Courtney DiNardo, MD¹, Stéphane de Botton^2*, Daniel A Pollyea^3*, Eytan M Stein, M.D.⁴, Amir T. Fathi, MD⁵, Gail J Roboz, MD⁶, Robert Collins, MD⁷, Ronan T. Swords, MD, PhD, FRCPI, FRCPath⁸, Ian W. Flinn, MD, PhD⁹, Jessica K Altman^10*, Martin S Tallman, MD¹¹, Hagop M. Kantarjian, MD¹², Adnan Derti^13*, Meredith Goldwasser^13*, Malia Prahl^13*, Bin Wu^13*, Katharine Yen^13*, Sam Agresta¹³ and Richard M. Stone, MD¹⁴

¹University of Texas MD Anderson Cancer Center, Houston, TX
²Institut Gustave Roussy, Villejuif, France
³University of Colorado Cancer Center, Aurora, CO
⁴Memorial Sloan Kettering Cancer Center, New York, NY
⁵Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA
⁶Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, NY
⁷University of Texas Southwestern Medical Center, Dallas, TX
⁸Hematology/Oncology, Sylvester Comprehensive Cancer Center, University of Miami Hospitals, Miami, FL
⁹Hematologic Malignancies Research Program, Sarah Cannon Research Institute, Nashville, TN
¹⁰Robert H. Lurie Comprehensive Cancer Center, Chicago, IL
¹¹Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
¹²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
¹³Agios Pharmaceuticals, Cambridge, MA
¹⁴Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA

Etienne Paubelle^1*, Alice Marceau^2*, Florence Zylbersztejn^3*, Mickael Dussiot^4*, Ivan Cruz Moura, PhD⁵, Pascale Cornillet-Lefebvre, MD^6*, Jacques Delaunay, MD^7*, Alan K. Burnett⁸, Sylvie Castaigne⁹, Philippe Guardiola, MD¹⁰, Norbert Ifrah, MD, PhD¹¹, Hervé Dombret¹², Claude Preudhomme², Robert K Hills, DPhil¹³ and Olivier Hermine^14,15*

¹Hôpital Necker - APHP, Paris Descartes – Sorbonne Paris Cité University, paris, France
²Hematology Laboratory, CHRU Lille, Lille, France
³Imagine Institute- Inserm UMR 1163, Paris Descartes – Sorbonne Paris Cité University, paris, France
⁴UMR 1163, Institut Imagine, Paris, France
⁵Department of Hematology, Imagine Institute, Hôpital Universitaire Necker -Enfants Malades Paris, Paris, France
⁶CHU Reims, reims, France
⁷Department of Hematology, Nantes University Hospital, Nantes, France
⁸Haematology, Haematology, NCRI Working Group, United Kingdom, Cardiff, United Kingdom
⁹Dept. Hematologie, Hopital Mignot, Le Chesnay, France
¹⁰Service des Maladies du Sang, CHU Angers, Angers, France
¹¹Hematology Department, University Hospital, Angers, France
¹²Hematology, Hôpital Saint-Louis, Paris, France
¹³Department of Haematology, Cardiff University School of Medicine, Cardiff, United Kingdom
¹⁴LABEX GR-Ex, Paris, France
¹⁵Hematology, Hôpital Necker Enfants Malades, Paris, France

Selina Luger, MD¹, Victoria X Wang^2*, Elisabeth Paietta, PhD³, Rhett P. Ketterling, MD^4*, Witold Rybka, MD⁵, Hillard M. Lazarus, MD⁶, Mark R Litzow, MD⁷, Jacob M. Rowe, MD⁸, Richard A. Larson, MD⁹, Frederick R Appelbaum, MD¹⁰ and Martin S. Tallman, MD^11,12

¹Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
²ECOG-ACRIN Biostatistics Center, Dana Farber Cancer Institute, Boston, MA
³Cancer Center, Montefiore Medical Center North Division, Bronx, NY
⁴Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁵Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, PA
⁶Adult Hematologic Malignancies & Stem Cell Transplant Section, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH
⁷Division of Hematology, Mayo Clinic, Rochester, MN
⁸Hematology, Shaare Zedek Medical Center, Jerusalem, Israel
⁹University of Chicago, Chicago, IL
¹⁰Fred Hutchinson Cancer Research Center & University of Washington, Seattle, WA
¹¹Memorial Sloan-Kettering Cancer Center, New York, NY
¹²Northwestern University Feinberg School of Medicine, Chicago, IL

Theresa Kretschmann^1*, Christoph Röllig, MD^2*, Brigitte Mohr^1*, Michael Kramer, MSc.^3*, Matthias Stelljes⁴, Martin Kaufmann, MD⁵, Kerstin Schäfer-Eckart^6*, Claudia D. Baldus, MD, PhD^7*, Alwin Krämer^8*, Hermann Einsele⁹, Mathias Hänel^10*, Regina Herbst, MD^11*, Stefan W. Krause, MD^12*, Andreas Neubauer, MD¹³, Kristina Sohlbach^14*, Martin Bornhäuser, MD^2*, Christian Thiede, MD¹⁵, Wolfgang E. Berdel, MD¹⁶, Hubert Serve, MD^17*, Johannes Schetelig, MD, M.Sc^18,19, Gerhard Ehninger, MD³ and Friedrich Stölzel, MD^15,20*

¹Universitätsklinikum TU Dresden, Dresden, Germany
²Department of Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany
³Medical Dept. 1, University Hospital TU Dresden, Dresden, Germany
⁴Department of Medicine A/Hematology and Oncology, University of Münster, Münster, Germany
⁵Robert Bosch Krankenhaus, Stuttgart, Germany
⁶Klinikum Nord, Nürnberg, Germany
⁷Charité University Hospital, Berlin, Germany
⁸Universitätsklinikum Heidelberg, Heidelberg, Germany
⁹2Department of Internal Medicine. II, Wuerzburg, Germany
¹⁰Klinik für Innere Medizin III, Klinikum, Chemnitz, Germany
¹¹Klinikum Chemnitz, Chemnitz, Germany
¹²Medizinische Klinik 5, Hämatologie und Internistische Onkologie, Universitätsklinikum Erlangen, Erlangen, Germany
¹³Dept. Hematology, Oncology, Immunology, Philipps University of Marburg, Medical Center of the University Giessen and Marburg, Marburg, Germany
¹⁴Philipps University of Marburg, Medical Center of the University Giessen and Marburg, Marburg, Germany
¹⁵Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus der TU Dresden, Dresden, Germany
¹⁶Universitätsklinikum Münster, Münster, Germany
¹⁷Dept. of Internal Medicine, University Hospital of Frankfurt, Frankfurt, Germany
¹⁸Medizinische Klinik I, Universitaetsklinikum C.G.Carus, Dresden, Germany
¹⁹DKMS German Bone Marrow Donor Center, Dresden, Germany
²⁰Study Alliance Leukemia SAL, Dresden, Germany

Bin Fan, PhD^*, Kha Le, PhD^*, Erika Manyak, BASc^*, Hua Liu^*, Malia Prahl^*, Chris J Bowden^*, Scott Biller^*, Sam Agresta, MD and Hua Yang, PhD^*

Agios Pharmaceuticals, Cambridge, MA

Hideki Muramatsu, MD, PhD¹, Tomoyuki Watanabe^2*, Daisuke Hasegawa, MD, PhD^3*, Park Myoung-ja^4*, Shotaro Iwamoto^5*, Takashi Taga, MD, PhD^6*, Etsuro Ito, MD, PhD⁷, Tsutomu Toki, PhD⁷, Kiminori Terui⁷, Ryu Yanagisawa^8*, Katsuyoshi Koh, MD, PhD^9*, Akiko M. Saito^10*, Keizo Horibe, MD, PhD¹⁰, Yasuhide Hayashi, MD, PhD⁴, Souichi Adachi, MD, PhD¹¹, Shuki Mizutani, MD, PhD^12* and Kenichiro Watanabe^13*

