57th ASH Annual Meeting and Exposition (December 5-8, 2015): 102. Regulation of Iron Metabolism: Advances in Iron Metabolism

Regulation of Iron Metabolism Oral and Poster Abstracts
Oral

W414AB, Level 4 (Orange County Convention Center)

Moderators:

Tomas Ganz, University of California, Los Angeles and Elizabeta Nemeth, PhD, UCLA

Disclosures:

Nemeth: Intrinsic LifeSciences: Consultancy , Equity Ownership , Membership on an entity’s Board of Directors or advisory committees ; Merganser Biotech: Consultancy , Equity Ownership ; Silarus: Consultancy , Equity Ownership .

7:00 AM

403

The Oxidant Response Transcription Factor NRF2 Mediates Heme Activation of Placenta Growth Factor Expression in Erythroid Cells, a Contributor to Pulmonary Hypertension in Sickle Cell Disease

Maria G Kapetanaki, PhD¹^*, Deva Sharma, MD, MS¹, Oluwabukola T Gbotosho, PhD¹^*, Valerie Schrott, MS¹^*, Frances Weidart, BS¹^*, Solomon Fiifi Ofori-Acquah, PhD^1,2, Grant C Bullock, MD, PhD³ and Gregory J. Kato, M.D.¹

¹Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA
²Division of Hematology/Oncology, Department of Medicine, Center for Translational and International Hematology, University of Pittsburgh, Pittsburgh, PA
³Heart, Lung and Blood Vascular Medicine Institute and Department of Pathology, University of Pittsburgh, Pittsburgh, PA

7:15 AM

404

Pcbp1 and Ncoa4 Regulate the Flux of Iron through Ferritin in Developing Erythroid Cells

Moon-Suhn Ryu, PhD¹^*, James Wohlschlegel, Ph. D.²^* and Caroline C. Philpott, MD¹^*

¹National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, MD
²UCLA, Los Angeles, CA

7:30 AM

405

Fam210b Is Required for Optimal Cellular and Mitochondrial Iron Uptake during Erythroid Differentiation

Yvette Y Yien, PhD¹, Caiyong Chen, PhD¹^*, Jiahai Shi, PhD²^*, Liangtao Li, PhD³^*, Daniel E. Bauer, M.D., Ph.D.⁴, Nicholas Huston¹^*, Paul D. Kingsley, PhD⁵, Julien Ablain⁴^*, Leonard I Zon, MD⁴, James Palis, MD⁶, Stuart H. Orkin, M.D.⁴, Jerry Kaplan, Ph.D.³^*, John D Phillips, PhD⁷, Harvey F. Lodish, PhD² and Barry Paw, M.D., Ph.D.^1,4

¹Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
²Whitehead Institute for Biomedical Research, Cambridge, MA
³Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT
⁴Division of Hematology/Oncology, Harvard Medical School/Children's Hospital Boston, Boston, MA
⁵Pediatrics, University of Rochester, Rochester, NY
⁶Department of Pediatrics, University of Rochester Medical Center, Rochester, NY
⁷Medicine/Hematology, University of Utah School of Medicine, Salt Lake City, UT

7:45 AM

406

Peroxiredoxin-2: A Novel Factor Involved in Iron Homeostasis

Alessandro Mattè, PhD¹^*, Luigia De Falco²^*, Enrica Federti¹^*, Sonia Levi, PhD³^*, Achille Iolascon, MD, PhD², Giorgia Federico⁴^*, Narla Mohandas, DSc⁵, Anne Janin, MD, PhD⁶, Mariasole Bruno¹^*, Christophe Leboeuf, PhD⁶^*, Soo Young Choi, PhD⁷^*, Dae Won Kim⁷^*, Francesco Dima, MD⁸^*, Angela Siciliano¹^* and Lucia De Franceschi, MD¹

¹Department of Medicine, University of Verona and AOUI-Verona, Verona, Italy
²Department of Molecular Medicine and Medical Biotechnologies, “Federico II” University of Naples, Naples, Italy
³Vita-Salute San Raffaele University, Milan, Italy
⁴Dept of Cellular and molecular biology and pathology, Federico II University of Naples, Naples, Italy
⁵New York Blood Center, New York, NY
⁶University Paris-Diderot, Institut Universitaire d'Hématologie, INSERM UMR-S 1131 & 1165, AP-HP-Saint-Louis Hospital, Paris, France
⁷Department of Biomedical Science - Institute of Bioscience and Biotechnology - Hallym University, Chuncheon, South Korea
⁸AOUI Verona, Verona, Italy

8:00 AM

407

Interaction of Transferrin-Endosomes with Mitochondria: Implications for Iron Transport to Ferrochelatase in Erythroid Cells

Amel Hamdi, PhD^1,2^*, Tariq Roshan, MD³^*, Alex Sheftel, PhD^4,5^* and Prem Ponka, MD, PhD, FCMA^1,2

¹Department of Physiology and Medicine, McGill University, Montreal, QC, Canada
²Lady Davis Institute for Medical Research, Montreal, QC, Canada
³McGill University, Montreal, QC, Canada
⁴High Impact Editing, Ottawa, Canada
⁵Spartan Bioscience Inc, Ottawa, Canada

8:15 AM

408

Inactivation of Tmprss6 Hampers Hepcidin Inhibition By Erythroferrone through Upregulation of the BMP-SMAD Pathway

Laura Silvestri, PhD^1,2, Antonella Nai, PhD^1,2^*, Alessandro Campanella, PhD^1,2^*, Irene Artuso, BSc²^*, Jessica Bordini, BSc²^* and Clara Camaschella, MD^1,2

¹Vita Salute University, Milan, Italy
²Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy

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^*signifies non-member of ASH

102.O1.6 102. Regulation of Iron Metabolism: Advances in Iron Metabolism