Gertjan Lugthart, MD^1*, Carly Vervat^1*, Janine E Melsen^1*, Monique M Van Ostaijen-ten Dam^1*, Dave L Roelen, PhD^2*, Maarten JD van Tol, PhD^1*, Arjan C Lankester, MD, PhD¹ and Marco W Schilham, PhD^1*

¹Dept. of Pediatrics, Leiden University Medical Center, Leiden, Netherlands
²Dept. of ImmunoHematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands

Darina Ocadlikova, Ph.D.^1*, Mariangela Lecciso, M.S.^1*, Elisa Orioli, M.S.^2*, Elena De Marchi, M.S.^2*, Sabina Sangaletti, Ph.D.^3*, Sara Trabanelli, Ph.D.^4*, Camilla Jandus, MD, Ph.D.^5*, Valentina Salvestrini, Ph.D.^6*, Pedro Romero, professor^7*, Mario Paolo Colombo, M.S.^3*, Francesco Di Virgilio^8*, Roberto M Lemoli, Professor⁹, Michele Cavo^10*, Elena Adinolfi^8* and Antonio Curti, MD, PhD^11*

¹University of Bologna, Dept. Experimental, Diagnostic, and Specialty Medicine (DIMES), Bologna, Italy
²University of Ferrara, Department of Morphology, Surgery and Experimental Medicine, Ferrara, Italy
³European Institute of Oncology, Milan, Italy
⁴University of Lausanne, Ludwig Cancer Research Center, Faculty of Biology and Medicine, Lausanne, Switzerland
⁵University of Lausanne, Deparment of Fundamental Oncology, Ludwig Center for Cancer Research, Faculty of Biology and Medicine, Lausanne, Switzerland
⁶Dept. Experimental, Diagnostic, and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy
⁷University of Lausanne, Deparment of Fundamental Oncology, Ludwig Cancer Research Center, Faculty of Biology and Medicine, Lausanne, Switzerland
⁸Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy
⁹University of Genoa, Genoa, Italy
¹⁰Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
¹¹University of Bologna, Bologna, Italy

Simon Voelkl, PhD^1*, Anne Rensing-Ehl^2*, Andrea Allgaeuer^1*, Elisabeth Schreiner^1*, Myriam Ricarda Lorenz^3*, Jan Rohr^2*, Christian Klemann^4*, Ilka Fuchs^2*, Volker Schuster^5*, Andre von Bueren^6*, Eleonora Gambineri^7*, Kathrin Siepermann^8*, Robin Kobbe^9*, Peter Arkwright^10*, Daniel Stachel, MD^11*, Markus Metzler, MD, PhD^12*, Klaus Schwarz^3*, Anita Kremer, MD^13*, Carsten Speckmann, MD^2*, Stephan Ehl, MD^2* and Andreas Mackensen, MD¹

¹Dept. of Internal Medicine 5 - Hematology/Oncology, University Hospital Erlangen, Erlangen, Germany
²University Medical Center Freiburg, Freiburg, Germany
³University of Ulm, Ulm, Germany
⁴University Mediacal Center Freiburg, Freiburg, Germany
⁵University of Leipzig, Leipzig, Germany
⁶University Medical Center Göttingen, Göttingen, Germany
⁷University of Florence, Florence, Italy
⁸HELIOS Klinikum Krefeld, Krefeld, Germany
⁹University Medical Centre Hamburg, Hamburg, Germany
¹⁰University of Manchester, Manchester, United Kingdom
¹¹Department of Pediatric Hematology/Oncology, University Erlangen, Children's Hospital, Erlangen, Germany
¹²Pediatric Hematology & Oncology, Univ. Hospital Erlangen, Erlangen, Germany
¹³University Hospital Erlangen, Erlangen, Germany

Tatsunori Goto, MD^*, Tetsuya Nishida, MD, PhD^*, Erina Takagi, MD^*, Kotaro Miyao, MD^*, Daisuke Koyama, MD^*, Reona Sakemura, MD^*, Ryo Hanajiri, MD^*, Keisuke Watanabe, MD, PhD^*, Nobuhiko Imahashi, MD, PhD^*, Seitaro Terakura, MD, PhD^*, Makoto Murata, MD, PhD and Hitoshi Kiyoi, MD, PhD

Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan

Masatoshi Takagi, MD, PhD¹, Kohsuke Imai, MD, PhD^2*, Jinhua Piao, DDS, PhD^2*, Motoy Yamashita, MD^2*, Akihiro Hoshino, MD^2*, Tsubasa Okano, MD^2*, Hirokazu Kanegane, MD, PhD^2*, Hideki Muramatsu, MD, PhD³, Yusuke Okuno, MD, Ph.D.^3*, Yuichi Shiraishi, MD, Ph.D.^4*, Kenichi Chiba, BA^4*, Hiroko Tanaka, BA^4*, Satoru Miyano, MD, Ph.D.^4*, Kenichi Yoshida, MD, Ph.D.^5*, Hiroo Ueno, MD^5*, Seishi Ogawa, MD, Ph.D.⁵, Yasuhide Hayashi, MD, PhD^6*, Seiji Kojima, MD, PhD^3* and Tomohiro Morio, MD, PhD^2*

