57th ASH Annual Meeting and Exposition (December 5-8, 2015): 641. CLL: Biology and Pathophysiology, excluding Therapy: Characterizing and Targeting the Microenvironment in CLL

CLL: Biology and Pathophysiology, excluding Therapy Oral and Poster Abstracts
Oral

Valencia A (W415A), Level 4 (Orange County Convention Center)

Moderators:

Fabienne McClanahan, MD, PhD, Queen Mary University of London and Silvia Deaglio, MD, University of Torino and Human Genetics Foundation (HuGeF)

Disclosures:

No relevant conflicts of interest to declare.

10:30 AM

613

Ibrutinib Targets Nurse-like Cells Supporting an Immunosuppressive Phenotype in Chronic Lymphocytic Leukemia

Stefania Fiorcari, PhD¹^*, Rossana Maffei, PhD¹^*, Valentina Audrito, PhD²^*, Silvia Martinelli, PhD¹^*, Elisa Ten Hacken, PhD³^*, Giulia Grisendi, PhD¹^*, Patrizia Zucchini¹^*, Chiara Quadrelli, PhD¹^*, Mario Luppi, M.D., PhD¹^*, Jan A. Burger, M.D., Ph.D.⁴, Silvia Deaglio⁵ and Roberto Marasca, M.D.¹

¹Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy
²Department of Medical Sciences, University of Turin and Human Genetics Foundation, Turin, Italy
³MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Medical Sciences, University of Turin, Turin, Italy

10:45 AM

614

Chronic Lymphocytic Leukemia Patients and Eµ-TCL1 Mice Share a Phenotype of Functional Granulocyte-like and Dysfunctional Monocyte-like Myeloid Derived Suppressor Cells

Gerardo Ferrer, PhD¹^*, Xiao-Jie Yan, MD, PhD¹, Brendan Franca²^*, Jacqueline C. Barrientos, MD^3,4, Jonathan E. Kolitz, MD³, Steven L Allen, MD³, Kanti R Rai, MD^3,4 and Nicholas Chiorazzi, MD.^1,3

¹Experimental Immunology, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, NY
²College of the Holy Cross, Worcester, MA
³Department of Medicine, Hofstra North Shore-LIJ School of Medicine, Hempstead, NY
⁴Hematology/Oncology, North Shore-LIJ Health System, New Hyde Park, NY

11:00 AM

615

In-Vivo Labelling Studies in Patients with Chronic Lymphocytic Leukemia Studies Demonstrate the Existence of Apparently Distinct Subpopulations That Differ in Phenotype and Proliferative Capacity

Kirsty Cuthill, FRCPath, MBBS, MRCP¹^*, Yan Zhang, PhD²^*, Andrea Buggins, PhD, MBA¹^*, Eve Coulter, PhD¹^*, Piers E. Patten, BSc, MRCP, MRCPath, PhD³, Derek Macallan, PhD, MBBS⁴^* and Stephen Devereux, FRCP, FRCPath, PhD³

¹Haematology, King's College London, London, United Kingdom
²Infection and Immunity, St George's University London, London, United Kingdom
³Haematology, King's College Hospital, London, United Kingdom
⁴Institute for Infection and Immunity, St George's University London, London, United Kingdom

11:15 AM

616

Microenvironment Regulation of IL23R/IL-23 Axis Drives Chronic Lymphocytic Leukemia (CLL) Progression

Fortunato Morabito, MD^1,2^*, Giovanna Cutrona, PhD³^*, Anna Grazia Recchia, PhD⁴^*, Marina Fabbi⁵^*, Silvano Ferrini⁶^*, Massimo Gentile, MD⁷^*, Ernesto Vigna⁸^*, Monica Colombo, PhD⁹^*, Carlotta Massucco, PhD⁵^*, Sabrina Bossio⁴^*, Laura De Stefano⁴^*, Ugo Consoli, MD¹⁰^*, Iolanda D. Vincelli¹¹^*, Caterina Musolino¹²^*, Stefano Molica, MD¹³, Antonino Neri, MD¹⁴, Claudio Tripodo, MD¹⁵^* and Manlio Ferrarini, MD¹⁶

¹Section of Hematology, A.O. L'Annunziata of Cosenza, Cosenza, Italy
²Biotechnology Research Unit, Aprigliano (Cosenza), Italy
³UO Molecular Patology, IRCCS San Martino-IST, Genoa, Italy
⁴Unità di Ricerca Biotecnologica, Aprigliano (CS), Italy
⁵IRCCS AOU San Martino-IST, Genova, Italy
⁶IRCCS AOU San Martino-IST,, Genova, Italy
⁷U.O.C. di Ematologia, Azienda Ospedaliera di Cosenza, Cosenza, Italy
⁸Hematology Unit, A.O. of Cosenza, Cosenza, Italy, Cosenza, Italy
⁹Direzione Scientifica, IRCCS San Martino-IST, Genoa, Italy
¹⁰Hematology-Oncology Division,, Garibaldi-Nesima Hospital of Catania, Catania, Italy
¹¹Hematology Division, AO Reggio Calabria, Reggio Calabria, Italy
¹²Section of Hematology, A.O.U. Policlinico, Messina, Italy
¹³Oncology/Hematology, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro, Italy
¹⁴Centro di Ricerca per lo Studio delle Leucemie, Fondazione IRCCS, Università di Milano, Milano, Italy
¹⁵Tumor Immunology Unit, Human Pathology Section, Department of Health Sciences, University of Palermo, Palermo, Palermo, Italy
¹⁶Scientific Direction, IRCCS San Martino-IST, Genova, Italy

11:30 AM

617

Overexpression of HMGB1 Receptor RAGE Is Associated with Worse Clinical Outcome in Patients with Chronic Lymphocytic Leukemia

Faith Norster, MBiochem^*, Andrew James Clear^*, Janet Matthews^*, Elena Hoxha, MSc^*, John Gribben, MD, DSc and Li Jia, PhD, MD

Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom

11:45 AM

618

Next Generation Sequence Immunoprofiling of the T-Cell Repertoire in Chronic Lymphocytic Leukemia Supports Selection By Shared Antigenic Elements

Anna Vardi^1,2^*, Maria Karipidou¹^*, Aikaterini Gemenetzi¹^*, Elissavet Vlachonikola¹^*, Vassileios Bikos³^*, Evangelia Stalika¹^*, Eva Koravou¹^*, Christos Maramis^1,4^*, Alexandra Siorenta⁵^*, Achilles Anagnostopoulos⁶, Sarka Pospisilova³^*, Nikolaos Maglaveras^1,4^*, Ioanna Chouvarda^1,4^*, Kostas Stamatopoulos^1,7^* and Anastasia Hadzidimitriou^1,7^*

¹Institute of Applied Biosciences, CERTH, Thessaloniki, Greece
²Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
³Central European Institute of Technology, Masaryk University and University Hospital Brno, Brno, Czech Republic
⁴Laboratory of Medical Informatics, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
⁵Immunology and National Tissue Typing Center, General Hospital of Athens ‘G. Gennimatas’, Athens, Greece
⁶Hematology-BMT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
⁷Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

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^*signifies non-member of ASH

641.O2.6 641. CLL: Biology and Pathophysiology, excluding Therapy: Characterizing and Targeting the Microenvironment in CLL