Chao Hu^1,2,3*, Xi Jiang, PhD^1,2, Bryan Ulrich^2*, Yungui Wang, PhD^1,2,3*, Rui Su, PhD¹, Hengyou Weng, PhD^1,2*, Huilin Huang, PhD¹, Jennifer Strong^1*, Ping Chen^2*, Shenglai Li^2*, Jianjun Chen, PhD^1,2 and Jie Jin, MD, PhD⁴

¹Department of Cancer Biology, University of Cincinnati, Cincinnati, OH
²Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL
³Department of Hematology, The First Affiliated Hospital Zhejiang University, Hangzhou, China
⁴Key Laboratory of Hematopoietic Malignancies, Zhejiang Province, Hangzhou, China

Thomas H Shin^1,2* and David A Sweetser, M.D., Ph.D.²

¹Department of Molecular and Translational Medicine, Boston University School of Medicine, Boston, MA
²Department of Pediatrics, Massachusetts General Hospital, Boston, MA

Huanbin Zhao, PHD candidate^1*, Ping Liu, MD^1*, Ruihong Zhang, BS^1*, Min Wu, MD^1*, Donghe Li, BS^1*, Xuemei Zhao, BS^1*, Chun Zhang, MS^1*, Bo Jiao, PHD^1*, Zhu Chen, MD, PHD¹ and Ruibao Ren, MD, PhD^1,2

¹State Key Laboratory of Medical Genomics and Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
²Department of Biology, Brandeis University, Waltham, MA

Klara Srutova^1,2*, Nikola Curik^1*, Koblihova Jitka^1*, Filipp Savvulidi^3*, Hana Klamova^1,2*, Danilo Perrotti⁴, Tomas Stopka³ and Katerina Machova Polakova^1,2*

¹Institute of Hematology and Blood Transfusion, Prague, Czech Republic
²Institute of Clinical and Experimental Hematology, First Faculty of Medicine, Charles University, Prague, Czech Republic
³Pathological Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic
⁴Department of Medicine, Greenebaum Cancer Center, University of Maryland Baltimore, Baltimore, MD

Kathrin Krowiorz^1*, Razan Jammal^2*, Stephan Emmrich, PhD, MSc^2*, Arefeh Rouhi, PhD^1*, Michael Heuser, M.D.³, Lars Bullinger⁴, Konstanze Döhner, MD¹, Lai Courteney^5*, Tobias Maetzig, PhD^6*, Vera Martins^1*, Medhanie Assmelash Mulaw, BSc, MSc, PhD^7*, Dirk Heckl, PhD^2*, Christian M. Zwaan, MD, PhD⁸, Jan Stary⁹, Andre Baruchel, MD^10,11, Valerie De Haas, MD, PhD¹², Dirk Reinhardt, MD¹³, Maarten Fornerod^14*, Hartmut Döhner, MD^1*, Jens Ruschmann^5*, Marry M van den Heuvel-Eibrink, MD, PhD^15,16*, R. Keith Humphries, MD, PhD⁶, Florian Kuchenbauer, MD, PhD¹ and Jan-Henning Klusmann, MD²

¹Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
²Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
³Hematology, Hemostasis, Oncology and SCT, Hannover Medical School, Hannover, Germany
⁴Department of Internal Medicine III, Ulm, Germany
⁵Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada
⁶Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada
⁷Institute for Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany
⁸Department of Pediatric Oncology, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands
⁹CLIP- Childhood Leukaemia Investigation Prague, Department of Paediatric Haematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
¹⁰Pediatric Hematology and Immunology Department, Robert Debré Hospital - APHP and University Paris Diderot, Paris, France
¹¹Hematology, St. Louis Hospital, Paris, France
¹²Dutch Childhood Oncology Group, The Hague, Netherlands
¹³AML-BFM Study Group, Pediatric Hematology/Oncology, University Children’s Hospital Essen, Essen, Germany
¹⁴Pediatric Oncology/Hematology, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands
¹⁵Department of Pediatric Oncology, Princess Maxima Center for Paediatric Oncology, Utrecht, Netherlands
¹⁶Department of Paediatric Oncology/Hematology, Erasmus MC-Sophia’s Children’s Hospital, Rotterdam, Netherlands

Hamza Celik, PhD¹, Andrew Martens^1*, Cates Mallaney^1*, Elizabeth Eultgen^1*, Alok Kothari, M.D.^2*, Gregory Fishberger^3* and Grant A. Challen, PhD¹

