Xiaoli Cao, MD^1*, Mingfeng Zhao, MD&PhD¹, Deguan Li, PhD^2*, Yi Xing, MD^1*, Jie Chen, MD^1* and Xiaoyuan He, MD^1*

¹Department of Hematology, Tianjin First Central Hospital, Tianjin, China
²Tianjin Key Lab of Radiation Medicine and Molecular Nuclear Medicine,Institute of Radiation Medicine, Academy of Medical Science and Peking Union Medical College, Tianjin, China

Grant C Bullock, MD, PhD¹, Chanté L Richardson, MS, PhD^2*, Valerie Schrott, MS^3*, Naomi D Gunawardena, BS⁴, Teague Nolan Cole, BS^5*, Catherine G Corey, BS^5* and Sruti S Shiva, PhD^6*

¹Heart, Lung and Blood Vascular Medicine Institute and Department of Pathology, University of Pittsburgh, Pittsburgh, PA
²Alabama College of Osteopathic Medicine, Dothan, AL
³Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA
⁴Vascular Medicine Institute and Physician Scientist Training Program, University of Pittsburgh, Pittsburgh, PA
⁵Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA
⁶Vascular Medicine Institute and Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA

Angela Vitrano^1*, Giuseppina Calvaruso^1*, Lorenzo Tesè^2*, Francesco Gioia^2*, Filippo Cassarà^1*, Saveria Campisi^3*, Franco Butera^3*, Valeria Commendatore^3*, Michele Rizzo, MD^4*, Vincenzo Santoro^5*, Valeria Cigna^6*, Alessandra Quota^7*, Sabrina Bagnato^8*, Crocetta Argento^9*, Carmelo Fidone^10*, Dario Schembari^10*, Calogera Gerardi^11*, Filippo Barbiera^11*, Giuseppe Bellissima^12*, Giovanni Giugno^12*, Gesualdo Polizzi^13*, Rosamaria Rosso^14*, Giovanna Abbate^15*, Vincenzo Caruso, MD^16*, Elisabetta Chiodi^17*, Maria Rita Gamberini^18*, Benedetta Giorgi^19*, Maria Caterina Putti, MD^19*, Maria Rosaria De Ritis^20*, Aldo Filosa, MD^21*, Esther Natalie Oliva, Doctor²², Nicola Arcadi^23*, Massimiliano Sacco^1*, Rosario Di Maggio^1*, Laura Mistretta^1*, Veronica Di Salvo^1*, Antonino Giangreco^1* and Aurelio Maggio¹

¹Campus of Haematology Franco e Piera Cutino- A.O.O.R. “Villa Sofia-Cervello”, Palermo, Italy
²UO of Radiology, Campus of Haematology Franco e Piera Cutino- A.O.O.R. “Villa Sofia-Cervello”, Palermo, Italy
³Ospedale Umberto I, Siracusa, Italy
⁴Section of Hematology, A.O. Sant'Elia, Caltanissetta, Italy
⁵Ospedale S. Elia, Caltanissetta, Italy
⁶Centro Spoke Talassemia, Gela (CL), Italy
⁷Centro Microcitemia, A.O., Gela (CL), Italy
⁸Centro Microcitemia, A.O. "V. Emanuele III", Gela (CL), Italy
⁹U.O.S. di Talassemia, Ospedale San Giovanni di Dio, Agrigento, Italy
¹⁰A.O.‘‘M. Paternò Arezzo’’, Ragusa, Italy
¹¹A.O.O.C.R., Sciacca, Italy
¹²ASP CT, P.O., Caltagirone, Italy
¹³Ospedale Vittorio Emanuele, Catania, Italy
¹⁴U.O. Talassemie ed Emoglobinopatie, Ospedale, Catania, Italy
¹⁵U.O. Talassemia Ospedale Garibaldi, Catania, Italy
¹⁶Garibaldi Hospital, Catania, Italy
¹⁷Servizio Radiologia Ospedaliera-Universitaria, Arcispedale “S.Anna”, Ferrara, Italy
¹⁸Pediatria, Adolescentologia e Talassemia, Arcispedale “S.Anna”, Ferrara, Italy
¹⁹A.O di Padova, Padova, Italy
²⁰UOD Malattie rare del globulo rosso, AORN "A. Cardarelli", Napoli, Italy
²¹UOD Malattie rare del globulo rosso, AORN, Napoli, Italy
²²A.O. Bianchi-Melacrino-Morelli, Haematology, Reggio Calabria, Italy
²³A.O. Bianchi-Melacrino-Morelli, Hematology, Reggio Calabria, Italy

Jacquelyn M. Powers, MD¹, Timothy L. Mccavit, MD¹, Leah Adix, CCRP^2* and George R. Buchanan, MD¹

¹Pediatric Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas, TX
²Children's Health, Dallas, TX

Yukari Matsuo-Tezuka^1*, Mariko Noguchi-Sasaki, Ph.D.^2*, Mitsue Kurasawa^2*, Keigo Yorozu, Ph.D.^2* and Yasushi Shimonaka^2*

¹Product Research Department, Chugai Pharmaceutical. Co., Ltd., 200 Kajiwara Kamakura, Japan
²Product Research Department, Chugai Pharmaceutical Co., Ltd., Kamakura, Japan

