Pieter Fokko Van Loo, PhD^1*, Robert Doornbos, PhD^1*, Harry Dolstra, PhD^2*, Setareh Shamsili, MD, PhD^1* and Lex Bakker, PhD^1*

¹Merus B.V., Utrecht, Utrecht, Netherlands
²Nijmegen Centre for Molecular Life Sciences, Dept. of Laboratory Medicine, Laboratory of Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands

Julia Etchin, PhD^1,2*, Alla Berezovskaya^3*, Amy Saur Conway^3*, Weihsu Claire Chen, PhD^4*, Erkan Baloglu, PhD^5*, Yosef Landesman, PhD^6*, William Senapedis, PhD^5*, Joel Ellis, PhD^6*, Dilara McCauley, PhD^5*, Richard M. Stone, MD⁷, Ilene Galinsky, ANP⁷, Daniel J. DeAngelo, MD, PhD⁷, Michael Kauffman^8*, Sharon Shacham^5*, Jean C.Y. Wang, MD PhD^9,10,11 and A. Thomas Look, MD¹²

¹Harvard Medical School, Boston
²Department of Pediatric Oncology, Dana-Farber Cancer Institute, Children's Hospital Boston, Harvard Medical School, Boston, MA
³Dana-Farber Cancer Institute, Boston
⁴Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁵Karyopharm Therapeutics, Inc, Newton, MA
⁶Karyopharm Therapeutics Inc., Newton, MA
⁷Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁸Karyopharm Therapeutics, Newton, MA
⁹Division of Medical Oncology and Hematology, University Health Network, Toronto, ON, Canada
¹⁰Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
¹¹Department of Medicine, University of Toronto, Toronto, ON, Canada
¹²Dana-Farber Cancer Institute, Boston, MA

Courtney DiNardo, MD¹, Daniel Pollyea, MD, MS², Keith Pratz, MD³, Michael J. Thirman, MD⁴, Anthony Letai, MD, PhD⁵, Mark Frattini, MD, PhD⁶, Brian Jonas, MD, PhD⁷, Joel Leverson, PhD^8*, Ming Zhu, PhD^8*, Martin Dunbar, DrPH^8*, Nancy Falotico^8*, Rachel Kirby, BA^8*, Suresh Agarwal, PhD^8*, Mack Mabry, MD^8*, Jalaja Potluri, MD⁸, Rod A. Humerickhouse, MD, PhD⁸, Hagop M. Kantarjian, MD¹ and Marina Konopleva, MD, PhD¹

¹University of Texas MD Anderson Cancer Center, Houston, TX
²Division of Hematology, University of Colorado School of Medicine, Aurora, CO
³Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD
⁴University of Chicago, Chicago, IL
⁵Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁶Columbia University Medical Center, New York, NY
⁷UC Davis Comprehensive Cancer Center, Sacramento, CA
⁸AbbVie Inc., North Chicago, IL

Qi Zhang^1*, Rongqing Pan, MS², Lina Han, PhD^1*, Ce Shi, PhD^1,3*, Stephen E. Kurtz, PhD^4*, Hong Mu, MD, PhD^1*, Helen Ma^1*, Michael Andreeff, MD, PhD⁵, Joel Leverson, PhD^6*, Jeffrey W. Tyner, PhD⁷, Yingchang Mi, MD, PhD⁸ and Marina Konopleva, MD, PhD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, First Affiliated Hospital, Harbin Medical University, Harbin, China
⁴Division of Hematology and Medical Oncology, Oregon Health & Science University, Knight Cancer Institute, Portland, OR
⁵Section of Molecular Hematology and Therapy, Leukemia Department, UT MD Anderson Cancer Center, Houston, TX
⁶AbbVie Inc., North Chicago, IL
⁷Knight Cancer Institute, Oregon Health & Science University, Portland, OR
⁸State Key Laboratory of Experimental Hematology, Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

Giuseppe Visani, M.D.^1*, Federica Loscocco, PhD^1*, Fabio Fuligni^2*, Eliana Zuffa, M.D.^3*, Alberto Sensi, M.D.^4*, Alfonso Zaccaria, M.D.^3*, Gerardo Musuraca, M.D.^5*, Barbara Giannini^4*, Alessandro Lucchesi^5*, Francesca Fabbri^5*, Anna Maria Mianulli^6*, Patrizia Tosi, MD^6*, Michela Tonelli^4*, Anna Candoni, MD^7*, Renato Fanin⁸, Giovanni Sparaventi^1*, Marco Gobbi, MD^9*, Marino Clavio^10*, Marco Rocchi^11*, Pier Paolo Piccaluga, MD, PhD¹² and Alessandro Isidori, MD, PhD¹

¹Hematology and Stem Cell Transplant Center, AORMN Hospital, Pesaro, Italy
²The Hospital for Sick Children, Paediatric Laboratory Medicine (PLM), Toronto, ON, Canada
³Hematology, Ravenna Hospital, Ravenna, Italy
⁴Genetica Medica, Centro Servizi Laboratorio Unico AVR, Pievesistina di Cesena, Italy
⁵Onco-hematology, IRST, Meldola, Italy
⁶Hematology, Infermi Hospital, Rimini, Italy
⁷Hematology, Santa Maria della Misericordia University Hospital, Udine, Italy
⁸Division of Hematology and BMT, Department of Experimental and Clinical Medical Sciences, Azienda Ospedaliero-Universitaria di Udine, Udine, Italy
⁹Chair of Hematology, Department of Internal Medicine (DiMI), IRCCS AOU San Martino-IST, University of Genoa, Genoa, Italy
¹⁰Hematology, S. Martino University Hospital, Genova, Italy
¹¹Institute of Biomathematics, Urbino University, Urbino, Italy
¹²Department of Experimental, Diagnostic, and Specialty Medicine, Bologna University, Bologna, Italy

May S.K. Sutherland, PhD^1*, Changpu Yu^1*, Roland B. Walter, MD, PhD², Lori Westendorf^1*, John Valliere-Douglass, PhD^3*, Lucy Pan, PhD^3*, Django Sussman, PhD^1*, Martha Anderson^1*, Weiping Zeng^1*, Ivan Stone^1*, Kerry Klussman^1*, Michelle Ulrich^1*, Mechthild Jonas, PhD^1*, Peter Senter, PhD^4*, Jonathan G. Drachman, MD⁵ and Dennis Benjamin, PhD^1*

¹Translational Research, Seattle Genetics, Inc., Bothell, WA
²Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
³Process Sciences, Seattle Genetics, Inc., Bothell, WA
⁴Chemistry, Seattle Genetics, Inc., Bothell, WA
⁵Research & Clinical Development, Seattle Genetics, Inc., Bothell, WA