57th ASH Annual Meeting and Exposition (December 5-8, 2015): 622. Non-Hodgkin Lymphoma: Biology, excluding Therapy: Deregulated Signaling Mechanisms in Lymphoid Malignancies

Non-Hodgkin Lymphoma: Biology, excluding Therapy Oral and Poster Abstracts
Oral

W311EFGH, Level 3 (Orange County Convention Center)

Moderators:

Mamta Gupta, PhD, Mayo clinic and George z. Rassidakis, MD, PhD, Karolinska Institute

Disclosures:

No relevant conflicts of interest to declare.

7:00 AM

A Phosphodiesterase 4B-Mediated Interplay Between Tumor Cells and the Microenvironment Regulates Angiogenesis in B Cell Lymphoma

Avvaru Suhasini^*, Long Wang^*, Kenneth Holder^*, An-Ping Lin^*, Sang-Woo Kim^*, Harshita Bhatnagar^*, August Moritz^* and Ricardo C Aguiar, MD, PhD

University of Texas Health Science Center at San Antonio, San Antonio, TX

7:15 AM

464

B-Cell Receptor Signaling in Diffuse Large B-Cell Lymphoma: Tonic Alone in the Germinal Center B-Cell Subtype, Plus Self Antigen-Induced in the Activated B-Cell Subtype

Ondrej Havranek, MD PhD¹, Stefan Koehrer, MD²^*, Jingda Xu, PhD¹^*, Lisa Becker¹^*, Justin M Comer¹^*, Anusha R Karri¹^*, Zhiqiang Wang, PhD¹^*, Wencai Ma, PhD¹^*, Jason R Westin, MD¹, Tomasz Zal, PhD³^*, Jan A Burger, MD, PhD² and R Eric Davis, MD¹^*

¹Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX

7:30 AM

465

NPM-ALK Mediated Tyrosine Phosphorylation of ATP Citrate Lyase Regulates Lipid Metabolism and Promotes Oncogenesis of Anaplastic Large Cell Lymphoma

Johnvesly Basappa, PhD¹^*, Mahmoud A ElAzzouny, PhD²^*, Delphine CM Rolland, Pharm D, PhD¹^*, Thirunavukkarasu Velusamy, PhD³^*, Steven Hwang, BS³^*, Venkatesha Basrur, PhD³^*, Kevin Conlon, MS³^*, Lili Zhao, PhD⁴^*, Nathanael G. Bailey, MD³, Charles F Burant, MD PhD²^*, Kojo SJ Elenitoba-Johnson, MD¹^* and Megan S Lim, MD, PhD¹^*

¹Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA
²Department of Internal Medicine, University of Michigan, Ann Arbor, MI
³Department of Pathology, University of Michigan, Ann Arbor, MI
⁴Department of Biostatistics, University of Michigan, Ann Arbor

7:45 AM

466

FOXO1-p300-Txn Circuit Regulates Oxidative Stress Responses in Diffuse Large B-Cell Lymphomas Characterized By Enhanced Oxidative Phosphorylation

Tomasz Sewastianik, MSc¹^*, Maciej Szydlowski, PhD¹^*, Emilia Bialopiotrowicz, PhD¹^*, Ewa Jablonska, PhD¹^*, Przemyslaw Kiliszek, MSc¹^*, Anna Polak, MSc¹^*, Monika Prochorec-Sobieszek, MD, PhD¹^*, Anna Szumera-Cieckiewicz, MD, PhD¹^*, Tomasz S. Kaminski, MSc²^*, Patryk Gorniak, PhD¹^*, Sergiusz Markowicz, PhD³^*, Eliza Nowak, MSc³^*, Monika A. Grygorowicz, MSc³^*, Krzysztof Warzocha, MD, PhD⁴^* and Przemyslaw Juszczynski, MD, PhD¹^*

¹Dept. of Diagnostic Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland
²Dept. of Soft Condensed Matter, Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland
³Dept. of Immunology, Maria Sklodowska-Curie Memorial Cancer Center – Institute of Oncology, Warsaw, Poland
⁴Dept. of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland

8:00 AM

467

Microrna-16 Mediates the Regulation of a Senescence-Apoptosis Switch in Cutaneous T-Cell and Other Non-Hodgkin Lymphomas

Akihiro Kitadate, MD¹^*, Sho Ikeda, MD¹^*, Kazuaki Teshima, MD, PhD¹^*, Mitsugu Ito, MD, PhD¹^*, Naoto Takahashi, MD, PhD¹, Tomomitsu Miyagaki, MD, PhD²^*, Makoto Sugaya, MD, PhD²^* and Hiroyuki Tagawa, MD, PhD¹

¹Department of Hematology, Nephrology and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan
²Department of Dermatology, University of Tokyo, Tokyo, Japan

8:15 AM

468

Amplification of hnRNP K Drives c-Myc-Dependent Malignancies and Represent a Novel Therapeutic Opportunity for Hematologic Malignancies

Miguel Gallardo, PhD¹^*, Xiaorui Zhang, BS¹^*, Mark McArthur²^*, Taghi Manshouri, PhD³^* and Sean M. Post, PhD¹

¹Department of Leukemia, MD Anderson Cancer Center, Houston, TX
²Department of Pathology, MD Anderson Cancer Center, Houston
³Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX

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^*signifies non-member of ASH

622.O1.6 622. Non-Hodgkin Lymphoma: Biology, excluding Therapy: Deregulated Signaling Mechanisms in Lymphoid Malignancies