-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

503. Clonal Hematopoiesis, Aging, and Inflammation: Poster II

Symposia: Clonal Hematopoiesis, Aging, and Inflammation Program: Oral and Poster Abstracts
Type: Poster
Sunday, December 8, 2024: 6:00 PM-8:00 PM
Halls G-H (San Diego Convention Center)

Hui Hui Li, PhD1, Althea Agdamag, MD2, Zixing Huang3*, Anisa A. Gumerova, MD, PhD, DSc4*, Georgii Pevnev, MD5*, Paul S. Frenette, MD6*, Mone Zaidi, MD, PhD5*, Jeffrey A. Glassberg, MD7, Yelena Ginzburg, MD8 and Ronald Hoffman, MD9

1Emergency Medicine, Pharmacological Science, Icahn School of Medicine at Mount Sinai, New York, NY
2Icahn school of Medicine at Mount Sinai, New York
3Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
4The Mount Sinai Bone Program, Departments of Pharmacological Sciences and of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
5Icahn School of Medicine at Mount Sinai, New York, NY
6Department of Medicine, Albert Einstein College of Medicine, Bronx, NY
7Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
8Department of Medicine, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY
9Tisch Cancer Institute, Department of Medicine, Division of Hematology/Oncology, Myeloproliferative Neoplasm-Research Consortium, Icahn School of Medicine at Mount Sinai, New York, NY

Alexander R. Marr, BS1, Madeline Halpin, BS1*, Dominique L. Corbin, BS1*, Britten K. Gordon, BS1, Samon Benrashid, BS1*, Ethan C. Whipp, MSc2*, Jean Truxall, BS1*, Olivia Cahn1*, Bethany L. Mundy-Bosse, PhD1, Julia Cooper, MS, LGC3*, Marina Beltrami Moreira, MD, PhD1, James S. Blachly, MD1, Uma Borate, MD1, Jennifer A. Woyach, MD1, Rosa Lapalombella, PhD1 and Nicole R. Grieselhuber, MD, PhD4

1The Ohio State University, Columbus, OH
2Comprehensive Cancer Center - Wexner Medical Center, The Ohio State University, Columbus, OH
3The Ohio State University Wexner Medical Center, Division of Human Genetics, Columbus, OH
4The Ohio State University, Columbus

Jahanara Rajwani1, Marco Buttigieg, BSc1*, Caitlyn Vlasschaert, MD, PhD2* and Michael J. Rauh, MD, PhD3

1Queen's University, Kingston, ON, Canada
2Department of Medicine, Queen's University, Kingston, ON, CAN
3Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada

Jennifer Yeung, PhD, BS1, Sophia Philbrook, B.S.2*, Kwangmin Choi, PhD3*, Kathleen Hueneman, MBA2*, Erin K. Hertlein, PhD4, John C. Byrd, MD4 and Daniel Starczynowski, PhD2,5,6,7,8,9,10

1Divison of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
2Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
3Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
4Department of Internal Medicine, University of Cincinnati, Cincinnati, OH
5Cincinnati Children's Hospital, Cincinnati, OH
6University of Cincinnati College of Medicine, Cincinnati, OH
7Department of Cancer Biology, University of Cincinnati, Cincinnati, OH
8University of Cincinnati Cancer Center, Cincinnati, OH
9Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
10Cincinnati Children’s Hospital, Cincinnati, OH

Dongxu Jiang, PhD1,2, Daniel J Vail1*, Yahan Zhang, MS1,2, Raziullah Khan1*, Anand Tiwari3*, Simon Schlanger, MS1*, Kunho Chung, PhD4, Cassandra Gilmour1*, Xiaorong Gu, PhD2*, Yvonne Parker, MS2*, J. Joseph Melenhorst, PhD4, Daniel Lindner, MD, PhD2*, Jaroslaw Maciejewski5 and Babal K. Jha, PhD1,2

