Hui Hui Li, PhD¹, Althea Agdamag, MD², Zixing Huang^3*, Anisa A. Gumerova, MD, PhD, DSc^4*, Georgii Pevnev, MD^5*, Paul S. Frenette, MD^6*, Mone Zaidi, MD, PhD^5*, Jeffrey A. Glassberg, MD⁷, Yelena Ginzburg, MD⁸ and Ronald Hoffman, MD⁹

¹Emergency Medicine, Pharmacological Science, Icahn School of Medicine at Mount Sinai, New York, NY
²Icahn school of Medicine at Mount Sinai, New York
³Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
⁴The Mount Sinai Bone Program, Departments of Pharmacological Sciences and of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
⁵Icahn School of Medicine at Mount Sinai, New York, NY
⁶Department of Medicine, Albert Einstein College of Medicine, Bronx, NY
⁷Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
⁸Department of Medicine, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY
⁹Tisch Cancer Institute, Department of Medicine, Division of Hematology/Oncology, Myeloproliferative Neoplasm-Research Consortium, Icahn School of Medicine at Mount Sinai, New York, NY

Alexander R. Marr, BS¹, Madeline Halpin, BS^1*, Dominique L. Corbin, BS^1*, Britten K. Gordon, BS¹, Samon Benrashid, BS^1*, Ethan C. Whipp, MSc^2*, Jean Truxall, BS^1*, Olivia Cahn^1*, Bethany L. Mundy-Bosse, PhD¹, Julia Cooper, MS, LGC^3*, Marina Beltrami Moreira, MD, PhD¹, James S. Blachly, MD¹, Uma Borate, MD¹, Jennifer A. Woyach, MD¹, Rosa Lapalombella, PhD¹ and Nicole R. Grieselhuber, MD, PhD⁴

¹The Ohio State University, Columbus, OH
²Comprehensive Cancer Center - Wexner Medical Center, The Ohio State University, Columbus, OH
³The Ohio State University Wexner Medical Center, Division of Human Genetics, Columbus, OH
⁴The Ohio State University, Columbus

Jahanara Rajwani¹, Marco Buttigieg, BSc^1*, Caitlyn Vlasschaert, MD, PhD^2* and Michael J. Rauh, MD, PhD³

¹Queen's University, Kingston, ON, Canada
²Department of Medicine, Queen's University, Kingston, ON, CAN
³Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada

Jennifer Yeung, PhD, BS¹, Sophia Philbrook, B.S.^2*, Kwangmin Choi, PhD^3*, Kathleen Hueneman, MBA^2*, Erin K. Hertlein, PhD⁴, John C. Byrd, MD⁴ and Daniel Starczynowski, PhD^{2,5,6,7,8,9,10}

¹Divison of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
³Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
⁴Department of Internal Medicine, University of Cincinnati, Cincinnati, OH
⁵Cincinnati Children's Hospital, Cincinnati, OH
⁶University of Cincinnati College of Medicine, Cincinnati, OH
⁷Department of Cancer Biology, University of Cincinnati, Cincinnati, OH
⁸University of Cincinnati Cancer Center, Cincinnati, OH
⁹Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
¹⁰Cincinnati Children’s Hospital, Cincinnati, OH

Dongxu Jiang, PhD^1,2, Daniel J Vail^1*, Yahan Zhang, MS^1,2, Raziullah Khan^1*, Anand Tiwari^3*, Simon Schlanger, MS^1*, Kunho Chung, PhD⁴, Cassandra Gilmour^1*, Xiaorong Gu, PhD^2*, Yvonne Parker, MS^2*, J. Joseph Melenhorst, PhD⁴, Daniel Lindner, MD, PhD^2*, Jaroslaw Maciejewski⁵ and Babal K. Jha, PhD^1,2

¹Center for Immunotherapy & Precision Immuno-Oncology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
²Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
³Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁴Center for Immunotherapy and Precision Immuno-Oncology, Cell Therapy & Immuno-Engineering Program, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
⁵Taussig Cancer Center, Cleveland, OH

