-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

603.P1.66 603. Oncogenes and Tumor Suppressors: Poster I

Oncogenes and Tumor Suppressors Program: Oral and Poster Abstracts
Type: Poster
Saturday, December 5, 2015: 5:30 PM-7:30 PM
Hall A, Level 2 (Orange County Convention Center)

Chao Hu1,2,3*, Xi Jiang, PhD1,2, Bryan Ulrich2*, Yungui Wang, PhD1,2,3*, Rui Su, PhD1, Hengyou Weng, PhD1,2*, Huilin Huang, PhD1, Jennifer Strong1*, Ping Chen2*, Shenglai Li2*, Jianjun Chen, PhD1,2 and Jie Jin, MD, PhD4

1Department of Cancer Biology, University of Cincinnati, Cincinnati, OH
2Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL
3Department of Hematology, The First Affiliated Hospital Zhejiang University, Hangzhou, China
4Key Laboratory of Hematopoietic Malignancies, Zhejiang Province, Hangzhou, China

Thomas H Shin1,2* and David A Sweetser, M.D., Ph.D.2

1Department of Molecular and Translational Medicine, Boston University School of Medicine, Boston, MA
2Department of Pediatrics, Massachusetts General Hospital, Boston, MA

Huanbin Zhao, PHD candidate1*, Ping Liu, MD1*, Ruihong Zhang, BS1*, Min Wu, MD1*, Donghe Li, BS1*, Xuemei Zhao, BS1*, Chun Zhang, MS1*, Bo Jiao, PHD1*, Zhu Chen, MD, PHD1 and Ruibao Ren, MD, PhD1,2

1State Key Laboratory of Medical Genomics and Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Biology, Brandeis University, Waltham, MA

Klara Srutova1,2*, Nikola Curik1*, Koblihova Jitka1*, Filipp Savvulidi3*, Hana Klamova1,2*, Danilo Perrotti4, Tomas Stopka3 and Katerina Machova Polakova1,2*

1Institute of Hematology and Blood Transfusion, Prague, Czech Republic
2Institute of Clinical and Experimental Hematology, First Faculty of Medicine, Charles University, Prague, Czech Republic
3Pathological Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic
4Department of Medicine, Greenebaum Cancer Center, University of Maryland Baltimore, Baltimore, MD

Kathrin Krowiorz1*, Razan Jammal2*, Stephan Emmrich, PhD, MSc2*, Arefeh Rouhi, PhD1*, Michael Heuser, M.D.3, Lars Bullinger4, Konstanze Döhner, MD1, Lai Courteney5*, Tobias Maetzig, PhD6*, Vera Martins1*, Medhanie Assmelash Mulaw, BSc, MSc, PhD7*, Dirk Heckl, PhD2*, Christian M. Zwaan, MD, PhD8, Jan Stary9, Andre Baruchel, MD10,11, Valerie De Haas, MD, PhD12, Dirk Reinhardt, MD13, Maarten Fornerod14*, Hartmut Döhner, MD1*, Jens Ruschmann5*, Marry M van den Heuvel-Eibrink, MD, PhD15,16*, R. Keith Humphries, MD, PhD6, Florian Kuchenbauer, MD, PhD1 and Jan-Henning Klusmann, MD2

1Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
2Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
3Hematology, Hemostasis, Oncology and SCT, Hannover Medical School, Hannover, Germany
4Department of Internal Medicine III, Ulm, Germany
5Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada
6Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada
7Institute for Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany
8Department of Pediatric Oncology, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands
9CLIP- Childhood Leukaemia Investigation Prague, Department of Paediatric Haematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
10Pediatric Hematology and Immunology Department, Robert Debré Hospital - APHP and University Paris Diderot, Paris, France
11Hematology, St. Louis Hospital, Paris, France
12Dutch Childhood Oncology Group, The Hague, Netherlands
13AML-BFM Study Group, Pediatric Hematology/Oncology, University Children’s Hospital Essen, Essen, Germany
14Pediatric Oncology/Hematology, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands
15Department of Pediatric Oncology, Princess Maxima Center for Paediatric Oncology, Utrecht, Netherlands
16Department of Paediatric Oncology/Hematology, Erasmus MC-Sophia’s Children’s Hospital, Rotterdam, Netherlands

