Xue Chen, MD^1*, Lili Yuan, MD^1*, Fang Wang, MD^2*, Yang Zhang, MD^2*, Xiaoli Ma, MD^2*, Panxiang Cao, MD^1*, Jiancheng Fang, MD^3*, Tong Wang, MD^1*, Jiaqi Chen, PhD^4*, Xiaosu Zhou, PhD^5* and Hongxing Liu, MD^1,6

¹Department of Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Langfang, China
²Department of Clinical Laboratory, Hebei Yanda Lu Daopei Hospital, Langfang, China
³Department of Clinical Laboratory, Hebei Yanda Lu Daopei Hospital, Langfang, Hebei, China
⁴Pathology & Laboratory Medicine Division, Hebei Yanda Lu Daopei Hospital, Langfang, China
⁵Precision Medicine Center, Beijing Lu Daopei Institute of Hematology, Beijing, AL, China
⁶Precision Medicine Center, Beijing Lu Daopei Institute of Hematology, Beijing, China

Nadine Wolgast^1,2,3*, Thomas Beder^1,2,3*, Mayukh Mondal^2,4*, Wencke Walter, PhD⁵, Stephan Hutter, PhD^5*, Sonja Bendig^1,2,3*, Jan Kässens^1,3*, Björn-Thore Hansen^3,6,7*, Katharina Iben^1,2,3*, Barz Malwine^1,2,3*, Martin Neumann, MD^1,2,3*, Nicola Goekbuget, MD⁸, Claudia Haferlach, MD⁵, Monika Brüggemann, MD^1,2,3*, Claudia D Baldus, MD^1,2,3*, Alina M. Hartmann^2,3,9* and Lorenz Bastian^1,2,3*

¹Medical Department II, Hematology and Oncology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany
²Clinical Research Unit CATCH ALL (KFO 5010/1) funded by the Deutsche Forschungsgemeinschaft, Kiel, Germany
³University Medical Center Schleswig-Holstein, University Cancer Center Schleswig-Holstein, Kiel, Germany
⁴Christian Albrechts University Kiel, Institute for Clinical Molecular Biology, Kiel, Germany
⁵MLL Munich Leukemia Laboratory, Munich, Germany
⁶(DFG, German Research Foundation): 413490537, Clinician Scientist Program in Evolutionary Medicine funded by the Deutsche Forschungsgemeinschaft, Kiel, Germany
⁷Department of Internal Medicine II (Hematology/Oncology), University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany
⁸Hematology/Oncology, Goethe University Hospital, Frankfurt/M., Department of Medicine II, Frankfurt/M., Germany
⁹Department of Internal Medicine II (Hematology/Oncology), University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany

Mingying Zhang^1*, Yuanyuan Zhang^1*, Peijing Qi^1*, Wei Lin^1*, Ying Wu^1*, Jiaole Yu^1*, Huyong Zheng² and Ruidong Zhang^1*

¹Hematology Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China
²Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Hematology Center, Beijing, China

Hrishi Venkatesh, PhD^1*, Kyra Boorsma Bergerud^1*, Miriam A. Arroyo^2*, Enoc Granadas Centeno^2*, Todd P. Knutson^3*, Yinjie Qiu, PhD^3*, Kristina Springer^4*, Xenia Meshik, PhD^4*, Veronika Bachanova, MD, PhD⁵, Michael A. Farrar, PhD⁶ and Sean I. Tracy, MD, PhD^7*

¹Center for Immunology, University of Minnesota, Minneapolis, MN
²420 Delaware St. SE., MMC 480, University of Minnesota, Minneapolis, MN
³Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN
⁴Bruker Spatial Biology, Saint Louis, MO
⁵Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN
⁶Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN
⁷Center for Immunology, Masonic Cancer Center, Division of Hematology Oncology and Transplantation, University of Minnesota, Minneapolis, MN

Venkata Sesha Sai Abhinav Ayyadevara, PhD, MS^1*, Ashley Paik^2*, Ria Perencsik^3*, Monika Toma, PhD^4*, Tomasz Skorski, MD, PhD⁴, Rozbeh Jafari, PhD^5*, Gerald Wertheim, MD, PhD^6*, Huimin Geng, PhD^7* and Christian Hurtz, PhD⁸

¹Division of Cancer Sciences, Loma Linda University, Philadelphia, PA
²Southern Adventist University, Collegedale, TN
³University of British Columbia, Vancouver, Canada
⁴Fels Cancer Institute for Personalized Medicine, Temple University School of Medicine, Philadelphia, PA
⁵Department of Oncology-Pathology and Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden
⁶Division of Hematology/Oncology, Department of Medicine, The Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA
⁷Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA
⁸Division of Cancer Sciences, Loma Linda University, Loma Linda, CA

Giacomo Gotti, MD^1*, Claudia Saitta^2*, Daniela Silvestri^2*, Arianna Colombo^2*, Federica Colnaghi^2*, Stefano Rebellato^2*, Matilde Marzorati^2*, Nicolò Peccatori^2*, Nicoletta Bertorello, MD^3*, Luca Lo Nigro, MD⁴, Franco Locatelli, MD⁵, Rosanna Parasole^6*, Maria Caterina Putti^7*, Valentino Conter, MD^2*, Antonella Colombini, MD^1*, Barbara Buldini, MD, PhD⁸, Andrea Biondi^1,9, Maria Grazia Valsecchi, PhD^9,10*, Giovanni Cazzaniga, PhD^2,9, Grazia Fazio, PhD^2,9* and Carmelo Rizzari, MD, PhD^1*

¹Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
²Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
³Pediatric Oncohematology, University of Turin-Regina Margherita Children Hospital, Turin, Italy
⁴Center of Pediatric Hematology Oncology, Azienda Policlinico “San Marco", Catania, Italy
⁵IRCCS Bambino Gesù Children's Hospital, Rome, Italy
⁶6 Department of Pediatric Oncology, Hematology and Cellular Therapy, AORN Santobono-Pausilipon, Naples, Italy
⁷Department of Pediatric Hematology and Oncology, University of Padova, Padova, Italy
⁸University of Padova, Padua, Italy
⁹School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy
¹⁰Biostatistics and Clinical Epidemiology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy

Lukasz Sedek, Ph.D.^1*, Beatriz Soriano^2*, Łukasz Słota^3*, Monika Brüggemann^4*, Aleksandra Lasia^3*, Saskia Kohlscheen^4*, Michaela Reiterova^5*, Stefan Nierkens, PhD^6*, Anja De Jong^6*, Giuseppe Gaipa⁷, Cristina Bugarin, MSc^7*, Cristiane Ferreira-Facio^8*, Elaine Sobral da Costa^8*, Ludovic Lhermitte^9*, Julia Almeida^2*, Alberto Orfao, MD, PhD^2*, Jacques JM van Dongen, MD, PhD^2,10* and Tomasz Szczepanski, MD, PhD³

¹Department of Microbiology and Immunology, Medical University of Silesia, Zabrze, Poland
²Cancer Research Center (IBMCC-CSIC/USAL-IBSAL), Cytometry Service (NUCLEUS) and Department of Medicine, University of Salamanca, Salamanca, Spain
³Department of Pediatric Hematology and Oncology, Medical University of Silesia, Zabrze, Poland
⁴University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
⁵CLIP - Childhood Leukaemia Investigation Prague, Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
⁶Princess Maxima Center, Utrecht, Netherlands
⁷Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
⁸University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil
⁹Laboratory of Onco-Hematology, Necker Enfants-Malades Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, France
¹⁰European Scientific Foundation for Laboratory Hemato-Oncology (ESLHO), Zutphen, Netherlands

Sogand Sajedi, PhD, Nicholas J. Short, MD, Enes Dasdemir, BS^*, Bofei Wang, PhD, Cedric Nasnas, MD^*, Elias Jabbour^*, Hagop M. Kantarjian, MD, Patrick K. Reville, MD, MPH and Hussein A. Abbas, MD, PhD

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

So Yeon Park^1,2*, Jae-Ho Yoon, MD, PhD^1,2, Daehun Kwag^1,2*, Jung Yeon Lee^1,2*, Gi June Min, MD, PhD^1,2, Sung-Soo Park, MD, PhD^1,2*, Silvia Park, MD, PhD^1,2*, Sung-Eun Lee, MD, PhD^1,2*, Byoung-Sik Cho, MD, PhD^1,2*, Ki-Seong Eom, MD, PhD^1,2*, Yoo-Jin Kim^1,2, Hee-Je Kim, MD, PhD^1,2, Chang-Ki Min^1,2*, Seok-Goo Cho^1* and Seok Lee, MD^1,2

¹Department of Hematology, Seoul St. Mary’s Hematology Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
²Leukemia Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)

Meera Patel, MD^1*, Ahmed N Mohamed, MD^2*, Hadil Zureigat, MD², Emily C. Zabor, DrPH^3*, Daniel P. Nurse, DO^2*, Yohana B. Bedelu^3*, Mark Jinan Chen, PhD^4*, Joy Nakitandwe, PhD^5*, Akriti G. Jain, MD⁶, John C. Molina, MD, MEd⁶, Sophia Balderman, MD^6*, Abhay Singh, MD, MPH⁶, Aaron T. Gerds, MD, MS⁶, Sudipto Mukherjee, MD, PhD, MPH⁶, Hetty E. Carraway, MD, MBA⁶, Anjali S. Advani, MD⁶ and Moaath K. Mustafa Ali, MD, MPH⁶

¹Department of Internal Medicine, Cleveland Clinic, Elgin, IL
²Department of Internal Medicine, Cleveland Clinic, Cleveland, OH
³Department of Quantitative Health Sciences, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
⁴Diagnostics Institute, Cleveland Clinic Department of Pathology and Laboratory Medicine, Cleveland, OH
⁵Department of Pathology and Laboratory Medicine, Cleveland Clinic Diagnostics Institute, Cleveland, OH
⁶Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH

Alexander Chassiakos, BSc^*, Ming Zhan, MD/PhD^*, Zhilian Jia, PhD^*, Zunsong Hu, PhD and Zhaohui Gu, PhD

City of Hope, Duarte, CA

Burak Yuzuguldu, MD^1*, Caroline R.M. Wiggers, PhD^2*, Nathaniel G. Tadros^2*, Eugene Y. Cho^2*, Jens G. Lohr, MD, PhD³ and Birgit Knoechel, MD, PhD²

¹Pediatric Oncology, Dana Farber Cancer Institute, BUFFALO, NY
²Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA
³Medical Oncology, Dana-Farber Cancer Institute, Boston, MA

Iman Sarami, MD^1*, Ruchi Singhal, MD^1*, Mark Routbort, MD, PhD^2*, Koji Sasaki, MD³, Daniel Domogala III^4*, Gokce A. Toruner, MD PhD^5*, Shibu Ninan^6*, Nitin Jain, MD³, Keyur P. Patel, MBBS, PhD⁷, Elias Jabbour, MD⁸, Hagop M. Kantarjian, MD³, Carlos E. Bueso-Ramos, MD, PhD⁷, L. Jeffrey Medeiros, MD⁷, Raja Luthra, Ph.D^2*, Guilin Tang, MD, PhD^7* and Rashmi Kanagal-Shamanna, MD⁹

¹The University of Texas MD Anderson Cancer Center, Houston, TX
²Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴The University fo Texas MD Anderson Cancer Center, Houston
⁵Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁶The University of Texas MD Anderson Cancer Center, Houston
⁷Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁸Department of Leukemia, University of Texas M.D. Anderson Cancer Ctr., Houston, TX
⁹Department of Hematopathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Yu Xia^1,2*, Kai Wang^1*, Keyan Yang^3*, Ling Jin^4*, Ying Liu, MD^5*, Yueping Jia^6*, Yunpeng Dai^7*, Lihua Yang^8*, Rong Liu^9*, Lian Jiang^10*, Zhongjin Xu^11*, Ansheng Liu^12*, Xiaojun Yuan^13*, Jian Wang^14*, Yonghong Zhang, MD^5* and Qinlong Zheng, MD^2*

¹Beijing Gobroad Boren Hospital, Beijing, China
²Laboratory of Molecular Diagnostics, Beijing GoBroad Boren Hospital, Beijing, China
³Department of Medical Laboratory, Beijing Gaobo Boren Hospital, Beijing, China
⁴Department of Hematology/Oncology, National Center for Children’s Health, Beijing Children’s Hospital, Capital Medical University, Beijing, China
⁵Department of Pediatric Lymphoma, Beijing GoBroad Boren Hospital, Beijing, China
⁶Department of Pediatrics, Peking University People's Hospital, Beijing, China
⁷Department of Pediatrics Hematology and Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China
⁸Department of Pediatric Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
⁹Capital institute of pediatrics affiliated children's hospital, Beijing, Beijing, China
¹⁰Department of Pediatrics, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China
¹¹Jiangxi Provincial Children's Hospital, Nanchang, China
¹²Xi'an Children's Hospital, Xi'an, China
¹³Department of Pediatric Hematology/Oncology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
¹⁴Department of Hematology and Oncology, Anhui Provincial Children’s Hospital, Hefei, China

Jansen N Seheult, M.D.^1*, Matthew J Weybright^1*, Min Shi, MD, PhD^2*, Dragan Jevremovic, M.D., Ph.D^3*, April Chiu, MD^1*, Michael M Timm^1*, Gregory E Otteson^1*, Horatiu Olteanu, M.D., Ph.D.¹ and Pedro Horna, MD¹

¹Division of Hematopathology, Mayo Clinic, Rochester, MN
²Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine and Science, Rochester, MN
³Mayo Clinic, Rochester, MN

Sandro S Bräunig, PhD^1*, Carl Dencker, MS^1*, Dang Nghiem Vo, PhD^1*, Anne Hultquist, MD, PhD^1,2*, Jens Enoksson, MD, PhD^2*, Hongzhe Li, PhD^1* and Stefan Scheding, MD^1,3

¹Division of Molecular Hematology and Stem Cell Center, Lund University, Lund, Sweden
²Laboratory Medicine Skane, Department of Clinical Pathology, Lund, Sweden
³Hematology, Skane University Hospital, Lund, Sweden

Babette D. J. Hoen^*, Tamara J. J. Manuputty^*, Judith M. Boer, PhD, Cesca Van De Ven, PhD^* and Monique L. den Boer, PhD

Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands

Caleb Ho, MD¹, Natalie Danziger^2*, Jessica Lee^2*, Douglas Lin, MD^2*, Richard Huang, MD^3*, Chelsea Marcus, MD^2* and Douglas Mata, MD, MPH^4*

¹Pathology, Foundation Medicine, Cambridge, MA
²Pathology, Foundation Medicine, Boston, MA
³Clinical Development, Foundation Medicine, Boston, MA
⁴Molecular Pathology, Foundation Medicine, Cambridge, MA