1Center for Immunotherapy & Precision Immuno-Oncology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
2Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
3Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
4Center for Immunotherapy and Precision Immuno-Oncology, Cell Therapy & Immuno-Engineering Program, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
5Taussig Cancer Center, Cleveland, OH

Reyhan Diz-Kucukkaya, MD1*, Taner Iyigun2*, Özgür Albayrak3*, Candan Eker4* and Tuba Günel1*

1Department of Molecular Biology and Genetics, Istanbul University Faculty of Science, ISTANBUL, Turkey
2Department of Cardiovascular Surgery, Mehmet Akif Ersoy Chest and Cardiovascular Surgery Education and Research Hospital, ISTANBUL, Turkey
3Flow Cytometry Core Facility, Research Center for Translational Medicine, Koc University Hospital, ISTANBUL, Turkey
4Department of Genetic and Bioengineering, Faculty of Engineering and Natural Sciences, Istanbul Bilgi University, ISTANBUL, Turkey

Michele C Buck, MSc1*, Jennifer Rivière, PhD1*, Anna Navarro Figueredo1*, Daniele Scarcella, MSc2*, Maximilian Buser, PhD2*, Judith S. Hecker, MD1*, Mark van der Garde, PhD1*, Carsten Marr, PhD2,3* and Katharina S. Götze, MD4

1Department of Medicine III, Hematology and Oncology, Technical University of Munich (TUM), School of Medicine and Health, Munich, Germany
2Institute of AI for Health, Helmholtz Zentrum Munich - German Research Center for Environmental Health, Neuherberg, Germany
3Helmholtz AI, Helmholtz Zentrum Munich - German Research Center for Environmental Health, Neuherberg, Germany
4Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany

Mahmoud Yacout1,2*, Bahga Katamesh1*, Yazan Jabban, MD3*, Rong He, MD4, Patricia Greipp, DO4, Dragan Jevremovic, M.D., Ph.D1*, James M. Foran, MD5, Cecilia Y. Arana Yi, MD6, Antoine N. Saliba, MD7, Abhishek A. Mangaonkar, MBBS1, Mithun V Shah, M.D., Ph.D.7, Mrinal M. Patnaik, MD, MBBS1, Hassan B Alkhateeb, MD7* and Aref Al-Kali, MD7

1Mayo Clinic, Rochester, MN
2Corewell Health William Beaumont University Hospital, Royal Oak, MI
3Divis, Mayo Clinic, Rochester, MN
4Division of Hematopathology, Mayo Clinic, Rochester, MN
5Division of Hematology & Medical Oncology, Mayo Clinic, Jacksonville, FL
6Division of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ
7Division of Hematology, Mayo Clinic, Rochester, MN

Jeanette YC Sullivan, BS1, Jane H Chen, BS2*, Xin (Helen) Huang, BS3*, Jianhong C Heidmann, BS3*, Gajalakshmi Ramanathan, PhD3*, Nneamaka Iwobi, BS4*, Nicole Sparks, PhD4*, David Herman, PhD4*, Michael Kleinman, PhD4* and Angela G. Fleischman, MD, PhD5

1Biological Chemistry, University of California, Irvine, IRVINE, CA
2University of California, Irvine, Irvine
3University of California, Irvine, Irvine, CA
4Environmental and Occupational Health, University of California, Irvine, Irvine, CA
5Division of Hematology/Oncology, University of California, Irvine, Irvine, CA

Brittany Knick Ragon, MD1, Manisha Bhutani, MD1, Barry Paul, MD, MS1, Yifan Pang, MD1, Cindy Varga, MD, BSc1, Srinivasa Reddy Sanikommu, MD1, Bei Hu, MD1, Ryan Jacobs1, Tamara K Moyo, MD1*, Shebli Atrash, MD, MS1, Christopher J Ferreri, MD1*, Steven I. Park, MD1, David M Foureau, PhD2, Nilanjan Ghosh, MD, PhD1, Peter M. Voorhees, MD1, Ariel Bell, MPH3*, Phillip Holmes-Snowden, MHA3*, Olga Better, MS3*, Nury M. Steuerwald, PhD4, Wei Sha, PhD5*, Lawrence J. Druhan, PhD3 and Michael R. Grunwald, MD1

1Department of Hematologic Oncology and Blood Disorders, Atrium Health Levine Cancer Institute, Charlotte, NC
2Immune Monitoring Core Laboratory, Atrium Health Levine Cancer Institute, Charlotte, NC
3Hematology Oncology Translational Research Laboratory, Atrium Health Levine Cancer Institute, Charlotte, NC
4Molecular Biology Core Laboratory, Atrium Health Levine Cancer Institute, Charlotte, NC
5Department of Biostatistics and Data Sciences, Atrium Health Levine Cancer Institute, Charlotte, NC

Marie Demmerle1*, Alessa Klär1*, Alexander Streuer, MD2*, Vladimir Riabov1*, Eva Altrock1*, Felicitas Rapp1*, Ann-Christin Belzer1*, Teresa Klink1*, Meret Hahn1*, Franziska Hofmann1*, Verena Nowak1*, Nadine Weimer1*, Julia Oblaender1*, Iris Palme1*, Melda Göl1*, Ali Darwich, MD3*, Mohammed Abba, MD2*, Georgia Metzgeroth, MD1*, Wolf-Karsten Hofmann, MD2, Daniel Nowak, MD2* and Nanni Schmitt1*

1Department of Hematology and Oncology, Medical Faculty Mannheim of the Heidelberg University, Mannheim, Germany
2Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
3Department of Orthopedic Surgery, Medical Faculty Mannheim of the Heidelberg University, Mannheim, Germany

Lamis Naddaf, PhD1, Marco De Dominici, PhD2, Xiaowen Chen, PhD3*, Parveen Kumar, PhD3*, James S Chavez4*, Travis Roeder5*, Shilpita Karmakar, PhD3, Eric M. Pietras, PhD6, Hideyuki Oguro, PhD7, James DeGregori, PhD8* and Sheng Li, PhD9*

1USC Keck School of Medicine - University of Southern California, Farmington, CT
2University of Colorado Anschuz Medical Campus, Aurora, CO
3Jackson Laboratory, Farmington, CT
4Cancer Institute, Stanford University School of Medicine, Stanford, CA
5University of Connecticut School of Medicine, Farmington, CT
6Division of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO
7University of Connecticut Health Center, Farmington, CT
8University of Colorado Anschutz Medical Campus, Aurora, CO
9Biochemistry and Molecular Medicine, University of Southern California, Los Angeles, CA

Ridzky A. A. Yuda, PhD1*, Valerie Kellet, BS1*, Haruna B. Choijilsuren, BS1*, Zewen Ha1*, Fan Yang, MS1* and Moonjung Jung, MD, MS1,2,3

1Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
2Sidney Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD
3Division of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD

Michael Spencer Chapman, MBBS1,2*, Emily Mitchell, FRCPath3*, Kenichi Yoshida, MD, PhD4, Nicholas Williams, PhD3*, Margarete A. Fabre5,6*, Anna Maria Ranzoni, PhD3*, Philip S. Robinson3*, Lori Kregar, MPhil3*, C. Matthias Wilk7*, Steffen Boettcher, MD8*, Krishnaa Mahbubani9*, Kourosh Saeb-Parsy9*, Stanley Ng3*, George S Vassiliou, MD, PhD6,10, Kate Gowers11*, Sam Janes12*, Matt Hoare13*, Anthony R Green14, Ana Cvejic15,16*, Markus G. Manz, MD17, Elisa Laurenti, PhD18,19*, Inigo Martincorena3*, Michael Stratton3*, Jyoti Nangalia, MBBChir3, Tim H.H. Coorens, PhD3,20* and Peter Campbell, PhD3*

1Barts Cancer Institute, Department of Haemato-oncology, London, United Kingdom
2Wellcome Sanger Institute, London, ENG, United Kingdom
3Wellcome Sanger Institute, Hinxton, United Kingdom
4Division of Cancer Evolution, National Cancer Center Research Institute, Tokyo, Japan
5Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom
6Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom
7University of Zurich and University Hospital Zurich, Department of Medical Oncology and Hematology, Zurich, Switzerland
8Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Zurich, Zurich, Switzerland
9University of Cambridge, Cambridge, GBR
10Department of Haematology and Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
11UCL Respiratory, University College London, Lungs For Living Research Centre, London, United Kingdom
12UCL Respiratory, University College London,, Lungs For Living Research Centre, London, United Kingdom
13Early Cancer Institute, Cambridge, United Kingdom
14University of Cambridge, Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom
15University of Cambridge, Cambridge, ENG, United Kingdom
16University of Copenhagen, Biotech Research & Innovation Centre (BRIC), Copenhagen, Denmark
17Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Zurich, Switzerland
18Department of Hematology, Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
19Department of Haematology, University of Cambridge, Cambridge, ENG, United Kingdom
20Broad Institute of MIT and Harvard, Cambridge, MA

Mael Heiblig, MD, PhD1*, Vincent Jachiet2*, Jerome Hadjadj, MD, PhD3,4*, Lin Pierre Zhao, MD, PhD5*, Thibault Comont6*, Hervé Lobbes7*, Valentin Lacombe8*, Anne Blandine Boutin9*, Joris Galland10*, Yesim Dargaud, MD, PhD11, Benjamin Terrier, MD, PhD12*, Sophie Georgin-Lavialle13*, Pierre Fenaux, MD14,15,16 and Arsene Mekinian, MD, PhD2*

1Centre Hospitalier Lyon Sud, Pierre Bénite, France
2Saint Antoine Hospital AP-HP, Paris, France
3Saint Antoine Hospital, APHP, Paris, France
4INSERM UMR 1163-Institut Imagine, PARIS, FRA
5Hôpital Saint-Louis, Université de Paris 7, Paris, France
6Internal Medicine and Immune Diseases, University Hospital Toulouse - Cancer Institute, Toulouse, France
7Clermont-Ferrand University Hospital, Clermont-Ferrand, FRA
8Angers University Hospital, Angers, France
9Centre Alpes Lémant, Contamine S/ Arve, FRA
10Département de médecine interne, CH Bourg en Bresse, Bourg en Bresse, France
11Hopital Louis Pradel, Hemophilia Center and Clinical Haemostasis Unit, France, Lyon, France
12Department of Internal Medicine, National Referral Center for Rare and Systemic Autoimmune Diseases, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France
13INSERM and AP-HP, Paris, FRA
14INSERM UMR-S1131 Institut de la Recherche Saint Louis, Univeristy Paris Cité, Paris, France
15EuroBloodNet, Paris, France
16Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France

Zachary Brady1*, Nakisha D Williams, MBBS1*, Arda Durmaz, PhD2*, Luca Guarnera, MD1,3*, Matteo D'Addona1,4*, Aashray Mandala, BS1*, Heesun J. Rogers, MD5*, Carmelo Gurnari, MD, PhD1,3, Jaroslaw Maciejewski1, Carlos Bravo-Perez, MD1,6* and Valeria Visconte, PhD7

1Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
2Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, CLEVELAND, OH
3Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
4Department of Medicine and Surgery, University of Salerno, University of Salerno, Baronissi, Salerno, Italy
5Diagnostics Institute, Robert J. Tomsich Department of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH
6Department of Hematology and Medical Oncology, Hospital Universitario Morales Meseguer, University of Murcia, IMIB-Pascual Parrilla, CIBERER - Instituto de Salud Carlos III, Murcia, Spain
7Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH

*signifies non-member of ASH