Toru Sakura^1*, Fumihiko Hayakawa, MD, PhD^2*, Isamu Sugiura, MD, PhD³, Kiyotoshi Imai, MD, Ph.D.^4*, Noriko Usui, MD⁵, Shin Fujisawa, MD^6*, Tohru Murayama^7*, Toshiaki Yujiri, MD, PhD⁸, Hitoshi Kiyoi, MD, PhD², Kazunori Ohnishi, MD, PhD⁹, Yasushi Miyazaki, MD¹⁰, Shigeki Ohtake, MD, PhD¹¹, Yukio Kobayashi, MD, PhD¹², Keitaro Matsuo, MD, PhD^13* and Tomoki Naoe, MD, Ph.D.¹⁴

¹Leukemia Research Center, Saiseikai Maebashi Hospital, Gunma, Japan
²Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
³Toyohashi Municipal Hospital, Toyohashi, Japan
⁴Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan
⁵Clinical Oncology and Hematology, The Jikei University School of Medicine, Tokyo, Japan
⁶Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan
⁷Department of Hematology, Hyogo Cancer Center, Akasi, Japan
⁸Third Department of Internal Medicine, Yamaguchi University School of Medicine, Yamaguchi, Japan
⁹Japanese Red Cross Aichi Blood Center, Seto City, Japan
¹⁰Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan
¹¹Clinical Laboratory Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
¹²Department of Hematology, National Cancer Center Hospital, Tokyo, Japan
¹³Division of Moleculer Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan
¹⁴National Hospital Organization Nagoya Medical Center, Nagoya, Japan

Daniel J. DeAngelo, MD, PhD¹, Kristen Stevenson, MS^2*, Donna S Neuberg, ScD², Lewis B. Silverman, MD³, Karen K. Ballen, MD⁴, Julie D. Asch, MD⁵, Yasser Abou Mourad, MD^6*, Kristjan Paulson, MD, FRCPC⁷, Matthew D. Seftel, MBChB, FRCP(C), MRCP⁸, David Avigan, MD⁹, Julie Bergeron, MD¹⁰, Stephen Couban, MD¹¹, William Blum, MD¹², John Storring, MD¹³, Martha Wadleigh, MD¹, David P. Steensma, MD¹, Jeffrey Supko, PhD^4*, Stephen E. Sallan, MD¹⁴ and Richard M. Stone, MD¹

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
²Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA
³Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA
⁴Massachusetts General Hospital, Boston, MA
⁵Intermountain Blood and Marrow Transplant/Acute Leukemia Program, Salt Lake City, UT
⁶Vancouver General Hospital, BC Cancer Center, Vancouver, BC, Canada
⁷CancerCare Manitoba, Winnipeg, MB, Canada
⁸Department of Medical Oncology/Hematology, CancerCare Manitoba, Winnipeg, MB, Canada
⁹Beth Israel Deaconess Medical Center, Boston, MA
¹⁰Blood and Marrow Transplant Program and Division of Hematology, Hôpital Maisonneuve-Rosemont, Université de Montréal, Montreal, QC, Canada
¹¹Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada
¹²James Cancer Center, The Ohio State University, Columbus, OH
¹³McGill Montreal General Hospital, Montreal, QC, Canada
¹⁴Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA

Sabina Chiaretti^1*, Antonella Vitale^1*, Loredana Elia^1*, Anna Lucia Fedullo^1*, Silvana Albino^1*, Alfonso Piciocchi^2*, Paola Fazi^2*, Francesco Di Raimondo³, Antonella Fornaro^4*, Francesco Fabbiano⁵, Alfonso Maria D'Arco^6*, Giovanni Martinelli, MD, PhD⁷, Francesca Ronco^8*, Lidia Edwige Santoro^9*, Nicola Cascavilla, MD^10*, Piero Galieni^11*, Alessandra Tedeschi, MD^12*, Simona Sica^13*, Nicola Di Renzo¹⁴, Angela Melpignano^15*, Angelo Michele Carella¹⁶, Felicetto Ferrara¹⁷, Marco Vignetti^2* and Robin Foà^1*

¹Hematology, Department of Cellular Biotechnologies and Hematology, “Sapienza” University, Rome, Italy
²GIMEMA Data Center, Rome, Italy
³Department of Biomedical Sciences, Division of Hematology, Ospedale Ferrarotto, University of Catania, Italy, Catania, Italy
⁴Department of Hematology, Ospedale Civile dello Spirito Santo - Pescara, Pescara, Italy
⁵Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy, Palermo, Italy
⁶Division of Onco-hematology – Ospedale Umberto I - Nocera Inferiore (SA), Nocera Inferiore, Italy
⁷Bologna University School of Medicine, Bologna, Italy
⁸hematology, azienda ospedaliera bianchi-melacrino-morelli, reggio calabria, Italy
⁹Division of Hematology -Azienda Ospedaliera S.G.Moscati, Avellino, Italy, Avellino, Italy
¹⁰Hematology and BMT Unit, Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
¹¹Hematology and Cellular Therapy, Ospedale Mazzoni, Ascoli Piceno, Italy
¹²Division of Hematology, Niguarda Ca' Granda Hospital, Milan, Italy
¹³Institute of Hematology, Catholic University, Rome, Italy
¹⁴Hematology, Vito Fazzi Hospital, Lecce, Italy
¹⁵Ospedale A. Perrino, Brindisi, Brindisi, Italy
¹⁶Division of Hematology 1, IRCCS A.O.U. San Martino IST, Genova, Genova, Italy
¹⁷Division of Hematology, Cardarelli Hospital, Napoli, Italy