Reyhan Diz-Kucukkaya, MD^1*, Taner Iyigun^2*, Özgür Albayrak^3*, Candan Eker^4* and Tuba Günel^1*

¹Department of Molecular Biology and Genetics, Istanbul University Faculty of Science, ISTANBUL, Turkey
²Department of Cardiovascular Surgery, Mehmet Akif Ersoy Chest and Cardiovascular Surgery Education and Research Hospital, ISTANBUL, Turkey
³Flow Cytometry Core Facility, Research Center for Translational Medicine, Koc University Hospital, ISTANBUL, Turkey
⁴Department of Genetic and Bioengineering, Faculty of Engineering and Natural Sciences, Istanbul Bilgi University, ISTANBUL, Turkey

Michele C Buck, MSc^1*, Jennifer Rivière, PhD^1*, Anna Navarro Figueredo^1*, Daniele Scarcella, MSc^2*, Maximilian Buser, PhD^2*, Judith S. Hecker, MD^1*, Mark van der Garde, PhD^1*, Carsten Marr, PhD^2,3* and Katharina S. Götze, MD⁴

¹Department of Medicine III, Hematology and Oncology, Technical University of Munich (TUM), School of Medicine and Health, Munich, Germany
²Institute of AI for Health, Helmholtz Zentrum Munich - German Research Center for Environmental Health, Neuherberg, Germany
³Helmholtz AI, Helmholtz Zentrum Munich - German Research Center for Environmental Health, Neuherberg, Germany
⁴Department of Medicine III, TUM University Hospital, Technical University of Munich, Munich, Germany

Mahmoud Yacout^1,2*, Bahga Katamesh^1*, Yazan Jabban, MD^3*, Rong He, MD⁴, Patricia Greipp, DO⁴, Dragan Jevremovic, M.D., Ph.D^1*, James M. Foran, MD⁵, Cecilia Y. Arana Yi, MD⁶, Antoine N. Saliba, MD⁷, Abhishek A. Mangaonkar, MBBS¹, Mithun V Shah, M.D., Ph.D.⁷, Mrinal M. Patnaik, MD, MBBS¹, Hassan B Alkhateeb, MD^7* and Aref Al-Kali, MD⁷

¹Mayo Clinic, Rochester, MN
²Corewell Health William Beaumont University Hospital, Royal Oak, MI
³Divis, Mayo Clinic, Rochester, MN
⁴Division of Hematopathology, Mayo Clinic, Rochester, MN
⁵Division of Hematology & Medical Oncology, Mayo Clinic, Jacksonville, FL
⁶Division of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ
⁷Division of Hematology, Mayo Clinic, Rochester, MN

Jeanette YC Sullivan, BS^1*, Jane H Chen, BS^2*, Xin (Helen) Huang, BS^3*, Jianhong C Heidmann, BS^3*, Gajalakshmi Ramanathan, PhD^3*, Nneamaka Iwobi, BS^4*, Nicole Sparks, PhD^4*, David Herman, PhD^4*, Michael Kleinman, PhD^4* and Angela G. Fleischman, MD, PhD⁵

¹Biological Chemistry, University of California, Irvine, IRVINE, CA
²University of California, Irvine, Irvine
³University of California, Irvine, Irvine, CA
⁴Environmental and Occupational Health, University of California, Irvine, Irvine, CA
⁵Division of Hematology/Oncology, University of California, Irvine, Irvine, CA

Brittany Knick Ragon, MD¹, Manisha Bhutani, MD¹, Barry Paul, MD, MS¹, Yifan Pang, MD¹, Cindy Varga, MD, BSc¹, Srinivasa Reddy Sanikommu, MD¹, Bei Hu, MD¹, Ryan Jacobs¹, Tamara K Moyo, MD^1*, Shebli Atrash, MD, MS¹, Christopher J Ferreri, MD^1*, Steven I. Park, MD¹, David M Foureau, PhD², Nilanjan Ghosh, MD, PhD¹, Peter M. Voorhees, MD¹, Ariel Bell, MPH^3*, Phillip Holmes-Snowden, MHA^3*, Olga Better, MS^3*, Nury M. Steuerwald, PhD⁴, Wei Sha, PhD^5*, Lawrence J. Druhan, PhD³ and Michael R. Grunwald, MD¹

