Zalaya K. Ivy, BS, MS¹, Adetola A. Kassim, MD, MS², Amanda B. Payne, PhD.^3*, Eric A. Macklin, PhD.^4*, Mark J. Rodeghier, PhD^5*, Robert C. Strunk, MD^6* and Michael R. DeBaun, MD, MPH⁷

¹Meharry College of Medicine, Nashville, TN
²Department of Medicine, Division of Hematology-Oncology, Vanderbilt University Medical Center, Nashville, TN
³National Center on Birth Defects and Developmental Disabilities, Atlanta, GA
⁴MGH Biostatistics, Massachusetts General Hospital, Boston, MA
⁵Rodeghier Consultants, Chicago, IL
⁶Washington University School of Medicine, St. Louis, MO
⁷Vanderbilt-Meharry-Matthew Walker Center of Excellence in Sickle Cell Disease, Vanderbilt University School of Medicine, Nashville, TN

Nathaniel Z. Piety^1*, Alex George, M.D., Ph.D.², Sonia Serrano^3*, Maria Rosa Lanzi^3*, Palka R. Patel, M.D.^4*, Maria Paz Noli, M.D.^5*, Damian Nirenberg, M.D.^4*, Joao Camanda^6*, Gladstone Airewele, M.B.B.S., M.P.H.⁷ and Sergey S. Shevkoplyas, Ph.D.⁸

¹Department of Biomedical Engineering, University of Houston, Houston, TX
²Hematology Center, Texas Children's Hospital, Houston, TX
³Angola Sickle Cell Initiative, Cabinda, Angola
⁴Global Health Corps, Baylor College of Medicine, Houston, TX
⁵Global Health Corps, Baylor College of Medicine, Houston, TN
⁶Universidade Onze de Novembro Medical School, Cabinda, Angola
⁷Texas Children's Cancer and Hematology Centers, Houston, TX
⁸Biomedical Engineering, University of Houston, Houston, TX

Stephanie G. Cohen, MD^1*, Zayir M Malik, BS^2*, Robert Hagbom, MD^3*, Adina L Alazraki, MD^4*, April G. Zmitrovich, MSW.MPH^5*, Olufolake Adisa, MD⁶ and Claudia R. Morris, MD⁷

¹Department of Pediatrics, Division of Pediatric Emergency Medicine, Emory University School of Medicine, Atlanta
²Emory University School of Medicine, Atlanta, GA
³Emory University School of Medicine, Atlanta
⁴Department of Radiology, Division of Pediatric Radiology, Emory University School of Medicine, Atlanta, GA
⁵Division of Pediatric Emergency Medicine, Children's Healthcare of Atlanta, Atlanta
⁶Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, GA
⁷Department of Pediatrics, Division of Pediatric Emergency Medicine, Emory-Children's Center for Cystic Fibrosis and Airways Disease Research, Emory University School of Medicine, Atlanta, GA

Nancy S. Green, MD¹, Monica Bhatia, MD^1*, Erica Griffin, BS^2*, Mahvish Qureshi, MD, MBA^1*, Courtney Briamonte, NP^1*, Mirko Savone, BA^1*, Stephen Sands, PsyD^1*, Margaret T. Lee, MD, MS¹, Angela Lignelli, MD^3* and Adam M. Brickman, PhD^2*

¹Pediatric Hematology/Oncology/Stem cell transplantation, Columbia University Medical Center, New York, NY
²Neurology and Taub Research Center, Columbia University Medical Center, New York, NY
³Radiology, Columbia University Medical Center, New York, NY

Patrick T. McGann, MD, MS¹, Min Dong, PhD^2*, Russell E. Ware, MD, PhD³ and Alexander A Vinks, PharmD, PhD^2*

¹Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
³Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Vimal K. Derebail, MD, MPH^1*, Susan K Jones, RN^2*, Jessica Shen, BS^2*, Melissa Caughey, PhD^3*, Alan L. Hinderliter, MD^3*, David M. Pollock, PhD^4*, David R. Archer, PhD⁵ and Kenneth I. Ataga, MD⁶

¹UNC Kidney Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
²University of North Carolina at Chapel Hill, Chapel Hill, NC
³Division of Cardiology, University of North Carolina at Chapel Hill, Chapel Hill, NC
⁴Division of Nephrology, University of Alabama - Birmingham, Birmingham, AL
⁵Emory University, Atlanta, GA
⁶Division of Hematology/Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC

Nicholas Farris, BS^1*, Craig A Branch, MS, PhD^1*, Molly E Zimmerman, PhD^2*, Asif K Suri, MD PhD^3* and Henny H Billett, MD⁴

¹Albert Einstein College of Medicine, Bronx, NY
²Dept of Neurology, Albert Einstein College of Medicine, Bronx, NY
³Div of Neuroradiology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY
⁴Div of Hematology, Dept of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY

Nitya Bakshi, MBBS, MS¹, Ines Lukombo^2*, Inna Belfer, MD, PhD^3,4* and Lakshmanan Krishnamurti, MD¹

¹Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University, Atlanta, GA
²University of Pittsburgh, Pittsburgh, PA
³Center for Drug Evaluation and Research (CDER), Food and Drug Administration, Silver Spring, MD
⁴Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA

Nina Kuei, BS^1*, Niren Patel, MBBS^1*, Hongyan Xu, PhD^1,2*, Leigh Wells, MS^1*, Latanya Bowman, BS^1*, Pritam Bora^1*, Kavita Natrajan, MBBS³ and Abdullah Kutlar, MD⁴

¹Sickle Cell Center, Georgia Regents University, Augusta, GA
²Department of Biostatistics & Epidemiology, Georgia Regents University, Augusta, GA
³Department of Medicine, George Washington University, Washington, DC
⁴Georgia Regents University, Augusta, GA

Marianne E. Yee, MD, MSc¹, Peter A. Lane, MD², James R. Eckman, MD^3,4* and Antonio Guasch, MD^5*

¹Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University, Atlanta, GA
²Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA
³Winship Cancer Institute, Emory University, Atlanta, GA
⁴Georgia Comprehensive Sickle Cell Center, Grady Health System, Atlanta, GA
⁵Department of Medicine, Renal Division, Emory University, Atlanta, GA

Alexis Leonard, MD^1*, Nihal Godiwala, MD^2*, Robert McCarter, ScD^3*, Matthew Sharron, MD^2* and Emily Riehm Meier, MD¹

¹Hematology Division, Children's National Medical Center, Washington, DC
²Center for Hospital Based Specialties, Children's National Medical Center, Washington, DC
³Division of Biostatistics and Study Methodology, Children's National Medical Center, Washington, DC

Raffaela Colombatti, MD, PhD^1*, Soundrie Padayachee, PhD^2*, Corrina Macmahon, MD, FRCPath^3*, Sukhleen Momi, BSC^4*, Claire Jane Hemmaway, MD^5*, Maddalena Casale^6* and Baba Inusa, MD^7,8

¹university of padova, Padova, Italy
²Guy's and St Thomas NHS Trust, London, London, United Kingdom
³Our Lady's Crumlin, Dublin, Ireland
⁴School of Medicine, King's College London, London, United Kingdom
⁵Haematology, Barking Havering and Redbridge University NHS Trust, Romford, United Kingdom
⁶Centro per la Cura delle Microcitemie, Cardarelli Hospital, Napoli, Italy
⁷Faculty of Medicine, King's College London, London, United Kingdom
⁸Evelina Children's Hospital / Guy's and St Thomas' Hospitals, London, United Kingdom

Louise Smith, RCN MSc^1*, Kate L E Phillips, PhD^2* and Russell D Keenan, MB ChB, PhD, FRCP, FRCPath³

¹Department of Pediatric Haematology, Alder Hey Children's Hospital, Liverpool, United Kingdom
²Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
³Dept. of Pediatric Onc. & Hem., Alder Hey Children's Hospital, Liverpool, United Kingdom

Stephon T Martin, BA^1*, Christopher Worsham, MD^1*, Robyn T Cohen, MD^1* and Elizabeth S Klings, MD²

¹Boston University School of Medicine, Boston, MA
²The Pulmonary Center, R-304, Boston University Sch. of Med., Boston, MA

Fuad El Rassi, MD^1,2, Eldrida Randall, MS^2,3*, Sidney F. Stein, MD⁴, Hanna Jean Khoury, MD⁵, James R. Eckman, MD^2,3* and Morgan L. McLemore, MD^2,6

¹Hematology and Medical Oncology, Winship Cancer Institute of Emory University School of Medicine, Atlanta, GA
²The Georgia Comprehensive Sickle Cell Center at Grady Health System, Atlanta, GA
³Winship Cancer Institute of Emory University School of Medicine, Atlanta, GA
⁴Department of Hematology & Medical Oncology, Emory University School of Medicine, Atlanta, GA
⁵Emory University, Atlanta, GA
⁶Winship Cancer Institute of Emory University, Atlanta, GA

Jo Howard, MD¹, Baba Inusa, MD², Christina Liossi^3*, David C. Rees, FRCP, FRCPath, MA, MBBS^4*, Swee Lay Thein, MD, DSc^5,6, Edith Cheng^3*, Sati Sahota^7*, Nicholas Hart, MD^8*, Patrick Murphy, MD^8*, Johanna Gavlak^3*, Maria Chorozoglou^3*, Eufemia Jacob, PhD, RN^9*, Carol Nwosu^10*, Maureen Gwam^10*, SallyAnn Wakeford^11* and Fenella Kirkham, MD^12*

¹Department of Haematology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
²Evelina Children's Hospital / Guy's and St Thomas' Hospitals, London, United Kingdom
³Southampton University Hospital, Southampton, United Kingdom
⁴King's College Hospital, London, United Kingdom
⁵National Heart, Lung and Blood Institute, Sickle Cell Branch, National Institutes of Health, Bethesda, MD
⁶Molecular Haematology, Division of Cancer Studies, King's College London, London, United Kingdom
⁷Unversity College London, London, United Kingdom
⁸Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
⁹School of Nursing, UCLA, Los Angeles, CA
¹⁰Sickle Cell and Young Stroke Survivors, London, United Kingdom
¹¹University Hospital Southampton, Southampton, United Kingdom
¹²UCL Institute of Child Health, London, United Kingdom