66th ASH Annual Meeting: 301. Platelets and Megakaryocytes: Basic and Translational: Poster III

Symposia: Platelets and Megakaryocytes: Basic and Translational Oral and Poster Abstracts
Poster

Research, Bleeding and Clotting, Bleeding disorders, Fundamental Science, Adult, Drug development, Translational Research, Genomics, Bioinformatics, Platelet disorders, Hematopoiesis, Thromboembolism, Diseases, Cell expansion, Treatment Considerations, Biological therapies, Immunology, Thrombotic disorders, Biological Processes, Emerging technologies, Technology and Procedures, Molecular biology, Study Population, Human, Imaging, Transfusion, Animal model

Halls G-H (San Diego Convention Center)

3925

Enhanced Detection and Functional Analysis of Reticulated Platelets in Myocardial Ischemia/Reperfusion Injury

Muataz A. Hamad^1,2,3,4,5^*, Krystin Krauel, PhD⁴^*, Nancy Schanze, PhD⁴^*, Stefanie Perez-Feliz⁶^*, Josef Madl, PhD⁶^*, Pia Iaconianni⁶^*, Mark Zurek, MD⁷^*, Thomas Nuehrenberg, MD⁷^* and Daniel Duerschmied, MD⁴^*

¹Heart Center, Department of Cardiology and Angiology I, Faculty of Medicine, University of Freiburg, Freiburg, Germany
²Faculty of Biology, University of Freiburg, Freiburg, Germany
³Spemann Graduate School of Biology and Medicine (SGBM), Freiburg, Germany
⁴University Medical Centre Mannheim, Department of Cardiology, Angiology, Haemostaseology, and Medical Intensive Care, Heidelberg University, Mannheim, Germany
⁵Partner Site Heidelberg/Mannheim, European Center for AngioScience (ECAS) and German Center for Cardiovascular Research (DZHK), Mannheim, Germany
⁶University Heart Center, Faculty of Medicine, Institute for Experimental Cardiovascular Medicine, Freiburg, Germany
⁷University Heart Center, Faculty of Medicine, University of Freiburg, Bad Krozingen, Germany

3926

Large Scale Manufacturing of GMP Grade Cord Blood Derived Megakaryocytes for Chemotherapy Induced Thrombocytopenia

Hila Shaim, MD¹, Mayela Carolina Mendt, PhD¹^*, Hani Lee²^*, Bijender Kumar, PhD¹^*, Min Soon Cho, PhD³^*, Alejandro Ramirez³^*, Indreshpal Kaur, PhD¹^*, Torey Mallory³^*, Arthur Aquino³^*, Patrick Olivares³^*, Cody Hensley³^*, Kendall Friedman³^*, Mecit Kaplan¹, Ana K. Nunez Cortes, MD¹^*, Jeff Wilson⁴^*, Jeremy Ramdial, MD¹, Uday Popat, MD¹, Vahid Afshar-Kharghan, MD², Katayoun Rezvani, MD, PhD¹ and Elizabeth J. Shpall, MD¹

¹Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
²M.D. Anderson Cancer Center, Houston, TX
³MD Anderson Cancer Center, Houston, TX
⁴MD Anderson, Houston, TX

3927

Identification of Megakaryocytes As a Functional Component of Circulation Blood

Ying Lei¹^*, Jia Si, PhD^1,2^*, Yu Liu^1,2^*, Pucai Xia^1,2^*, Yukuan Liu^1,2^*, Jie Zhang^1,2^*, Xiaohui Zhang, MD³, Yueying Li, PhD^1,2^* and Qian-Fei Wang, PhD^1,2

¹Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
²China National Center for Bioinformation, Beijing, China
³Peking University People's Hospital, Beijing, China

3928

Chromatin Remodeling By GATA1s Alters Megakaryocytic Gene Expression

Carini Picardi Morais de Castro¹^*, Gerard Martínez-Cebrián, PhD¹^*, Miguel Quijada-álamo, PhD²^*, Grace Freed²^*, Lucía Lorenzi, PhD¹^*, Sébastien Malinge, PhD³^*, Elvin Wagenblast, PhD⁴ and Sergi Cuartero, PhD¹^*