¹Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
²Department of Nutritional Science, Faculty of Psychological and Physical Science, Aichi Gakuin University, Nisshin, Japan
³Department of Pediatrics, St. Luke's International Hospital, Tokyo, Japan
⁴Department of Hematology/Oncology, Gunma Children's Medical Center, Shibukawa, Japan
⁵Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Japan
⁶Department of Pediatrics, Shiga University of Medical Science, Otsu, Japan
⁷Department of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
⁸Department of Hematology and Oncology, Nagano Children's Hospital, Azumino, Japan
⁹Department of Hematology and Oncology, Saitama Children's Medical Center, Saitama, Japan
¹⁰Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
¹¹Department of Human Health Sciences, Kyoto University, Kyoto, Japan
¹²Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Bunkyo-ku, Japan
¹³Department of Hematology and Oncology, Shizuoka Children's Hospital, Shizuoka, Japan

Aditya Deshpande^1*, Maria Monica Gramatges, MD, PhD², Ghadir S. Sasa, MD^2*, Philip J Lupo, PhD, MPH^3*, Rachel E Rau, MD², Michele S. Redell, MD, PhD², Terzah M. Horton, MD, PhD², Michael E Scheurer, PhD, MPH^3* and Karen R. Rabin, MD, PhD²

¹University of Texas School of Public Health, Houston, TX
²Pediatrics, Hematology/Oncology, Baylor College of Medicine, Houston, TX
³Department of Pediatrics , Hematology-Oncology Section, Baylor College of Medicine, Houston, TX

Birendra KC, MD^*, Hagop M. Kantarjian, MD, Guillermo Garcia-Manero, MD, Naval Daver, MD, Gautam Borthakur, MD, Marina Konopleva, MD, PhD, Michael Andreeff, MD, PhD, Dai Chihara, MD, PhD, Tapan Kadia, MD, Prithviraj Bose, MD^*, Zeev Estrov, MD, Naveen Pemmaraju, MD, Farhad Ravandi, MD and Jorge E. Cortes, MD

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

Taeha Kim, MD^1*, Joseph Shatzel, MD^2*, Harley Friedman, MD^3* and Frederick Lansigan, MD⁴

¹Dartmouth Hitchcock Medical Center, Lebanon, NH
²Department of Hematology/Oncology, Oregon Health and Science University, Portland, OR
³Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH
⁴Hematology, Dartmouth-Hitchcock Medical Center, Lebanon, NH

Chezi Ganzel^1*, Larry D. Cripe, MD², Zhouxin Sun^3*, Hugo F. Fernandez, M.D.⁴, Peter A Cassileth, MD⁵, Dan Douer, MD⁶, Jacob M. Rowe, MD^1,7, Elisabeth Paietta, PhD⁸, Michael O'Connell^9*, Peter H Wiernik^10*, John M. Bennett, MD¹¹, Mark R Litzow, MD¹², Selina Luger, MD¹³, Hillard M. Lazarus, MD¹⁴ and Martin S. Tallman, MD¹⁵

¹Hematology, Shaare Zedek Medical Center, Jerusalem, Israel
²Indiana University Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN
³Dana Farber Cancer Institute, Tampa, FL
⁴Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center, Tampa, FL
⁵Deceased prior to publication, University of Miami, Miami, FL
⁶Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁷Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel
⁸Cancer Center, The North Division of Montefiore Medical Center, Bronx, NY
⁹Mayo Clinic, Rochester, MN
¹⁰Beth Israel Medical Center, New York
¹¹University of Rochester, Rochester, NY
¹²Division of Hematology, Mayo Clinic, Rochester, MN
¹³Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
¹⁴Medicine - Hematology and Oncology, University Hospitals Case Medical Center, Cleveland, OH
¹⁵Memorial Sloan Kettering Cancer Center, New York

Taiki Ando, MD^1*, Etsuko Yamazaki, MD^2,3, Haruka Teshigawara, MD^4*, Fujii Eriko, MD^5*, Yoshimi Ishii, MD^1*, Wataru Yamamoto, MD^1*, Kenji Motohashi, MD^1*, Takayoshi Tachibana, MD^2*, Maki Hagihara, MD^2*, Kenji Matsumoto, MD^1*, Masatsugu Tanaka^5*, Hashimoto Chizuko, MD^6*, Koharazawa Hideyuki, MD^4*, Fujimaki Katsumichi, MD^7*, Jun Taguchi, MD^4*, Naoto Tomita, MD², Hiroyuki Fujita, MD⁸, Heiwa Kanamori⁵ and Shin Fujisawa, MD^1*

¹Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan
²Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
³Clinical Laboratory Department, Yokohama City University Hospital, Yokohama, Japan, Yokohama, Japan
⁴Department of Hematology, Shizuoka Red Cross Hospital, Shizuoka, Japan
⁵Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan
⁶Hematology/Oncology, Yamato Municipal Hospital, Yamato, Japan
⁷Hematology/Immunology, Fujisawa City Hospital, Fujisawa, Japan
⁸Department of Hematology, Saiseikai Yokohamashi Nanbu Hospital, Yokohama, Japan

Bailleux Caroline^1*, Fieux Thomas^2*, Doyen Jerome^3*, Gastaud Lauris^4*, Gallamini Andrea^4*, Kaphan Regis^5*, Re Daniel^4*, Gutnecht Jean^6*, Garnier Georges^7*, Rossignol Benoit^8*, Thyss Antoine^2*, Franck E. Nicolini⁹ and Frederic Peyrade, MD^10*

¹Hematology, Antoine Lacassagne Center, NICE, France
²Oncology hematology, Antoine Lacassagne Center, Nice, France
³Radiation oncology, Antoine Lacassagne Center, NICE, France
⁴Oncology hematology, Antoine Lacassagne Center, NICE, France
⁵Internal Medicine, Cannes General Hospital, Cannes, France
⁶Oncology, Frejus Saint Raphael Hospital, Frejus, France
⁷Hematology and Oncology, Princess Grace Hospital, Monaco, France
⁸Oncology and hematology, Draguignan Hospital, Draguignan, France
⁹Hématologie, Centre Hospitalier Lyon Sud, Pierre Benite, & INSERM, Lyon, France
¹⁰Department of Hematology, Centre Antoine Lacassagne, Nice, France

Kaixun Hu, MD^1*, Yajing Huang, MD^1*, Huisheng Ai, MD^2*, Mei Guo^1*, Yu Changlin^1*, Qiao Jianhui^1*, Qiyun Sun^1*, Zheng Dong^1*, Hongli Zuo^1*, Bo CAI^3* and Xuliang Shen, MD^4*

¹Department of Hematology and Transplantation, Affiliated Hospital of Academy of Military Medical Sciences, beijing, China
²Department of Hematology and Transplantation, Affiliated Hospital of Academy of Military Medical Sciences, BEIJING, China
³Affiliated Hospital of Academy of Military Medical Sciences, BEIJING, China
⁴Heping Hospital of Changzhi Medical College, Changzhi, China

Ahmad Zarzour, MD¹, Aziz Nazha, MD², Matt Kalaycio, MD³, Bhumika J. Patel^4*, Aaron T. Gerds, MD, MS¹, Michael J. Clemente^5*, Cassandra M Hirsch^6*, Jennifer S. Carew, PhD⁴, Anjali S. Advani, MD¹, Srinivasa R. Sanikommu, MBBS⁷, Bartlomiej Przychodzen, MSc^4*, Hetty E. Carraway, MD, MBA¹, Sudipto Mukherjee, MD, PhD¹, Jaroslaw P. Maciejewski, MD, Ph.D.⁴ and Mikkael A. Sekeres, MD, MS¹

¹Leukemia Program, Cleveland Clinic, Cleveland, OH
²Leukemia Program, Department of Hematology and Oncology, Cleveland Clinic, Taussig Cancer Institute, Cleveland, OH
³Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁴Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁵Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, OH
⁶Department of Translational Hematology and Oncology Research, Taussing Cancer Institute, Cleveland Clinic, Cleveland, OH
⁷Cleveland Clinic Taussing Cancer Institute, Cleveland, OH

