Description:

The daily production of myeloid cells is highly adaptable, and the consequences of deregulated myeloid cell production are profoundly life threatening. This session will describe how inflammatory signaling not only contributes to emergency myelopoiesis, but also is critical for the establishment of a healthy organism. Recent discoveries have provided exciting new insights regarding the interplay between microorganisms and innate immunity in triggering emergency myelopoiesis. Our understanding of how inflammatory signals exacerbate myeloid malignancies including myeloproliferative neoplasms (MPN) and acute myeloid leukemia (AML) is expanding rapidly, and leading to new opportunities for therapeutic interventions.

Dr. Worthen will review how neonatal gut colonization, and timed release of inflammatory mediators, instructs innate immunity and shape myelopoiesis during development.

Dr. Silke will address how inflammatory and cell-death signals regulate emergency myelopoiesis and their role in AML development.

Dr. Carlesso will describe how an inflammatory microenvironment drives aberrant myelopoiesis and its contribution to MPN development.