¹Josep Carreras Leukemia Research Institute, Badalona, Spain
²Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY
³Telethon Kids Institute, Perth, Australia
⁴The Mount Sinai Hospital, Icahn School of Medicine, New York, NY

3929

12-HETE Regulates Procoagulant Platelet Formation By Promoting Mitochondrial Depolarization

Hem Kumar Tamang, PhD¹, Michael Kamradt, PhD²^*, Jessica Seifert¹^*, Catherine Makarewich, PhD^2,3^* and Benjamin Tourdot, PhD^4,5

¹Experimental Hematology, Cincinnati Children's Hospital, Cincinnati, OH
²Molecular Cardiovascular Biology, Cincinnati Children's Hospital, Cincinnati, OH
³Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH
⁴Department of Pediatrics, Cincinnati Children's Hospital, Cincinnati, OH
⁵Department of Pediatrics, Cincinnati Children's Hospital, CINCINNATI, OH

3930

Bone Marrow Remodeling and Pro-Inflammatory Megakaryocytes in a Murine Model of Chronic Kidney Disease

Estelle Carminita, PhD^1,2^*, Virginia Camacho, PhD^1,3, Isabelle C Becker, PhD, MSc^1,3, Maria Barrachina, PhD^4,5, Karen Guo⁴^*, Kellie R. Machlus, PhD⁶ and Joseph E. Italiano, PhD^1,3

¹Vascular Biology Program, Boston Children's Hospital, Boston, MA
²Surgery Departement, Harvard Medical School, Boston, MA
³Harvard Medical School, Boston, MA
⁴Vascular Biology Program, Boston Children's Hospital, Boston
⁵Surgery Department, Harvard Medical School, Boston
⁶Vascular Biology Program, Harvard Medical School and Boston Children's Hospital, Boston, MA

3931

Post-Injury Treatment with Rapid Intraosseous Injection of Lyophilized Synthetic Platelets Enhances Survival, Hemostasis, and Hemodynamics in a Rat Model of Liver Laceration

Zeyu Liu¹, Zachary A Secunda, MA²^*, Abiha Abdullah, MBBS²^*, Riya Sharma²^*, Norman F Luc, MS³^*, Lauren Jackson, BS²^*, Baylee Traylor, BS⁴^*, Dante Disharoon, PhD³^*, Christa Pawlowski, PhD⁴^*, Ujjal Didar Singh Sekhon, PhD⁴^*, Emma Quill⁴^*, Philip Charles Spinella, MD²^*, Susan M Shea, PhD², Michael A Bruckman, PhD⁴^*, Anirban Sen Gupta, PhD³^* and Matthew Neal, MD⁵

¹Trauma and Transfusion Medicine Research Center, Department of Surgery, University of Pittsburgh, Pittsburgh, CA
²Trauma and Transfusion Medicine Research Center, Department of Surgery, University of Pittsburgh, Pittsburgh, PA
³Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH
⁴Haima Therapeutics, Cleveland, OH
⁵University of Pittsburgh, Pittsburgh, PA

3932

12-Hepe Regulates the Antiplatelet Effects of Epa, the ω-3 Fatty Acid

Krista A Goerger, BSc¹^*, Livia Stanger¹, Andrew Rickenberg²^*, Theodore Holman³^* and Michael Holinstat, PhD¹

¹Pharmacology, University of Michigan, Ann Arbor, MI
²University of Michigan, Ann Arbor, MI
³UCSC, Santa Cruz, CA

3933

Comparison of the Anti-Platelet and Anti-Thrombotic Effects of the Dual SGLT1/2 Inhibitor Sotagliflozin to the Relatively Selective SGLT2 Inhibitor Empagliflozin

Livia Stanger¹, Pooja Yalavarthi¹^*, Mariane Flores, PhD¹^*, David Creen¹^*, Bertram Pitt, MD²^* and Michael Holinstat, PhD¹

¹Pharmacology, University of Michigan, Ann Arbor, MI
²Internal Medicine, University of Michigan, Ann Arbor, MI

3934

Cathepsin G Potentiates Biased Signaling through Protease Activated Receptor 4

NaShea Kendrick, BS and Marvin T. Nieman, PhD

Department of Pharmacology, Case Western Reserve University, Cleveland, OH

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^*signifies non-member of ASH