Margareth Castro Ozelo, MD, PhD¹, Johnny Mahlangu^2*, Godfrey Chan^3*, Margareta Holmstrom^4*, Nicolas Novitzky⁵, David J Perry⁶, Huixing Yuan^7*, Lynda M Cristiano^7* and Baisong Mei^7*

¹INCT do Sangue Hemocentro UNICAMP, Campinas, Brazil
²Faculty of Health Sciences, University of the Witwatersrand and NHLS, Johannesburg, South Africa
³Department of Pediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong, Hong Kong
⁴Karolinska University Hospital, Stockholm, Sweden
⁵University of Cape Town, Cape Town, South Africa
⁶Addenbrooke’s Hospital, Cambridge, United Kingdom
⁷Biogen, Cambridge, MA

Shannon Meeks, MD, W. Hunter Baldwin, BS^* and Courtney Cox, MS^*

Aflac Cancer and Blood Disorders Center, Emory University/Children's Healthcare of Atlanta, Atlanta, GA

Florian Langer^1*, Minna Voigtländer^1*, Katharina Holstein^1*, Brigitte Spath^1*, Walter Fiedler, MD² and Carsten Bokemeyer, MD^1*

¹II. Medizinische Klinik und Poliklinik, Universitätsklinikum Eppendorf, Hamburg, Germany
²Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Laurent Frenzel, MD, PhD^1,2,3*, Stephanie Luzy, MD^4*, Cecile Lozach, MD^4*, Richard Delarue, MD¹, Olivier Hermine^1,5*, Annie Harroche, MD^3*, Chantal Rothschild, MD^3* and Sylvain Breton, MD^4*

¹Hematology Department, AP-HP Hôpital Necker, Paris, France
²Molecular and cellular mecanisms of hemophilic arthropathy - Institut Imagine, INSERM U 1163/CNRS ERL 8254, Paris, France
³Hemophilia Center, AP-HP Hôpital Necker, Paris, France
⁴Pediatric radiology unit, AP-HP Hopital Necker, Paris, France
⁵Institut Imagine, INSERM 1163/CNRS ERL 8254, Paris, France

K John Pasi¹, David J Perry², Johnny Mahlangu^3*, Barbara A Konkle, MD⁴, Savita Rangarajan⁵, Simon Brown^6*, Hideji Hanabusa^7*, Shannon Jackson⁸, Ingrid Pabinger⁹, Lynda M Cristiano^10*, Yingwen Dong^10*, Elisa Tsao^10*, Glenn F Pierce¹⁰ and Geoffrey Allen¹⁰

¹Barts and the London Comprehensive Care Center, London, United Kingdom
²Addenbrooke’s Hospital, Cambridge, United Kingdom
³University of the Witwatersrand Faculty of Health Sciences, Johannesburg, South Africa
⁴BloodworksNW Research Institute, Seattle, WA
⁵Basingstoke and North Hampshire Hospital, Basingstoke, United Kingdom
⁶Lady Cilento Children’s Hospital, Brisbane, Australia
⁷Department of Hemalotogy, Ogikubo Hospital, Tokyo, Japan
⁸St Paul’s Hospital, Vancouver, BC, Canada
⁹Medizinsche Universitat Wien, Vienna, Austria
¹⁰Biogen, Cambridge, MA

Johnny Mahlangu^1*, Amy D Shapiro, MD², K John Pasi³, Margaret V Ragni⁴, Margareth Castro Ozelo, MD, PhD⁵, Johannes Oldenburg⁶, Tadashi Matsushita, MD, PhD⁷, Ross I Baker, MD⁸, Huixing Yuan^9*, Alejandra Ramirez-Santiago^9*, Glenn F Pierce⁹, Geoffrey Allen⁹ and Baisong Mei^9*

¹Haemophilia Comprehensive Care Centre, Faculty of Health Sciences, University of the Witwatersrand and NHLS, Johannesburg, South Africa
²Indiana Hemophilia & Thrombosis Center, Indianapolis, IN
³Royal London Haemophilia Centre, Barts and the London School of Medicine and Dentistry, London, United Kingdom
⁴Hemophilia Center of Western Pennsylvania, University of Pittsburgh, Pittsburgh, PA
⁵INCT do Sangue Hemocentro Unicamp, University of Campinas, Unicamp, Campinas, SP, Brazil
⁶Institute of Experimental Haematology and Transfusion Medicine, University of Bonn, Bonn, Germany
⁷Department of Transfusion Medicine, Nagoya University Hospital, Nagoya, Japan
⁸Western Australia Centre for Thrombosis and Haemostasis, Murdoch University, Perth, Australia
⁹Biogen, Cambridge, MA

Kyung-Hwa Shin^1* and In-Suk Kim^2*

¹Department of laboratory medicine, Pusan national university, Busan, South Korea
²Department of Laboratory Medicine, Pusan National University Yangsan Hospital, Pusan, South Korea

Sandra L Haberichter, PhD¹, Tricia L Slobodianuk^1*, Andrew Podd^1*, Kenneth D Friedman, MD¹ and Veronica H Flood, MD²

¹Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI
²BloodCenter of Wisconsin, Medical College of Wisconsin, Department of Pediatrics, Milwaukee, WI

Joseph Shatzel, MD^1*, Sharl Azar, MD^2,3, Nathanael David Gay, MD⁴, Jai Luo, MD^5*, Thomas G. Deloughery, MD⁶, Michael Recht, MD, PhD⁷ and Jason A. Taylor, MD, PhD²

¹Department of Hematology/Oncology, Oregon Health and Science University, Portland, OR
²The Hemophilia Center, Oregon Health & Science University, Portland, OR
³Portland Veterans Affairs Medical Center, Portland, OR
⁴Oregon Health & Science University, Portland, OR
⁵Department of Medicine, Oregon Health and Science University, Portland, OR
⁶Oregon Health and Science University, Portland, OR
⁷The Hemophilia Center, Oregon health & Science University, Portland

Amin Benyounes, MD¹, Nellowe Candelario, MD^2*, Leonard Braitman, PhD^1*, John C. Leighton Jr., MD³, William Tester, MD^4* and Gabor Varadi, MD⁵

¹Einstein Medical Center, Philadelphia, PA
²Department of Medicine, Einstein Medical Center, Philadelphia, PA
³Albert Einstein Cancer Center, Philadelphia
⁴Albert Einstein Cancer Center, Philadelphia, PA
⁵Division of Hematology/Oncology, Einstein Medical Center, Philadelphia, PA

Roshni Kulkarni¹, Beatrice Nolan^2*, Carolyn M. Bennett^3*, Kathelijn Fischer^4*, David J Perry⁵, Christopher Barnes^6*, Huixing Yuan^7*, Alejandra Ramirez-Santiago^7*, Glenn F Pierce⁷ and Baisong Mei^7*

¹Dept. Of Pediatrics and Human Development, Michigan State University, East Lansing, MI
²Our Lady's Children's Hospital, Dublin, Ireland
³Emory University School of Medicine, Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center, Atlanta, GA
⁴University Medical Center, Utrecht, Netherlands
⁵Addenbrooke’s Hospital, Cambridge, United Kingdom
⁶Royal Childrens Hospital, Parkville, Melbourne, Australia
⁷Biogen, Cambridge, MA

Patrick Van Dreden, Ph.D.¹, Sophie Hillaire^2*, Matthieu Grusse^3*, Dominique François^4*, Catherine Gorin^5* and Marc Vasse, PharmD^6*

¹Clinical Research Department, R&D, Diagnostica Stago, Gennevilliers, France
²Internal Medicine department, Hôpital Foch, Suresnes, France
³Clinical Research Department, Diagnostica Stago, Gennevilliers, France
⁴Biology department, Hôpital Foch, Suresnes, France
⁵Diagnostica Stago, Gennevilliers, France
⁶Biology department & INSERM U1176, Hôpital Foch, Suresnes, France

Dirk Garmann^1*, Matthias Frede^1*, Anita Shah^2* and Bart Ploeger^1*

¹Quantitative Pharmacology, Bayer Pharma AG, Wuppertal/Berlin, Germany
²Bayer HealthCare, Whippany, NJ

Aaron Lubetsky, MD¹, Uri Martinowitz, MD^1*, Toshko Lissitchkov, MD^2*, Christine Voigt, PhD^3*, Denise Wolko^3*, Iris C. Jacobs, MD³ and Elena Santagostino, MD, PhD⁴

¹The Israeli National Hemophilia Center, Chaim Sheba Medical Center, Tel Hashomer, Israel
²Department of Coagulation Disorders and Anemia, SHAT Joan Pavel, Sofia, Bulgaria
³CRD, CSL Behring, King of Prussia, PA
⁴Centro Emofilia e Trombosi, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy

Naomi Sanda, Msc^1,2*, Nobuaki Suzuki, MD, PhD^3*, Takeshi Kanematsu, MD^4*, Mika Ogawa, MD^4*, Mayuko Kishimoto, MD, PhD^5*, Shigeo Nakamura, MD, PhD² and Tadashi Matsushita, MD, PhD^3,5

¹Department of Medical Technique, Nagoya University Hospital, Nagoya, Japan
²Department of Pathology and Clinical Laboratories, Nagoya University Graduate School of Medicine, Nagoya, Japan
³Department of Transfusion Medicine, Nagoya University Hospital, Nagoya, Japan
⁴Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
⁵Department of Clinical Laboratory, Nagoya University Hospital, Nagoya, Japan

Lana A Castellucci, MD, MSc^1,2,3*, Joseph Shaw, MD¹, Gregoire Le Gal, MD, PhD^3,4, Stephen Hawken, PhD^2*, Lauralyn McIntyre, MD, MSc^2* and Marc Carrier, MD, MSc^2,5,6

¹University of Ottawa, Ottawa, ON, Canada
²Ottawa Hospital Research Institute, Ottawa, ON, Canada
³The Ottawa Hospital, Ottawa, ON, Canada
⁴The Ottawa Hospital Research Institute, Ottawa, ON, Canada
⁵Department of Medicine, University of Ottawa, Ottawa, ON, Canada
⁶Ottawa Hospital General Campus, Ottawa, ON, Canada