Tomoki Naoe, MD, Ph.D.¹, Toru Sakura, MD, PhD^2*, Yukio Kobayashi, MD, PhD³, Kensuke Usuki, MD, Ph.D.^4*, Toshihiro Miyamoto, MD, PhD⁵, Hiroatsu Iida, MD, PhD^1*, Satoshi Morita, PhD^6*, Erkut Bahceci, MD⁷, Masahito Kaneko, RPh^8*, Shunsuke Yamada, M.Eng^8*, Shigeru Takeshita, MSc^8* and Shuichi Miyawaki, MD, Ph.D.⁹

¹National Hospital Organization Nagoya Medical Center, Nagoya, Japan
²Saiseikai Maebashi Hospital, Gunma, Japan
³National Cancer Center Hospital, Tokyo, Japan
⁴Deptartment of Hematology, NTT Medical Center Tokyo, Tokyo, Japan
⁵Kyushu University Hospital, Fukuoka, Japan
⁶Kyoto University Hospital, Kyoto, Japan
⁷Astellas Pharma US, Inc., Northbrook, IL
⁸Astellas Pharma, Inc., Tokyo, Japan
⁹Tokyo Metropolitan Ohtsuka Hospital, Tokyo, Japan

Elzbieta Patkowska, MD^1,2*, Joanna Gora Tybor, MD PhD^1*, Ewa Lech Maranda, MD PhD^1,2*, Maciej Kazmierczak, MD PhD^3*, Marta Baranska, MD, PhD^3*, Andrzej Szczepaniak, MD^3*, Monika Paluszewska, MD, PhD^4*, Wieslaw W Jedrzejczak, MD PhD^4*, Renata Guzicka Kazmierczak, MD, PhD^5*, Wanda Knopinska Posluszny, MD, PhD^6*, Olga Grzybowska Izydorczyk, MD, PhD^7*, Jaroslaw Piszcz, MD, PhD⁸, Izabela Deren Wagemann, MD, PhD^9* and Krzysztof Warzocha, MD, PhD^1*

¹Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland
²Department of Hematology and Transfusion Medicine, Centre of Postgraduate Medical Education, Warsaw, Poland
³Department of Hematology and Bone Marrow Transplantation, University of Medical Sciences, Poznan, Poland
⁴Department of Hematology, Oncology and Internal Diseases, Warsaw Medical University, Warsaw, Poland
⁵Department of Hematology, Pomeranian Medical University, Szczecin, Poland
⁶Department of Hematology, Hospital of the Ministry of Interior, Warmia and Mazury University, Olsztyn, Poland
⁷Department of Hematology, Medical University of Lodz, Lodz, Poland
⁸Hematology Department, Medical University of Bialystok, Bialystok, Poland
⁹Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw, Poland

Hind Bennani, PharmD^1*, Véronique Saada, PharmD^2*, Christophe Willekens, MD^3* and Jacques Vargaftig, MD^4*

¹Laboratoire de Biologie, Hôpital René Huguenin - Institut Curie, Saint-Cloud, France
²Département de biologie-pathologie, Institut Gustave Roussy, Villejuif, France
³Service d’Hématologie, Gustave Roussy Cancer Center, Villejuif, France
⁴Service d’Hématologie, Hôpital René Huguenin - Institut Curie, Saint-Cloud, France

Renata Abrahão, MD, MSc^1,2*, Ruth H Keogh, DPhil^3*, Daphne Y Lichtensztajn, MD, MPH^2*, Rafael Marcos-Gragera, MD, PhD^4*, Bruno C. Medeiros, MD⁵, MIchel P Coleman, FFPH^1*, Raul C. Ribeiro, MD⁶ and Theresa HM Keegan, PhD, MSc^2,7*

¹Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, England
²Cancer Prevention Institute of California, Fremont, CA
³Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, England
⁴Epidemiology Unity and Cancer Registry of Girona, Institute for Biomedical Research de Girona, Girona, Spain
⁵Department of Medicine, Division of Hematology, Stanford University, Stanford, CA
⁶St. Jude Children's Research Hospital, Memphis, TN
⁷Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA