66th ASH Annual Meeting: 102. Iron Homeostasis and Biology: Poster III

Symposia: Iron Homeostasis and Biology Oral and Poster Abstracts
Poster

Research, Antibody Therapy, Autoimmune disorders, Fundamental Science, Clinical Practice (Health Services and Quality), Translational Research, Genetic Disorders, Thalassemia, Hemoglobinopathies, Hematopoiesis, Diseases, Immune Disorders, Treatment Considerations, Biological therapies, Metabolism, Biological Processes, Study Population, Pathogenesis, Animal model

Halls G-H (San Diego Convention Center)

3848

Hetrombopag, an Emerging Iron-Chelating Agent, Alleviates Systemic Iron Overload

Yufei Zhao, MD¹^*, Xin Zhao², Wenrui Yang³^* and Fengkui Zhang⁴^*

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical Colleg, Tianjin, China
²State Key Laboratory of Experimental Hematology,National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
³Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China
⁴State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Anemia Therapeutic Center, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

3849

Anti-Hemojuvelin Monoclonal Antibody Reverses Anemia and Exerts Disease-Modifying Effects in a Mouse Model of Inflammatory Bowel Disease

Julia Xu^*, Brian MacDonald, MD^* and Min Wu, PhD

Disc Medicine Inc., Watertown, MA

3850

Homozygous C282Y Hereditary Hemochromatosis: Evolution and Prognosis in a Cohort of Patients Followed up over 30 Years

Cristina Sanz, MD, PhD¹^*, Eduardo Aguilar-Meseguer, MD²^*, Marie Solange Flores-Moran, M.D.³^*, Zoe Mariño, MD, PhD⁴^*, Alexandra Pedraza, M.D., PhD⁵^*, Ana Isabel Faundez⁶^*, Nuria Guanyabens, MD, PhD⁷^*, Aurora Sanchez, MD, PhD⁸^*, Meritxell Nomdedeu, MD, PhD⁹^* and Arturo Pereira, MD, PhD¹⁰^*

¹Transfusion Service, Biomedical Diagnostic Service (CDB), Hospital Clinic, Barcelona, ESP
²Instituto del cancer y enfermedades hematologicas, Hospital Clinic, Barcelona, Barcelona, Spain
³Transfusion Service, Biomedical Diagnostic Service (CDB), Blood and Tissue Bank, Hospital Clinic, Barcelona, Cataluña, Spain
⁴Liver Unit, Hospital Clinic Barcelona, IDIBAPS, ERN-RARE Liver, CIBERehd, Universitat de Barcelona, Hospital Clinic, Barcelona, Barcelona, Spain
⁵Transfusion Service, Biomedical Diagnostic Service (CDB), Blood and Tissue Bank, Hospital Clinic, Barcelona, Spain
⁶. Transfusion Service, Biomedical Diagnostic Service (CDB),, Hospital Clinic, Barcelona, Barcelona, Spain
⁷Reumatology department, ICMiD institut, IDIBAPS,, Hospital Clinic, Barcelona, Barcelona, Spain
⁸Biochemical and molecular genetics department, Biomedical Diagnostic Service (CDB),IDIBAPS,, Hospital Clínic, Barcelona, Barcelina, Spain
⁹Department of Hemotherapy and Hemostasis, Hospital Clinic of Barcelona, Barcelona, Spain
¹⁰Transfusion Service, Biomedical Diagnostic Service (CDB),, Hospital Clínic, Barcelona, ESP

3851

Mouse Models of Hereditary Xerocytosis-Associated PIEZO1 Mutations Reveal Genotype-Phenotype Differences in Hematological Defects and Iron Loading

Karin E Finberg, MD, PhD¹, Ludmila Peres Diaz, PhD²^*, Peiying Shan, MD²^*, Eileen Chua, BS¹^*, Kiran Lalwani, PhD³^* and Patrick G. Gallagher, MD^4,5

¹Department of Pathology, Yale School of Medicine, New Haven, CT
²Department of Pediatrics, Yale School of Medicine, New Haven, CT
³Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH
⁴Center for Perinatal Research, Nationwide Childrens, Ohio State University, Columbus, CT
⁵Center for Perinatal Research, Nationwide Childrens, Ohio State University, Columbus, OH

3852

Hyperactive Erythropoiesis Induced By Hematopoietic Tfr2 Deletion Corrects Glucose Abnormalities in β-Thalassemic Mice

Simona Maria Di Modica, MSc^1,2,3^*, Emanuele Tanzi, MSc^1,2^*, Alessia Pagani, PhD¹^*, Laura Silvestri, PhD^1,2 and Antonella Nai, PhD^1,2

¹Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milano, Italy
²Vita-Salute San Raffaele University, Milano, Italy
³Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy

3853

Erythroferrone Overexpression Mitigates Anemia and Improves Kidney Function in a Mouse Model of CKD

Brian Czaya, PhD¹^*, Elizabeta Nemeth, PhD² and Tomas Ganz, MD, PhD²

¹Center for iron disorders, David Geffen School of Medicine At UCLA, Los Angeles, CA
²Center for Iron Disorders, University of California, Los Angeles, Los Angeles, CA

3854

Long-Acting Anti-Matriptase-2 Antibody As a Potentially Best-in-Class Therapy for Iron Overload Diseases

Mark Ma, MD

Translational Sciences and Early Development, Rallybio, New Haven, CT

See more of: Oral and Poster Abstracts

<< Previous Session | Next Session >>

^*signifies non-member of ASH