-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

508. Bone Marrow Failure: Acquired: Poster III

Symposia: Bone Marrow Failure: Acquired Program: Oral and Poster Abstracts
Type: Poster
Monday, December 9, 2024: 6:00 PM-8:00 PM
Halls G-H (San Diego Convention Center)

Michael Cole, MD, DPhil1, Nikhil Ranjan, PhD1, Daniel G. Flores1*, Molly Kuzma1*, Alexis Reed, RN1*, Robert A. Brodsky, MD1 and Gloria F. Gerber, MD2

1Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
2Division of Hematology, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD

Morag Griffin, MBChB, MRCP1*, Richard J. Kelly, MBChB, PhD1*, Mathilde Gavillet, MD, PhD2*, Petra Muus, MD1, Britta Hoechsmann, MD3,4*, W. Jason Cummings, PhD5*, John Efthimiou, BSc, MBBS, MD, FRCP5*, William Pullman, BMedSc, MBBS, PhD, FRACP5, Hubert Schrezenmeier, MD3,4 and Jens Panse, MD6,7

1Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
2Service and Central Laboratory of Hematology, Department of Oncology, Lausanne University Hospital (CHUV), Lausanne, Switzerland
3Institute of Transfusion Medicine, University of Ulm, Ulm, Germany
4Institute for Clinical Transfusion Medicine, German Red Cross Blood Transfusion Service and University Hospital Ulm, Ulm, Germany
5Omeros Corporation, Seattle, WA
6Universitätsklinikum RWTH, Aachen, Germany
7Center of Integrated Oncology (CIO), Aachen, Bonne, Cologne, Düsseldorf (ABCD), Germany

Peiyuan Dong1,2*, Yilin Liu3*, Zhongxing Jiang2*, Huimin Sun4*, Yanhong Zhao1*, Linjie Wu1*, Jiali Huo1*, Jing Zhang1*, Meili Ge1*, Fang Dong1*, Sha Hao1,5* and Tao Cheng5,6

1State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
2Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
3State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China, Tianjin, China
4State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, AL, China
5Tianjin Institutes of Health Science, Tianjin, China
6State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

Xinyan Zhang, MS1*, Li-Ping Guo1*, Jin-Song Jia1*, Ya-Zhe Wang1*, Mi Liang1*, Mengzhu Shen, PhD2*, Zhenkun Wang1*, Chen-Yuan Li1*, Zhong-Shi Lyu, PhD1*, Tong Xing1*, Zhi-Wei Zhang1*, Yuan-Yuan Zhang1*, Xiao-Jun Huang, MD1 and Yuan Kong, MD, PhD1*

1Peking University People’s Hospital, Beijing, China
2Peking University People’s Hospital, Beijing, AL, China

Arthur Sterin1*, Cécile Renard, MD2*, Virginie Gandemer3*, Mony Fahd, MD MSc4,5*, Benedicte Bruno6*, Gaelle Stofleth7*, Nimrod Buchbinder, MD8*, Marie Angoso, MD9*, Cecile Pochon10*, Fanny Rialland Battisti, MD11*, Marie Robin, MD12*, Stéphanie Nguyen-Quoc, MD, PhD13*, Jacques-Emanuel Galimard14*, Jean-Hugues Dalle, MD, PHD15, Regis Peffault De Latour16,17* and Flore Sicre De Fontbrune18,19,20,21,22,23*

1Department of Pediatric Hematology, Immunology and Oncology, APHM, La Timone Children Hospital, Department of Pediatric Hematology, Immunolog, Marseille, France
2Institute of Hematology and Pediatric Oncology, Lyon, France
3CHU Hopital Sud, Rennes, FRA
4Pediatric hematology and immunology department, Robert-Debré Hospital, GHU APHP Nord Université Paris-Cité, Paris, France
5Hematology and Immunology Pediatric Department, Robert-Debré Academic Hospital, GHU AP-HP Nord Université Paris Cité, Paris, France
6Chru Lille, Jeanne De Flandre Hématologie Pédiatrique, Lille, FRA
7Pôle Couple Enfants, HCE Immunohématologie et oncologie pédiatriques, grenoble, France
8Department of Pediatric Hematology and Oncology, Rouen University Hospital, Rouen, France
9CHU Bordeaux, bordeaux, France
10Department of Hematology, Centre Hospitalier Régional Universitaire (CHRU), Vandoeuvre-les-Nancy, France
11Hématologie et oncologie pédiatrique, CHU Hôtel Dieu, Nantes, FRA
12Hopital Saint Louis, APHP, Paris, France
13Hematology Department, Pitié-Salpêtrière University Hospital, AP-HP, Paris, France
14EBMT Paris Study Office, Paris, FRA
15Department of Pediatric Hematology and Immunology, University Hospital Robert Debré, Assistance Publique des Hôpitaux de Paris (APHP), Paris, France
16BMT unit, Hôpital Saint-Louis,, Paris, France
17French Référence Center for Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria, Paris, France
18Hematology and Transplant Unit, Saint Louis Hospital, APHP, Paris, France
19French Reference Center for Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria, Saint Louis Hospital, Paris, France
20Centre de Référence Aplasie Médullaire, Service d'Hématologie Greffe, Assistance Publique des Hôpitaux de Paris, Hôpital Saint-Louis, PARIS, FRA
21Service Hematologie Greffe, Centre de Reference des Aplasies Medullaires Acquises et Constitutionnelles, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris, Paris, France
22French National Reference Center for Aplastic Anemia, Paris, France
23Hôpital Saint-Louis, Université Paris Cité, Paris, France

Bruno Fattizzo, MD1, Carmelo Gurnari, MD, PhD2, Sabrina Giammarco, MD, PhD3*, Antony Ricchiuti4*, Hussein Awada5, Marta Bortolotti, MD6*, Giacinto Luca Pedone7*, Francesco Versino, MD8*, Dario Consonni9*, Roochi Trikha10*, Shreyans Gandhi, MD, MBBS, DNB, FRCPath, MPhil, MRCP11*, Simona Sica, MD, PhD3,12,13*, Jaroslaw Maciejewski5, Austin G. Kulasekararaj, MD, MBBS, FRCPath, MRCP14 and Wilma Barcellini, MD15*

1Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy
2Cleveland Clinic Foundation, Cleveland, OH
3Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
4Univeristy of Milan, Milan, ITA
5Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
6S.C. Ematologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
7FONDAZIONE IRCCS CA' GRANDA OSPEDALE MAGGIORE POLICLINICO, MILAN, Italy
8University of Milan, Milano, Italy
9Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
10King's College Hospital NHS, London, United Kingdom
11Department of Haematological Medicine, King's College Hospital NHS, London, United Kingdom
12UOC Ematologia e Trapianto Cellule Staminali Emopoietiche, Fondazione Policlinico Universitario A. Gemelli IRCCS Roma, Rome, Italy
13UNIVERSITA' CATTOLICA SACRO CUORE, ROME, ITA
14King’s College Hospital-NHS Foundation Trust, NIHR/Wellcome King’s Clinical Research Facility, and King’s College London, London, United Kingdom
15Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

Xijuan Lin*, Chen Yang*, Ziwei Liu*, Junling Zhuang, MD, PhD, Miao Chen* and Bing Han*

Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China

Phillip Scheinberg, MD1, Hazza Alzahrani, MD2*, Alejandro Contento Gonzalo3*, Martin Höglund, MD, PhD4, Jin Seok Kim, MD, PhD5*, Jens Panse, MD6,7, Melissa J Rose, DO8,9, Jörg Schubert, MD10*, Yasutaka Ueda, MD, PhD11, Eng Soo Yap, MBBS12*, Muriel Buri13*, Nicolo' Compagno, MD14, Brittany Gentile, PhD15*, Sasha Sreckovic, MD16* and Austin G. Kulasekararaj, MD, MBBS, FRCPath, MRCP17,18