¹Washington University School of Medicine, St Louis, MO
²Washington University School of Medicine, Saint Louis, MO
³Washington University in St Louis, St Louis, MO

Su-Fern Tan, PhD^1*, Xin Liu, MD, PhD^2*, Kathleen Broeg, B.S.^2*, Todd E. Fox, Ph.D.^3*, David J. Feith, Ph.D.^1,4* and Thomas P. Loughran Jr., MD⁴

¹Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA
²Pennsylvania State Hershey Cancer Institute, Hershey, PA
³Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA
⁴University of Virginia Cancer Center, Charlottesville, VA

Megan A. Hatlen, Ph.D.^1*, Kanika Arora, MS^2*, Vladimir Vacic, PhD^2*, Ewa A. Grabowska, BS^2*, Willey Liao, BS^2*, Bridget Riley-Gillis, PhD^2*, Dayna M. Oschwald, BS^2*, Lan Wang, PhD^3*, Jacob E. Joergens^1*, Alan H. Shih, MD, PhD^1,4, Franck Rapaport, PhD^5*, Shengqing Gu, PhD^6*, Francesca Voza, BS^1*, Takashi Asai, MD, PhD^3*, Benjamin Neel, MD, PhD⁷, Michael G. Kharas, PhD⁸, Mithat Gonen, PhD^9*, Ross L. Levine, MD^4,10 and Stephen D. Nimer, MD¹¹

¹Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY
²New York Genome Center, New York, NY
³University of Miami, Miami, FL
⁴Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Department of Bioinformatics, Memorial Sloan Kettering Cancer Center, New York, NY
⁶University Health Network Research, Toronto, ON, Canada
⁷Cancer Biology Program, Beth Israel Deaconess Med. Ctr., Boston, MA
⁸Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY
⁹Statistics, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁰Memorial Sloan Kettering Cancer Center, New York, NY
¹¹Sylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, and Department of Medicine, University of Miami Miller School of Medicine, Miami, FL

Erin K Hertlein, PhD¹, Timothy L Chen^1*, David M Lucas, PhD¹, Nikhil Gupta^1*, Jessica MacMurray^1*, Virginia M. Goettl, DVM , PhD^2*, Amy M. Lehman, MAS^3*, Amy J. Johnson, PhD² and John C Byrd, MD¹

¹Comprehensive Cancer Center, The Ohio State University, Columbus, OH
²Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH
³Center for Biostatistics, Department of Bioinformatics, The Ohio State University, Columbus, OH

Zhi Wen, PhD, MD¹ and Jing Zhang, PhD²

¹Oncology, University of Wisconsin-Madison, Madison, WI
²McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI

Johanna Melo-Cardenas, Yuanming Xu^*, Beixue Gao^* and Deyu Fang^*

Northwestern University, Chicago, IL

Florida Voli, MSc^1*, Hangyu Yi, BA^1*, Brendon Martinez, BA^1*, Richard J D'Andrea, PhD² and Jenny Yingzi Wang, PhD¹

¹Children’s Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, Australia
²Centre for Cancer Biology, SA Pathology & University of South Australia, Adelaide, Australia

Xi Yang^1* and Yuping Gong, MD, PhD²

¹Department of Hematology, West China Hospital, Sichuan University, chengdu, China
²Department of Hematology, West China Hospital, Sichuan University, Chengdu, China

Pei-Yu Kuo, MS^1*, Zewei Jiang, MD^1*, Deepak Perumal, PhD^1*, Violetta V Leshchenko, PhD^1*, Alessandro Lagana', Ph.D^1*, Samuel G. Katz, MD, PhD^2*, Loren D. Walensky, MD, Ph.D^3*, Rita Shaknovich, M.D., PhD.^4*, B. Hilda Ye, PhD⁵ and Samir Parekh, MD¹

¹Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY
²Yale University, New Haven, CT
³Department of Pediatric Oncology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA
⁴Weill Cornell Medical College, Division of Hematology/Oncology, New York, NY
⁵Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY

Juo-Chin Yao, BS^1*, Terrence Neal Wong, MD PhD¹, Maria Trissal, BS^1*, Yaping Sun, MD, PhD², Timothy J. Ley, MD¹, Pavan Reddy, MD³ and Daniel C. Link, MD¹

