Eric M Vroegindeweij, PhD^1*, Tim Lammens, PhD^2*, Erik Splinter, PhD^3*, Anne Uyttebroeck^4*, Kirsten Canté-Barrett, PhD¹, Jessica GCAM Buijs-Gladdines^1*, Wilco K Smits^1*, Peter Vandenberghe, MD, PhD⁵, Max J van Min, PhD^3*, Rob Pieters, MD, PhD⁶, Pieter Van Vlierberghe, PhD^7* and Jules PP Meijerink, PhD¹

¹Department of Pediatric Oncology/Hematology, Erasmus MC - Sophia Children's Hospital, Rotterdam, Netherlands
²Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
³Cergentis BV, Utrecht, Netherlands
⁴Center for Human Genetics, University Hospitals Leuven, Leuven, Belgium
⁵Center for Human Genetics, Catholic University of Leuven, Leuven, Belgium
⁶Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
⁷Center for Medical Genetics, Ghent University, Ghent, Belgium

Sabina Chiaretti^1*, Sara Grammatico^1*, Alfonso Piciocchi^2*, Monica Messina^1*, Anna Lucia Fedullo^1*, Valentina Gianfelici^1*, Grazia Fazio, PhD^3*, Nadia Peragine^1*, Maria Paola Martelli^4*, Paola Fazi^2*, Marco Vignetti^2*, Antonella Vitale^1*, Cyril Salek^5*, Gianni Cazzaniga, PhD⁶, Anna Guarini^1* and Robin Foà^1*

¹Hematology, Department of Cellular Biotechnologies and Hematology, “Sapienza” University, Rome, Italy
²GIMEMA Data Center, Rome, Italy
³Centro Ricerca Tettamanti, Clinica Pediatrica, Università di Milano-Bicocca, Ospedale San Gerardo/Fondazione MBBM, Monza, Italy
⁴Institute of Hematology, Centro Ricerche Onco-Ematologiche (CREO), University of Perugia, Perugia, Italy
⁵Institute of Hematology and Blood Transfusion U Nemocnice 1 128 20 Prague 2 Czech Republic, Prague, Czech Republic
⁶Department of Pediatrics, Tettamanti Research Center, University of Milano-Bicocca, Fondazione MBBM/San Gerardo Hospital, Monza, Italy

Michaela Kotrova, MD^1*, Henrik Knecht^2*, Jack Bartram, MD^3*, Vojtech Bystry^4*, Giovanni Cazzaniga⁵, Grazia Fazio, PhD^6*, Simone Ferrero^7*, Elisa Genuardi^7*, Ramon Garcia-Sanz, MD, PhD^8*, Andrea Grioni^9*, Jeremy Hancock, PhD^10*, Cristina Jiminez^11*, Marco Ladetto¹², John Moppett, MD, PhD^13*, Simona Songia^9*, Dietrich Herrmann^14*, Christiane Pott, MD, PhD^15*, Anton W. Langerak^16,17*, Nikos Darzentas^4*, Jan Trka¹⁸, Eva Fronkova^19* and Monika Bruggemann^14*

¹CLIP Laboratory Centre, Department of Pediatric Hematology and Oncology, Second Medical Faculty and University Hospital Motol, Prague, Czech Republic
²Hematologic Diagnostic Laboratory, University Clinic Schleswig-Holstein Campus Kiel, Kiel, Germany
³Department of Haematology, Great Ormond Street Hospital For Children, London, United Kingdom
⁴Central European Institute of Technology, Masaryk University, Brno, Czech Republic
⁵Centro Ricerca Tettamanti, Department of Pediatrics, University of Milano-Bicocca, Fondazione MBBM/San Gerardo Hospital, Monza, Italy
⁶Centro Ricerca Tettamanti, Clinica Pediatrica, Università di Milano-Bicocca, Ospedale San Gerardo/Fondazione MBBM, Monza, Italy
⁷Department of Molecular Biotechnologies and health sciences, Hematology Division, University of Torino, Torino, Italy
⁸Department of Hematology, Hospital Universitario de Salamanca, Salamanca, Spain
⁹Centro Ricerca Tettamanti, University of Milano Bicocca, Monza, Italy
¹⁰Bristol Genetics Laboratory, Southmead Hospital, Bristol, United Kingdom
¹¹IBMCC-CSIC, Hospital Universitario de Salamanca-IBSAL, Salamanca, Spain
¹²Hematology, Department of Molecular Biotechnologies and Health Sciences, University of Torino, Torino, Italy
¹³Department of Pediatric Haematology, Bristol Royal Hospital for Children, Bristol, England
¹⁴Department of Hematology, University Hospital Schleswig-Holstein, Kiel, Germany
¹⁵University Hospital Schleswig-Holstein, Kiel, Germany
¹⁶Department of Immunology, Erasmus MC Rotterdam, Rotterdam, Netherlands
¹⁷on behalf of EuroClonality NGS Consortium, Rotterdam, Netherlands
¹⁸Department of Paediatric Haematology and Oncology, 2nd School of Medicine, Charles University, Prague, Czech Republic
¹⁹CLIP Laboratory Centre, Department of Pediatric Hematology and Oncology, 2nd Medical School, Charles University in Prague, Prague, Czech Republic

David O'Connor, MD, PhD^1*, Jack Bartram, MD^1*, Amir Enshaei, PhD^2*, Anthony V Moorman, PhD², Christine Harrison, PhD FRCPath FMedSci², Rachel Wade, MSc^3*, Rachel Clack, MSc^4*, Jeremy Hancock, PhD^5*, Sujith Samarasinghe, MD, PhD^1*, John Moppett, MD, PhD^6*, Ajay J. Vora⁷ and Nicholas Goulden, MD, PhD¹

¹Department of Haematology, Great Ormond Street Hospital For Children, London, United Kingdom
²Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom
³CTSU, Oxford, United Kingdom
⁴CTSU, University of Oxford, Oxford, United Kingdom
⁵Bristol Genetics Laboratory, Southmead Hospital, Bristol, United Kingdom
⁶Department of Pediatric Haematology, Bristol Royal Hospital for Children, Bristol, England
⁷Dept. of Pediatric Hematology, The Children's Hospital, Sheffield, United Kingdom

Bartolomeo Rossi, MD^1*, Mimma Campeggio^1*, Elisa Magrin, PhD^1*, Marco Zecca, MD^2*, Laura Rubert, MD^2*, Franca Fagioli, MD^3*, Paola Quarello, MD^4*, Federica Lovisa, PhD^1* and Giuseppe Basso, MD¹

¹Clinic of Pediatric Hemato-Oncology, Department of Women’s and Children’s Health, University of Padua, Padua, Italy
²Pediatric Hematology/Oncology, IRCCS Policlinico San Matteo, Pavia, Italy
³Regina Margherita Children's Hospital, Pediatric Onco-Hematology, Stem Cell Transplantation and Cellular Therapy Division, Torino, Italy
⁴Pediatric Onco-Hematology, Regina Margherita Children's Hospital, Torino, Italy

Ester Mejstrikova, MD, PhD^1*, Julie Irving², Leonid Karawajew^3*, Marian Case^4*, Jenny Jesson^5*, Vaskar Saha, PhD, FRCP, FRCPath^6,7,8, Nicholas Goulden, MD, PhD⁹, Jeremy Hancock, PhD^10*, Arend Stackelberg, MD^3*, Sarah Lawson^11*, Michael Dworzak, MD^12*, Renate Panzer-Grumayer^13*, Barbara Buldini^14*, Lisa Eyre^5*, Giuseppe Basso, MD¹⁵, Maddalena Paganin^14*, Jan Trka¹⁶, Daniela Kužílková^17*, Jan Stary¹⁸, Lucie Sramkova, MD^19*, Ondrej Hrusak, MD, PhD²⁰ and Cornelia Eckert^3*