Hamza Celik, PhD1, Andrew Martens1*, Cates Mallaney1*, Elizabeth Eultgen1*, Alok Kothari, M.D.2*, Gregory Fishberger3* and Grant A. Challen, PhD1

1Washington University School of Medicine, St Louis, MO
2Washington University School of Medicine, Saint Louis, MO
3Washington University in St Louis, St Louis, MO

Su-Fern Tan, PhD1*, Xin Liu, MD, PhD2*, Kathleen Broeg, B.S.2*, Todd E. Fox, Ph.D.3*, David J. Feith, Ph.D.1,4* and Thomas P. Loughran Jr., MD4

1Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA
2Pennsylvania State Hershey Cancer Institute, Hershey, PA
3Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA
4University of Virginia Cancer Center, Charlottesville, VA

Megan A. Hatlen, Ph.D.1*, Kanika Arora, MS2*, Vladimir Vacic, PhD2*, Ewa A. Grabowska, BS2*, Willey Liao, BS2*, Bridget Riley-Gillis, PhD2*, Dayna M. Oschwald, BS2*, Lan Wang, PhD3*, Jacob E. Joergens1*, Alan H. Shih, MD, PhD1,4, Franck Rapaport, PhD5*, Shengqing Gu, PhD6*, Francesca Voza, BS1*, Takashi Asai, MD, PhD3*, Benjamin Neel, MD, PhD7, Michael G. Kharas, PhD8, Mithat Gonen, PhD9*, Ross L. Levine, MD4,10 and Stephen D. Nimer, MD11

1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY
2New York Genome Center, New York, NY
3University of Miami, Miami, FL
4Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
5Department of Bioinformatics, Memorial Sloan Kettering Cancer Center, New York, NY
6University Health Network Research, Toronto, ON, Canada
7Cancer Biology Program, Beth Israel Deaconess Med. Ctr., Boston, MA
8Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY
9Statistics, Memorial Sloan Kettering Cancer Center, New York, NY
10Memorial Sloan Kettering Cancer Center, New York, NY
11Sylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, and Department of Medicine, University of Miami Miller School of Medicine, Miami, FL

Erin K Hertlein, PhD1, Timothy L Chen1*, David M Lucas, PhD1, Nikhil Gupta1*, Jessica MacMurray1*, Virginia M. Goettl, DVM , PhD2*, Amy M. Lehman, MAS3*, Amy J. Johnson, PhD2 and John C Byrd, MD1

1Comprehensive Cancer Center, The Ohio State University, Columbus, OH
2Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH
3Center for Biostatistics, Department of Bioinformatics, The Ohio State University, Columbus, OH

Zhi Wen, PhD, MD1 and Jing Zhang, PhD2

1Oncology, University of Wisconsin-Madison, Madison, WI
2McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI

Johanna Melo-Cardenas, Yuanming Xu*, Beixue Gao* and Deyu Fang*

Northwestern University, Chicago, IL

Florida Voli, MSc1*, Hangyu Yi, BA1*, Brendon Martinez, BA1*, Richard J D'Andrea, PhD2 and Jenny Yingzi Wang, PhD1

1Children’s Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, Australia
2Centre for Cancer Biology, SA Pathology & University of South Australia, Adelaide, Australia

Xi Yang1* and Yuping Gong, MD, PhD2

1Department of Hematology, West China Hospital, Sichuan University, chengdu, China
2Department of Hematology, West China Hospital, Sichuan University, Chengdu, China

Pei-Yu Kuo, MS1*, Zewei Jiang, MD1*, Deepak Perumal, PhD1*, Violetta V Leshchenko, PhD1*, Alessandro Lagana', Ph.D1*, Samuel G. Katz, MD, PhD2*, Loren D. Walensky, MD, Ph.D3*, Rita Shaknovich, M.D., PhD.4*, B. Hilda Ye, PhD5 and Samir Parekh, MD1

1Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY
2Yale University, New Haven, CT
3Department of Pediatric Oncology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA
4Weill Cornell Medical College, Division of Hematology/Oncology, New York, NY
5Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY

Juo-Chin Yao, BS1*, Terrence Neal Wong, MD PhD1, Maria Trissal, BS1*, Yaping Sun, MD, PhD2, Timothy J. Ley, MD1, Pavan Reddy, MD3 and Daniel C. Link, MD1