Christian Rose, MD,¹, Fathi Driss^2*, Veronique Mansat De Mas^3*, Odile Beyne-Rauzy, MD, PhD^4*, Emmanuel Gyan, MD, PhD⁵, Yongmin MA^6*, Robert Hider^7*, Pierre Fenaux, MD, PhD⁸ and Carole Beaumont, PhD⁹

¹Hématologie clinique, Hôpital Saint Vincent de Paul, Université Catholique de Lille, Lille, France
²Laboratoire de Génétique,, AP-HP, Hôpital Bichat,, Paris, France
³laboratoire d'hematologie, CHU purpan, Toulouse, France
⁴Service de medecine Interne, CHU Purpan, Toulouse, France
⁵Service d'Hématologie et thérapie cellulaire, Centre Hospitalier Universitaire, Tours, France
⁶king's college Hopsital, london, England
⁷King's college hospital, london, United Kingdom
⁸Service d'Hématologie Clinique, Hopital Avicenne Université Paris XIII, Bobigny, France
⁹Inserm U773, University Paris Diderot, Paris, France

Rebecca O'Toole, MSc.^1*, Collette Bromhead, PhD^2* and Kenneth R. Romeril, FRACP, FRCPA^3,4

¹Haematology, Aotea Pathology Ltd., Wellington, New Zealand
²Institute of Food and Nutrition, College of Health, Massey University, Wellington, New Zealand
³Wellington Blood and Cancer Centre, Wellington Hospital, Wellington, New Zealand
⁴Aotea Pathology Ltd., Wellington, New Zealand

Mariane De Montalembert, MD, PhD^1,2, Jean-Antoine Ribeil, MD, PhD^2,3*, Valentine Brousse^1,2,4*, Agnes Guerci-Bresler, MD^5*, Aspasia Stamatoullas, MD^6*, Jean Pierre Vannier, MD^7*, Agnes Lahary, MD^8*, Mohamed Touati, MD^9*, Krimo Bouabdallah, MD^10*, Marina Cavazzana, MD, PhD^3,11, Emmanuelle Chauzit, MD^12*, Amandine Baptiste, MD^13*, Thibaud Lefebvre, MD^2,14,15*, Herve Puy, MD, PhD^2,14,15*, Caroline Elie, MD, PhD^13*, Zoubida Karim, PhD^2,14*, Olivier Ernst, MD, PhD^16* and Christian Rose¹⁷

¹Pediatrics Department, Hopital Universitaire Necker-Enfants Malades, Paris, France
²Laboratory of Excellence, GR-ex, Paris, France
³Biotherapy Department, Hopital Universitaire Necker-Enfants Malades, Paris, France
⁴UMR_S1134, Inserm, Paris, France
⁵Hematology department, Hôpital d'Adultes du Brabois, CHU Nancy, Nancy, France
⁶Clinical Hematology, CENTRE HENRI BECQUEREL, Rouen, France
⁷Pediatric Oncology and Hematology Unit, Hopital Charles Nicolle, Rouen, France
⁸Department of Biochemistry, Hopital Charles Nicolle, Rouen, France
⁹Service Hematologie Clinique et Thérapie cellulaire, Hopital Dupuytren, Limoges, France
¹⁰CHU de Bordeaux, Bordeaux, France
¹¹IMAGINE Institute, Université Paris Descartes, Sorbonne Paris Cité, Paris, France
¹²Departement de Pharmacologie Clinique et Toxicologique, CHU, Bordeaux, France
¹³Clinical Research Unit, Hopital Necker, Paris, France
¹⁴Inserm UMR 1149/ERL CNRS 8252, Paris, France
¹⁵French Center for Porphyria, Paris, France
¹⁶Radiology Department, Hopital Huriez, Lille, France
¹⁷Dept. of Hematology, Hopital St. Vincent, Lille, France

Noppadol Siritanaratkul¹, Jong Wook Lee^2*, Jun Ma^3*, Mustafa Pehlivan^4*, Elena Volodicheva^5*, Qian Jiang^6*, Fatiha Grifi^7*, Bor-Sheng Ko^8*, Raymond Wong^9*, Vernon Louw¹⁰, Abderrahim Khelif^11*, Ali El-Ali^12*, Jackie Han^13*, Alfonso Losco^12* and Osman Ilhan^14*

¹Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
²Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea
³Harbin Institute of Hematology & Oncology, Harbin, China
⁴Medical Faculty, Department of Hematology, Gaziantep University, Gaziantep, Turkey
⁵Tula Regional Clinical Hospital, Tula, Russia
⁶Peking University People's Hospital, Beijing, China
⁷Centre Hospitalier Universitaire Annaba, Annaba, Algeria
⁸National Taiwan University Hospital, Taipei, Taiwan
⁹The Chinese University of Hong Kong, Shatin, Hong Kong
¹⁰University of the Free State, Bloemfontein, South Africa
¹¹Farhat Hached University Hospital, Sousse, Tunisia
¹²Novartis Pharma AG, Basel, Switzerland
¹³Novartis Pharmaceuticals, East Hanover, NJ
¹⁴Department of Hematology, Ankara University School of Medicine, Ankara, Turkey