¹CLIP-DPHO, Charles University, Hospital Motol, Prague, Czech Republic
²Northern Institute for Cancer Research, Newcastle upon Tyne, United Kingdom
³Department of Pediatric Oncology/Hematology, Charité Universitätsmedizin, Berlin, Germany
⁴New Castle University, Newcastle upon Tyne, United Kingdom
⁵Birmingham Children's Hospital NHS Foundation Trust, Birmingham, United Kingdom
⁶Children's Cancer Group, Institute of Cancer Sciences, University of Manchester, Manchester, United Kingdom
⁷Tata Medical Center, Kolkata, India
⁸Tata Translational Cancer Research Centre, Kolkata, India
⁹Department of Haematology, Great Ormond Street Hospital For Children, London, United Kingdom
¹⁰Bristol Genetics Laboratory, Southmead Hospital, Bristol, United Kingdom
¹¹Department of Haematology, Birmingham Childrens Hospital, Birmingham, United Kingdom
¹²Department of Pediatrics, Medical University of Vienna, St. Anna Children's Hospital and Children’s Cancer Research Institute, Vienna, Austria
¹³CCRI - CHILDREN'S CANCER RESEARCH INSTITUTE, Vienna, Austria
¹⁴University of Padova, Padova, Italy
¹⁵Dipartimento di Salute della Donna e del Bambino, Università di Padova, Padova, Italy
¹⁶Department of Paediatric Haematology and Oncology, 2nd School of Medicine, Charles University, Prague, Czech Republic
¹⁷Charles University, Prague, Czech Republic
¹⁸CLIP- Childhood Leukaemia Investigation Prague, Department of Paediatric Haematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
¹⁹Charles university, Hospital Motol, Prague, Czech Republic
²⁰2nd Faculty of Medicine, Dept. Pediatric Hem/Onc, CLIP, Charles University, Hospital Motol, Prague, Czech Republic

Caroline L Furness, MD^1*, Clare Rowntree^2*, Ajay J. Vora³, Amy A Kirkwood^4*, Christopher Mitchell, MBBS, PhD, FRCP^5*, Nicholas Goulden, MD, PhD⁶, Anthony V. Moorman, PhD⁷ and Rachael Hough, MD, BMBS, FRCP, FRCPath^8*

¹Haemato-Oncology, Royal Marsden NHS Foundation Trust, London, United Kingdom
²Heath Hospital, Cardiff, United Kingdom
³Dept. of Pediatric Hematology, The Children's Hospital, Sheffield, United Kingdom
⁴CRUK and UCL Cancer Trials Centre, UCL, London, United Kingdom
⁵John Radcliffe Hospital, Oxford, United Kingdom
⁶Department of Haematology, Great Ormond Street Hospital For Children, London, United Kingdom
⁷Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom
⁸Cancer Institute, University College London, London, United Kingdom

Nicholas J. Short, MD¹, Hagop M. Kantarjian, MD¹, Elias Jabbour¹, Susan O'Brien, MD², Stefan Faderl, MD³, Jan A. Burger, MD, PhD¹, Rebecca Garris^1*, Wei Qiao^4*, Xuelin Huang, PhD^4*, Nitin Jain, MD¹, Marina Konopleva, MD, PhD¹, Tapan Kadia, MD¹, Naval Daver, MD¹, Gautam Borthakur, MD¹, Jorge E. Cortes¹ and Farhad Ravandi, MD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²University of California - Irvine, Orange, CA
³John Theurer Cancer Center, Hackensack, NJ
⁴Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX

Henning Fedders, PhD^1*, Denis Martin Schewe, MD^1*, Martin Zimmermann, PhD^2*, Ameera Alsadeq, PhD^1*, Anja Moericke, MD^1*, Udo zur Stadt, PhD^3*, Martin A. Horstmann, MD^3*, Rob Pieters, MD, PhD⁴, Martin Schrappe, MD, PhD¹, Gunnar Cario, MD^1* and Martin Stanulla, MD^2*

¹Department of General Pediatrics, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany
²Department of Paediatric Haematology and Oncology, Hannover Medical School, Hannover, Germany
³University Medical Center Hamburg-Eppendorf, Clinic of Pediatric Hematology and Oncology, Hamburg, Germany
⁴Department of Pediatric Oncology/Hematology, Erasmus MC - Sophia Children's Hospital, Rotterdam, Netherlands

Nitin Jain, MD¹, Audrey Lamb, BS^2*, Susan M. O'Brien, MD^3*, Farhad Ravandi, MD¹, Marina Konopleva, MD, PhD⁴, Elias Jabbour¹, Zhuang Zuo, MD, PhD^2*, Jeffrey L. Jorgensen, MD, PhD², Pei Lin, MD², Sherry Pierce, BSN, BA^1*, Deborah A Thomas, MD¹, Michael Rytting, M.D.¹, Gautam Borthakur, MD¹, Tapan Kadia, MD¹, Jorge E. Cortes, MD⁵, Hagop M. Kantarjian, MD¹ and Joseph D Khoury, MD²

