57th ASH Annual Meeting and Exposition (December 5-8, 2015): 301. Platelet Activation and Biochemistry: Poster I

Platelet Activation and Biochemistry Oral and Poster Abstracts
Poster

Hall A, Level 2 (Orange County Convention Center)

The Second CGHC Motif of Protein Disulfide Isomerase Mediates Thrombosis

Junsong Zhou, BS¹^*, Yi Wu², Lu Wang, BS³^*, Lubica Rauova, MD, PhD⁴, Vincent M Hayes, BS⁴^*, Mortimer Poncz, MD⁴ and David W Essex, MD⁵

¹The Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China
²Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia
³Temple University, Philadelphia
⁴Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA
⁵Hematology, Temple University School of Medicine, Philadelphia, PA

1033

Platelet CD36 Induces ERK5 Activation through a Redox-Regulated Signaling Pathway to Promote a Prothrombotic Phenotype

Moua Yang^1,2, Jeannette M. Vasquez-Vivar, PhD³^*, Yiliang Chen, PhD²^*, Scott J. Cameron, PhD, MD⁴^*, Craig N. Morrell, DVM, PhD⁴^* and Roy L. Silverstein, MD^2,5

¹Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI
²Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI
³Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI
⁴Aab Cardiovascular Research Institute, University of Rochester School of Medicine, Rochester, NY
⁵Department of Medicine, Medical College of Wisconsin, Milwaukee, WI

1034

Surface Ifitms on Megakaryocytes and Platelets Regulate Fibrinogen Endocytosis Under Inflammatory Conditions

Robert A. Campbell, PhD¹^*, Jesse W Rowley, PhD²^*, Andrew S. Weyrich, PhD^3,4 and Matthew T. Rondina, MD⁵

¹University of Utah, Salt Lake City, UT
²Program in Molecular Medicine University of Utah, Salt Lake City, UT
³The Program in Molecular Medicine, University of Utah, Salt Lake City, UT
⁴Dept of Internal Med., The University of Utah, Salt Lake City, UT
⁵Molecular Medicine, Univ. of Utah, Salt Lake City, UT

1035

Activated, But Not Unactivated, αIIbβ3 Can Mediate Adhesion to Fibrinogen Lacking the γ Chain Dodecapeptide

Hina Zafar, M.S.¹^*, Jihong Li, MD¹^*, George A David III, B.A.²^* and Barry S. Coller, MD¹

¹Allen and Frances Adler Laboratory of Blood and Vascular Biology, The Rockefeller University, New York, NY
²Valeant Pharmaceuticals, Bridgewater, NJ

1036

Inverse Effects of EDTA on αIIbβ3-Mediated Adhesion to Immobilized Fibrinogen Versus the D98 Plasmin Fragment of Fibrinogen

Hina Zafar, M.S.¹^*, Jihong Li, MD¹^*, George A David III, B.A.²^* and Barry S. Coller, MD¹

¹Allen and Frances Adler Laboratory of Blood and Vascular Biology, The Rockefeller University, New York, NY
²Valeant Pharmaceuticals, Bridgewater, NJ

1037

Functional Protection of Platelets By Tri-Block Polymer (Poloxamer-188 ) As Studied in Agonist Induced Platelet Aggregation Systems

Nil Guler, MD¹^*, Schuharazad Abro¹^*, Martin Emanuele, PhD², Omer Iqbal, MD¹, Debra Hoppensteadt, PhD¹^* and Jawed Fareed, PhD¹

¹Department of Pathology, Loyola University Medical Center, Maywood, IL
²Mast Therapeutics, San Diego, CA

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^*signifies non-member of ASH

301.P1.18 301. Platelet Activation and Biochemistry: Poster I