57th ASH Annual Meeting and Exposition (December 5-8, 2015): 702. Experimental Transplantation: Immune Function, GVHD, and Graft-versus-Tumor Effects: Shifting the Balance Between GVH, GVT, and Post-transplant Immunity

Experimental Transplantation: Immune Function, GVHD and Graft-versus-Tumor Effects Oral and Poster Abstracts
Oral

W414AB, Level 4 (Orange County Convention Center)

Moderators:

Robert Zeiser, MD, University Medical Center Freiburg and Stefanie Sarantopoulos, MD, PhD, Duke University Medical Center

Disclosures:

No relevant conflicts of interest to declare.

9:30 AM

229

Donor T Cells Intrinsic Responses to Damps Regulated By Siglec-G-CD24 Axis Mitigate Gvhd but Maintain GVL in Experimental BMT Model

Tomomi Toubai, MD, PhD¹, Corinne Rossi, MD¹^*, Katherine Oravecz-Wilson, MS¹^*, Nathan Mathewson, PhD¹, Cynthia Zajac, BS¹^*, Chen Liu, MD, PhD²^*, Stuart Brabbs¹^*, Bailey Redman, BS³^*, Hiroya Tamaki, MD, PhD⁴^*, Julia Wu, BS¹^*, Yaping Sun, MD, PhD¹, Pang Zheng, MD, PhD⁵^*, Yang Liu, PhD⁵^* and Pavan Reddy, MD¹

¹Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI
²Department of Pathology, University of Florida, Gainesville, FL
³University of Michigan Comprehensive Cancer Center, Ann Arbor, MI
⁴Department of Internal Medicine, Division of Hematology and Oncology, Hyogo College of Medicine, Nishinomiya, Japan
⁵Center for Cancer and Immunology Research, Children's National Medical Center, Washington DC, DC

9:45 AM

230

R-spondin1 Promotes Paneth Cell Growth, Maintains Intestinal Microbial Ecology, and Ameliorates GvHD

Eiko Hayase, MD¹^*, Daigo Hashimoto, MD, PhD¹, Kiminori Nakamura, PhD²^*, Yoshitoshi Ogura, PhD³^*, Tetsuya Hayashi, MD, PhD³^*, Ken Kurokawa, PhD⁴^*, Tokiyoshi Ayabe, MD, PhD²^* and Takanori Teshima, MD, PhD¹

¹Department of Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
²Department of Cell Biological Science, Graduate School of Life Science, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan
³Department of Bacteriology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
⁴Department of Biological Information, Tokyo Institute of Technology, Yokohama, Japan

10:00 AM

231

IL-33/ST2 Triggering of IL-9-Secreting T Cells Alters the Balance of Fatal Immunity and Tumor Immunity

Abdulraouf Ramadan, PhD¹^*, Jilu Zhang, PhD¹^*, Mohammad Abu Zaid, MD¹^*, Heather O'Leary, PhD¹^*, Reuben Kapur, Ph.D.¹, Helmut Hanenberg, MD¹, Jie Sun, PhD¹^*, Hal E. Broxmeyer, Ph.D.², Mark H. Kaplan, PhD¹^* and Sophie Paczesny, MD, PhD¹

¹Indiana University School of Medicine, Indianapolis, IN
²Department of Microbiology/Immunology, Indiana University School of Medicine, Indianapolis, IN

10:15 AM

232

Trispecific Killer Engagers (TriKEs) that contain IL-15 to make NK cells antigen specific and to sustain their persistence and expansion

Jeffrey S. Miller, MD¹, Martin Felice¹^*, Ron McElmurry¹^*, Valerie McCullar¹^*, Xianzheng Zhou²^*, Jakub Tolar, MD, PhD¹, Joerg Uwe Schmohl³^*, Angela Panoskaltsis-Mortari, PhD¹, Bin Zhang¹^*, Elizabeth Taras³^*, Michael R. Verneris, MD¹, Sarah Cooley, MD¹, Daniel J. Weisdorf, MD¹, Bruce R. Blazar, MD¹ and Dan Vallera, PhD³^*