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
³University of California, Irvine/Chao Family Comprehensive Cancer Center, Orange, CA
⁴Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX

Susan L Heatley, PhD, MEd^1,2*, Teresa Sadras, PhD^1,2*, Eva Nievergall, PhD^1,2*, Chung Hoow Kok, PhD^1,2*, Phuong Dang, BSci (Hon)^1*, Kelly Quek, PhD^1*, Nicola C Venn^3*, Sarah Moore, BSc (Hon), FFSc (RCPA)^4*, Tamara Law, BSc (Hons)^3*, Anthea Ng, BAppSc, MSc^5,6*, Murray D Norris, PhD^7,8*, Tamas Revesz, MD, PhD^6,9*, Michael P Osborn, MBBS^6,9*, Chris Fraser, FRACP, MBBS, MPH^6,10*, Frank Alvaro, MBBS, FRACP^6,11*, Glenn M Marshall, MBBS, MD, FRACP^6,12,13, Luciano Dalla Pozza, MBBS, FRACP^5,6*, Timothy P. Hughes, MD, MBBS, FRACP, FRCPA^1,2,14, Charles G. Mullighan, MBBS, MSc, MD¹⁵, Rosemary Sutton, PhD^6,16* and Deborah L White, PhD, FFSc (RCPA)^1,2,6

¹Cancer Theme, South Australian Health & Medical Research Institute (SAHMRI), Adelaide, Australia
²School of Medicine, University of Adelaide, Adelaide, Australia
³Molecular Diagnostics, Children's Cancer Institute Australia, Sydney, Australia
⁴Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, Australia
⁵Department of Oncology, The Children's Hospital at Westmead, Westmead, Australia
⁶Australian and New Zealand Children's Haematology/Oncology Group, Melbourne, Australia
⁷Molecular Diagnostics, Children's Cancer Institute, Sydney, Australia
⁸Centre for Childhood Cancer Research, University of New South Wales, Sydney, Australia
⁹Department of Haematology & Oncology, Women's & Children's Hospital, Adelaide, Australia
¹⁰Children's Health Queensland, Lady Cilento Children's Hospital, Brisbane, Australia
¹¹John Hunter Children's Hospital, Newcastle, Australia
¹²School of Women's and Children's Health, University of New South Wales, Sydney, Australia
¹³Kids Cancer Centre, Sydney Children's Hospital, Randwick, Australia
¹⁴Department of Haematology, SA Pathology, Adelaide, Australia
¹⁵Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
¹⁶Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, Australia

Gabriel N. Mannis, MD¹, Thomas G. Martin III, MD¹, Lloyd E. Damon, MD^1*, Charalambos Andreadis, MD, MSCE¹, Rebecca L. Olin, MD, MSCE¹, Katie Kong^2*, Malek Faham, MD, PhD², Weiyun Z. Ai, MD, PhD¹, Karin ML Gaensler, MD¹, Peter H. Sayre, MD, PhD¹, Jeffrey L. Wolf, MD, PhD¹ and Aaron C. Logan, MD, PhD¹

¹University of California San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA
²Adaptive Biotechnologies, South San Francisco, CA

Mari H Dallas, MD¹, Paul Thomas, PhD^2*, John Choi^3*, William E. Evans, PharmD⁴, Hiroto Inaba, MD, PhD⁵, Sima Jeha, MD⁶ and Ching-Hon Pui, MD⁵

¹Department of Bone Marrow Transplantation and Cellular Therapy, St Jude Children's Research Hospital, Memphis, TN
²Immunology, St. Jude Children's Research Hospital, Memphis, TN
³Pathology, St. Jude's Childrens Hospital, Memphis, TN
⁴Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN
⁵Oncology, St. Jude Children's Research Hospital, Memphis, TN
⁶Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN

Franck Rapaport, PhD^1*, Jay Patel^2*, Jie He, PhD^3*, Timothy A Brennan, MS^3*, Michelle Nahas, PhD^3*, Sohail Balassubramanian, MS^4*, Geoff Otto, PhD^3*, Doron Lipson, PhD^3*, Phil Stephens, PhD^3*, Vincent A. Miller, MD^3*, Janis Racevskis, MD^5*, Mark R Litzow, MD⁶, Peter H. Wiernik, M.D.⁷, Anthony H. Goldstone, FRCP, FRCPath⁸, Selina Luger, MD⁹, Marcel van den Brink, MD, PhD¹⁰, Agnes Viale, PhD^11*, Jacob M. Rowe, MD¹², Martin S. Tallman, MD¹³, Ari Melnick, MD¹⁴, Elisabeth Paietta, PhD¹⁵, Mithat Gonen, PhD^16* and Ross L. Levine, MD²

¹Leukemia Center, Memorial Sloan Kettering Cancer Center, New York City, NY
²Memorial Sloan Kettering Cancer Center, New York, NY
³Foundation Medicine, Inc., Cambridge, MA
⁴Foundation Medicine, Inc, Cambridge, MA
⁵Department of Medicine (Oncology), Albert Einstein College of Medicine, Montefiore Medical Center, New York, NY
⁶Division of Hematology, Mayo Clinic, Rochester, MN
⁷Department of Oncology, Montefiore Medical Center North Division, Bronx, NY
⁸Univ. College London Hosp., London, England
⁹Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
¹⁰Department of Medicine, Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY
¹¹Memorial Sloan Kettering, New York City, NY
¹²Hematology, Shaare Zedek Medical Center, Jerusalem, Israel
¹³Northwestern University Feinberg School of Medicine, Chicago, IL
¹⁴Weill Cornell Medical College, New York, NY
¹⁵Cancer Center, The North Division of Montefiore Medical Center, Bronx, NY
¹⁶Statistics, Memorial Sloan Kettering Cancer Center, New York, NY

Thai Hoa Tran, MD¹, Jonathan Van Nguyen^1*, Catherine C. Smith, MD², Kathryn G. Roberts, PhD³, Charles G. Mullighan, MBBS, MSc, MD³, Neil P. Shah² and Mignon L. Loh, MD¹

¹Department of Pediatrics, Benioff Children’s Hospital, University of California at San Francisco, San Francisco, CA
²Department of Medicine, University of California at San Francisco, San Francisco, CA
³Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN

Chihiro Tomoyasu, MD^1*, Toshihiko Imamura, MD¹, Mio Yano, MD^1*, Daisuke Asai, MD^2*, Meixian Huang, MD^3*, Hiroaki Goto, MD, PhD^4*, Akira Shimada, MD, PhD⁵, Takeshi Inukai, MD, PhD^6*, Kanji Sugita, MD, PhD³ and Hajime Hosoi, MD^1*

¹Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
²Department of Pediatrics, Division of Pediatrics, North Medical Center, Kyoto Prefectural University of Medicine, Kyoto, Japan
³Pediatrics, School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan
⁴Division of Hemato-oncology/Regenerative Medicine, Kanagawa Children's Medical Center, Yokohama, Japan
⁵Pediatrics/Pediatric Hematology & Oncology, Okayama University Hospital, Okayama, Japan
⁶Department of Pediatrics, School of Medicine, University of Yamanashi, Chuo, Japan

Yuka Yamashita, MS^1*, Masashi Sanada, MD, Ph.D.^2*, Kenichi Yoshida, MD, Ph.D.^3*, Hiroo Ueno, MD^3*, Hiroko Tanaka, BA^4*, Yuichi Shiraishi, MD, Ph.D.^4*, Kenichi Chiba, BA^4*, Toshihiko Imamura, MD, PhD⁵, Satoru Miyano, MD, Ph.D.^4*, Koji Kato, MD, PhD⁶, Seiji Kojima, MD, PhD^7*, Seishi Ogawa, MD, Ph.D.⁸ and Keizo Horibe, MD, PhD¹

¹Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
²Department of Advanced Diagnosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
³Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⁴Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
⁵Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
⁶Department of Hematology and Oncology, Children's Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
⁷Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
⁸Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan, Kyoto, Japan

Lisa Jane Russell, PhD^1*, Lisa Jones, BSc^1*, Amir Enshaei, PhD^1*, Jamie Rutherford, BSc^1*, Stefano Tonin, PhD^1*, Sarra Ryan, PhD^1*, Jeyanthy Eswaran, PhD^1*, Elli Papaemmanuil, PhD^2*, Jose Tubio, PhD^3*, Peter J Campbell, MD, PhD^4*, Anthony V Moorman, PhD¹ and Christine Harrison, PhD FRCPath FMedSci¹