¹Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Bunkyo-ku, Japan
²Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan
³Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
⁴Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
⁵Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⁶Gunma Red Cross Blood Center, Gunma, Japan

Chiara Cattaneo, MD^1*, Roberta Di Blasi, MD^2*, Crisitina Skert^3*, Anna Candoni, MD^4*, Marco Picardi, MD^5*, Maria Rosaria De Paolis, MD^6*, Valentina Mancini, MD^7*, Mario Delia, MD^8*, Francesco Mazziotta^9*, Luca Facchini, MD^10*, Francesco Marchesi, MD^11*, Domenico Russo³, Vincenza Orlando^1*, Bruno Martino, MD^12*, Stelvio Ballanti, MD^13*, Mario Tumbarello, MD^14*, Giuseppe Rossi, MD¹⁵ and Livio Pagano^16*

¹Hematology, Spedali Civili di Brescia, Brescia, Italy
²Institute of Hematology, Catholic University of Sacred Heart, Rome, Italy
³Chair of Hematology, University of Brescia, Brescia, Italy
⁴Hematology, Santa Maria della Misericordia University Hospital, Udine, Italy
⁵Clinical medicine and surgery, University of Napoli, Napoli, Italy
⁶Hematology, Ospedale di Lecce, Lecce, Italy
⁷Department of Hematology and Oncology, A.O. Ospedale Niguarda Cŕ Granda, Milan, Italy
⁸Hematology, University of Bari, Bari, Italy
⁹Hematology Unit, Azienda Ospedaliero-Universitaria Pisana, Ospedale Santa Chiara, Pisa, Italy
¹⁰Hematology, AO S. Maria Nuova, IRCCS, Reggio Emilia, Italy
¹¹Hematology and Stem Cell transplantation Unit, Regina Elena National Cancer Institute, Roma, Italy
¹²Hematology Unit, Bianchi-Melacrino-Morelli Hospital, Reggio Calabria, Italy
¹³Hematology, Ospedale S. Maria della Misericordia, Universitŕ di Perugia, Perugia, Italy
¹⁴Institute of Infectious Diseases, Catholic University of Sacred Heart, Rome, Italy
¹⁵Department of Hematology, Spedali Civili di Brescia, Brescia, Italy
¹⁶Institute of Hematology, Catholic University, Rome, Italy

Mervi H Taskinen, MD, PhD^1*, Satu Mustjoki, MD, PhD², Kirsi Jahnukainen, MD, PhD^1*, Luca Trotta, MSc^3*, Timo Siitonen, MD, PhD^4*, Timo Hautala, MD, PhD^5*, Andrey Zavialov, PhD^6*, Kaarina Heiskanen, MD, PhD^1*, Emma M Haapaniemi, MD, PhD^7*, Janna Saarela, MD, PhD^8* and Mikko Seppänen, MD, PhD^9*

¹Children and Adolescents, Helsinki University Hospital, Helsinki, Finland
²Hematology Research Unit Helsinki (HRUH), Department of Hematology, University of Helsinki and Helsinki University Central Hospital Comprehensive Cancer Center, Helsinki, Finland
³Institute for Molecular Medicine Finland, Helsinki, Finland
⁴Hematology-Oncology Unit, Oulu University Hospital, Oulu, Finland
⁵Department of Internal Medicine, Oulu University Hospital, Oulu, Finland
⁶Center for Biotechnology, University of Turku, Turku, Finland
⁷Karolinska Institute, Department of Biosciences and Nutrition, Stockholm, Sweden
⁸Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
⁹Helsinki University Central Hospital, Helsinki, Finland

Stephanie Humblet-Baron, MD, PhD^1*, Dean Franckaert, MSc^1*, Simon Bornschein, MSc^1*, Bénédicte Cauwe, PhD^1*, Susann Schonefeldt, MSc^1*, Carine Wouters, MD, PhD^1*, Patrick Matthys, PhD^1*, Frederic Baron, MD, PhD² and Adrian Liston, PhD^1*

¹KULeuven, Leuven, Belgium
²University of Liege, Liege, Belgium

Marcin Lyszkiewicz, PhD^1,2*, Daniel Kotlarz, MD, PhD^2,3*, Natalia Zietara, PhD^1,2*, Gudrun Brandes, PhD^4*, Jana Diestelhorst^5*, Silke Glage, DVM^6*, Eliash Hobeika, PhD^7*, Michael Reth, Prof., PhD^7*, Lukas Huber, MD, Prof.^8*, Andreas Krueger, PhD, Prof.^1* and Christoph Klein, MD, PhD²

