethesda, MD
⁴Genomic Medicine Section, Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD
⁵NIH/NHLBI, Bethesda, MD
⁶NIDDK/NIH, Bethesda
⁷NHLBI, National Institutes of Health, Bethesda, MD, Bethesda

Athiwat Hutchaleelaha, Ph.D.^*, Mira Patel, PhD^*, Abel Silva^*, Donna Oksenberg, PhD^* and Brian Metcalf, Ph.D.^*

Global Blood Therapeutics, South San Francisco, CA

Marina Pereira Colella, MD, PhD^1*, Barbara Santana, PhD^2*, Rodrigo T. Calado, MD, PhD³ and Sara T Saad, M.D., PhD¹

¹Hematology and Hemotherapy Center, University of Campinas, UNICAMP , INCT do Sangue, Campinas, Brazil
²Department of Internal Medicine, University of São Paulo at Ribeirão Preto Medical School, Ribeirao Preto, Brazil
³Department of Internal Medicine, University of São Paulo at Ribeirão Preto Medical School, Ribeirão Preto, Brazil

Barbara Sandor^1*, Mickael Marin^2*, Claudine Lapoumeroulie^2*, Miklos Rabai^1*, Sophie Lefevre^2*, Nathalie Lemonne^3*, Wassim El Nemer^2*, Olivier Francais^4*, Bruno Le Pioufle^4*, Yves Colin Aronovicz², Philippe Connes, PhD^5* and Caroline Le Van Kim^2*

¹Department of Medicine, University of Pecs Medical School, Pecs, Hungary, Pecs, Hungary
²UMR_S1134, University Paris Diderot/Inserm/INTS, Paris, France
³Unité Transversale de la Drépanocytose, CHU de Pointe-à-Pitre, Guadeloupe, Pointe à Pitre, France
⁴SATIE, ENS Cachan/CNRS/UMR8029, Paris, France
⁵Center of Research and Innovation in Sports, Université Claude Bernard Lyon 1, Villeurbanne, France