1Hospital A Beneficência Portuguesa, Sao Paulo, SP, Brazil
2Department of Hematology, Stem Cell Transplantation, and Cellular Therapy, Cancer Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
3Complejo Hospitalario Central de Málaga, Málaga, Spain
4Department of Medical Sciences, Uppsala University, Uppsala, Sweden
5Yonsei University College of Medicine, Severance Hospital, Seoul, Korea, Republic of (South)
6Center for Integrated Oncology - Aachen Bonn Cologne Duesseldorf (CIO-ABCD), Aachen, Germany
7Center of Integrated Oncology (CIO), Aachen, Bonne, Cologne, Düsseldorf (ABCD), Germany
8Department of Pediatrics, The Ohio State University, Colombus, OH
9Division of Pediatric Hematology Oncology, Nationwide Children’s Hospital, Columbus, OH
10Elblandklinikum Riesa, Riesa, Germany
11Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan
12Department of Laboratory Medicine, National University Hospital, Singapore, Singapore
13F. Hoffmann-La Roche Ltd, Basel, Switzerland
14F. Hoffmann-La Roche Ltd, Basel, Basel-Stadt, Switzerland
15Genentech, Inc., South San Francisco, CA
16Genentech, Inc, South San Francisco
17King’s College Hospital-NHS Foundation Trust, NIHR/Wellcome King’s Clinical Research Facility, and King’s College London, London, United Kingdom
18King's College London, National Institute for Health and Care Research and Wellcome King’s Research Facility, London, United Kingdom

Antonio M Risitano, MD, PhD1,2,3, Bing Han4*, Austin G. Kulasekararaj, MD, MBBS, FRCPath, MRCP3,5,6,7, Yasutaka Ueda8*, Phillip Scheinberg, MD9, Carlos de Castro10*, Jaroslaw Maciejewski11, Josefin Snellman12*, Olivier Somenzi, PhD12*, Randall Winnette13*, Samopriyo Maitra14*, Shujie Li15*, Marion Dahlke, MD, MSc12* and Regis Peffault De Latour3,16,17*

1AORN Moscati, Avellino, Italy
2University of Naples Federico II, Naples, Italy
3The Severe Aplastic Anemia Working Party of the European Society for Blood and Marrow Transplantation, Barcelona, Spain
4Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
5King’s College Hospital NHS, London, United Kingdom
6National Institute for Health and Care Research and Wellcome King’s Research Facility, London, United Kingdom
7King’s College London, London, United Kingdom
8Osaka University Graduate School of Medicine, Suita, Japan
9Hospital A Beneficência Portuguesa, São Paulo, Brazil
10Duke University School of Medicine, Duke Cancer Institute, Durham, NC
11Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
12Novartis Pharma AG, Basel, Switzerland
13Novartis Pharmaceutical Corporation, East Hanover, NJ
14Novartis Healthcare Private Limited, Hyderabad, India
15China Novartis Institutes for BioMedical Research Co Ltd, Shanghai, China
16French Reference Center for Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria, Saint-Louis Hospital, Paris, France
17Université Paris Cité, Paris, France

Orianne Wagner-Ballon, MD, PhD1, Jean-Philippe Vial, MD2*, Valerie Soenen, PharmD, PhD3*, Anna Raimbault, PharmD, PhD4*, Camille Debord, PharmD5*, Anne-Catherine Lhoumeau, PharmD, PhD6*, Melanie Pannetier, PharmD7*, Francois Vergez, DVM, Ph.D.8*, Caroline Mayeur-Rousse, MD9*, Marie-Christine Jacob, MD10*, Caroline Bret, PhD, PharmD11*, Veronique Harrivel, MD12*, Nicolas Chapuis, PharmD, PhD13*, Elsa Bera, MD14*, Juliette Vo Xuan, PharmD1*, Veronique Latger-Cannard, MD15*, Stéphanie Mathis, PharmD4*, Marie Loosveld, MD, PhD16*, Gerard Socie17, Flore Sicre de Fontbrune, MD17*, Regis Peffault de Latour, MD, PhD17*, Ekbel Amri18*, Yannis Bencherif18*, Bernard Drenou, MD19*, Agathe Debliquis, PharmD19* and Magali Le Garff-Tavernier, PharmD, PhD20*