1Division of Oncology, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO
2Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI
3Blood and Marrow Transplant Program, University of Michigan, Ann Arbor, MI

Lai N Chan, PhD1*, Zhengshan Chen, PhD/MD1*, Daniel Braas, PhD2*, Huimin Geng, PhD1*, Christian Hurtz, PhD3*, Seyedmehdi Shojaee, PhD1*, Valeria Cazzaniga, PhD1*, Carina Ng1*, Thomas Ernst, MD4*, Andreas Hochhaus, MD5, Steven M Kornblau, PhD6*, Giovanni Cazzaniga, PhD7, Grace Liu, PhD8*, Thomas Milne, PhD9*, H. Phillip Koeffler, MD10, Scott A. Armstrong, MD, PhD11, Ross Alexander Dickins, PhD12*, Keith R Yamamoto, PhD13*, Thomas G Graeber, PhD14* and Markus Muschen, MD PhD15

1University of California San Francisco, San Francisco, CA
2University of California Los Angeles, Los Angeles, CA
3UCSF, San Francisco, CA
4Universitätsklinikum Jena, Jena, Germany
5Abteilung Hämatologie/Onkologie, Universitätsklinikum Jena, Jena, Germany
6The University of Texas M.D. Anderson Cancer Center, Houston, TX
7Centro Ricerca Tettamanti, Department of Pediatrics, University of Milano-Bicocca, Fondazione MBBM/San Gerardo Hospital, Monza, Italy
8Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
9Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
10UCLA School of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA
11Memorial Sloan-Kettering Cancer Center, New York, NY
12Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
13University of California San Francisco, San Francisco
14University of California Los Angeles, Los Angeles
15Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA

Charisa Cottonham, PhD*, Jon Akutagawa*, Inbal Epstein*, Lana Bogdanova* and Benjamin S. Braun, MD, PhD

Dept. of Pediatrics and the Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA

Ruchi Pandey, Ph.D.1*, Raghuveer Mali, Ph.D.2*, Anindya Chatterjee, MS, PhD1*, Fabrice Paublant3*, Renaud Prudent3*, Laurence Lafanechere3* and Reuben Kapur, Ph.D.1

1Indiana University School of Medicine, Indianapolis, IN
2Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN
3University of Grenoble Alpes, Grenoble, France

Kyle A. Beckwith, BS1*, Erich I. Williams, BS2*, Mark D. Wright, PhD3*, Annemiek B. van Spriel, PhD4*, John C. Byrd, MD2,5 and Natarajan Muthusamy, DVM, Ph.D.2,6

1Division of Hematology, Department of Medicine, The Ohio State University, Columbus, OH
2Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH
3Department of Immunology, Monash University, Melbourne, Australia
4Department of Tumor Immunology, Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands
5Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH
6Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH

Bartlomiej Przychodzen, MSc1*, Xiaorong Gu, PhD2*, Dewen You, PhD3*, Cassandra M. Hirsch4*, Michael J. Clemente1*, Aaron D. Viny, MD, MS5, Ross L. Levine, MD6, Torsten Haferlach7, Manja Maggendorfer8*, Mikkael A. Sekeres, MD, MS9, Hetty E. Carraway, MD, MBA10, Aziz Nazha, MD11, Francis Enane12* and Jaroslaw P. Maciejewski, MD, Ph.D.13

1Department of Translational Hematology and Oncology Research, Taussing Cancer Institute, Cleveland Clinic, Cleveland, OH
2Taussig Cancer Institute/Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, OH
3Translasional Hematology Oncology Research, Cleveland Clinic, Cleveland, OH
4Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, OH
5Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY
6Memorial Sloan Kettering Cancer Center, New York, NY
7MLL Munich Leukemia Laboratory, Munich, Germany
8MLL, Munich, Germany
9Leukemia Program, Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
10Leukemia Program, Cleveland Clinic, Cleveland, OH
11Leukemia Program, Department of Hematology and Oncology, Cleveland Clinic, Taussig Cancer Institute, Cleveland, OH
12Department of Translational Hematology Oncology Research Cleveland Clinic, Cleveland
13Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH

*signifies non-member of ASH