¹Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom
²Memorial Sloan Kettering Cancer Center, New York
³Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⁴Cancer genome Project, Wellcome Trust Sanger Institute, Cambridge, United Kingdom

Shiven B. Patel, MD^1,2*, Clinton C. Mason, PhD^2*, Martha Glenn, MD¹, Christian N. Paxton, PhD^3*, Sarah T. South, PhD^3,4*, Melissa H. Cessna, MD^5*, Julie D. Asch, MD⁶, Erin F. Cobain, MD^7*, Dale Bixby, MD, PhD⁸, Lauren B. Smith, MD⁹, Shalini C. Reshmi, PhD^10*, Julie M. Gastier-Foster, PhD¹⁰, Joshua D. Schiffman, MD² and Rodney R. Miles, MD, PhD^2,3,4

¹Division of Hematology and Hematologic Malignancies, University of Utah School of Medicine, Salt Lake City, UT
²Huntsman Cancer Institute, Salt Lake City, UT
³ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT
⁴Department of Pathology, University of Utah, Salt Lake City, UT
⁵Intermountain Mecial Center, Salt Lake City, UT
⁶Intermountain Blood and Marrow Transplant/Acute Leukemia Program, Salt Lake City, UT
⁷University of Michigan Health System, Ann Arbor, MI
⁸Univ. of Michigan Comprehensive Cancer Ctr., Ann Arbor, MI
⁹Department of Pathology, University of Michigan, Ann Arbor, MI
¹⁰The Ohio State University, Nationwide Children's Hospital, Columbus, OH

Paulina Pechanska^1*, Joachim Kunz, MD^2*, Tobias Rausch^3*, Obul Reddy Bandapalli, PhD¹, Elena Orlova^1*, Judit Sagi^1*, Martin Stanulla, MD^4*, Martin Schrappe, MD, PhD⁵, Renate Kirschner-Schwabe, PhD^6*, Jana Hof^6*, Cornelia Eckert^7*, Rolf Köhler^8*, Martina U. Muckenthaler, PhD⁹, Jan o. Korbel^3* and Andreas E Kulozik, MD PhD¹⁰

¹Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University, Heidelberg, Germany
²Heidelberg University, Heidelberg, Germany
³European Molecular Biology Laboratory, Heidelberg, Germany
⁴Department of Paediatric Haematology and Oncology, Hannover Medical School, Hannover, Germany
⁵Dept. of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
⁶Universitätsmedizin Charité, Berlin, Germany
⁷Department of Pediatric Oncology/Hematology, Charité Universitätsmedizin, Berlin, Germany
⁸Department of Human Genetics, Heidelberg University, Heidelberg, Germany
⁹Department of Pediatric Oncology, Hematology, Immunology and Pulmunology, University of Heidelberg, Heidelberg, Germany
¹⁰Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany

Zach Dixon, BSc Hons, MRes^1*, Julie A.E. Irving, PhD¹ and Lindsay Nicholson, PhD^2*

¹Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom
²Haematological Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom

Suzanne M. Johnson^1*, Clare Dempsey^1*, Amy Chadwick^2*, Stephanie Harrison^1*, Jizhong Liu^1*, Yujun Di^1*, Owen McGinn^1*, Mayur Parihar^3*, Federica Sotgia^2*, Michael Lisanti^2*, Shekhar Krishnan^3,4* and Vaskar Saha, PhD, FRCP, FRCPath^3,4,5

¹Children’s Cancer Group, Institute of Cancer Sciences, The University of Manchester, Manchester, United Kingdom
²Manchester Centre for Cellular Metabolism, Institute of Cancer Sciences, The University of Manchester, Manchester, United Kingdom
³Tata Medical Center, Kolkata, India
⁴Tata Translational Cancer Research Centre, Kolkata, India
⁵Children's Cancer Group, Institute of Cancer Sciences, University of Manchester, Manchester, United Kingdom

Jianhong Lin, M.D, M.Sc^1*, Chun Yang, M.D. Ph.D.^1,2*, Ariel Kwart, B.S.^1*, Jianjun Zhao, M.D. Ph.D.¹, Mehmet K Samur, Ph.D^3*, Weihong Zhang, M.D^1,4*, Purushothama Nanjappa, M.S.^1,5*, Teresa Calimeri, M.D, Ph.D⁶, Xiubao Ren, M.D^4*, Dongdong Ma, M.D. Ph.D.^7*, Xiaofeng Jiang, M.D. Ph.D.^2*, Yi Zhou, Ph.D^8*, Masood Shammas, PhD^1,5, Kenneth C. Anderson, M.D¹, Jon C. Aster, M.D, Ph.D⁹, Leonard I. Zon, M.D^8,10, Robert I. Handin, M.D⁷ and Nikhil C. Munshi, MD^5,11

¹Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
²Department of Clinical Laboratory, the 4th Hospital of Harbin Medical University, Harbin, China
³Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA
⁴Biotherapy Department, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
⁵VA Boston Healthcare System, West Roxbury, MA
⁶Unit of Lymphoid Malignancies Division of OncoHematological Medicine, Department of OncoHematology, San Raffaele Scientific Institute, Milano, Italy
⁷Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
⁸Stem Cell Program and Division of Hematology/Oncology, Howard Hughes Medical Institute, Boston Children's Hospital/Harvard Medical School, Boston, MA
⁹Department of Pathology, Brigham &Women's Hospital, Boston, MA
¹⁰Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA
¹¹Jerome Lipper Multiple Myeloma Center, Dana Farber Cancer Institute, Boston, MA

Christopher Daniel Chien, PhD, Sang Minh Nguyen, BS^*, Haiying Qin, MS^*, Elad Jacoby, MD and Terry J. Fry, M.D.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD

Shella Saint Fleur-Lominy, MD, PhD¹, Mate Maus, Ph.D.^2* and Stefan Feske, M.D.^2*

¹Laura and Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, NY
²Pathology, New York University School of Medicine, New York, NY

Jae-Woong Lee, PHD^1*, Zhengshan Chen, MD PhD^1*, Huimin Geng, PhD^2*, Gang Xiao, PhD^1*, Eugene PARK, PHD^1*, Samir Parekh, MD³, Steven M. Kornblau, MD⁴, Ari Melnick, MD⁵, Abul Abbas^1*, Elisabeth Paietta^6* and Markus Muschen, MD, PhD¹

¹Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA
²Laboratory Medicine, University of California, San Francisco, San Francisco, CA
³Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY
⁴M.D. Anderson Cancer Center, University of Texas, Houston, TX
⁵Weill Cornell Medical College, New York, NY
⁶Albert Einstein College of Medicine, BRONX, NY

Floris C. Loeff^1*, Kevin Rijs^1*, Willem H. Zoutman^2*, Esther H.M. Egmond^1*, Maarten H. Vermeer, MD, PhD^2*, J.H. Frederik Falkenburg, MD, PhD¹, Constantijn J.M. Halkes, MD, PhD¹ and Inge Jedema, PhD¹

¹Department of Hematology, Leiden University Medical Center, Leiden, Netherlands
²Department of Dermatology, Leiden University Medical Center, Leiden, Netherlands

Tomasz Sewastianik, MSc^1*, Patryk Gorniak, PhD^1*, Przemyslaw Kiliszek, MSc^1*, Anna Polak, MSc^1*, Emilia Bialopiotrowicz, PhD^1*, Ewa Jablonska, PhD^1*, Maciej Szydlowski, PhD^1*, Ewa Lech-Maranda, MD, PhD^2,3*, Katarzyna Borg, PhD^1*, Hanna Makuch-Lasica, MSc^1*, Adam Zabek, MSc^4*, Piotr Mlynarz, PhD^4*, Tomasz Stoklosa, MD, PhD⁵, Sebastian Giebel, MD, PhD^6*, Krzysztof Warzocha, MD, PhD^3* and Przemyslaw Juszczynski, MD, PhD^1*

¹Dept. of Diagnostic Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland
²Dept. of Hematology and Transfusion Medicine, Centre of Postgraduate Medical Education, Warsaw, Poland
³Dept. of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland
⁴Bioorganic Chemistry Group, Dept. of Chemistry, Wroclaw University of Technology, Wroclaw, Poland
⁵Dept. of Immunology, Medical University of Warsaw, Warsaw, Poland
⁶Dept. of Bone Marrow Transplantation and Oncohematology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland