57th ASH Annual Meeting and Exposition (December 5-8, 2015): 113. Hemoglobinopathies, Excluding Thalassemia – Basic and Translational Science: Poster I

Hemoglobinopathies, Excluding Thalassemia – Basic and Translational Science Oral and Poster Abstracts
Poster

Hall A, Level 2 (Orange County Convention Center)

No Evidence for Cell Activation or Vaso-Occlusion with Plerixafor Treatment of Sickle Cell Mice

Erika Choi, BA¹^*, Min-Hui Cui, Ph.D.²^*, Narla Mohandas, DSc¹, Karina Yazdanbakhsh, PhD¹, Henny Heisler Billett, MD², Craig A Branch, MS, PhD²^* and Patricia A Shi, MD¹

¹New York Blood Center, New York, NY
²Albert Einstein College of Medicine, Bronx, NY

965

Vessel Geometry Interacts with Red Blood Cell Stiffness to Promote Endothelial Dysfunction in Sickle Cell Disease

Yichen Wang^1,2^*, Robert G Mannino, BS^1,2^*, David R Myers, PhD^1,2, Wei Li²^*, Clinton H. Joiner, MD, PhD² and Wilbur A Lam, MD, PhD^1,2

¹Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA
²Department of Pediatrics, Aflac Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA

966

Resolvin D1 and Resolvin D2 Protect Against Hypoxia/Reoxygenation Induced Lung and Kidney Damage in a Sickle Cell Mouse Model of Acute Vaso-Occlusive Crisis

Alessandro Mattè, PhD¹^*, Antonio Recchiuti, PhD²^*, Charles Serhan, PhD³, Angela Siciliano¹^*, Enrica Federti¹^*, Olga Weinberg, MD⁴^*, Brian Kalish, MD⁴, Carlo Brugnara, MD⁵ and Lucia De Franceschi, MD¹

¹Department of Medicine, University of Verona and AOUI-Verona, Verona, Italy
²University of Chieti, Chieti, Italy
³Harvard Medical School, Boston
⁴Boston Children's Hospital, Boston, MA
⁵Laboratory Medicine, Boston Children's Hospital, Boston, MA

967

Peg-Cohb Mediated Carbon Monoxide and Oxygen Transfer to Hypoxic Red Blood Cells Prevent, Slow, and/or Reverse Sickling in Vitro.

Peter Buontempo, MSc, BSc^*, Rick Yglesias^*, Yuli Chen^*, Catherine Buontempo^*, Ronald G. Jubin, PhD and Abraham Abuchowski, PhD^*

Prolong Pharmaceuticals, South Plainfield, NJ

968

Cerebral Perfusion Patterns in Transgenic Murine Models of Sickle Cell Disease As Seen By MRI Is Reflective of Their Anemia Profile and Parallels the Human Disease

Craig A Branch, MS, PhD¹^*, Min-Hui Cui, Ph.D.¹^*, Nicholas Branch²^* and Seetharama Acharya¹^*

¹Albert Einstein College of Medicine, Bronx, NY
²Aerospace, Georgia Technicial University, Atlanta, GA

969

Therapeutic Potential of Beta-Nicotinamide Adenine Dinucleotide to Reverse Endothelial Barrier Dysfunction in Sickle Cell Mouse Model

Nagavedi S Umapathy, PhD¹^*, Levi C Makala, DVM, MBA, PhD², Mayuko Takezaki, MS³^* and Betty Pace, MD⁴

¹Department of Medicine-Sickle Cell Disease, Georgia Regents University, Augusta, GA
²Department of Pediatrics and Cancer Center, Georgia Regents University, Augusta, GA
³Pediatrics, Georgia Regents University, Augusta, GA
⁴Sickle Cell Center, Georgia Regents University, Augusta, GA

970

Thrombospondin-1 Gene Polymorphism Is Associated with Estimated Pulmonary Artery Pressure in Patients with Sickle Cell Anemia

Seethal A. Jacob, MD¹, Yanxia Chu, MD²^*, Enrico M Novelli, MD, MS³, Jeffrey S Isenberg, MD, MPH³^*, Gregory J. Kato, M.D.³ and Yingze Zhang, PhD²^*

¹Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA
²Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA
³Department of Medicine, Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA

971

Recognition of Biomarkers of Brain Connectivity and Pain Using Multi-Modal Imaging in Patients with Sickle Cell Disease

Michelle Case, BS¹^*, Clara Zhang, PhD¹^*, John Mundahl¹^*, Yvonne Datta, MD², Stephen C Nelson, MD³, Kalpna Gupta, PhD² and Bin He, PhD¹^*

¹Biomedical Engineering, University of Minnesota, Minneapolis, MN
²Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN
³Children’s Hospitals and Clinics of Minnesota, Minneapolis, MN

972

Evaluation of Cell Types and Morphologies in Sickle Cell Disease with an Imaging Flow Cytometer

Hasan Tahsin Ozpolat, MD¹^*, Tim Chang, PhD²^*, Junmei Chen, PhD¹, Xiaoping Wu, PhD¹^*, Colette Norby, MS³^*, Barbara A Konkle, MD^3,4 and Jose A. Lopez, MD^3,5

¹Bloodworks Norhwest Research Institute, Seattle, WA
²Amnis Corporation, Seattle, WA
³BloodworksNW Research Institute, Seattle, WA
⁴Department of Medicine, University of Washington, Seattle, WA
⁵Medicine, Division of Hematology, University of Washington, Seattle, WA

973

Novel Epigenetic Modulators That Promote Fetal Hemoglobin Production for the Prevention of Sickle Cell Disease Related Complications

Rebecca M. Cafiero, MD¹, Steven Holshouser²^*, Craig Kutz³^*, Julie Kanter, MD⁴ and Patrick Woster, PhD⁵^*

¹Medical University of South Carolina, Charleston, SC
²Dept of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, SC
³College of Medicine, Medical University of South Carolina, Charleston, SC
⁴Division of Pediatric Hematology-Oncology, Department of Pediatrics, Medical University of South Carolina, Charleston, SC
⁵SCCP Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charles, SC

974

Sustained Elevation of Adenosine-ADORA2B Signaling Promotes Chronic Pain through Neuro-Immune Interaction in Sickle Cell Disease

Morayo G. Adebiyi, BS¹^*, Xia Hu, MD²^*, Jialie Luo, PhD³^*, Kaiqi Sun, BS¹, Thanh-Thuy T. Le, MD, PhD¹^*, Yujin Zhang, MD¹^*, Hongyu Wu, PhD¹^*, Hong Liu, MD¹^*, Aji Huang, BS, MS¹^*, Rodney E. Kellems, PhD¹^*, Michael R. Blackburn, PhD¹^*, Edgar T. Walters, PhD⁴^*, Hongzhen Hu, PhD³^* and Yang Xia, MD, PhD¹

¹Department of Biochemistry and Molecular Biology, UTHSC-Houston Medical School, Houston, TX
²Department of Anesthesiology, Third XiangYa Hospital, Hunan, China
³Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO
⁴Department of Integrative Biology and Pharmacology, UTHSC-Houston Medical School, Houston, TX

975

Heme Concentration As a Biomarker of Sickle Cell Disease Severity: Its Role in Steady-State and in Crisis Patients

Magda Oliveira Seixas Carvalho, MD, PhD¹^*, Larissa Carneiro Rocha, MD²^*, João Henrique Oliveira Reis, MD³^*, Théo de Araújo Santos, MD, PhD⁴^*, Valma Maria Lopes do Nascimento, Physician²^*, Mauricio Batista Carvalho, Pharmacist⁵^*, Nívea Farias Luz, MD, PhD⁶^*, Valeria de Matos Borges, MD, PhD⁷^* and Marilda Souza Goncalves, MD, Ph.D.⁸^*

¹Laboratorio Central, Hospital Universitario Professor Edgard Santos - Universidade Federal da Bahia, Salvador, Brazil
²Fundacao de Hematologia e Hemoterapia da Bahia (Hemoba), Salvador, Brazil
³LHGB, Centro de Pesquisas Gonçalo Moniz - Fiocruz Bahia, Salvador, Brazil
⁴Centro das Ciências Biológicas e da Saúde, Universidade Federal do Oeste da Bahia, Barreiras, Brazil
⁵Universidade Federal da Bahia, Salvador, Brazil
⁶Centro de Pesquisas Gonçalo Moniz - Fiocruz Bahia, Salvador, Brazil
⁷Centro de Pesquisas Goncalo Moniz-FIOCRUZ-Bahia, Salvador, Brazil
⁸LHGB, Centro de Pesquisas Goncalo Moniz-FIOCRUZ-Bahia, Salvador, Brazil

976

Moderate Exercise Training Attenuates Inflammation in Transgenic Sickle Cell Mice

Emmanuelle Charrin^1,2^*, Cyril Martin, PhD¹^*, John Dube, PhD³^*, Philippe Connes, PhD¹^*, Vincent Pialoux, PhD¹^* and Solomon Fiifi Ofori-Acquah, PhD⁴

¹Center of Research and Innovation in Sports, Université Claude Bernard Lyon 1, Villeurbanne, France
²Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA
³Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, PA
⁴Division of Hematology/Oncology, Department of Medicine, Center for Translational and International Hematology, University of Pittsburgh, Pittsburgh, PA

977

Placenta Growth Factor Links the IL-13 Response and the Leukotriene Pathway to Augment Airway Hyper-Responsiveness

Marthe-Sandrine Eiymo Mwa Mpollo, PhD¹^*, Eric Brandt, PhD²^*, Shiva Kumar Shanmukhappa, DVM, PhD³^*, Paritha Arumugam, PhD⁴^*, Swati Tiwari⁵^*, Anastacia Loberg⁵^*, Tilat Rizvi, PhD⁶^*, Mark Lindsey²^*, Bart Jonckx, PhD⁷^*, Peter Carmeliet, Prof MD, PhD⁸^*, Vijay Kalra⁹^*, Timothy Lecras, PhD¹⁰^*, Nancy Ratner, PhD⁶^*, Marsha wills-Karp, PhD¹¹^*, Gurjit Khurana hershey, MD, PhD²^* and Punam Malik, MD¹²

¹Cincinnati Children's Medical center, Cincinnati, OH
²Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati
³Department of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati
⁴Translational Pulmonary Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁵Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati
⁶Division of Experimental Hematology and Cancer and Blood Institute, Cincinnati Children's Hospital Medical Center, Cincinnati
⁷ThromBogenics, Leuven, Belgium
⁸Laboratory of Angiogenesis and Neurovascular Link, VIB - Katholieke Universiteit Leuven, Vesalius Research Center, LEUVEN, Belgium
⁹University of Southern California, Los Angeles
¹⁰Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati
¹¹Johns Hopkins Bloomberg School of Public Health., baltimore
¹²Divisions of Hematology, Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

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^*signifies non-member of ASH

113.P1.47 113. Hemoglobinopathies, Excluding Thalassemia – Basic and Translational Science: Poster I