¹Institute of Immunology, Hannover Medical School, Hannover, Germany
²Dr. von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany
³Dr von Hauner Children's Hospital, Ludwig Maximillian’s University, Munich, Germany
⁴Institute of Cellular Biology in the Centre for Anatomy, Hannover Medical School, Hannover, Germany
⁵Dr. von Hauner Children's Hospital, Ludwig Maximilians University, Hannover, Germany
⁶Experimental Pathology, Hannover Medical School, Hannover, Germany
⁷Department of Cellular and Molecular Immunology, Max Planck Institute of Immunbiology and Epigenetics, Freiburg, Germany
⁸Division of Cell Biology, Innsbruck Medical University, Innsbruck, Austria

Sebastian P. Haen, MD^1,2*, Daniel Johannes Kowalewski^3*, Stefan Stevanovic, PhD^3*, Linus Backert^2,4*, Florian Dengler^2,5*, Daniel Backes^2,5*, Stefan Beckert^6*, Wagner Silvia^6*, Ingmar Koenigsrainer^6*, Hans-Georg Kopp, MD^1*, Oliver Kohlbacher^7*, Alfred Koenigsrainer, MD^6*, Lothar Kanz, MD¹, Hans-Georg Rammensee, PhD^3* and Markus W. Loeffler, MD^2,6*

¹Department of Hematology and Oncology, University of Tuebingen, Tuebingen, Germany
²Department of Immunology, Interfacultary Institute for Cell Biology, Tuebingen, Germany
³Department of Immunology, Interfaculty Institute of Cell Biology, University of Tübingen, Tuebingen, Germany
⁴Applied Bioinformatics, Center for Bioinformatics and Department of Computer Science, University of Tuebingen, Tuebingen, Germany
⁵Department of Hematology and Oncology, Eberhard Karls University, Tuebingen, Germany
⁶Department of General, Visceral and Transplant Surgery, University of Tuebingen, Tuebingen, Germany
⁷Applied Bioinformatics Group, Eberhard-Karls-Universitaet Tuebingen, Tuebingen, Germany

Christopher T Petersen, Graduate^1*, Katarzyna Anna Darlak, PhD^2*, Jian-Ming Li, PhD^1,3 and Edmund K Waller, MD, PhD¹

¹Winship Cancer Institute, Department of Hematology and Medical Oncology, Emory University, Atlanta, GA
²Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA
³Emory University, Winship Cancer Inst., Atlanta, GA

Qi Cao, doctor^1*, Xuan Zhao, Doctor^2*, Sigal Gery, Doctor^1*, Zhengshan Chen, PhD/MD^3*, Ruishu Deng, MD, PhD^4*, Haibo Sun, Doctor^1*, De-chen Lin, Doctor^5*, Zhiqiang Zhao, Doctor^6*, Jonathan W Said, MD^7*, Quan-zhen Li, Doctor^8*, Markus Muschen, MD PhD³, Ronald M. Evans, PhD^9* and H. Phillip Koeffler, MD, PhD^10,11

¹Hem/Onc, Cedars-Sinai Medical Center, Los Angeles, CA
²Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA
³Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA
⁴Beckman Research Institute, City of Hope National Medical Center, Duarte
⁵Hem/Onc, Cedars-Sinai Medical Center, Los Angeles
⁶The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
⁷UCLA Medical Center, Los Angeles, CA
⁸Department of Immunology and Internal Medicine, Microarray Core Facility, University of Texas Southwestern Medical Center, Dallas
⁹GEL-E, The Salk Institute for Biological Studies, La Jolla, CA
¹⁰Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA
¹¹Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

Kerstin Wennhold, PhD^1*, Martin Thelen^2*, Maria gracia Marquez^2*, Christof Scheid³, Alexander Shimabukuro-Vornhagen, MD^4* and Michael von Bergwelt-Baildon, Prof. Dr. Dr.^1*

¹University Hospital of Cologne, Cologne, Germany
²Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany
³University of Cologne, Cologne, Germany
⁴Department I of Internal Medicine, Department I of Internal Medicine and Center of Integrated Oncology Cologne Bonn, Cologne, Germany

Luxi Chen^1*, Long Yi^1*, Yuning Ren^2*, Jianying Zhang^1*, A. Douglas Kinghorn^2*, Michael A. Caligiuri, MD¹ and Jianhua Yu, PhD¹

¹The Ohio State University Comprehensive Cancer Center, Columbus, OH
²The Ohio State University Pharmacy School, Columbus, OH