Yu Liu, PhD^1*, John Easton, PhD^2*, Ying Shao^2*, Mark Wilkinson^3*, Michael Edmonson, PhD^1*, Xiaotu Ma, PhD^4*, Malcolm A. Smith, MD, PhD⁵, Michael Rusch, BA^6*, Jaime Guidry Auvil^7*, Daniela S. Gerhard, PhD^8*, Mary V. Relling, PharmD⁹, Naomi J. Winick, MD¹⁰, Elizabeth Raetz, MD¹¹, Meenakshi Devidas, PhD¹², Cheryl L. Willman, MD¹³, Richard C. Harvey, PhD¹³, William L. Carroll, MD¹⁴, Kimberly P. Dunsmore, MD¹⁵, Stuart S. Winter, MD¹⁶, Brent L Wood, MD, PhD¹⁷, James R. Downing, MD^3*, Mignon L. Loh, MD¹⁸, Stephen P Hunger, MD¹⁹, Jinghui Zhang, PhD^6* and Charles G. Mullighan, MBBS, MSc, MD³

¹Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN
²Pediatric Cancer Genome Project Laboratory, St. Jude Children’s Research Hospital, Memphis, TN
³Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
⁴Department of Computational Biology and Bioinformatics, St. Jude Children’s Research Hospital, Memphis, TN
⁵Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD
⁶Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, TN
⁷National Cancer Institute, Bethesda
⁸Office of Cancer Genomics, National Cancer Institute, Bethesda, MD
⁹Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN
¹⁰University of Texas Southwestern Medical Center, Dallas, TX
¹¹Department of Pediatrics, Huntsman Cancer Institute and Primary Children's Hospital, University of Utah, Salt Lake City, UT
¹²Department of Biostatistics, Colleges of Medicine, Public Health & Health Profession, University of Florida, Gainesville, FL
¹³Department of Pathology, The Cancer Research and Treatment Center, University of New Mexico, Albuquerque, NM
¹⁴Department of Pediatrics, Perlmutter Cancer Center,, New York University Medical Center, New York, NY
¹⁵Health Sciences Center, University of Virginia, Charlottesville, VA
¹⁶Department of Pediatrics, University of New Mexico, Albuquerque, NM
¹⁷Seattle Cancer Care Alliance, Seattle, WA
¹⁸Department of Pediatrics, Benioff Children’s Hospital, University of California at San Francisco, San Francisco, CA
¹⁹Department of Pediatrics, Children’s Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

Esmé Waanders, PhD^1,2, Stephanie M Dobson, MSc^3,4*, Xiaotu Ma, PhD^5*, Debbie Payne-Turner, BS^1*, Guangchun Song, PhD^1*, Yiping Fan^5*, Zhaohui Gu, PhD^1*, Ying Shao^6*, Michael Rusch, BA^7*, Kelly McCastlain, BS^8*, Ilaria Iacobucci, PhD^1*, Kathryn G. Roberts¹, Shann-Ching Chen, PhD^8*, Pankaj Gupta^5*, Ji Wen^8*, Gang Wu, PhD^7*, Jing Ma, PhD^1*, Colin Bailey^9*, Matthew Lear^9*, Scott Olsen^10*, Deanna Naeve^10*, Geoffrey A. Neale, PhD^10*, John Easton, PhD^6*, Sima Jeha, MD¹¹, Ching-Hon Pui, MD¹¹, James R. Downing, MD^1*, William E. Evans, PharmD¹², Mary V. Relling, PharmD¹², Jun J Yang, PhD¹², John E. Dick, PhD^3,4, Jinghui Zhang, PhD^7* and Charles G. Mullighan, MBBS, MSc, MD¹

