Description:

Recent technological advances have allowed us to capture a vast amount of information regarding the normal and malignant (epi)genome. However, we have yet to fully understand how these complex genetic and epigenetic traits contribute to normal development and disease. This session will focus on how state-of-the-art functional genomics and next-generation sequencing approaches can be applied to unravel the complexity of normal development and human disease in primary specimens, thus allowing us to accurately model it in appropriate systems.

Dr. Tyler Jacks will review current strategies in functional genomics using CRISPR/Cas9 technology to model combinatorial genetic events in human cancer.

Dr. H. Leighton Grimes will discuss the use of single cell RNA-seq to unravel the complexity of transcriptional regulation dynamics during lineage fate decisions in myeloid cells.

Dr. Steven Henikoff will discuss novel approaches for mapping epigenome dynamics and how they can be harnessed to inform our understanding of epigenetic regulation in development and disease.