¹Division of Oncology, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO
²Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI
³Blood and Marrow Transplant Program, University of Michigan, Ann Arbor, MI

Lai N Chan, PhD^1*, Zhengshan Chen, PhD/MD^1*, Daniel Braas, PhD^2*, Huimin Geng, PhD^1*, Christian Hurtz, PhD^3*, Seyedmehdi Shojaee, PhD^1*, Valeria Cazzaniga, PhD^1*, Carina Ng^1*, Thomas Ernst, MD^4*, Andreas Hochhaus, MD⁵, Steven M Kornblau, PhD^6*, Giovanni Cazzaniga, PhD⁷, Grace Liu, PhD^8*, Thomas Milne, PhD^9*, H. Phillip Koeffler, MD¹⁰, Scott A. Armstrong, MD, PhD¹¹, Ross Alexander Dickins, PhD^12*, Keith R Yamamoto, PhD^13*, Thomas G Graeber, PhD^14* and Markus Muschen, MD PhD¹⁵

¹University of California San Francisco, San Francisco, CA
²University of California Los Angeles, Los Angeles, CA
³UCSF, San Francisco, CA
⁴Universitätsklinikum Jena, Jena, Germany
⁵Abteilung Hämatologie/Onkologie, Universitätsklinikum Jena, Jena, Germany
⁶The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁷Centro Ricerca Tettamanti, Department of Pediatrics, University of Milano-Bicocca, Fondazione MBBM/San Gerardo Hospital, Monza, Italy
⁸Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
⁹Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
¹⁰UCLA School of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA
¹¹Memorial Sloan-Kettering Cancer Center, New York, NY
¹²Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
¹³University of California San Francisco, San Francisco
¹⁴University of California Los Angeles, Los Angeles
¹⁵Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA

Charisa Cottonham, PhD^*, Jon Akutagawa^*, Inbal Epstein^*, Lana Bogdanova^* and Benjamin S. Braun, MD, PhD

Dept. of Pediatrics and the Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA

Ruchi Pandey, Ph.D.^1*, Raghuveer Mali, Ph.D.^2*, Anindya Chatterjee, MS, PhD^1*, Fabrice Paublant^3*, Renaud Prudent^3*, Laurence Lafanechere^3* and Reuben Kapur, Ph.D.¹

¹Indiana University School of Medicine, Indianapolis, IN
²Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN
³University of Grenoble Alpes, Grenoble, France

Kyle A. Beckwith, BS^1*, Erich I. Williams, BS^2*, Mark D. Wright, PhD^3*, Annemiek B. van Spriel, PhD^4*, John C. Byrd, MD^2,5 and Natarajan Muthusamy, DVM, Ph.D.^2,6

¹Division of Hematology, Department of Medicine, The Ohio State University, Columbus, OH
²Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH
³Department of Immunology, Monash University, Melbourne, Australia
⁴Department of Tumor Immunology, Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands
⁵Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH
⁶Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH

Bartlomiej Przychodzen, MSc^1*, Xiaorong Gu, PhD^2*, Dewen You, PhD^3*, Cassandra M. Hirsch^4*, Michael J. Clemente^1*, Aaron D. Viny, MD, MS⁵, Ross L. Levine, MD⁶, Torsten Haferlach⁷, Manja Maggendorfer^8*, Mikkael A. Sekeres, MD, MS⁹, Hetty E. Carraway, MD, MBA¹⁰, Aziz Nazha, MD¹¹, Francis Enane^12* and Jaroslaw P. Maciejewski, MD, Ph.D.¹³

¹Department of Translational Hematology and Oncology Research, Taussing Cancer Institute, Cleveland Clinic, Cleveland, OH
²Taussig Cancer Institute/Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, OH
³Translasional Hematology Oncology Research, Cleveland Clinic, Cleveland, OH
⁴Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, OH
⁵Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY
⁶Memorial Sloan Kettering Cancer Center, New York, NY
⁷MLL Munich Leukemia Laboratory, Munich, Germany
⁸MLL, Munich, Germany
⁹Leukemia Program, Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
¹⁰Leukemia Program, Cleveland Clinic, Cleveland, OH
¹¹Leukemia Program, Department of Hematology and Oncology, Cleveland Clinic, Taussig Cancer Institute, Cleveland, OH
¹²Department of Translational Hematology Oncology Research Cleveland Clinic, Cleveland
¹³Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH