Maitri Shah, MS¹, Valentina Pilecki^2*, Roxana Redis^2*, Linda Fabris^2*, Maria Ciccone, MD^3,4*, Cristina Ivan^2*, Ioana Berindan-Neago^2*, Riccardo Fodde^5*, Carlos E. Bueso-Ramos, MD⁶, Mihai Gagea^2*, Guillermo Garcia Manero^2* and George Calin, MD PhD¹

¹Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX
²University of Texas M D Anderson Cancer Center, Houston, TX
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Hematology Section, Azienda Ospedaliero-Universitaria S. Anna, University of Ferrara, Ferrara, Italy
⁵Erasmus MC, Rotterdam, Netherlands
⁶The University of Texas MD Anderson Cancer Center, Department of Hematopathology, Houston

Maria E. Balasis^1*, Jane Merelvede^2*, Sateesh Kunigal^1*, Xiaoyi Ren^1*, Yan Ma^1*, Qing Zhang, PhD^1*, Jeff Painter^1*, Nathalie M. Droin, PhD^2*, Joseph Johnson^1*, Sean Yoder, M.S^3*, Rami S. Komrokji, MD¹, Ling Zhang, MD⁴, Sheng Wei, MD¹, Torsten Haferlach⁵, Robert MacLeod, PhD^6*, Alan F. List, MD⁷, Eric Solary, MD, Prof^2*, P.K. Epling-Burnette, PhD¹ and Eric Padron, MD¹

¹H. Lee Moffitt Cancer Center, Tampa, FL
²Gustave Roussy, Villejuif, France
³Molecular Genomics Core Facility, Moffit Cancer Center and Research Institute, Tampa, FL
⁴Department of Hematopathology and Laboratory Medicine, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
⁵MLL Munich Leukemia Laboratory, Munich, Germany
⁶Antisense Drug Discovery, Isis Pharmaceuticals, Inc., Carlsbad, CA
⁷Department of Hematologic Malignancies, Moffitt Cancer Center and Research Institute, Tampa, FL

Marcio Andrade-Campos, MD^1,2*, Marta Andres-Coduras, PhD.^3*, Fernando Ramos, MD, PhD, MPH^4* and Pilar Giraldo, PhD⁵

¹CIBERER, Carlos III Institute. CIBER Enfermedades Raras, Zaragoza, Spain
²Traslational Research Unit, Instituto Investigación Sanitaria Aragón, Zaragoza, Spain
³Aragon Health Research Institute (IIS-A), Translational Research Unit., Zaragoza, Spain
⁴Hospital Universitario de León, León, Spain
⁵Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Spanish Foundation for the Study and Therapy of Gaucher Disease (FEETEG), Aragon Institute of Health Sciences (IACS), Zaragoza, Spain

Silvia Buonamici, PhD¹, Rachel Darman, PhD^1*, Samantha Perino, BS^1*, Anant Agrawal, PhD^1*, Shouyong Peng, PhD^1*, Michael Seiler, PhD^1*, Kian Huat Lim, PhD^1*, Erica B. Bhavsar^2*, Jacob Feala, PhD^1*, Esther A. Obeng, MD, PhD³, Suzanna Bailey, PhD^1*, Betty Chan, PhD^1*, Peter Fekkes, PhD^1*, Gregg F. Keaney, PhD^1*, Pavan Kumar, PhD^1*, Kaiko Kunii^1*, Linda Lee, MS^1*, Crystal Mackenzie^4*, Mark Matijevic^4*, Yoshiharu Mizui, PhD^1*, Khin Myint^4*, Eunice Park^1*, Ermira Pazolli^1*, Michael Thomas^1*, John Wang^1*, Markus Warmuth, MD^1*, Lihua Yu, PhD^1*, Ping Zhu^1*, Richard R. Furman, MD⁵, Benjamin L Ebert, MD, PhD⁶ and Peter G Smith, PhD^1*

¹H3 Biomedicine, Cambridge, MA
²Department of Hematology/Oncology, Weill Cornell Medical College, New York, NY
³Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, MA
⁴Eisai, Andover, MA
⁵New York-Presbyterian/Weill Cornell Medical Center, New York, NY
⁶Division of Hematology, Brigham and Women's Hospital, Boston, MA

Christopher N Hahn, PhD^1,2,3*, Milena Babic, BMPharBio (Hons)^1,2*, Andreas W Schreiber, PhD^4*, Monika M Kutyna, MSc^5*, L Amilia Wee, BSc (Hons)^5*, Anna L Brown, PhD^1,2,5, Michelle Perugini, PhD^5*, Deepak Singhal, MD, FRCPA^6*, Smita Hiwase, PhD^5*, Jinghua Feng, PhD^4*, Wendy T Parker, PhD^2,4, Sarah Moore, BSc (Hon), FFSc (RCPA)^2*, Peter G Bardy, MBBS, FRACP, FRCPA^7*, Russell Saal, MMSc, BSMedTech^8,9*, Paula Marlton, MBBS, FRACP, FRCPA^10,11,12, Andrew S. Moore, MBBS, FRACP, PhD^8,10,12,13, Thomas J Gonda, PhD¹⁴, Paul Leo, PhD^15*, Susan Branford, PhD², Richard J D'Andrea, PhD^1,5,16, Ian D Lewis, MBBS, PhD, FRACP, FRCPA⁵, Luen Bik To, MBBS, PhD⁵, Hamish S Scott, BSc, PhD, FFSc (RCPA)^{1,2,3,17,18,19} and Devendra Hiwase, MBBS, FRACP, FRCPA, MD, PhD⁵

¹Centre for Cancer Biology, SA Pathology & University of South Australia, Adelaide, Australia
²Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, Australia
³School of Medicine, University of Adelaide, Adelaide, Australia
⁴Centre for Cancer Biology, ACRF Cancer Genomics Facility, SA Pathology, Adelaide, Australia
⁵Haematology, SA Pathology, Adelaide, Australia
⁶Haematology, Royal Adelaide Hospital, Adelaide, Australia
⁷Haematology/Oncology, The Queen Elizabeth Hospital, Woodville, Australia
⁸Translational Research Institute, Brisbane, Australia
⁹The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, Australia
¹⁰UQ Child Health Research Centre, The University of Queensland, Brisbane, Australia
¹¹Australasian Leukaemia and Lymphoma Group Tissue Bank, Princess Alexandra Hospital, Brisbane, Australia
¹²Queensland Children’s Cancer Centre and Queensland Children’s Medical Research Institute, Children’s Health Queensland Hospital and Health Service, Brisbane, Australia
¹³The University of Queensland Diamantina Institute, Brisbane, Australia
¹⁴School of Pharmacy, University of Queensland, Woolloongabba, Australia
¹⁵Faculty of Medicine and Biomedical Sciences, The University of Queensland Diamantina Institute, Woolloongabba, Australia
¹⁶School of Pharmacy and Medical Sciences, Division of Health Sciences, University of South Australia, Adelaide, Australia
¹⁷School of Molecular and Biological Sciences, University of Adelaide, Adelaide, Australia
¹⁸Centre for Cancer Biology, University of South Australia, Adelaide, Australia
¹⁹ACRF Cancer Genomics Facility, SA Pathology, Centre for Cancer Biology, Adelaide, Australia

Aziz Nazha, MD¹, Manja Meggendorfer, PhD^2*, Niroshan Nadarajah, M.Sc.^2*, Kassy E Kneen^3*, Tomas Radivoyevitch, PhD^4*, Bartlomiej Przychodzen, MSc^5*, Hideki Makishima, MD, Ph.D.⁶, Bhumika J. Patel^7*, Srinivasa R. Sanikommu, MBBS⁸, Sean Hobson^9*, Mridul Mukherji, PhD^10*, Mikkael A. Sekeres, MD, MS¹¹, Torsten Haferlach² and Jaroslaw P. Maciejewski, MD, Ph.D.⁷

¹Leukemia Program, Department of Hematology and Oncology, Cleveland Clinic, Taussig Cancer Institute, Cleveland, OH
²MLL Munich Leukemia Laboratory, Munich, Germany
³Department of Translational Hematology, Cleveland Clinic, Taussig Cancer Institute, Cleveland
⁴Department of Hematology and Medical Oncology, Cleveland Clinic, Cleveland, OH
⁵Haematological Medicine, Department of Translational hematology and Oncology Research, Taussing Cancer Institute, Cleveland Clinic, London, United Kingdom
⁶Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⁷Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁸Cleveland Clinic Taussing Cancer Institute, Cleveland, OH
⁹Department of Translational Hematology and Oncology Research, Taussing Cancer Institute, Cleveland Clinic, Cleveland, OH
¹⁰UMKC School of Pharmacy, Kansas City
¹¹Leukemia Program, Cleveland Clinic, Cleveland, OH

Constance Regina Baer, PhD^1*, Niroshan Nadarajah, M.Sc.^1*, Yasunobu Nagata, MD^2*, Tamara Alpermann^1*, Genta Nagae, MD, PhD^3*, Yusuke Okuno, MD, Ph.D.^4*, Yuichi Shiraishi, MD, Ph.D.^5*, Satoru Miyano, MD, Ph.D.^5*, Claudia Haferlach, MD¹, Wolfgang Kern, MD¹, Hiroyuki Aburatani, MD, PhD^3*, Seishi Ogawa, MD, Ph.D.² and Torsten Haferlach¹

¹MLL Munich Leukemia Laboratory, Munich, Germany
²Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
³Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan
⁴Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
⁵Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Valeria Visconte, PhD^1*, Kevin R. Kelly, MD, PhD², Steffan T. Nawrocki, Ph.D.³, Yingchun Han, MD^1*, Hetty E. Carraway, MD, MBA⁴, Anjali S. Advani, MD⁴, Jaroslaw P. Maciejewski, MD, Ph.D.¹, Heesun J Rogers, MD, PhD^5*, Mikkael A. Sekeres, MD, MS⁴ and Jennifer S. Carew, PhD¹

¹Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²University of Southern California Keck School of Medicine, Los Angeles, CA
³CTRC Institute for Drug Development, University of Texas Health Science Center at San Antonio, San Antonio, TX
⁴Leukemia Program, Cleveland Clinic, Cleveland, OH
⁵Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH

Ana María Hurtado^1*, Gines Luengo-Gil^1*, Laura Palomo, MSc^2*, Eva Lumbreras^3*, Eva Caparrós^1*, Tzu Hua Chen-Liang^1*, Bartlomiej Przychodzen, MSc^4*, Maria Luz Amigo^1*, María Díez-Campelo, MD, PhD^3*, Lurdes Zamora, PhD^2*, Francisco José Ortuño^1*, Raul Teruel Montoya, PhD¹, Jaroslaw P. Maciejewski, MD, Ph.D.⁵, Consuelo Del Cañizo, MD, PhD³, Francesc Sole, PhD⁶, Francisca Ferrer-Marin^1* and Andres Jerez^1*

¹Hematology and Medical Oncology Department, Hospital Morales Meseguer. Centro Regional de Hemodonación. Universidad de Murcia. IMIB, MURCIA, Spain
²MDS Research Group, Institut de Recerca Contra la Leucèmia Josep Carreras, ICO-Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain
³Servicio de Hematología, Centro de Investigación del Cáncer, IBSAL (Instituto de Biomedicina de Salamanca) y BMCC, Universidad de Salamanca, Salamanca, Spain
⁴Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, OH
⁵Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁶Josep Carreras Leukaemia Research Institute, Barcelona, Spain

Ayana Kon, MD, Ph.D.^1*, Satoshi Yamazaki, PhD^2*, Yasunori Ota, MD, PhD^3*, Keisuke Kataoka, MD, Ph.D.^1*, Yusuke Shiozawa, MD^1*, Maiko Morita, MS^2*, Tetsuichi Yoshizato, MD^1*, Masashi Sanada, MD, Ph.D.^4*, Kenichi Yoshida, MD, Ph.D.^1*, Manabu Nakayama, PhD^5*, Haruhiko Koseki, PhD^6*, Hiromitsu Nakauchi, MD, PhD^2,7 and Seishi Ogawa, MD, Ph.D.¹

¹Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
²Division of Stem Cell Therapy, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
³Department of Pathology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
⁴Department of Advanced Diagnosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
⁵Laboratory of Medical Genomics, Department of Human Genome Research, Kazusa DNA Research Institute, Chiba, Japan
⁶Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
⁷Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA

Yayoi Shikama, MD, PhD^1*, Meiwan Cao, MD^2*, Tomoyuki Ono^2*, Michiko Anzai^2*, Hideyoshi Noji, MD, PhD^3*, Xiaomin Feng, MD, PhD^2*, Hideo Kimura, MD, PhD^4*, Kazuei Ogawa, MD, PhD^3*, Kazuhiko Ikeda, MD, PhD³, Yasuchika Takeishi, MD, PhD^3* and Junko Kimura, MD, PhD^2*

¹Center for Medical Education and Career Development, Fukushima Medical University, Fukushima, Japan
²Department of Pharmacology, Fukushima Medical University, Fukushima, Japan
³Department of Cardiology and Hematology, Fukushima Medical University, Fukushima, Japan
⁴Department of Hematology, Kita-Fukushima Medical Center, Date, Japan

Wenhui Shi^1*, Feng Xu^2*, Chunkang Chang, MD, PhD^3* and Xiao Li, MD, PhD³

¹Hematology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China
²Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China
³Department of Hematology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

Eiju Negoro, MD, PhD^1*, Naoko Hosono, MD, PhD.^2*, Wenyi Shen, MD^3*, Tetsuichi Yoshizato, MD^4*, Bhumika J. Patel^1*, Cassandra Hirsh, BSc^5*, Bartlomiej Przychodzen, MSc^1*, Michael J. Clemente^1*, Reda Z. Mahfouz, MD/PhD¹, Aleksandra Wodnar-Filipowicz, PhD^6*, Hideki Makishima, MD, Ph.D.⁴, Seishi Ogawa, MD, Ph.D.⁴, Mikkael A. Sekeres, MD, MS⁷ and Jaroslaw P. Maciejewski, MD, Ph.D.⁵

¹Department of Translational Hematology and Oncology Research, Taussing Cancer Institute, Cleveland Clinic, Cleveland, OH
²Department of Hematology and Oncology, University of Fukui, Fukui, Japan
³The First Affilliated Hospitla of Nanjing Medical University, Nanjing, China
⁴Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⁵Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁶University Hospital Basel, Basel, Switzerland
⁷Leukemia Program, Department of Hematology and Medical Oncology, Cleveland Clinic, Cleveland, OH

Cara Lunn Shirai, PhD^1*, Manorama Tripathi, Ph.D.^2*, James N Ley^2*, Matthew Ndonwi, PhD^3*, Brian S White, PhD^4*, Roberto Tapia^2*, Borja Saez, PhD⁵, Amy Bertino, Ph.D.^6*, Jin Shao^7*, Sanghyun Kim⁸, Thomas R Webb, Ph.D.^9*, Timothy A. Graubert, MD¹⁰ and Matthew J. Walter, MD⁷

¹Washington University in St. Louis, Saint Louis, MO
²Washington University in St. Louis, St. Louis, MO
³Oncology/Stem Cell Biology, Washington University School of Medicine, St. Louis, MO
⁴Washington University School of Medicine, Saint Louis, MO
⁵Department of Stem Cell and Regenerative Biology, Harvard University. Center for Regenerative Medicine, Massachusetts General Hospital. Harvard Stem Cell Institute, Cambridge, MA
⁶Massachusetts General Hospital, Boston, MA
⁷Division of Oncology, Washington University School of Medicine, St. Louis, MO
⁸Washington University In St. Louis, Saint Louis, MO
⁹SRI International, Menlo Park, CA
¹⁰Massachusetts General Hospital / Harvard Medical School, Boston, MA

Eric J. Duncavage, MD¹, Jennifer O'Brien, MD, PhD^1*, Kiran R. Vij, MD², Chris A Miller, PhD^3*, Jin Shao^2*, Meagan A. Jacoby, MD, PhD², Robert S. Fulton, PhD^4*, Sharon Heath^2*, Megan Janke², Catrina C. Fronick^3*, Michelle O'Laughlin^3*, Richard K Wilson, PhD^5*, Timothy J. Ley, MD² and Matthew J. Walter, MD²

¹Department of Pathology and Immunology, Washington University in St. Louis, Saint Louis, MO
²Department of Medicine, Division of Oncology, Washington University in St. Louis, Saint Louis, MO
³McDonnell Genome Institute, Washington University in St. Louis, Saint Louis, MO
⁴McDonnell Genome Institute, Washington University, St Louis, MO
⁵Washington University School of Medicine, Saint Louis, MO

Christopher Felix Krombholz^1,2*, Angelina Meier^1*, Konrad Aumann^3*, Silvia Fluhr^1,4*, Matthias Kollek^1,2*, Daniel B Lipka^5*, Christoph Plass^5,6*, Tania Witte^5*, Charlotte Niemeyer^1,6, Miriam Erlacher^1* and Christian Flotho^1,6*

¹Division of Pediatric Hematology/Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany
²Faculty of Biology, University of Freiburg, Freiburg, Germany
³Department of Pathology, University Medical Center, Freiburg, Germany
⁴Hermann Staudinger Graduate School, University of Freiburg, Freiburg, Germany
⁵Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
⁶German Cancer Consortium, Heidelberg, Germany

Manja Meggendorfer, PhD^*, Claudia Haferlach, MD, Wolfgang Kern, MD, Susanne Schnittger, PhD and Torsten Haferlach

MLL Munich Leukemia Laboratory, Munich, Germany

Demi de Winter^1*, Marry M van den Heuvel-Eibrink, MD, PhD^2,3*, Vincent H.J. van der Velden, PhD^4*, Anton W. Langerak^5*, Jacques J.M. Dongen^1*, Michael Dworzak, MD^6*, Barbara De Moerloose, MD, PhD^7*, Jan Starý, MD^8*, Charlotte M Niemeyer, MD, PhD⁹, Franco Locatelli, MD¹⁰, Henrik Hasle, MD¹¹, Markus Schmugge, MD¹², C. Michel Zwaan, MD, PhD¹³ and Rob Pieters, MD, PhD^14,15

¹Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
²Department of Pediatric Oncology, Princess Maxima Center for Paediatric Oncology, Utrecht, Netherlands
³Department of Paediatric Oncology/Hematology, Erasmus MC-Sophia’s Children’s Hospital, Rotterdam, Netherlands
⁴Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
⁵Department of Immunology, Erasmus MC Rotterdam, Rotterdam, Netherlands
⁶Department of Pediatrics, Medical University of Vienna, St. Anna Children's Hospital and Children’s Cancer Research Institute, Vienna, Austria
⁷Department of Pediatrics, Ghent University, Ghent, Belgium
⁸Department of Pediatric Hematology and Oncology, Charles University and Univ Hospital Motol, Prague, Czech Republic
⁹Universitaets-Kinderklinik, Freiburg, Germany
¹⁰Department of Pediatric Hematology and Oncology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy
¹¹Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark
¹²Haematology, University Children's Hospital Zurich, Zurich, Switzerland
¹³Pediatric Oncology/Hematology, Erasmus MC-Sophia Children's hospital, Rotterdam, Netherlands
¹⁴Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
¹⁵Department of Pediatric Oncology/Hematology, Erasmus MC - Sophia Children's Hospital, Rotterdam, Netherlands

Yan Ma, MD^1*, Lily Remsing Rix^1*, Qing Zhang, MD^1*, Maria E. Balasis^1*, Rami S. Komrokji, MD¹, Uwe Rix, PhD^1*, Alan F. List, MD² and Eric Padron, MD¹

¹H. Lee Moffitt Cancer Center, Tampa, FL
²Department of Hematologic Malignancies, Moffitt Cancer Center and Research Institute, Tampa, FL

Syed A Mian, BSc, M.Phil^1*, Austin G. Kulasekararaj, MBBS, MD, MRCP, FRCPath^2*, Aytug Kizilors, PhD^3,4*, Kathy L McGraw, Ph.D.⁵, Shahram Kordasti, MD, PhD^1,6*, Stephan Menzel, PhD^7*, Alexander e Smith, PhD^1*, Pilar Perezabellan, MSc^1*, David Sallman, M.D.⁸, Alan F. List, MD^9,10 and Ghulam J Mufti, FRCP, FRCPath¹¹

¹Department of Haematological Medicine, King's College London, London, United Kingdom
²Department of Haematological Medicine, Kings College Hospital NHS Foundation Trust, London, United Kingdom
³Haematology, King's College London, London, United Kingdom
⁴Haematology, Laboratory for Molecular Haemato-Oncology, King's College Hospital NHS Foundation Trust/King's College London, London, United Kingdom
⁵H Lee Moffitt Cancer Center & Research Institute, Tampa, FL
⁶Haematological Medicine, King's College Hospital, London, United Kingdom
⁷Molecular Haematology, Kings College London, London, United Kingdom
⁸Dept. of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
⁹Department of Hematologic Malignancies, Moffitt Cancer Center and Research Institute, Tampa, FL
¹⁰Dept. of Oncologic Sciences, University of South Florida, Morsani College of Medicine, Tampa, FL
¹¹Department of Haematological Medicine, King’s College London, London, United Kingdom

Feng Xu^1*, Chunkang Chang, MD, PhD^2*, Wenhui Shi^3* and Xiao Li, MD, PhD²

¹Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China
²Department of Hematology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
³Hematology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China