O'Hare Thomas, PhD¹, Matthew S. Zabriskie^2*, Christopher A. Eide^3*, Nadeem A. Vellore, PhD^2*, Brian J. Druker, MD³ and Michael W Deininger, MD, PhD⁴

¹Huntsman Cancer Institute, Division of Hematology and Hematologic Malignancies, University of Utah, Salt Lake City, UT
²Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
³Knight Cancer Institute, Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, OR
⁴Huntsman Cancer Institute, The University of Utah, Division of Hematology and Hematologic Malignancies, Salt Lake City, UT

Hongsheng Zhou, MD^1,2*, Po Yee Mak, MPhil^3*, Hong Mu, MD, PhD^4*, Duncan Mak, BSc, MPhil^3*, Zhihong Zeng, MD⁵, Jorge Cortes, MD⁶, Michael Andreeff, MD, PhD¹ and Bing Z Carter¹

¹Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
²Department of Hematology, Nanfang Hospital,Southern Medical University, Guangzhou, China
³Section of Molecular Hematology & Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Section of Molecular Hematology and Therapy, Leukemia Department, UT MD Anderson Cancer Center, Houston, TX
⁵Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX

Hanyang Lin, BSc, MSc^1,2, Jonathan Zeng^2*, Katharina Rothe, BSc, MSc^2,3, Jens Ruschmann, PhD^2*, Oleh Petriv, PhD^4*, Kieran O'Neill, PhD^2*, Tobias Maetzig, PhD^2*, David Knapp, BSc^1,2*, Ryan R. Brinkman, PhD^2,3*, Inanc Birol, PhD^3,5*, Donna L. Forrest, MD⁶, Carl Hansen, PhD^4,7*, Connie J. Eaves, PhD^1,2,3, R. Keith Humphries, MD, PhD^1,2 and Xiaoyan Jiang, MD PhD^1,2,3

¹Department of Medicine, University of British Columbia, Vancouver, BC, Canada
²Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada
³Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
⁴Center for High-Throughput Biology, University of British Columbia, Vancouver, BC, Canada
⁵Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, British Columbia Cancer Agency, Vancouver, BC, Canada
⁶Leukemia/Bone Marrow Transplant Program of BC, British Columbia Cancer Agency, Vancouver, BC, Canada
⁷Department of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada

Taehyung Simon Kim^1*, Zhaolei Zhang, PhD^2*, Marc Tyndel^1*, Jae-Sook Ahn, MD, PhD^3*, Seunghyun Choi, PhD^4*, Hyeoung Joon Kim⁵, Jeffrey H. Lipton, MD, PhD⁶ and Dennis Dong Hwan Kim, MD, PhD⁷

¹Department of Computer Science, University of Toronto, Toronto, Canada
²The Donnelly Centre, University of Toronto, Toronto, Canada
³Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, South Korea
⁴Genome Research Center for Hematopoietic Diseases, Chonnam National University Hwasun Hospital, Hwasun, South Korea
⁵Chonnam National University,Hwasun Hospital, Hwasun, South Korea
⁶Allogeneic Blood and Marrow Transplant Program, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada
⁷Department of Medical Oncology & Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada

Isabel Ben Batalla, PhD^1,2*, Robert Erdmann, PhD^1,2*, Heather Jørgensen, PhD^3*, Rebecca Mitchell^3*, Thomas Ernst, MD^4*, Gunhild von Amsberg, MD^1*, Philippe Schafhausen, MD^1*, Stephen Rankin, MD^3*, Richard E. Clark, Prof MD^5*, Steffen Koschmieder, MD⁶, Alexander Schultze, MD^1*, Subir Mitra, MD^7*, Peter Vandenberghe, Prof MD, PhD⁸, Tim H. Brümmendorf, Prof MD^6*, Peter Carmeliet, Prof MD, PhD^9*, Gudmundur Helgason, PhD^10*, Andreas Hochhaus, MD⁴, Klaus Pantel, Prof MD, PhD^2*, Carsten Bokemeyer, MD^11*, Tessa L Holyoake, Prof PhD^3* and Sonja Loges, MD PhD^1,2*

¹Department of Hematology and Oncology with Sections BMT and Pneumology, Hubertus Wald Tumorzentrum, University Hospital Hamburg-Eppendorf, Hamburg, Germany
²Institute of Tumor Biology, University Hospital Hamburg-Eppendorf, Hamburg, Germany
³Paul O’Gorman Leukaemia Research Centre, College of Medical, Veterinary & Life Sciences, Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom
⁴Department of Haematology and Medical Oncology, Department of Internal Medicine II, University Hospital Jena, Jena, Germany
⁵Department of Haematology, Royal Liverpool University Hospital, Liverpool, United Kingdom
⁶Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, RWTH Aachen University Hospital, Aachen, Germany
⁷Department of Haematology, Milton Keynes Hospital NHS Foundation Trust, Milton Keynes, United Kingdom
⁸Human Genetics, KULeuven, Leuven, Belgium
⁹Laboratory of Angiogenesis and Neurovascular Link, VIB - Katholieke Universiteit Leuven, Vesalius Research Center, LEUVEN, Belgium
¹⁰Wolfson Wohl Cancer Research Centre, College of Medical, Veterinary & Life Sciences Institute of Cancer Sciences University of Glasgow, Glasgow, United Kingdom
¹¹Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Santa Errichiello, PhD^1*, Simona Caruso^2*, Concetta Quintarelli, PhD^3*, Biagio De Angelis, PhD^4*, Novella Pugliese, MD^2*, Roberta Della Pepa^2*, Barbara Izzo^2*, Luigia Luciano, MD⁵, Simona Soverini⁶, Carolina Terragna, PhD^7*, Giovanni Martinelli⁸, Daniela Cilloni, MD, PhD⁹, Giuseppe Saglio¹⁰, Mario Annunziata, MD^11*, Giovanni Caocci^12*, Luciano Levato, MD^13*, Emilio Usala, MD^14*, Massimo Breccia, MD^15*, Angelo Michele Carella¹⁶, Nicola Cascavilla, MD^17*, Mariella D'Adda, MD^18*, Claudia Galimberti^19*, Frank Giles, MD, MB, FRCPI, FRCPath²⁰, Andreas Hochhaus, MD²¹ and Fabrizio Pane, MD²²

¹Department of Clinical Medicine and Surgery, University of Naples “Federico II", Naples, Italy
²Department of Clinical Medicine and Surgery, University of Naples “Federico II”, Naples, Italy
³Department of Clinical Medicine and Surgery, University Federico II of Naples, Napoli, Italy
⁴Department of Clinical Medicine and Surgery, University of Naples “Federico II”, Naples, TX, Italy
⁵Area Funzionale di Ematologia- II Policlinico, University of Naples “Federico II”, Naples, Italy
⁶Institute of Hematology, S.Orsola-Malpighi University Hospital, Bologna, Italy
⁷DIMES - Department of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology, University of Bologna, Bologna, Italy
⁸"Seràgnoli" Institute of Hematology, University of Bologna, Bologna, Italy
⁹Department of Clinical and Biological Sciences, University of Turin, Orbassano, Turin, Italy
¹⁰University of Turin, Orbassano, Italy
¹¹Hematology, OSPEDALE CARDARELLI, NAPOLI, Italy
¹²Department of Medical Sciences, University of Cagliari, Cagliari, Italy
¹³Section of Hematology, A.O. Pugliese-Ciaccio, Catanzaro, Italy
¹⁴Hematology Unit, "A.Businco" Hospital, Cagliari, Italy
¹⁵Chair of Hematology, "Sapienza" University, Roma, Italy
¹⁶Division of Hematology 1, IRCCS A.O.U. San Martino IST, Genova, Italy
¹⁷Hematology and BMT Unit, Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
¹⁸Division of Hematology, A.O. Spedali Civili of Brescia, Brescia, Italy
¹⁹NOVARTIS ONCOLOGY COMPANY, ORIGGIO VARESE, Italy
²⁰Cancer Therapy & Research Center, University of Texas Health Science Center, San Antonio, TX
²¹Universitätsklinikum Jena, Jena, Germany
²²A.F. di Oncologia Ematologica Diagnostica, Azienda Ospedaliera, Napoli, Italy

Barbara Peter, DVM^1,2*, Gregor Eisenwort^1,2*, Gabriele Stefanzl^2*, Daniela Berger^2*, Wolfgang R Sperr, MD^1,2*, Johannes Zuber, MD, PhD^3* and Peter Valent, MD^1,2

¹Ludwig Boltzmann Cluster Oncology, Medical University of Vienna, Vienna, Austria
²Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria
³Research Institute of Molecular Pathology (IMP), Vienna, Austria

Hu Lei^1*, Chunmin Ma^1*, Zhen Liu^1*, Shenmeng Gao^2*, Li Zhou^3*, Weiwei Wang^1*, Hanzhang Xu^1*, Fenghou Gao^4*, Yingli Wu^5* and Han Liu, PhD⁶

¹Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, shanghai, China
²Wenzhou Medical College, wenzhou, China
³Shanghai Jiao Tong University School of Medicine,ruijin hospital, shanghai, China
⁴Shanghai Jiao Tong University School of Medicine,Shanghai 1th People's Hospital, shanghai, China
⁵Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⁶State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine,, Shanghai, China

Manuela Mancini, PhD^1*, Simona Soverini², Elisa Leo, PhD^3*, Fausto Castagnetti, PhD³, Caterina De Benedittis, PhD^1*, Gabriele Gugliotta, PhD^3*, Gianantonio Rosti, MD^3*, Maria Alessandra Santucci, MD^3*, Michele Cavo^4* and Giovanni Martinelli, MD, PhD⁵

¹"Seràgnoli" Institute of Hematology, Bologna University School of Medicine, Bologna, Italy
²Institute of Hematology, S.Orsola-Malpighi University Hospital, Bologna, Italy
³DIMES - University of Bologna, Bologna, Italy
⁴Institute of Hematology, Bologna, Italy
⁵Bologna University School of Medicine, Bologna, Italy