1Hematology and Immunology Department, Henri Mondor University Hospital, UPEC, IMRB, Assistance Publique Hopitaux de Paris, Créteil, France
2CHU Bordeaux, PESSAC, France
3Laboratoire d’Hématologie, CHU Lille, Lille, France
4Laboratory of Hematology and Flow cytometry, Saint Louis Hospital, APHP, Paris, France
5Nantes University Hospital, Nantes, FRA
6Laboratory of Hematology and Flow cytometry, Cancer Biology department, Institut Paoli-Calmettes, Marseille, France
7Laboratoire d’Hématologie, CHU Rennes, Rennes, France
8Laboratoire d'Hématologie, CHU de Toulouse - Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France
9Laboratory of Hematology and Flow cytometry, CHU Strasbourg, Strasbourg, France
10CHU Grenoble Alpes, La Tronche, France
11CHU Montpellier, Montpellier, France
12Laboratory of Hematology and Flow cytometry, CHU Amiens, Amiens, France
13Institut Cochin, Paris, FRA
14Laboratory of Hematology and Flow cytometry, CHU Rouen, Rouen, France
15CHU Nancy, Nancy, France
16Hematology Laboratory, Marseille, FRA
17Hematology and Transplant Unit, Saint Louis Hospital, APHP, Paris, France
18Alexion Pharma France, Paris, France
19Laboratoire d’Hématologie, Groupe Hospitalier de la Région Mulhouse Sud Alsace, Mulhouse, France
20Hematology Laboratory, Assistance Publique-Hôpitaux de Paris, Pitie-Salpetriere Hospital, Paris, France

W. Jason Cummings, PhD1*, Yi Li, MS1*, Siobhan Hayes2*, Richard Mills2*, Colm Farrell2*, Morag Griffin, MBChB, MRCP3*, J. Steve Whitaker, MD1* and William Pullman, BMedSc, MBBS, PhD, FRACP1

1Omeros Corporation, Seattle, WA
2ICON Clinical Research UK Ltd, Reading, United Kingdom
3Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

Jeanette Walter, MD1,2*, Benjamin Rolles, MD1,2,3,4*, Yannic Schumacher1,2*, Frauke Theis, MD5,6*, Leo Hansmann, MD7,8*, Markus P. Radsak, MD9,10*, Michael Heuser, MD11, Julia-Annabell Georgi, MD12*, Jörg Chromik, MD13*, Beatrice Drexler, MD14*, Jörg Schubert, MD15*, Kim Kricheldorf1,2*, Jens Panse, MD1,2, Thomas Stiehl16*, Tim H. H. Brummendorf, MD1,2, Bhavisha A. Patel, MD17, Neal S. Young, MD17, Emma M. Groarke, MD17 and Fabian Beier, MD1,2*

1Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany
2Center for Integrated Oncology - Aachen Bonn Cologne Duesseldorf (CIO-ABCD), Aachen, Germany
3Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
4Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
5Department of Internal Medicine III, Hematology, Oncology and Palliative Care, University Medical Center Rostock, Rostock, Germany
6University Hospital of Ulm, Ulm, Baden-Württemberg, DEU
7Department of Hematology, Oncology, and Tumor Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
8Department of Internal Medicine III, Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany
9Department of Hematology and Medical Oncology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
10DONAUISAR Klinikum, Deggendorf, Germany
11Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
12Department of Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany
13Department of Medicine, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, Germany
14Department of Hematology, University Hospital Basel, Basel, Switzerland
15Elblandklinikum Riesa, Riesa, Germany
16Institute for Computational Biomedicine and Disease Modeling, RWTH Aachen University, Aachen, Germany
17Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD

Tian Zhang1*, Zixuan Liu1*, Chunyan Liu1*, Nan Song1* and Rong Fu, MD1,2,3

1Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China
2Tianjin Key Laboratory of Bone Marrow Failure and Malignant Hemopoietic Clone Control, Tianjin, China
3Tianjin Institute of Hematology, Tianjin, China

Aashray Mandala, BS1*, Carlos Bravo-Perez, MD1,2*, Matteo D'Addona1,3*, Zachary Brady1*, Mark Orland, MD1, Luca Guarnera, MD1,4*, Kartik Lakhotiya, MS1*, Christopher Haddad, BS1*, Praveena Thiagarajan, MD, PhD1*, Arooj Ahmed, MD1*, Simona Pagliuca, MD, PhD5, Carmelo Gurnari, MD, PhD4,6, Valeria Visconte, PhD7, Arda Durmaz, PhD1* and Jaroslaw Maciejewski7

1Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
2Department of Hematology and Medical Oncology, Hospital Universitario Morales Meseguer, University of Murcia, IMIB-Pascual Parrilla, CIBERER - Instituto de Salud Carlos III, Murcia, Spain
3Hematology and Transplant Center, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Ercolano, Italy
4Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
5Department of Hematology, Nancy University Hospital, Vandœuvre-lès-Nancy, France, France
6Cleveland Clinic Foundation, Cleveland, OH
7Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH

Hussein Awada1, Arda Durmaz, PhD2*, Luca Guarnera, MD1*, Tyler Birkholz3*, Olisaemeka Ogbue, MBBS1, Mark Orland, MD1, Olga Lytvynova, MD4*, Matteo D'Addona1*, Praveena Thiagarajan, MD, PhD1*, Arooj Ahmed, MD1*, Zachary Brady1*, Carlos Bravo-Perez, MD1*, Valeria Visconte, PhD5, Jaroslaw Maciejewski5 and Carmelo Gurnari, MD, PhD6,7

1Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
2Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, CLEVELAND, OH
3Department of Translational Hematology & Oncology Research, Cleveland Clinic, Cleveland, OH
4Department of Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland
5Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
6Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
7Cleveland Clinic Foundation, Cleveland, OH

Huihui Fan1*, Wenrui Yang1*, Xin Zhao2, Li Zhang3*, Liping Jing, MD1* and Fengkui Zhang4*

1Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China
2Red Blood Cell Diseases Center & Regenerative Medicine Clinic, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
3State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Tianjin, China
4State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology Blood Diseases Hospital, Chinese Academy of Medical Sciences Peking Union Medical College, Tianjin, China

Regis Peffault De Latour1,2,3*, Austin G. Kulasekararaj, MD, MBBS, FRCPath, MRCP3,4,5,6, Phillip Scheinberg, MD7, Yasutaka Ueda8*, Carlos de Castro9*, Samopriyo Maitra10*, Philippe Ferber11*, Marion Dahlke, MD, MSc11* and Antonio M Risitano, MD, PhD3,12,13

1French Reference Center for Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria, Saint-Louis Hospital, Paris, France
2Université Paris Cité, Paris, France
3The Severe Aplastic Anemia Working Party of the European Society for Blood and Marrow Transplantation, Barcelona, Spain
4National Institute for Health and Care Research and Wellcome King’s Research Facility, London, United Kingdom
5King's College London, London, United Kingdom
6King’s College Hospital NHS, London, United Kingdom
7Hospital A Beneficência Portuguesa, São Paulo, Brazil
8Osaka University Graduate School of Medicine, Suita, Japan
9Duke University School of Medicine, Duke Cancer Institute, Durham, NC
10Novartis Healthcare Private Limited, Hyderabad, India
11Novartis Pharma AG, Basel, Switzerland
12AORN Moscati, Avellino, Italy
13University of Naples Federico II, Naples, Italy

*signifies non-member of ASH