Wendy Landier, PhD, CRNP^1*, Yanjun Chen, MS^1*, Lindsey Hageman, MPH^1*, Heeyoung Kim, MS^2*, Bruce C. Bostrom, MD³, Jacqueline Casillas, M.D., M.S.H.S.^4*, David Dickens, MD^5*, William E. Evans, PharmD⁶, Kelly W. Maloney, MD⁷, Leo Mascarenhas, MD, MS⁸, Arthur K. Ritchey, MD⁹, Amanda M. Termuhlen, MD^10*, William L. Carroll, MD¹¹, F. Lennie Wong^2*, Mary V. Relling, PharmD⁶ and Smita Bhatia, MD, MPH¹

¹Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL
²Department of Population Sciences, City of Hope, Duarte, CA
³Children's Hospitals & Clinics of Minnesota, Minneapolis, MN
⁴Dept. of Pediatrics, Div. of Hem./Onc., Univ. of California, Los Angeles, Los Angeles, CA
⁵Pediatric Hematology/Oncology, Helen DeVos Children's Hospital at Spectrum Health, Grand Rapids, MI
⁶Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN
⁷Center for Cancer & Blood Disorders, Childrens Hospital Colorado, Aurora, CO
⁸Pediatrics, USC Keck School of Medicine at CHLA, Los Angeles, CA
⁹Dept. of Pediatric Hem-Onc, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA
¹⁰Jonathan Jaques Children's Cancer Center, Miller Children's and Women's Hospital Long Beach, Long Beach, CA
¹¹Department of Pediatrics, Perlmutter Cancer Center,, New York University Medical Center, New York, NY

Elias Jabbour¹, Susan O'Brien, MD¹, Koji Sasaki, MD², Deborah A Thomas, MD¹, Guillermo Garcia-Manero, MD¹, Farhad Ravandi, MD¹, Gautam Borthakur, MD¹, Nitin Jain, MD¹, Marina Konopleva, MD, PhD¹, Jovitta Jacob, RN^1*, Rebecca Garris^1*, Jorge E. Cortes¹ and Hagop M. Kantarjian, MD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX

Marketa Zaliova¹, Anthony V. Moorman², Giovanni Cazzaniga³, Martin Stanulla^4*, Richard C. Harvey⁵, Kathryn G. Roberts⁶, Sue L. Heatley^7*, Mignon L. Loh⁸, Marina Konopleva⁹, I-Ming Chen⁵, Olga Zimmermannova^1*, Claire Schwab^2*, Owen Smith¹⁰, Marie-Joelle Mozziconacci^11*, Christian Chabannon¹², Myungshin Kim^13*, J.H. Frederik Falkenburg¹⁴, Alice Norton^15*, Karen Marshall^16*, Oskar A. Haas¹⁷, Julia Starkova^1*, Jan Stuchly^1*, Stephen P. Hunger¹⁸, Deborah White^7*, Charles G. Mullighan⁶, Cheryl L Willman⁵, Jan Stary¹, Jan Trka¹ and Jan Zuna¹

¹CLIP- Childhood Leukaemia Investigation Prague, Department of Paediatric Haematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
²Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom
³Centro Ricerca Tettamanti, Department of Pediatrics, University of Milano-Bicocca, Fondazione MBBM/San Gerardo Hospital, Monza, Italy
⁴Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
⁵University of New Mexico Cancer Center, Albuquerque, NM
⁶Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
⁷South Australian Health and Medical Research Institute (SAHMRI), Adelaide, Australia
⁸Department of Pediatrics, Hematology-Oncology, Benioff Children's Hospital, and the Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA
⁹Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
¹⁰Department of Haematology, Our Lady's Children's Hospital, Dublin, Ireland
¹¹Department of Cancer Biology, Institut Paoli Calmettes, Marseille, France
¹²Department of Hematology, Institut Paoli Calmettes, Marseille, France
¹³Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea
¹⁴Department of Hematology, Leiden University Medical Center, Leiden, Netherlands
¹⁵Birmingham Children's Hospital, NHS Foundation Trust, Birmingham, United Kingdom
¹⁶Department of Cytogenetics, Leicester Royal Infirmary NHS Trust, Leicester, United Kingdom
¹⁷St. Anna Children's Hospital, Childrens Cancer Research Institute, Vienna, Austria
¹⁸Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA