57th ASH Annual Meeting and Exposition (December 5-8, 2015): 321. Blood Coagulation and Fibrinolytic Factors: Poster I (61 abstracts)

Blood Coagulation and Fibrinolytic Factors Oral and Poster Abstracts
Poster

Hall A, Level 2 (Orange County Convention Center)

The Affinity of Factor X for the Intrinsic Xase Is Determined By Exosite Interactions Between the Substrate and the Enzyme Complex

Manjunath Goolyam Basavaraj, PhD^* and Sriram Krishnaswamy, PhD

Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA

1066

Anti-C1 Domain Antibodies Are Pathogenic in a Murine Tail Snip Model Despite Low Inhibitor Titers

Glaivy Batsuli, MD¹, John Healey, BS²^*, Ernest Parker, BS²^*, Wallace Hunter Baldwin, BS²^*, Courtney Cox, MSc²^*, Brenda Nguyen, BS³^*, Pete Lollar, MD³ and Shannon L. Meeks, MD⁴

¹Aflac Cancer and Blood Disorders Center, Emory University/Children's Healthcare of Atlanta, Atlanta, GA
²Pediatrics, Emory University, Atlanta, GA
³Emory University, Atlanta, GA
⁴Aflac Cancer Center and Blood Disorders Service, Emory University, Atlanta, GA

1067

The Impact of GPIba on the Efficacy of Platelet-Targeted FVIII Gene Therapy in Hemophilia a with Pre-Existing Anti-FVIII Immunity

Juan Chen, PhD^*, Jocelyn Schroeder^*, Xiaofeng Luo, MD^*, Robert R Montgomery, MD and Qizhen Shi, MD, PhD

Medical College of Wisconsin, Blood Research Institute, Children's Research Institute, Milwaukee, WI

1068

Marginal Zone B Cell Depletion Prevents Factor VIII Inhibitor Development in Model of Hemophilia

Courtney Cox, MS¹^*, Patricia Zerra, MD¹^*, Connie Authur, PhD²^*, Seema Patel, PhD²^*, Shannon Meeks, MD¹ and Sean R. Stowell, MD, PhD³

¹Aflac Cancer and Blood Disorders Center, Emory University/Children's Healthcare of Atlanta, Atlanta, GA
²Department of Pathology, Emory University, Atlanta, GA
³Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA

1069

Analysis of the Glycan Composition on Plasma Derived ADAMTS13 Employing Tandem Mass Spectrometry

Fabian Verbij, MSc¹^*, Eva Stokhuijzen, MSc¹^*, Floris van Alphen¹^*, Paul Kaijen¹^*, Alexander Meijer, PhD²^* and Jan Voorberg, PhD¹

¹Department of Plasma Proteins, Sanquin Research, Amsterdam, Netherlands
²Department of Plasma Proteins, Sanquin Blood Supply, Amsterdam, Netherlands

1070

Tumor Cell Thrombin/PAR-1 Signaling Drives Pancreatic Ductal Adenocarcinoma Growth and Dissemination

Matthew J. Flick, PhD¹, Cheryl Rewerts, M.S.¹^*, Carolina Cruz¹^*, Joseph S. Palumbo, MD², James P. Luyendyk, PhD³^*, Yi Yang⁴^* and Stephen F. Konieczny, PhD⁴^*

¹Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
³Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI
⁴Department of Biological Sciences and the Purdue Center for Cancer Research, Purdue University, West Lafayette, IN

1071

Immune Tolerance Developed in Platelet-Targeted FVIII Gene Therapy in Hemophilia Mice Is CD4⁺ T Cell-Mediated

Yingyu Chen, PhD^1,2^*, Xiaofeng Luo, MD^1,3^*, Juan Chen, PhD¹^*, Jocelyn Schroeder¹^*, Christina K Baumgartner, PhD¹^*, Jianda Hu, MD, PhD² and Qizhen Shi, MD, PhD¹

¹Medical College of Wisconsin, Blood Research Institute, Children's Research Institute, Milwaukee, WI
²Fujian Institute of Hematology, Fujian Medical University Union Hospital, Fuzhou, China
³Department of Hematology, Union Hospital, Fujian Medical University, Fuzhou, China

1072

Correlation between Factor (F)XIa, FIXa and Tissue Factor and Trauma Severity

Saulius Butenas, PhD¹^*, Shannon M Prior, BS¹^*, Amanda Conroy, BS²^*, Mary Nelson, RN MS²^*, Lucy Kornblith, MD²^*, Benjamin Howard, MD²^* and Mitchell Jay Cohen, MD²^*

¹Department of Biochemistry, University of Vermont, Colchester, VT
²Department of Surgery, University of California San Francisco, San Francisco, CA

1073

Pharmacokinetics of BAX 826, a Polysialylated Full-Length rFVIII, in Hemophilia a Mice, Rats, and Cynomolgus Monkeys

Alexandra Schiviz, DVM¹^*, Gerald Hoebarth²^*, Martin Wolfsegger²^*, Paolo Rossato²^*, Alfred Weber²^*, Herbert Gritsch²^*, Hanspeter Rottensteiner, PhD²^*, Peter L. Turecek, PhD², Friedrich Scheiflinger, PhD³, Werner Hoellriegl, DVM²^* and Marietta Putz, MS²^*

¹Nonclinical Development, Baxalta Innovations GmbH, Vienna, Austria
²Baxalta Innovations GmbH, Vienna, Austria
³Research & Innovation, Baxalta Innovations GmbH, Vienna, Austria

1074

Newly Diagnosed Multiple Myeloma Is Associated with Enhanced TF Pathway Activation, Thrombin Generation and Increased Concentration of Procoagulant Microparticles

Grigorios T. Gerotziafas, Dr¹^*, Flora Zagouri²^*, Despina Fotiou²^*, Theodoros N. Sergentanis²^*, Kimon Stamatelopoulos²^*, Theodora Psaltopoulou²^*, Efstathios Kastritis, MD²^*, Evangelos Terpos, MD², Patrick Van Dreden, Ph.D.³, Aurélie Rousseau^4,5^*, Ilias Evmorfiadis⁴^*, Ismail Elalamy, MD, PhD^4,6, Annette Larsen⁴^* and Meletios A. Dimopoulos^7,8

¹Service d'Hématologie Biologique, Tenon University Hospital. ER2-UPMC, Faculté de Médecine Pierre et Marie Curie, Université Paris 6, Paris, France
²Department of Clinical Therapeutics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece
³Clinical Research Department, R&D, Diagnostica Stago, Gennevilliers, France
⁴INSERM U938, Faculté de Médecine Pierre et Marie Curie, Université Paris VI, Paris,France, Paris, France
⁵Clinical Research Department, Diagnostica Stago, Gennevilliers, France
⁶Service d’Hématologie Biologique Hôpital Tenon, Hôpitaux Universitaires de l’Est Parisien, Assistance Publique Hôpitaux de Paris, Paris, France
⁷National and Kapodistrian University of Athens, Athens, Greece
⁸National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

1075

In Vitro Assessment of Altered Thrombin-Fibrinogen Interaction As a Mechanism for Acute Traumatic Coagulopathy

Michael Adam Meledeo, PhD¹^*, Armando C Rodriguez, BS¹^*, Chet R Voelker, BS¹^*, James A Bynum, PhD¹^* and Andrew P Cap, MD, PhD²

¹Institute of Surgical Research, US Army, San Antonio, TX
²Coagulation and Blood Research, US Army Institute of Surgical Research, JBSA Fort Sam Houston, TX

1076

A Factor VIII with Site-Specific Pegylation Attenuates the Binding with Inhibitors Results in the Retention of Hemostatic Effect

Koji Yada, MD, PhD¹^*, Keiji Nogami, MD, PhD¹^*, Chandra Patel²^*, Derek Sim²^*, Katalin Kauser, MD, PhD²^* and Midori Shima, MD, PhD¹

¹Department of Pediatrics, Nara Medical University, Kashihara, Japan
²Bayer HealthCare LLC, San Francisco, CA

1077

ACE910 Facilitates Its Hemostatic Effect with the Lower Concentration of Factor X Than That Required for Factor VIIa-Driven Coagulation

Koji Yada, MD, PhD¹^*, Keiji Nogami, MD. PhD¹^*, Takehisa Kitazawa, DVM²^*, Kunihiro Hattori, PhD²^* and Midori Shima, MD, PhD¹

¹Department of Pediatrics, Nara Medical University, Kashihara, Japan
²Chugai Pharmaceutical, Gotemba, Japan

1078

Pharmacokinetic Properties of Different rFVIII Products in Rabbits, Rats and FVIII Ko Mice

Sabine Pestel, DVM^*, Philipp Claar, Dr rer nat^*, Jochen Müller-Cohrs, Dr rer nat^*, Elmar Raquet^*, Hendrik Peil^*, Thomas Weimer, Dr rer nat^* and Eva Herzog, PhD^*

CSL Behring GmbH, Marburg, Germany

1079

Diastolic but Not Systolic Heart Failure Is Associated with Multiple Abnormalities on Platelet Aggregation Testing

Dharmesh Gopalakrishnan, MD¹^*, Heesun J Rogers, MD, PhD²^*, Paul Elson, PhD³^* and Keith R. McCrae, MD⁴

¹Department of Medicine, Cleveland Clinic, Cleveland, OH
²Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH
³Cleveland Clinic, Quantitative Health Sciences, Cleveland, OH
⁴Taussig Cancer Institute and Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH

1080

Soluble Endothelial Protein C Receptor (sEPCR) Is Increased in Cirrhotic Patients. A Possible Role in Procoagulant Imbalance?

Thomas Sinegre, PharmD¹^*, Cedric Duron, MD²^*, Ahmed Bouras¹^*, Arnaud Serres¹^*, Marc G Berger, MD, PhD, Professor¹, Anne-Françoise Sapin¹^*, Armand Abergel, MD, PhD²^* and Aurelien Lebreton, MD, PhD¹^*

¹CHU Clermont-Ferrand, Haematology department, Clermont-Ferrand, France
²CHU Clermont-Ferrand, Hepatology department, Clermont-Ferrand, France

1081

Recombinant FIX/X-Bp from the Japanese Habu Snake Is a Universal Ligand for Purification of Highly Carboxylated Factor IX Variants and Factor X

Oblaise Mercury, BS¹^*, Lucy Liu, PhD¹^*, Ayman Ismail, PhD¹^*, Ming Zhang, PhD¹^*, Qi Lu, PhD¹^*, Tom O Cameron, PhD²^*, Allison Goodman, BS¹^*, Liz Culyba, PhD¹^*, Rahul Ravindran Nair, BS, MS¹^*, Amy M Holthaus, BS, MS¹^*, John Kulman, PhD¹^* and Robert Peters, PhD¹

¹Hematology Research, Biogen, Cambridge, MA
²Chem & Mol Therapeutics, Biogen, Cambridge, MA

1082

Human Chorionic Villus Stem Cells May Contribute to Endogenous Factor VIII Production during Gestation

Maricel G. Miguelino, MD^1,2^*, Priyadarsini Kumar, Ph.D.²^*, Jerry S. Powell, MD¹ and Aijun Wang, PhD²^*

¹Department of Internal Medicine, University of California, Davis, Sacramento, CA
²Department of Surgery, University of California, Davis, Sacramento, CA

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^*signifies non-member of ASH

321.P1.61 321. Blood Coagulation and Fibrinolytic Factors: Poster I (61 abstracts)