57th ASH Annual Meeting and Exposition (December 5-8, 2015): 504. Hematopoiesis: Cytokines, Signal Transduction, Apoptosis and Cell Cycle Regulation: Poster I

Hematopoiesis: Cytokines, Signal Transduction, Apoptosis and Cell Cycle Regulation Oral and Poster Abstracts
Poster

Hall A, Level 2 (Orange County Convention Center)

Podocalyxin Negatively Regulates Stress Myelopoiesis, Directly Binds Rap-1A and Modulates Its G-CSF-Induced Activity

Pan Li^1,2^*, Rose McGlauflin¹^*, Amanda J Favreau¹, Edward Jachimowicz³^*, Calvin Vary¹^*, Kailin Xu²^*, Don M Wojchowski⁴ and Pradeep Sathyanarayana⁵

¹Maine Medical Center Research Institute, Scarborough, ME
²Department of Hematology, The Affiliated Hospital of Xuzhou Medical College, Xuzhou, China
³COBRE Center of Excellence in Stem & Progenitor Cell Biology and Regenerative Medicine, Maine Medical Center Research Institute, Scarborough, ME
⁴COBRE Center of Excellence in Stem Cell Biology and Regenerative Medicine, Maine Medical Center Research Institute, Scarborough, ME
⁵Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME

1185

Leukemia Cell Infiltration Causes Defective Erythropoiesis Partially through MIP-1alpha

Yajie Wang¹^*, Sha Hao, Ph.D.¹^*, Ping Lu, M.Sc.¹^*, Hui Cheng, Ph.D.^1,2^*, Yuemin Gong¹^* and Tao Cheng, MD^1,2,3

¹Institute of Hematology & Blood Diseases Hospital, State Key Laboratory of Experimental Hematology, Tianjin, China
²Center for Stem Cell Medicine, Tianjin, China
³Department of Stem Cell and Regenerative Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

1186

Thrombopoietin (TPO) Induces Hematopoietic Differentiation of Mouse ES Cells Via HIF-1 Alpha-Dependent Activation of a BMP4 Autoregulatory Loop

Azadeh Zahabi¹^*, Tatsuya Morishima, MD, PhD¹^*, Andri Pramono²^*, Dan Lan²^*, Lothar Kanz, MD³, Karl Welte, MD⁴^* and Julia Skokowa, Prof. Dr.¹^*

¹Division of Translational Oncology, Department of Oncology, Hematology, Immunology, Rheumatology and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany
²Division of Translational Oncology, Department of Hematology, Oncology, Immunology, Rheumatology and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany
³Dept. of Hematology, Oncology, Rheumatology, Immunology and Pulmology, University Hospital Tübingen, Tübingen, Germany
⁴University Children’s Hospital Tuebingen, Tuebingen, Germany

1187

ANF-Rho: A Dose-Ranging Phase I Study to Determine Safety, Pharmacokinetics and Pharmacodynamics in Healthy Volunteers

Deven V. Parmar, MD, Daniel Byczkowski^*, Ronald G. Jubin, PhD, Abraham Abuchowski, PhD^*, Peter Buontempo, MSc, BSc^*, Gerry Gitlin^*, Michelle Boro^* and Hemant K. Misra, PhD

Prolong Pharmaceuticals, South Plainfield, NJ

1188

The Gadd45 Family As Mediators of Hematopoietic Stem Cell Differentiation - from Genotoxic Stress to Cytokine-Induced Differentiation

Susanne Wingert, MSc¹^*, Frederic B Thalheimer, PhD¹^*, Nadine Haetscher, MSc¹^*, Maike Rehage, PhD¹^*, Hubert Serve, MD², Timm Schroeder, PhD³^* and Michael A. Rieger, PhD¹^*

¹LOEWE Center for Cell and Gene Therapy and Department for Hematology/Oncology, Goethe-University Hospital Frankfurt, Frankfurt am Main, Germany
²Department for Hematology/Oncology, Goethe-University Hospital Frankfurt, Frankfurt am Main, Germany
³Department of Biosystems Science and Engineering (D-BSSE), Swiss Federal Institute of Technology (ETH) Zürich, Basel, Switzerland

1189

Ott1(Rbm15) Regulates p53 Levels during Oncogenic and Proliferative Stress

Sakiko Suzuki, MD^*, Nathan A Manalo, B.A. M.A.^* and Glen D Raffel, M.D, Ph.D.

Division of Hematology/Oncology, University of Massachusetts Medical School, Worcester, MA

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^*signifies non-member of ASH

504.P1.18 504. Hematopoiesis: Cytokines, Signal Transduction, Apoptosis and Cell Cycle Regulation: Poster I