¹Department of Hematologic Oncology and Blood Disorders, Atrium Health Levine Cancer Institute, Charlotte, NC
²Immune Monitoring Core Laboratory, Atrium Health Levine Cancer Institute, Charlotte, NC
³Hematology Oncology Translational Research Laboratory, Atrium Health Levine Cancer Institute, Charlotte, NC
⁴Molecular Biology Core Laboratory, Atrium Health Levine Cancer Institute, Charlotte, NC
⁵Department of Biostatistics and Data Sciences, Atrium Health Levine Cancer Institute, Charlotte, NC

Marie Demmerle^1*, Alessa Klär^1*, Alexander Streuer, MD^2*, Vladimir Riabov^1*, Eva Altrock^1*, Felicitas Rapp^1*, Ann-Christin Belzer^1*, Teresa Klink^1*, Meret Hahn^1*, Franziska Hofmann^1*, Verena Nowak^1*, Nadine Weimer^1*, Julia Oblaender^1*, Iris Palme^1*, Melda Göl^1*, Ali Darwich, MD^3*, Mohammed Abba, MD^2*, Georgia Metzgeroth, MD^1*, Wolf-Karsten Hofmann, MD², Daniel Nowak, MD^2* and Nanni Schmitt^1*

¹Department of Hematology and Oncology, Medical Faculty Mannheim of the Heidelberg University, Mannheim, Germany
²Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
³Department of Orthopedic Surgery, Medical Faculty Mannheim of the Heidelberg University, Mannheim, Germany

Lamis Naddaf, PhD¹, Marco De Dominici, PhD², Xiaowen Chen, PhD^3*, Parveen Kumar, PhD^3*, James S Chavez^4*, Travis Roeder^5*, Shilpita Karmakar, PhD³, Eric M. Pietras, PhD⁶, Hideyuki Oguro, PhD⁷, James DeGregori, PhD^8* and Sheng Li, PhD^9*

¹USC Keck School of Medicine - University of Southern California, Farmington, CT
²University of Colorado Anschuz Medical Campus, Aurora, CO
³Jackson Laboratory, Farmington, CT
⁴Cancer Institute, Stanford University School of Medicine, Stanford, CA
⁵University of Connecticut School of Medicine, Farmington, CT
⁶Division of Hematology, Department of Medicine, University of Colorado, Aurora, CO
⁷University of Connecticut Health Center, Farmington, CT
⁸University of Colorado Anschutz Medical Campus, Aurora, CO
⁹Biochemistry and Molecular Medicine, University of Southern California, Los Angeles, CA

Ridzky A. A. Yuda, PhD^1*, Valerie Kellet, BS^1*, Haruna B. Choijilsuren, BS^1*, Zewen Ha^1*, Fan Yang, MS^1* and Moonjung Jung, MD, MS^1,2,3

¹Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
²Sidney Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD
³Division of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD

Michael Spencer Chapman, MBBS^1,2*, Emily Mitchell, FRCPath^3*, Kenichi Yoshida, MD, PhD⁴, Nicholas Williams, PhD^3*, Margarete A. Fabre^5,6*, Anna Maria Ranzoni, PhD^3*, Philip S. Robinson^3*, Lori Kregar, MPhil^3*, C. Matthias Wilk^7*, Steffen Boettcher, MD^8*, Krishnaa Mahbubani^9*, Kourosh Saeb-Parsy^9*, Stanley Ng^3*, George S Vassiliou, MD, PhD^6,10, Kate Gowers^11*, Sam Janes^12*, Matt Hoare^13*, Anthony R Green¹⁴, Ana Cvejic^15,16*, Markus G. Manz, MD¹⁷, Elisa Laurenti, PhD^18,19*, Inigo Martincorena^3*, Michael Stratton^3*, Jyoti Nangalia, MBBChir PhD³, Tim H.H. Coorens, PhD^3,20* and Peter Campbell, PhD^3*

