57th ASH Annual Meeting and Exposition (December 5-8, 2015): 301. Platelet Activation and Biochemistry: Platelet Production and Function

Platelet Activation and Biochemistry Oral and Poster Abstracts
Oral

W315, Level 3 (Orange County Convention Center)

Moderators:

Wolfgang Bergmeier, PhD, University of North Carolina at Chapel Hill and Walter H.A. Kahr, MD, PhD, The Hospital for Sick Children

Disclosures:

No relevant conflicts of interest to declare.

7:00 AM

415

Identification of the Genetic Mechanism Responsible for Racially-Dimorphic Expression of the Thrombin-Receptor Regulator, Pctp

Xiango Kong, MD¹^*, Lukas Simon, B.A², Katrina Leung¹^*, Michael Holinstat, Ph.D³, Chad Shaw, PhD²^*, Paul F. Bray, MD⁴ and Leonard C. Edelstein, PhD⁵

¹Cardeza Foundation for Hematologic Research, Thomas Jefferson University, Philadelphia, PA
²Baylor College of Medicine, Houston, TX
³Department of Pharmacology, University of Michigan, Ann Arbor, MI
⁴The Cardeza Foundation for Hematologic Research and the Department of Medicine, Thomas Jefferson University, Jefferson Medical College, Philadelphia, PA
⁵Cardeza Foundation for Hematologic Research and Department of Medicine, Thomas Jefferson University, Philadelphia, PA

7:15 AM

416

Extended Platelet In Vivo Survival Results in Exhausted Platelets

Irina Pleines^1,2^*, Marion Lebois¹^*, Amanda E.-L. Au^1,2^*, Rachael M. Lane¹^*, Katya J. Henley¹^*, Jason Corbin¹^*, Ping Cannon¹^*, Kate E Jarman^1,2^*, Sarah Ellis³^*, Shaun P Jackson^4,5, Simone M. Schoenwaelder⁴, Benjamin T. Kile^1,2^* and Emma C. Josefsson^1,2

¹The Walter & Eliza Hall Institute of Medical Research, Parkville, Australia
²Department of Medical Biology, The University of Melbourne, Parkville, Australia
³Peter MacCallum Cancer Centre, Melbourne, Australia
⁴Heart Research Institute and Charles Perkins Centre, The University of Sydney, Sydney, Australia
⁵The Scripps Research Institute, La Jolla, CA

7:30 AM

417

Glucose Transporter 3 in Platelets Facilitates Alpha-Granule Mediated Glucose Uptake, Driving Intragranular Glycolysis That Is Required for Platelet Degranulation and Activation

Fidler P.L Trevor¹^*, Elizabeth Middleton, MD²^*, Jesse W Rowley, PhD²^*, Luc Boudreau, PhD³^*, Robert A. Campbell, PhD⁴^*, Rhonda Souvenir, PhD⁵^*, Eric Boilard, PhD⁶, E. Dale Abel, MD, PhD⁵^* and Andrew S. Weyrich, PhD⁷

¹Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Carver College of Medicine, University of Iowa, Department of Pharmacology and Toxicology University of Utah, Salt Lake City, UT
²Program in Molecular Medicine University of Utah, Salt Lake City, UT
³Laval University/CHU de Quebec/Division of Infectious Diseases and Immunity Rheumatology and Immunology Research Center, Quebec City, QC, Canada
⁴University of Utah, Salt Lake City, UT
⁵Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Carver College of Medicine, University of Iowa, Iowa City, IA
⁶Laval University/CHU de Quebec/Division of Infectious Diseases and Immunity, Quebec, QC, Canada
⁷The Program in Molecular Medicine, University of Utah, Salt Lake City, UT

7:45 AM

418

Platelet Pitp-Alpha Promotes Thrombin Generation and the Dissemination of Tumor Metastasis, but Has Minimal Effect on Vascular Plug Formation

Liang Zhao, PhD¹^*, Lurong Lian¹^*, Aae Suzuki¹^*, Timothy J. Stalker, PhD¹, Sang H Min, MD¹, Sriram Krishnaswamy, PhD. MD², Amy Durham, VMD³^* and Charles S. Abrams, MD¹

¹School of Medicine, University of Pennsylvania, Philadelphia, PA
²The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
³School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA

8:00 AM

419

Dynamin 2 (DNM2) and PACSIN2 Regulate Megakaryocyte Demarcation Membrane System Formation and Platelet Production in Concert

Silvia Giannini, PhD^1,2, Markus Bender, PhD³^*, Fred G. Pluthero, PhD⁴^*, Hilary Christensen, PhD⁴^*, Richard Leung, PhD⁴^*, Richard W. Lo, PhD^4,5^*, Jan Kormann, PhD⁶^*, Markus Plomann, PhD⁶^*, Walter H.A. Kahr, MD, PhD^4,5 and Hervé Falet, PhD^2,7

¹Brigham and Women's Hospital, Boston, MA
²Department of Medicine, Harvard Medical School, Boston, MA
³Rudolf Virchow Center, University Clinic of Wuerzburg, Wuerzburg, Germany
⁴Program in Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada
⁵Departments of Paediatrics and Biochemistry, University of Toronto, Toronto, ON, Canada
⁶Center for Biochemistry, University of Cologne Faculty of Medicine, Cologne, Germany
⁷Division of Hematology, Brigham and Women's Hospital, Boston, MA

8:15 AM

420

Recognition of Megakaryocyte-Specific T-Antigen By Macrophages Negatively Regulates Platelet Production in Bone Marrow

Melissa M. Lee-Sundlov, PhD^1,2^*, Renata Grozovsky, PhD^1,2, Silvia Giannini, PhD^2,3, Martina McGrath, MD⁴^*, Haley Elizabeth Ramsey, PhD, MSc⁵^*, Reza Abdi, MD³^*, Martha Sola-Visner, MD⁵ and Karin M. Hoffmeister, MD^1,2

¹Division of Hematology, Brigham and Women's Hospital, Boston, MA
²Department of Medicine, Harvard Medical School, Boston, MA
³Brigham and Women's Hospital, Boston, MA
⁴Department of Medicine, Brigham and Women's Hospital, Boston, MA
⁵Division of Newborn Medicine, Boston Children's Hospital, Boston, MA

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^*signifies non-member of ASH

301.O1.6 301. Platelet Activation and Biochemistry: Platelet Production and Function