¹Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
²Department of Human Genetics, Radboud University Medical Centre and Radboud Center for Molecular Life Sciences, Nijmegen, Netherlands
³Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁴Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
⁵Department of Computational Biology and Bioinformatics, St. Jude Children’s Research Hospital, Memphis, TN
⁶Pediatric Cancer Genome Project Laboratory, St. Jude Children’s Research Hospital, Memphis, TN
⁷Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, TN
⁸Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN
⁹St. Jude Biorepository, St. Jude Children’s Research Hospital, Memphis, TN
¹⁰Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children’s Research Hospital, Memphis, TN
¹¹Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN
¹²Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN

Jinghui Zhang, PhD^1*, Kelly McCastlain^2*, Chunxu Qu, PhD^1*, Gang Wu, PhD^1*, Michael Edmonson, PhD^1*, Yongjin Li, PhD^1*, Lei Wei, PhD^2*, Debbie Payne-Turner, BS^2*, Hiroki Yoshihara, MD PhD^2*, Michelle L. Churchman, PhD^2*, Esmé Waanders, PhD^2,3, Panagiotis Ntziachristos, PhD⁴, Iannis Aifantis, PhD^4,5, Kathryn G. Roberts², Jing Ma, PhD^2*, Guangchun Song, PhD^2*, John Easton, PhD^6*, Heather L. Mulder, BS^6*, Xiang Chen, PhD^1*, Michael Rusch, BA^1*, Kristy Boggs, PhD^6*, Bhavin Vadodaria, BS^6*, James Dalton, BS^2*, Marcus L Valentine, PhD^7*, Li Ding, PhD^8*, Charles Lu, PhD^8*, Robert S. Fulton, PhD^8*, Lucinda Fulton, PhD^8*, Yashodan Tabib, PhD^8*, Kerri Ochoa^8*, Meenakshi Devidas, PhD⁹, Deqing Pei^10*, Cheng Cheng, Ph.D^10*, William E. Evans, PharmD¹¹, Ching-Hon Pui, MD¹², Sima Jeha, MD¹³, Richard C. Harvey, PhD¹⁴, I-Ming L Chen, DVM, MS¹⁴, Cheryl L. Willman, MD¹⁴, Guido Marcucci, MD¹⁵, Clara D. Bloomfield, MD¹⁶, Jessica Kohlschmidt, PhD, BS, MS¹⁶, Krzysztof Mrozek, MD, PhD¹⁶, Elisabeth Paietta, PhD¹⁷, Martin S. Tallman, MD¹⁸, Wendy Stock, MD¹⁹, Peter M. Voorhees, MD²⁰, Janis Racevskis, MD^21*, Jacob M. Rowe, MD²², Selina Luger, MD²³, Steven M. Kornblau, MD²⁴, Sheila A Shurtleff, PhD^2*, Susana C. Raimondi, PhD², Elaine R Mardis, PhD^8*, Richard K Wilson, PhD^25*, Stephen P Hunger, MD²⁶, Mignon L. Loh, MD²⁷, James R. Downing, MD^2,28* and Charles G. Mullighan²

¹Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, TN
²Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
³Department of Human Genetics, Radboud University Medical Centre and Radboud Center for Molecular Life Sciences, Nijmegen, Netherlands
⁴Department of Pathology, New York University, New York, NY
⁵Howard Hughes Medical Institute, New York, NY
⁶Pediatric Cancer Genome Project, St. Jude Children's Research Hospital, Memphis, TN
⁷Cytogenetics Core Facility, St. Jude Children's Research Hospital, Memphis, TN
⁸McDonnell Genome Institute, Washington University, St Louis, MO
⁹Department of Biostatistics, Colleges of Medicine, Public Health & Health Profession, University of Florida, Gainesville, FL
¹⁰Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
¹¹Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN
¹²Oncology, St. Jude Children's Research Hospital, Memphis, TN
¹³Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN
¹⁴Department of Pathology, The Cancer Research and Treatment Center, University of New Mexico, Albuquerque, NM
¹⁵Gehr Leukemia Center, City of Hope, Duarte, CA
¹⁶Comprehensive Cancer Center, The Ohio State University, Columbus, OH
¹⁷Cancer Center, Montefiore Medical Center North Division, Bronx, NY
¹⁸Memorial Sloan-Kettering Cancer Center, New York, NY
¹⁹University of Chicago Medical Center, Chicago, IL
²⁰Div. of Hematology/Oncology, University of North Carolina, Chapel Hill, NC
²¹Department of Medicine (Oncology), Albert Einstein College of Medicine, Montefiore Medical Center, New York, NY
²²Department of Hematology, Shaare Zedek Medical Center, Jerusalem, Israel
²³Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
²⁴Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
²⁵Washington University School of Medicine, Saint Louis, MO
²⁶Department of Pediatrics, Children’s Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
²⁷Department of Pediatrics, Benioff Children’s Hospital, University of California at San Francisco, San Francisco, CA
²⁸Administration, St. Jude Children's Research Hospital, Memphis, TN

Ksenia Matlawska-Wasowska, PhD¹, Huining Kang, PhD², Meenakshi Devidas, PhD³, Ji Wen, PhD^4*, Richard C Harvey, PhD⁵, Christian C Nickl^6*, Scott Ness, PhD^7*, Michael Rusch, BA^8*, Yongjin Li, PhD^8*, Masahiro Onozawa, MD, PhD.⁹, Carmen Martinez^10*, Brent L Wood, MD, PhD¹¹, Barbara Asselin, MD¹², I-Ming L Chen, DVM, MS¹³, Kathryn G. Roberts¹⁴, Andre Baruchel, MD¹⁵, Jean Soulier, MD¹⁶, Herve Dombret, MD, PhD, FRCP^17*, Jinghui Zhang, PhD^8*, Richard S. Larson, MD, PhD¹⁸, Elizabeth Raetz, MD¹⁹, William L. Carroll, MD²⁰, Naomi J. Winick, MD²¹, Peter D. Aplan, MD²², Mignon L. Loh, MD²³, Charles G. Mullighan, MBBS, MSc, MD²⁴, Stephen P Hunger, MD²⁵, Nyla A. Heerema, PhD²⁶, Andrew J. Carroll, PhD²⁷, Kimberly P. Dunsmore, MD²⁸ and Stuart S. Winter, MD²⁹

¹Department of Pediatrics, Hematology/Oncology, University of New Mexico Health Sciences Center, Albuquerque, NM
²University of New Mexico, Albuquerque
³Department of Biostatistics, Colleges of Medicine, Public Health & Health Profession, University of Florida, Gainesville, FL
⁴St. Jude Children’s Research Hospital, Memphis
⁵Pathology, University of New Mexico Cancer Center, Albuquerque, NM
⁶Pediatrics, University of New Meico, Albuquerque
⁷University of New Mexico Health Sciences Center, Albuquerque, NM
⁸Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, TN
⁹Genetics Branch, NIH/NCI/CCR, Bethesda, MD
¹⁰University of New Mexico, Albuuerque
¹¹Seattle Cancer Care Alliance, Seattle, WA
¹²Pediatric Hematology-Oncology, University of Rochester, Rochester, NY
¹³Department of Pathology, The Cancer Research and Treatment Center, University of New Mexico, Albuquerque, NM
¹⁴Pathology, St. Jude Children's Research Hospital, Memphis, TN
¹⁵Dept. of Pediatric Hematology, Hopital Saint Louis, Paris, France
¹⁶Hematology Laboratory, Saint-Louis Hospital, Paris, France
¹⁷Saint-Louis Hospital, Paris, France
¹⁸The University of New Mexico Health Sciences Center, Albuquerque, NM
¹⁹Department of Pediatrics, Huntsman Cancer Institute and Primary Children's Hospital, University of Utah, Salt Lake City, UT
²⁰Department of Pediatrics, Perlmutter Cancer Center,, New York University Medical Center, New York, NY
²¹University of Texas Southwestern Medical Center, Dallas, TX
²²NCI/CCR/Genetics branch, National Institutes of Health, Bethesda, MD
²³Department of Pediatrics, Benioff Children’s Hospital, University of California at San Francisco, San Francisco, CA
²⁴Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
²⁵Department of Pediatrics, Children’s Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
²⁶Pathology, The Ohio State University, Columbus, OH
²⁷Department of Genetics, University of Alabama at Birmingham, Birmingham, AL
²⁸Health Sciences Center, University of Virginia, Charlottesville, VA
²⁹Department of Pediatrics, University of New Mexico, Albuquerque, NM