¹Adult and Pediatric Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN
²New York Medical College, Valhalla, NY
³Masonic Cancer Center, Laboratory of Molecular Cancer Therapeutics, Department of Therapeutic Radiology-Radiation Oncology, University of Minnesota, Minneapolis, MN

10:30 AM

233

Programming of Donor T Cells Using Allogeneic Delta-like Ligand 4-Positive Dendritic Cells to Reduce Gvhd but Retain GVL Activity

Kazuhiro Mochizuki, MD, PhD^1,2^*, Lijun Meng³^*, Izumi Mochizuki, MD^1,2^*, Qing Tong, MD³^*, Shan He³, Yongnian Liu³^*, Janaki Purushe⁴^*, Hongxing Sun³^*, Henry Fung⁵^*, Raza Zaidi³^*, Ran Reshef, MD⁶, Bruce R. Blazar, MD⁷, Hideo Yagita, PhD⁸^*, Shin Mineishi, MD⁹ and Yi Zhang^3,4

¹Department of Internal Medicine, University of Michigan, Ann Arbor, MI
²Department of Pediatric Oncology, Fukushima Medical University, Fukushima, Japan
³Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA
⁴Department of Microbiology and Immunology, Temple University, Philadelphia, PA
⁵Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, PA
⁶Division of Hematology/Oncology and the Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, NY
⁷Division of Pediatrics, Department of Medicine, University of Minnesota Cancer Center, Minneapolis, MN
⁸Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
⁹BMT-Cell Therapy Program, University of Alabama, Birmingham, AL

10:45 AM

234

Pharmacological Inhibition of Hsp90 Destabilizes the Histone Methyltransferase Ezh2 in Alloreactive T Cells and Reduces Graft-Versus-Host Disease While Retaining Anti-Leukemic Effects in Mice

Qingrong Huang¹^*, Shan He², Yuanyuan Tian³^*, Changhong Li⁴^*, Yuting Gu³^*, Pan Chen⁵^*, Jiefang Huang⁶^*, Yongnian Liu²^*, Min Jin⁶^*, Qi Cao⁷^*, Ran Reshef, MD^8,9, Yi Zhang¹⁰ and Yanyun Zhang¹¹^*

¹Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, China
²Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA
³Shanghai Institute of Immunology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⁴The Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia
⁵The Division of Endocrinology and the Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia
⁶Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, China
⁷Houston Methodist Research Institute Center for Inflammation & Epigenetics, Houston Methodist Hospital, Houston
⁸Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York
⁹Division of Hematology/Oncology and the Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, NY
¹⁰Department of Microbiology and Immunology, Temple University, Philadelphia, PA
¹¹Shanghai Institutes For Biological Science, Shanghai, China

11:00 AM

637

Production of BMP4 By Endothelial Cells Is Crucial for Endogenous Thymic Regeneration

Tobias Wertheimer¹^*, Enrico Velardi, PhD¹^*, Christian Brede, PhD²^*, Shiyun Xiao³^*, Christopher C Kloss, PhD⁴, Andreas Beilhack, MD²^*, Nancy Manley, PhD³^*, Jason M. Butler, PhD⁴, Shahin Rafii, MD⁴, Marcel van den Brink, MD, PhD^1,5 and Jarrod A Dudakov, PhD^1,6

¹Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY
²Department of Medicine II, Würzburg University Clinics, Würzburg, Germany
³Department of Genetics, University of Georgia, Athens, GA
⁴Ansary Stem Cell Institute, Weill Cornell Medical College, New York, NY
⁵Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁶Department of Anatomy and Developmental Biology, Monash University, Melbourne, Australia

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702.O1.6 702. Experimental Transplantation: Immune Function, GVHD, and Graft-versus-Tumor Effects: Shifting the Balance Between GVH, GVT, and Post-transplant Immunity