57th ASH Annual Meeting and Exposition (December 5-8, 2015): 321. Blood Coagulation and Fibrinolytic Factors: Coagulation Proteins in Development and Disease

Blood Coagulation and Fibrinolytic Factors Oral and Poster Abstracts
Oral

W314, Level 3 (Orange County Convention Center)

Moderators:

Sriram Krishnaswamy, PhD, Children's Hospital of Philadelphia and Maartje Van Den Biggelaar, Sanquin Research

Disclosures:

No relevant conflicts of interest to declare.

7:00 AM

421

Factor XI Deficiency Protects Against Atherogenesis

Reut Shnerb¹^*, Dror Harats²^*, Ginette Schiby³^*, David Gailiani⁴^*, Hanna Levkovitz⁵^*, Ilia Tamarin⁶^*, Aviv Shaish⁵^* and Ophira Salomon⁷

¹The Strassburger Lipid Center, sheba Medical Center and Tel Aviv University, Tel Hashomer, Israel
²Strassburger Lipid Center, Sheba Medical Center and Tel Aviv University, Tel Hashomer, Israel
³Dept. of Pathology, Sheba Medical Center and Tel Aviv University, Tel Hashomer, Israel
⁴Dept. Pathology, Microbiology and Immunology, Vanderbilt Univ., Nashville
⁵Strassburger Lipid Center, Sheba Medical Center, Tel Hashomer, Israel
⁶Thrombosis Unit, Sheba Medical Center, Tel Hashomer, Israel
⁷Thrombosis Unit, Sheba Medical Center and Tel Aviv Univ., Tel Hashomer, Israel

7:15 AM

422

Hyperactivatable Protein C Expression Partially Rescues the Embryonic Lethality of TFPI Null Mice but Surviving Mice Develop Severe Hydrocephalus

Susan A Maroney, DVM, PhD¹, Paul Ellery, PhD¹^*, Nicholas D. Martinez, BS¹^*, Mark Zogg, BS²^*, Hartmut Weiler³ and Alan E. Mast, MD, PhD¹

¹Blood Center of Wisconsin, Milwaukee, WI
²BloodCenter of Wisconsin, Milwaukee, WI
³BloodCenter of Wisconsin, Medical College of Wisconsin, Children's Research Institute, Milwaukee, WI

7:30 AM

423

TFPIα Has Reduced Ability to Inhibit FV Leiden

Jeremy P. Wood, PhD¹, Lisa Baumann Kreuziger, MD²^*, Rodney M. Camire, PhD^3,4 and Alan E. Mast, MD, PhD²

¹Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI
²Blood Center of Wisconsin, Milwaukee, WI
³University of Pennsylvania, Philadelphia, PA
⁴Hematology, Children's Hospital of Philadelphia, Philadelphia, PA

7:45 AM

424

Thrombin and Factor XII Drive Prostate Tumor Growth In Vivo

Gregory Adams, PhD¹^*, Leah Rosenfeldt, BS¹^*, Malinda Frederick, BS¹^*, Keith Kombrinck, MS¹^*, Brett P. Monia, PhD², Alexey Revenko, PhD²^* and Joseph S. Palumbo, MD³

¹Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²Antisense Drug Discovery, Isis Pharmaceuticals, Inc., Carlsbad, CA
³Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

8:00 AM

425

Genetic Absence of Thrombin Receptor Par4 Overcomes the Obligate Requirement of EPCR in Mouse Placenta

Michelle M Storage, BS¹^*, Jianzhong An, MD¹^*, Helena Liang²^*, Qiuhui Yang, MD, PhD¹^*, Mark Zogg, BS²^*, Min Zhan, MS¹^*, Hartmut Weiler³ and Rashmi Sood, PhD¹

¹Medical College of Wisconsin, Milwaukee, WI
²BloodCenter of Wisconsin, Milwaukee, WI
³BloodCenter of Wisconsin, Medical College of Wisconsin, Children's Research Institute, Milwaukee, WI

8:15 AM

426

Factor X Mutant Zebrafish Tolerate a Severe Hemostatic Defect in Early Development Yet Develop Lethal Hemorrhage in Adulthood

Zhilian Hu, PhD¹^*, Yang Liu, PhD¹^*, Michael Huarng, BS¹, Deepak Reyon, PhD²^*, Catherine Richter, BS, MS¹^*, Alexandra Stapleton¹^*, J. Keith Joung, MD, PhD²^* and Jordan A. Shavit, MD, PhD¹

¹Pediatrics, University of Michigan, Ann Arbor, MI
²Pathology, Massachusetts General Hospital, Charlestown, MA

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^*signifies non-member of ASH

321.O2.6 321. Blood Coagulation and Fibrinolytic Factors: Coagulation Proteins in Development and Disease