Takaya Moriyama, MD^1,2, Monika Metzger, MD^3*, Gang Wu, PhD^4*, Rina Nishii^1,5*, Maoxiang Qian, PhD^1*, Meenakshi Devidas, PhD⁶, Wenjian Yang, PhD^1*, Emily Quinn, MS^3*, Julie Gastier-Foster, PhD^7*, Elizabeth Raetz, MD⁸, Eric C. Larsen, MD^9*, Paul L. Martin, MD, PhD¹⁰, W. Paul Bowman, MD^11*, Naomi J. Winick, MD¹², Yoshihiro Komada, MD, PhD², Elaine R Mardis, PhD^13*, Robert Fulton, PhD^14*, Ching-Hon Pui, MD^3,15, William E. Evans, PharmD^1,15, Jinghui Zhang, PhD^4*, Stephen P Hunger, MD^16,17, Mary V. Relling, PharmD^1,15, Kim E Nichols, MD³, Mignon Loh, MD¹⁸ and Jun J Yang, PhD^1,15

¹Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN
²Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Japan
³Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN
⁴Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, TN
⁵Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan
⁶Department of Biostatistics, Colleges of Medicine, Public Health & Health Profession, University of Florida, Gainesville, FL
⁷Department of Pathology and Laboratory Medicine, Nationwide Children’s Hospital, and Departments of Pathology and Pediatrics, Ohio State University, Columbus, OH
⁸Department of Pediatrics, Huntsman Cancer Institute and Primary Children's Hospital, University of Utah, Salt Lake City, UT
⁹Maine Children's Cancer Program, Scarborough, ME
¹⁰Duke University Medical Center, Durham, NC
¹¹Cook Childrens Medical Center, Fort Worth, TX
¹²University of Texas Southwestern Medical Center, Dallas, TX
¹³McDonnell Genome Institute, Washington University, St Louis, MO
¹⁴McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO
¹⁵Hematological Malignancies Program, Comprehensive Cancer Center, St. Jude Children's Research Hospital, Memphis, TN
¹⁶Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA
¹⁷Department of Pediatrics, Children’s Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
¹⁸Department of Pediatrics, Benioff Children’s Hospital and the Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, san francisco, CA

Roland P. Kuiper, PhD¹, Simon V. van Reijmersdal^1*, Marieke Simonis, PhD^2*, Jiangyan Yu, MSc^1*, Edwin Sonneveld, PhD^3*, Blanca Scheijen, PhD^4*, Judith M. Boer, PhD⁵, Aurélie Boeree, BSc^5*, Petra Klous, MSc^2*, Peter M Hoogerbrugge, MD, PhD^3,6, Mehmet Yilmaz, MSc^2*, Frank N. van Leeuwen, PhD⁴, Monique L. Den Boer, PhD⁵ and Erik Splinter, PhD^2*

¹Department of Human Genetics, Radboud university medical center, Nijmegen, Netherlands
²Cergentis BV, Utrecht, Netherlands
³Dutch Childhood Oncology Group, The Hague, Netherlands
⁴Laboratory of Pediatric Oncology, Radboud university medical center, Nijmegen, Netherlands
⁵Department of Pediatric Oncology/Hematology, Erasmus MC - Sophia Children's Hospital, Rotterdam, Netherlands
⁶Prinsess Máxima Center for Pediatric Oncology, De Bilt, Netherlands