Takeshi Kanematsu, MD^1*, Nobuaki Suzuki, MD, PhD^2*, Naomi Sanda, MSc^3*, Mika Ogawa, MD^1*, Mayuko Kishimoto, MD, PhD^3*, Atsuo Suzuki, PhD^3*, Hitoshi Kiyoi, MD, PhD¹, Ryu Kasai, MSc^4* and Tadashi Matsushita, MD, PhD²

¹Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
²Department of Transfusion Medicine, Nagoya University Hospital, Nagoya, Japan
³Department of Clinical Laboratory, Nagoya University Hospital, Nagoya, Japan
⁴Chugai Pharmaceutical Co., Ltd., Tokyo, Japan

Mario Von Depka, MD, PhD^*, Carsten Detering, MSc^*, Stefanie Döpke^* and Mahnaz Ekhlasi-Hundrieser, PhD^*

Werlhof-Institute, Hannover, Germany

Divya Nadella, BS^1*, Maha Al-Ghafry, MD², Hamayun Imran, MD^3* and Abdul H. Siddiqui, MBBS, MD^3*

¹College of Medicine, University of South Alabama, Mobile, AL
²University of South Alabama, Children's and Women's Hospital, Mobile, AL
³Pediatric Hematology-Oncology, University of South Alabama, Children's and Women's Hospital, Mobile, AL

Sumitha Elayaperumal, M.Sc^1*, Eunice Sindhuvi Edison, PhD^1*, Sankari Devi Govindanattar, B.Sc^1*, Surendar Singh, B.Sc^2*, Aby Abraham, MD, DM^1*, Biju George, DM¹, Auro Viswabandya, MD, DM³, Sukesh Nair, MD, FRCPA^2* and Alok Srivastava, MD, FRACP^1,4

¹Department of Haematology, Christian Medical College, Vellore, India
²Immunohaematology & Transfusion Medicine, Christian Medical College, Vellore, India
³Allogeneic Blood and Marrow Transplant Program, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada
⁴Christian Medical College, Centre for Stem Cell Research, Vellore, India

Nikki Church, MD, MBA^1*, Rajeev Ayyagari, PhD^2*, Jennifer Pocoski, PharmD^1*, Gautam Sajeev, ScD^2*, Sneha S Kelkar, MPH^3*, Ella X Du, MS^4*, Monika Mass-Enriquez, MD^5* and Jipan Xie, MD, PhD^3*

¹Bayer Healthcare Pharmaceuticals, Whippany, NJ
²Analysis Group Inc., Boston, MA
³Analysis Group Inc., New York, NY
⁴Analysis Group Inc., Los Angeles, CA
⁵Bayer Pharma AG, Wuppertal, Germany

Kazuo Kawasugi, MD, PhD¹, Tadashi Yamamoto, MD^1*, Naoki Shirafuji, MD, PhD¹, Shingo Yamada, PhD^2*, Ito Takashi, MD, PhD^3* and Ikuro Maruyama, MD, PhD^4*

¹Hematology/Oncology, Teikyo University School of Medicine, Tokyo, Japan
²Shino-Test Corporation, Sagamihara, Japan
³Department of Emergency and Critical Care Medicine, Kagoshima University Graduate School of Medical and Dental Science, Sakuragaoka, Japan
⁴Department of Systems Biology in Thromboregulation, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Japan

Alice D. Ma, MD¹, Robert Klamroth^2*, Marilyn J. Manco-Johnson, MD³, Werner Engl^4*, Jacqueline A Dyck-Jones, PhD^5* and Brigitt E. Abbuehl⁴

¹Department of Medicine, Division of Hematology/Oncology, University of North Carolina, Chapel Hill, NC
²Vivantes Clinic Friedrichshain, Berlin, Germany
³Mountain State Regional Hemophilia and Thrombosis Center, University of Colorado Anschutz Medical Campus, Aurora, CO
⁴Baxalta, Vienna, Austria
⁵Baxalta US Inc., Westlake Village, CA

Amanda P Waller, PhD^1*, Ruchika Sharma, MD^2*, Shipra Agrawal, PhD^1*, Roger C Wiggins, MD^3*, William E Smoyer, MD^1* and Bryce A. Kerlin, MD¹

¹Center for Clinical and Translational Research, Nationwide Children's Research Institute, Columbus, OH
²Division of Hematology/Oncology/BMT, Nationwide Children's Hospital, Columbus, OH
³Nephrology, University of Michigan, Ann Arbor, MI

Robert R. Montgomery, MD¹, Veronica H Flood, MD¹, Jieqing Zhu, PhD², Pamela A Christopherson^3*, Peter J. Newman, PhD², Daniel W. Bougie, PhD² and Patti Morateck^1*

¹Blood Research Institute, Medical College of Wisconsin, TS Zimmerman Program for the Molecular and Clinical Biology of VWD, Milwaukee, WI
²Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI
³Blood Research Institute, Zimmerman Program for the Molecular and Clinical Biology of VWD, Milwaukee, WI