¹Barts Cancer Institute, Department of Haemato-oncology, London, United Kingdom
²Wellcome Sanger Institute, London, ENG, United Kingdom
³Wellcome Sanger Institute, Hinxton, United Kingdom
⁴Division of Cancer Evolution, National Cancer Center Research Institute, Tokyo, Japan
⁵Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom
⁶Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom
⁷University of Zurich and University Hospital Zurich, Department of Medical Oncology and Hematology, Zurich, Switzerland
⁸Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Zurich, Zurich, Switzerland
⁹University of Cambridge, Cambridge, GBR
¹⁰Department of Haematology and Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
¹¹UCL Respiratory, University College London, Lungs For Living Research Centre, London, United Kingdom
¹²UCL Respiratory, University College London,, Lungs For Living Research Centre, London, United Kingdom
¹³Early Cancer Institute, Cambridge, United Kingdom
¹⁴University of Cambridge, Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom
¹⁵University of Cambridge, Cambridge, ENG, United Kingdom
¹⁶University of Copenhagen, Biotech Research & Innovation Centre (BRIC), Copenhagen, Denmark
¹⁷Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Zurich, Switzerland
¹⁸Department of Hematology, Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
¹⁹Department of Haematology, University of Cambridge, Cambridge, ENG, United Kingdom
²⁰Broad Institute of MIT and Harvard, Cambridge, MA

Mael Heiblig, MD, PhD^1*, Vincent Jachiet^2*, Jerome Hadjadj, MD, PhD^3,4*, Lin Pierre Zhao, MD, PhD^5*, Thibault Comont^6*, Hervé Lobbes^7*, Valentin Lacombe^8*, Anne Blandine Boutin^9*, Joris Galland^10*, Yesim Dargaud, MD, PhD¹¹, Benjamin Terrier, MD, PhD^12*, Sophie Georgin-Lavialle^13*, Pierre Fenaux, MD^14,15,16 and Arsene Mekinian, MD, PhD^2*

¹Centre Hospitalier Lyon Sud, Pierre Bénite, France
²Saint Antoine Hospital AP-HP, Paris, France
³Saint Antoine Hospital, APHP, Paris, France
⁴INSERM UMR 1163-Institut Imagine, PARIS, FRA
⁵Hôpital Saint-Louis, Université de Paris 7, Paris, France
⁶Internal Medicine and Immune Diseases, University Hospital Toulouse - Cancer Institute, Toulouse, France
⁷Clermont-Ferrand University Hospital, Clermont-Ferrand, FRA
⁸Angers University Hospital, Angers, France
⁹Centre Alpes Lémant, Contamine S/ Arve, FRA
¹⁰Département de médecine interne, CH Bourg en Bresse, Bourg en Bresse, France
¹¹Hopital Louis Pradel, Hemophilia Center and Clinical Haemostasis Unit, France, Lyon, France
¹²Department of Internal Medicine, National Referral Center for Rare and Systemic Autoimmune Diseases, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France
¹³INSERM and AP-HP, Paris, FRA
¹⁴INSERM UMR-S1131 Institut de la Recherche Saint Louis, Univeristy Paris Cité, Paris, France
¹⁵EuroBloodNet, Paris, France
¹⁶Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France

Zachary Brady^1*, Nakisha D Williams, MBBS^1*, Arda Durmaz, PhD^2*, Luca Guarnera, MD^1,3*, Matteo D'Addona^1,4*, Aashray Mandala, BS^1*, Heesun J. Rogers, MD^5*, Carmelo Gurnari, MD, PhD^1,3, Jaroslaw Maciejewski¹, Carlos Bravo-Perez, MD^1,6* and Valeria Visconte, PhD⁷

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, CLEVELAND, OH
³Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
⁴Department of Medicine and Surgery, University of Salerno, University of Salerno, Baronissi, Salerno, Italy
⁵Diagnostics Institute, Robert J. Tomsich Department of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH
⁶Department of Hematology and Medical Oncology, Hospital Universitario Morales Meseguer, University of Murcia, IMIB-Pascual Parrilla, CIBERER - Instituto de Salud Carlos III, Murcia, Spain
⁷Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH